ATE468403T2 - Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine - Google Patents

Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine Download PDF

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Publication number
ATE468403T2
ATE468403T2 AT98966468T AT98966468T ATE468403T2 AT E468403 T2 ATE468403 T2 AT E468403T2 AT 98966468 T AT98966468 T AT 98966468T AT 98966468 T AT98966468 T AT 98966468T AT E468403 T2 ATE468403 T2 AT E468403T2
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AT
Austria
Prior art keywords
vaccine
extraction
cps
proteins
isolation
Prior art date
Application number
AT98966468T
Other languages
English (en)
Inventor
Francis Michon
Milan Blake
Original Assignee
Baxter Healthcare Sa
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Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
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Publication of ATE468403T2 publication Critical patent/ATE468403T2/de

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
AT98966468T 1997-12-23 1998-12-23 Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine ATE468403T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6860897P 1997-12-23 1997-12-23
PCT/US1998/027375 WO1999032653A1 (en) 1997-12-23 1998-12-23 Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugates vaccines

Publications (1)

Publication Number Publication Date
ATE468403T2 true ATE468403T2 (de) 2010-06-15

Family

ID=22083630

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98966468T ATE468403T2 (de) 1997-12-23 1998-12-23 Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine

Country Status (14)

Country Link
US (1) US6248570B1 (de)
EP (3) EP3118225A1 (de)
JP (2) JP4435413B2 (de)
KR (2) KR100757630B1 (de)
AT (1) ATE468403T2 (de)
AU (1) AU754256C (de)
CA (1) CA2316975C (de)
CZ (1) CZ302615B6 (de)
DE (1) DE69841676D1 (de)
DK (1) DK1051506T4 (de)
ES (2) ES2611464T3 (de)
HU (1) HUP0100623A3 (de)
NO (1) NO331100B1 (de)
WO (1) WO1999032653A1 (de)

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US7923437B2 (en) * 2001-02-16 2011-04-12 Cargill, Incorporated Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same
US7816514B2 (en) 2001-02-16 2010-10-19 Cargill, Incorporated Glucosamine and method of making glucosamine from microbial biomass
US20020115639A1 (en) * 2001-02-16 2002-08-22 Weiyu Fan Glucosamine and method of making glucosamine from microbial blomass
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US20060003965A1 (en) * 2002-11-01 2006-01-05 Fosdick Lawrence D N-acetyl-d-glucosamine (nag) supplemented food products and beverages
ES2461350T3 (es) 2003-01-30 2014-05-19 Novartis Ag Vacunas inyectables contra múltiples serogrupos de meningococos
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CA2604363C (en) 2005-04-08 2015-06-16 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
AU2011253684B8 (en) * 2005-04-08 2013-07-11 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
AU2006283302B2 (en) * 2005-08-24 2012-11-15 Novartis Vaccines And Diagnostics Srl Zwitterionization of capsular saccharides
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GB0605757D0 (en) * 2006-03-22 2006-05-03 Chiron Srl Separation of conjugated and unconjugated components
PL2004225T3 (pl) 2006-03-22 2012-09-28 Novartis Ag Schematy immunizacji koniugatami meningokokowymi
US10828361B2 (en) 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
US8808707B1 (en) 2006-05-08 2014-08-19 Wyeth Llc Pneumococcal dosing regimen
EP1872791A1 (de) 2006-06-30 2008-01-02 Institut Pasteur Verwendung von Polysacchariden bakteriellen Ursprungs zur Hemmung der Bildung von Biofilmen
JP2010520320A (ja) 2007-02-28 2010-06-10 リポクセン テクノロジーズ リミテッド ポリシアル酸におけるエンドトキシンの低減
ES2665002T3 (es) 2007-03-05 2018-04-24 Om Pharma Extracto bacteriano para trastornos respiratorios y procedimiento para su preparación
PT2129693T (pt) * 2007-03-23 2017-02-14 Wyeth Llc Processo de purificação abreviado para a produção de polissacáridos capsulares de streptococcus pneumoniae
GB0818453D0 (en) 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
JP5339243B2 (ja) * 2008-04-24 2013-11-13 株式会社微生物化学研究所 ストレプトコッカス・スイス感染症予防用ワクチン
WO2011005587A1 (en) * 2009-06-24 2011-01-13 University Of Dubuque Vaccine compositions and methods of use to protect against infectious disease
BR112013024322B1 (pt) * 2011-03-22 2020-04-22 Serum Inst India Ltd processo para preparação de polissacarídeos
US9400250B2 (en) 2013-09-30 2016-07-26 Han Sheng Biotech Co., Ltd. Method for analyzing mushrooms
MY186874A (en) * 2014-02-25 2021-08-26 Msd Wellcome Trust Hilleman Laboratories Pvt Ltd A novel downstream process for purifying polysaccharides
EP2942396A1 (de) 2014-05-07 2015-11-11 Novartis AG Durch CPSC-Mutanten hergestellte Polysaccharide
EP3034516A1 (de) * 2014-12-19 2016-06-22 Novartis AG Reinigung von Streptokokkenkapselpolysaccharid
PE20220774A1 (es) 2015-05-04 2022-05-16 Pfizer Conjugados proteina-polisacarido de estreptococo grupo b, metodos para producir conjugados, composiciones inmunogenas que comprenden conjugados y sus usos
EP3551668A1 (de) * 2016-12-06 2019-10-16 GlaxoSmithKline Biologicals S.A. Reinigungsverfahren für kaspelpolysaccharid
JP7319929B2 (ja) * 2017-05-05 2023-08-02 セラム インスティテュート オブ インディア プライベート リミティド 細菌性莢膜多糖ベース調製物からの不純物の除去方法
EP3649247A4 (de) * 2017-07-05 2021-03-31 Inventprise, LLC. Reinigung von polysacchariden zur herstellung von impfstoffen unter verwendung lytischer enzyme, tangentialer strömungsfiltration und multimodaler chromatographie
PT3678654T (pt) 2017-09-07 2024-08-05 Merck Sharp & Dohme Llc Polissacáridos pneumocócicos e sua utilização em conjugados imunogénicos de polissacárido-proteína transportadora
FR3078977B1 (fr) 2018-03-16 2023-03-17 Biomerieux Sa Procede d'extraction d'acides nucleiques
JP2023546446A (ja) * 2020-10-22 2023-11-02 ファイザー・インク 細菌多糖を精製する方法
CN117512031B (zh) * 2023-10-16 2024-06-25 江苏金迪克生物技术股份有限公司 一种肺炎球菌荚膜多糖的纯化方法

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Also Published As

Publication number Publication date
US6248570B1 (en) 2001-06-19
JP5144613B2 (ja) 2013-02-13
JP2010011862A (ja) 2010-01-21
AU754256B2 (en) 2002-11-07
CA2316975C (en) 2009-03-24
JP4435413B2 (ja) 2010-03-17
EP1051506B8 (de) 2010-09-01
KR20060086978A (ko) 2006-08-01
DE69841676D1 (de) 2010-07-01
ES2611464T3 (es) 2017-05-09
EP2226336A1 (de) 2010-09-08
AU2307199A (en) 1999-07-12
EP1051506A1 (de) 2000-11-15
JP2001526902A (ja) 2001-12-25
KR20010033494A (ko) 2001-04-25
HUP0100623A3 (en) 2003-11-28
CZ20002373A3 (cs) 2000-12-13
CZ302615B6 (cs) 2011-08-03
EP3118225A1 (de) 2017-01-18
KR100757630B1 (ko) 2007-09-10
NO20003226D0 (no) 2000-06-21
AU754256C (en) 2004-05-20
NO331100B1 (no) 2011-10-03
HUP0100623A2 (hu) 2001-06-28
KR100641490B1 (ko) 2006-10-31
HK1147506A1 (en) 2011-08-12
DK1051506T3 (da) 2010-09-13
EP2226336B1 (de) 2016-10-19
WO1999032653A1 (en) 1999-07-01
EP1051506B2 (de) 2019-08-21
EP1051506B1 (de) 2010-05-19
DK1051506T4 (da) 2019-10-21
CA2316975A1 (en) 1999-07-01
ES2346022T3 (es) 2010-10-07
WO1999032653A9 (en) 1999-10-28

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