JP2004155778A - Nourishing tonic containing ubiquinone - Google Patents

Abstract

An object of the present invention is to provide an effective and safe nutritional tonic for modern physical and mental fatigue such as general malaise, eye fatigue, stiff shoulders, and numbness in limbs.
A nourishing tonic comprising ubiquinone and red ginseng. Or a nutritional tonic comprising at least 2.5 parts by mass of red ginseng per 1 part by mass of ubiquinone.
[Selection diagram] None

Description

  The present invention relates to a tonic, and more particularly to a tonic containing ubiquinone.

  Ubiquinone plays an important role in energy metabolism in the cytochrome electron transport system in biological mitochondria, has the effect of promoting oxidative phosphorylation, improves oxygen utilization efficiency under hypoxic conditions, and improves ATP (adenosine triphosphate). It is known that acid) production efficiency is increased. In addition, pharmacological actions for improving symptoms of angina, heart failure, ischemic heart disease, and muscular dystrophy have been clinically recognized (see Non-Patent Document 1).

  On the other hand, it is widely known that a nutritional tonic crude drug has a blood flow improving effect, an antithrombotic effect, an inotropic effect, a cardiac blood flow increasing effect, an anti-fatigue effect and the like.

  Then, a combination of ubiquinone and a nutrient tonic crude drug was developed to provide a more effective and safe nutrient tonic than conventional ones (see Patent Document 1).

  Here, ginseng is simply mentioned as a nourishing tonic, which refers to the root of Panax ginseng C.A. Meyer. However, Panax ginseng is classified into white ginseng, raw ginseng, red ginseng, etc. according to the preparation method, and it has been reported that red ginseng has different component composition and pharmacological action from white ginseng and raw ginseng. (See Non-Patent Document 2).

JP-A-7-278002 Takashi Katagiri, Basics and Clinical Practice, Vol. 30, p. 1559, 1996 14th Revision of the Japanese Pharmacopoeia, Hirokawa Shoten, 2001, p. D-363

  For modern people who are exposed to various stresses due to the progress of OA in offices, modern physical and mental fatigue such as general malaise, eye fatigue, stiff shoulders and numbness of limbs have become a serious social problem. .

  Therefore, it is still a great challenge to provide a safe and effective nutritional tonic for modern physical and mental fatigue.

  The present inventors have conducted intensive studies to solve the above problems, and as a result, among various nutrient tonic crude drugs, ginseng, particularly a nutrient tonic formulated by combining red ginseng with ubiquinone, enhances energy production in a living body and improves blood circulation. Has been found to be extremely effective in promoting modern physical fatigue.

  One embodiment of the present invention, which has been completed based on such findings, is a nutritional tonic comprising ubiquinone and red ginseng.

  ADVANTAGE OF THE INVENTION According to this invention, it became possible to provide an effective and safe nutrient tonic for modern physical fatigue and mental fatigue such as general malaise, eye fatigue, stiff shoulders, and numbness of limbs.

  Another embodiment of the present invention is a nutritional tonic, characterized by containing red ginseng in an amount of 2.5 parts by mass or more as a crude drug per 1 part by mass of ubiquinone.

  "Ubiquinone" used in the present invention is named as a quinone widely existing in living organisms, and is also called CoQ10 because it was essential for electron transfer in mitochondria. At present, it is clear at present that CoQ is a benzoquinone derivative (2,3-dimetoxy-5-methyl-6-polyprenyl-1,4-benzoquinone) having an isoprene unit of n = 1 to 12 in nature. In higher animals, CoQ10 is mainly used.

  In eukaryotes, the quinone skeleton is derived from tyrosine, the isoprenoid chain is derived from mevalonic acid, and the other side chains are derived from methionine. Synthetic enzymes from tyrosine and isopentenyl pyrophosphate to ubiquinone are present in the inner mitochondrial membrane system.

  The term “red ginseng” used in the present invention is obtained by steaming the roots of Panax ginseng (Panax ginseng CA Meyer), and removing the roots of the Panax ginseng excluding the fine roots or lightly blanched the roots (white ginseng, raw dried ginseng, Ginseng) is different from the others in the component composition and pharmacological action, and is also distinguished in the Japanese Pharmacopoeia.

  The general pharmacological actions of red ginseng include blood flow improving, cardiac blood flow increasing, blood coagulation inhibitory, antithrombin, platelet aggregation inhibitory, thrombolytic, anti-inflammatory, anti-fatigue, and anti-stress effects. It has been known.

  The amount of red ginseng is 2.5 parts by mass or more in terms of a crude drug per 1 part by mass of ubiquinone, and preferably 2.5 to 1000 parts by mass, 600 parts by mass is more preferable, and 5 to 400 parts by mass is further preferable.

  In the present invention, the effective dose of ubiquinone is 5 to 100 mg per day for an adult, preferably 20 to 60 mg. The effective dose of red ginseng is 100 to 5000 mg / day, preferably 500 to 3000 mg / day for an adult in terms of a crude drug.

  The ubiquinone-containing nutrient tonic of the present invention may be used as it is or as necessary with other known additives such as excipients, disintegrants, binders, lubricants, antioxidants, coating agents, coloring agents, and flavors. Oral preparations such as granules, powders, capsules, tablets, dry syrups and liquids can be prepared in a conventional manner by adding a flavoring agent, a surfactant, a plasticizer and the like.

  Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples. Each crude drug is incorporated as an extract, and the equivalent amount of the crude drug is indicated in parentheses.

Example 1
Ubiquinone 50 mg
Kojin 70 mg (1000 mg)
Taurine 1500 mg
dl-carnitine chloride 50 mg
Vitamin A 2000 mg
Vitamin B1 20 mg
Vitamin B2 12 mg
Vitamin B6 5 mg
Vitamin B12 10 mg
Vitamin C 90 mg
Vitamin E 10 mg
Nicotinamide 20 mg
Calcium pantothenate 30 mg
Lactose 500 mg
Corn starch 245 mg
33 mg of magnesium metasilicate aluminate
Light silicic anhydride 40 mg
Low-substituted hydroxypropylcellulose 50 mg
Hydroxypropyl cellulose 50 mg
957 g of the powder having the above composition was stirred and granulated by a wet method, and dried by a fluidized bed drier. The mixture was classified with a 24 mesh sieve, and the sieve residue was coarsely crushed. 2 g of magnesium stearate was added thereto and mixed to obtain granules for tableting. The granules for tableting were tableted with a tableting machine to obtain tablets weighing 200 mg per tablet.

Example 2
Ubiquinone 30 mg
Taurine 1500 mg
Royal jelly 200 mg
Red ginseng 42 mg (600 mg)
Astragalus 0.6 mL (600 mg)
Koujou 30 mg (600 mg)
Vitamin B1 5 mg
2.5 mg of vitamin B2
Vitamin B6 5 mg
Nicotinamide 20 mg
Inositol 100 mg
Caffeine 40 mg
Sodium malate 100 mg
Polyglycerin fatty acid ester 20 mg
Polyoxyethylene hydrogenated castor oil 60 10 mg
10 g sucrose
Citric acid suitable amount (pH 4.5)
The above-mentioned components were dissolved in purified water and sterilized by heating to obtain a total amount of 50 mL of an oral solution.

Example 3
Ubiquinone 30 mg
Muirapuama 15 mg (300 mg)
Red ginseng 80 mg (1200 mg)
Ground yellow 150 mg (300 mg)
0.3 g (300 mg)
Toki 0.05mg (50mg)
Astragalus 0.3 mL (300 mg)
Yellow spirit 0.3 mL (300mg)
Licorice 37.5 mg (150 mg)
Deer mushroom 1.08mL (300mg)
100ml of sheep kaku (1000mg)
Anti-nose 1.25mL (250mg)
Cinnamon bar 0.15mL (150mg)
Bukuryo 9.6 mg (300 mg)
Taurine 1000 mg
Vitamin B2 5 mg
Vitamin B6 5 mg
Nicotinamide 20 mg
Caffeine 50 mg
7 g sucrose
2.5 g of xylitol
Sodium malate 100 mg
Citric acid suitable amount (pH 4.5)
Polyoxyethylene hydrogenated castor oil 60 20 mg
Benzoic acid 30 mg
The above-mentioned components were dissolved in purified water and sterilized by heating to obtain a total amount of 50 mL of an oral solution.

Example 4
A herbal medicine having a mass composition of ginseng 1, cinnamon bark 1, astragalus 1, ripening ground yellow 1, shakuyaku 1, kawakyu (senkyu) 1, shiatsujutsu 1, toki 1, bukuryo 1, licorice 0.5 is prepared by water in a conventional manner. Extract extracted by heating with water and concentrated, 1500 mg of extract, 110 mg of red ginseng extract (equivalent to crude drug: 1500 mg), 50 mg of ubiquinone, 500 mg of lactose, 245 mg of corn starch, 37.5 mg of magnesium aluminate metasilicate, light anhydrous silicic acid 1300 g of a powder having a composition of 37.5 mg, low-substituted hydroxypropylcellulose 60 mg and hydroxypropylcellulose 60 mg was wet-stirred and granulated, and dried by a fluidized bed drier. The mixture was classified with a 30-mesh sieve, and the sieve residue was roughly crushed. 20 g of magnesium stearate was added thereto and mixed, and the obtained granules were divided into 1.5 g portions to obtain granules.

Example 5
A crude drug having a mass ratio composition of ground yellow 2, zawaha 1, bukuryo 1, botan skin 1, sanshuyu 1, mountain medicine 1, tomoha 1, yellow kashiwa 0.66 is extracted by heating with water in a conventional manner and concentrated. Extract 900 mg, red ginseng extract 72 mg (crude drug equivalent: 1000 mg), ubiquinone 30 mg, vitamin E 10 mg, nicotinamide 20 mg, lactose 500 mg, corn starch 245 mg, magnesium aluminate metasilicate 35.5 mg, light anhydrous silicic acid 37.5 mg Then, 975 g of powder composed of 50 mg of low-substituted hydroxypropylcellulose and 50 mg of hydroxypropylcellulose were dry-granulated, and 25 g of magnesium stearate and 100 g of talc were added and mixed, followed by crushing. The mixture was classified with a 24 mesh sieve, and the sieve residue was coarsely crushed. The obtained granules were filled into No. 1 capsules by 400 mg each to obtain capsules.

Test example 1
Experimental material: ubiquinone, red ginseng extract, white ginseng extract Experimental animal: ICR male mouse (6 weeks old, purchased from Charles River)
Test method: Endotoxin-induced lethality test This was performed according to the method of Sugino et al. (Surgery, 101, 746-752, 1987). Mice were orally administered (suspended in 0.2% sodium carboxymethylcellulose, 0.1 mL / 10 g) once a day for 3 consecutive days, and corresponded to 80% lethal dose 1 hour after the final oral administration. Endotoxin (30.3 mg / kg; dissolved in physiological saline) was intraperitoneally administered. The time from endotoxin administration to death of the mice due to endotoxin shock was measured over time until 36 hours after endotoxin administration, and the efficacy of the drug was evaluated. Table 1 shows the results.

  In the calculation of the average survival time of each group, the survival time of the mice surviving 36 hours was set to 36 hours.

Experimental result (combination effect of ubiquinone and red ginseng or white ginseng)
The survival rate of the control group was 20.0%, and the average survival time was 29.3 ± 1.1 hours. The average survival times of ubiquinone 6.0 mg / kg, red ginseng extract 250 mg / kg and white ginseng extract 250 mg / kg alone were 30.1 ± 1.0, 30.7 ± 1.0 and 30.8 ±, respectively. 1.1 hours. The average survival time in the combined administration of red ginseng extract 250 mg / kg and ubiquinone 6.0 mg / kg was extended to 33.8 ± 0.7 hours, and ubiquinone alone administration group, red ginseng extract alone administration group, white ginseng extract + Compared with the ubiquinone combination administration group, the average survival time was 31.4 ± 1.0 hours when combined with 250 mg / kg of white ginseng extract + 6.0 mg / kg of ubiquinone, which showed a significant survival time prolonging effect. .

  From the above, it became clear that red ginseng has a greater effect of enhancing the nutritive tonic effect of ubiquinone than white ginseng.

Test example 2
Experimental material: ubiquinone, red ginseng extract, white ginseng extract, ground yellow extract Experimental animal: SD male rat (8 weeks old, purchased from Charles River)
Test method: Anti-fatigue test The anti-fatigue test was evaluated using spontaneous movement after forced walking as an index. That is, the sample was orally administered daily for 3 days, and 2 hours after the final administration, the rats were forcedly walked at a speed of 3.0 m / min for 22 hours (16: 00 to 00: 00) using a forced walking device (manufactured by Nagasawa Rikagaku Kikai). 14:00 the next day). The self-issued momentum (Supermex; manufactured by Muromachi Kikai Co., Ltd.) for 12 hours from 5 hours after the end of walking was measured to evaluate the efficacy of the drug. The results are shown in FIG.

Experimental results (combination effect of ubiquinone and red ginseng, white ginseng or ground yellow)
The activity amount of the normal (non-walking) group at night (19:00 to 7:00 the next day) is 50748 ± 1333 count / 12 hours, and the activity amount of the control (walking load) group is 18972 ± 2219 count / It decreased significantly at 12 hours. The single administration group of ubiquinone 300 mg / kg and red ginseng extract 300 mg / kg significantly suppressed the decrease in locomotor activity due to walking load, and the single administration group of white ginseng extract 300 mg / kg and ground yellow extract 300 mg / kg suppressed locomotor activity. A tendency was observed. In contrast, when ubiquinone 300 mg / kg and red ginseng extract 300 mg / kg were administered in combination, the decrease in the amount of behavior was significantly suppressed as compared to those administered alone. On the other hand, even when ubiquinone was administered in combination with the white ginseng extract and the ground yellow extract, almost no increase in the action of ubiquinone for suppressing the decrease in the amount of action was observed.

  The present invention is expected to be applied to medicines, quasi-drugs, and foods that are effective and safe for physical and mental fatigue.

It is a graph which shows the action-amount reduction inhibitory action after forced walking of each administration group (Test Example 2).

Claims (2)

  A nourishing tonic comprising ubiquinone and red ginseng. A nutrient tonic comprising at least 2.5 parts by mass of red ginseng as a crude drug per 1 part by mass of ubiquinone.

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