JP2004508417A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004508417A5 JP2004508417A5 JP2002526417A JP2002526417A JP2004508417A5 JP 2004508417 A5 JP2004508417 A5 JP 2004508417A5 JP 2002526417 A JP2002526417 A JP 2002526417A JP 2002526417 A JP2002526417 A JP 2002526417A JP 2004508417 A5 JP2004508417 A5 JP 2004508417A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- proteins
- cbpx
- vaccine
- truncated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 11
- 230000002163 immunogen Effects 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 229960005486 vaccine Drugs 0.000 description 5
- 101100420868 Anuroctonus phaiodactylus phtx gene Proteins 0.000 description 3
- 241000193998 Streptococcus pneumoniae Species 0.000 description 3
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 3
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 101710099976 Photosystem I P700 chlorophyll a apoprotein A1 Proteins 0.000 description 2
- 101710183389 Pneumolysin Proteins 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 206010033078 Otitis media Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0022742.1A GB0022742D0 (en) | 2000-09-15 | 2000-09-15 | Vaccine |
| GB0022742.1 | 2000-09-15 | ||
| PCT/EP2001/010570 WO2002022168A2 (en) | 2000-09-15 | 2001-09-12 | Vaccine against streptococcus pneumoniae |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004508417A JP2004508417A (ja) | 2004-03-18 |
| JP2004508417A5 true JP2004508417A5 (2) | 2008-10-23 |
| JP4880184B2 JP4880184B2 (ja) | 2012-02-22 |
Family
ID=9899575
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526416A Expired - Fee Related JP4903975B2 (ja) | 2000-09-15 | 2001-09-12 | ワクチン |
| JP2002526417A Expired - Fee Related JP4880184B2 (ja) | 2000-09-15 | 2001-09-12 | ワクチン |
| JP2011198277A Pending JP2012006969A (ja) | 2000-09-15 | 2011-09-12 | ワクチン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526416A Expired - Fee Related JP4903975B2 (ja) | 2000-09-15 | 2001-09-12 | ワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011198277A Pending JP2012006969A (ja) | 2000-09-15 | 2011-09-12 | ワクチン |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US20060051361A1 (2) |
| EP (6) | EP2140878B1 (2) |
| JP (3) | JP4903975B2 (2) |
| KR (5) | KR101268790B1 (2) |
| CN (3) | CN1253205C (2) |
| AT (1) | ATE516815T1 (2) |
| AU (4) | AU2002220548B2 (2) |
| BR (2) | BR0113822A (2) |
| CA (2) | CA2421998C (2) |
| CY (1) | CY1111915T1 (2) |
| CZ (2) | CZ305343B6 (2) |
| DK (1) | DK1317279T3 (2) |
| ES (4) | ES2659400T3 (2) |
| GB (1) | GB0022742D0 (2) |
| HU (2) | HUP0301043A3 (2) |
| IL (4) | IL154608A0 (2) |
| MX (2) | MXPA03002265A (2) |
| NO (2) | NO336186B1 (2) |
| NZ (2) | NZ524286A (2) |
| PL (2) | PL209247B1 (2) |
| PT (1) | PT1317279E (2) |
| SI (1) | SI1317279T1 (2) |
| WO (2) | WO2002022168A2 (2) |
| ZA (2) | ZA200301524B (2) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7078042B2 (en) * | 1995-09-15 | 2006-07-18 | Uab Research Foundation | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| US7115731B1 (en) | 1997-07-02 | 2006-10-03 | sanofi pasteur limited/ sanofi pasteur limiteé | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| US20010016200A1 (en) | 1998-04-23 | 2001-08-23 | Briles David E. | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| ATE459373T1 (de) * | 1999-03-19 | 2010-03-15 | Glaxosmithkline Biolog Sa | Impfstoff gegen kapsulare polysaccharide von streptococcus pneumoniae |
| US7074415B2 (en) * | 2000-06-20 | 2006-07-11 | Id Biomedical Corporation | Streptococcus antigens |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| EP1456231A2 (en) | 2001-12-20 | 2004-09-15 | Shire Biochem Inc. | Streptococcus antigens |
| EP2275122A3 (en) * | 2002-04-02 | 2011-05-18 | Ben Gurion University Of The Negev Research And Development Authority | Protein-based streptococcus pneumoniae vaccines |
| US8691243B2 (en) | 2002-04-02 | 2014-04-08 | Ben-Gurion University Of The Negev Research And Development Authority | Protein-based Streptococcus pneumoniae vaccine |
| HUE031886T2 (en) | 2002-10-11 | 2017-08-28 | Glaxosmithkline Biologicals Sa | Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| US8229903B2 (en) * | 2002-12-19 | 2012-07-24 | International Business Machines Corporation | Suggesting data interpretations and patterns for updating policy documents |
| EP2172213B1 (en) | 2003-01-30 | 2013-04-03 | Novartis AG | Injectable vaccines against multiple meningococcal serogroups |
| RU2340627C2 (ru) | 2003-03-13 | 2008-12-10 | ГлаксоСмитКлайн Байолоджикалз с.а. | Способ очистки бактериального цитолизина |
| EP1477802A1 (en) * | 2003-05-16 | 2004-11-17 | Erasmus Universiteit Rotterdam | Method for selecting and producing vaccine components and vaccines based thereon |
| NZ546430A (en) | 2003-10-02 | 2009-04-30 | Novartis Vaccines & Diagnostic | Liquid vaccines for multiple meningococcal serogroups |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| MX2007003292A (es) * | 2004-09-21 | 2007-09-07 | Sanofi Pasteur Inc | Conjugados y vacuna con proteinas de polisacarido derivadas meningococales multivalentes. |
| EP3311836A1 (en) | 2005-04-08 | 2018-04-25 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| AU2011253684B8 (en) * | 2005-04-08 | 2013-07-11 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| GB0522765D0 (en) | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| KR101515078B1 (ko) | 2005-12-22 | 2015-04-24 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| CA2635208C (en) * | 2005-12-28 | 2018-03-20 | The Uab Research Foundation | Streptococcus pneumonia having a capsular polysaccharide repeating unit {>2)glucose 1(1>3) glucose 2 (1>3) rhamnose (1>3)ribitol (5>phosphate} |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| WO2008022299A1 (en) * | 2006-08-17 | 2008-02-21 | The Uab Research Foundation | Diagnosing pneumococcal pneumonia |
| JP5331105B2 (ja) * | 2007-05-24 | 2013-10-30 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 凍結乾燥抗原組成物 |
| CA2690708A1 (en) | 2007-06-26 | 2008-12-31 | Glaxosmithkline Biologicals S.A. | Vaccine |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| WO2009012588A1 (en) | 2007-07-23 | 2009-01-29 | Sanofi Pasteur Limited | Immunogenic polypeptides and monoclonal antibodies |
| US20160228500A9 (en) * | 2007-07-23 | 2016-08-11 | Martina Ochs | Immunogenic Polypeptides and Monoclonal Antibodies |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| WO2009033742A2 (en) * | 2007-09-14 | 2009-03-19 | Katholieke Universiteit Leuven | Streptococcus pneumoniae vaccines |
| EP2235531B1 (en) * | 2008-02-01 | 2015-01-14 | Sanofi Pasteur Limited | Assay for diagnosing streptococcus pneumoniae |
| CN102015651B (zh) | 2008-03-03 | 2014-12-31 | Irm责任有限公司 | 作为tlr活性调节剂的化合物和组合物 |
| EP3017826A1 (en) | 2009-03-24 | 2016-05-11 | Novartis AG | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| JP5867952B2 (ja) | 2009-06-10 | 2016-02-24 | ノバルティス アーゲー | ベンゾナフチリジン含有ワクチン |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| WO2011027222A2 (en) | 2009-09-02 | 2011-03-10 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| US20120237536A1 (en) | 2009-09-10 | 2012-09-20 | Novartis | Combination vaccines against respiratory tract diseases |
| CN101690810B (zh) * | 2009-10-21 | 2011-08-17 | 辽宁益康生物股份有限公司 | 一种鸡新城疫、传染性支气管炎、减蛋综合征、禽流感四联灭活疫苗佐剂及其制备方法 |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| BR112012014624A8 (pt) | 2009-12-15 | 2017-12-26 | Novartis Ag | suspensão homogênea de compostos de imunopotenciação e usos dos destes |
| CN102939105B (zh) | 2009-12-22 | 2016-11-16 | 赛诺菲巴斯德有限公司 | 免疫原性组合物和相关的方法 |
| AU2010335970B2 (en) * | 2009-12-22 | 2016-11-03 | Sanofi Pasteur Limited | Immunogenic compositions |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| GB201003920D0 (en) * | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
| EA031379B1 (ru) | 2010-03-23 | 2018-12-28 | Новартис Аг | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний |
| WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
| MX2013006255A (es) * | 2010-12-03 | 2015-08-05 | Sanofi Pasteur Ltd | Composicion para inmunizacion contra streptococcus pneumoniae. |
| CN103533953A (zh) * | 2011-05-17 | 2014-01-22 | 葛兰素史密丝克莱恩生物有限公司 | 针对肺炎链球菌的疫苗 |
| JP2015510872A (ja) | 2012-03-07 | 2015-04-13 | ノバルティス アーゲー | Ｓｔｒｅｐｔｏｃｏｃｃｕｓｐｎｅｕｍｏｎｉａｅ抗原の増強された製剤 |
| JP2014000016A (ja) * | 2012-06-15 | 2014-01-09 | National Agriculture & Food Research Organization | 豚丹毒菌の新規な抗原タンパク質、その遺伝子、及び組換えベクターとその利用 |
| RU2510281C2 (ru) * | 2012-06-22 | 2014-03-27 | Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") | ВАКЦИНА ПРОТИВ ПНЕВМОНИИ, ВЫЗЫВАЕМОЙ Streptococcus pneumoniae, НА ОСНОВЕ ГИБРИДНОГО БЕЛКА |
| GB201218660D0 (en) | 2012-10-17 | 2012-11-28 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| EA201590491A1 (ru) * | 2012-10-17 | 2016-01-29 | Глаксосмитклайн Байолоджикалс С.А. | Иммуногенная композиция |
| US9562129B2 (en) | 2013-01-01 | 2017-02-07 | Agfa Graphics Nv | (Ethylene, vinyl acetal) copolymers and their use in lithographic printing plate precursors |
| BR112015018014A2 (pt) | 2013-02-01 | 2017-07-11 | Glaxosmithkline Biologicals Sa | liberação intradérmica de composições imunológicas compreendendo agonistas do receptor do tipo toll |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| US20150344530A1 (en) * | 2014-05-29 | 2015-12-03 | Subhash V. Kapre | Synthetic Peptides as Carriers for Conjugation with Polysaccharides |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| JP2019510272A (ja) | 2016-03-16 | 2019-04-11 | アグファ・ナームローゼ・フェンノートシャップＡｇｆａ Ｎｖ | 平版印刷版の処理方法 |
| WO2018124959A2 (en) * | 2016-12-28 | 2018-07-05 | Henriques Normark Birgitta | Microparticles from streptococcus pneumoniae as vaccine antigens |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| WO2018227177A1 (en) | 2017-06-10 | 2018-12-13 | Inventprise, Llc | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
| JP7362667B2 (ja) | 2018-02-12 | 2023-10-17 | イニミューン・コーポレーション | Ｔｏｌｌ様受容体リガンド |
| EP3938046A1 (en) * | 2019-03-13 | 2022-01-19 | St. Jude Children's Research Hospital | Vaccine compositions and methods for reducing transmission of streptococcus pneumoniae |
| EP3778253A1 (en) | 2019-08-13 | 2021-02-17 | Agfa Nv | Method for processing a lithographic printing plate |
| WO2022035816A1 (en) | 2020-08-10 | 2022-02-17 | Inventprise, Llc | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
| JP2023547677A (ja) | 2020-11-04 | 2023-11-13 | エリゴ・バイオサイエンス | キューティバクテリウム・アクネス組換えファージ、その産生方法及び使用 |
| CN121548426A (zh) * | 2023-05-22 | 2026-02-17 | Gpn疫苗有限公司 | 修饰的链球菌免疫原和其用途 |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
| IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| BE889979A (fr) | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| US5360897A (en) * | 1981-08-31 | 1994-11-01 | The University Of Rochester | Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad |
| US4761283A (en) * | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
| US4882317A (en) * | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4709017A (en) | 1985-06-07 | 1987-11-24 | President And Fellows Of Harvard College | Modified toxic vaccines |
| US5173294A (en) | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5006914A (en) * | 1988-12-02 | 1991-04-09 | Advanced Technology Materials, Inc. | Single crystal semiconductor substrate articles and semiconductor devices comprising same |
| WO1990006951A1 (en) * | 1988-12-16 | 1990-06-28 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Pneumolysin mutants and pneumococcal vaccines made therefrom |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| US5476929A (en) | 1991-02-15 | 1995-12-19 | Uab Research Foundation | Structural gene of pneumococcal protein |
| US5980909A (en) * | 1991-02-15 | 1999-11-09 | Uab Research Foundation | Epitopic regions of pneumococcal surface protein A |
| US6592876B1 (en) | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
| FI933580A7 (fi) | 1991-02-15 | 1993-10-13 | Uab Research Foundation | Pneumokokkiproteiinin rakennegeeni |
| US5552146A (en) | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| US5371197A (en) * | 1991-09-24 | 1994-12-06 | Merck & Co., Inc. | Protein-dimeric polysaccharide conjugate vaccine |
| PT652758E (pt) | 1992-06-18 | 2000-04-28 | Harvard College | Vacinas de toxina da difteria |
| CA2138997C (en) | 1992-06-25 | 2003-06-03 | Jean-Paul Prieels | Vaccine composition containing adjuvants |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| IL107026A0 (en) * | 1992-09-16 | 1993-12-28 | Univ Tennessee Res Corp | Antigen of hybrid m protein and carrier for group a streptococcal vaccine |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| GB9224584D0 (en) | 1992-11-23 | 1993-01-13 | Connaught Lab | Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases |
| US5776468A (en) | 1993-03-23 | 1998-07-07 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A |
| JP3429313B2 (ja) | 1993-05-18 | 2003-07-22 | オハイオ・ステイト・リサーチ・ファウンデーション | 中耳炎ワクチン |
| WO1995008348A1 (en) | 1993-09-22 | 1995-03-30 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
| US5917017A (en) | 1994-06-08 | 1999-06-29 | President And Fellows Of Harvard College | Diphtheria toxin vaccines bearing a mutated R domain |
| EP1167379A3 (en) | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US5565204A (en) | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US6440425B1 (en) | 1995-05-01 | 2002-08-27 | Aventis Pasteur Limited | High molecular weight major outer membrane protein of moraxella |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5843464A (en) | 1995-06-02 | 1998-12-01 | The Ohio State University | Synthetic chimeric fimbrin peptides |
| EA199800046A1 (ru) | 1995-06-07 | 1998-06-25 | Байокем Вэксинс Инк. | Полипептид, последовательность днк, вакцинная композиция (варианты), антитело или его фрагмент, вакцина, применения указанных полипептида, последовательности днк и антитела или его фрагмента |
| GB9513074D0 (en) | 1995-06-27 | 1995-08-30 | Cortecs Ltd | Novel anigen |
| US6290970B1 (en) | 1995-10-11 | 2001-09-18 | Aventis Pasteur Limited | Transferrin receptor protein of Moraxella |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| US6090576A (en) | 1996-03-08 | 2000-07-18 | Connaught Laboratories Limited | DNA encoding a transferrin receptor of Moraxella |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US6245335B1 (en) * | 1996-05-01 | 2001-06-12 | The Rockefeller University | Choline binding proteins for anti-pneumococcal vaccines |
| ES2262177T3 (es) * | 1996-05-01 | 2006-11-16 | The Rockefeller University | Proteinas de union a colina para vacunas frente a neumococos. |
| US5744417A (en) | 1996-05-02 | 1998-04-28 | Lyondell Petrochemical Company | Supported catalyst |
| US7341727B1 (en) | 1996-05-03 | 2008-03-11 | Emergent Product Development Gaithersburg Inc. | M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same |
| CA2253549C (en) | 1996-06-18 | 2005-10-25 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
| WO1998006734A1 (en) | 1996-08-16 | 1998-02-19 | Smithkline Beecham Corporation | Novel prokaryotic polynucleotides, polypeptides and their uses |
| US5882871A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | Saliva binding protein |
| US5882896A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
| JP4469026B2 (ja) * | 1996-10-31 | 2010-05-26 | ヒューマン ジノーム サイエンシーズ，インコーポレイテッド | Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅの抗原およびワクチン |
| JP2002503087A (ja) | 1996-11-12 | 2002-01-29 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ストレプトコッカス・ニューモニアのｃ３結合タンパク質 |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| EP0957972B1 (en) | 1996-12-20 | 2003-03-19 | Alza Corporation | Device and method for enhancing transdermal agent flux |
| DE19708537A1 (de) | 1997-03-03 | 1998-09-10 | Biotechnolog Forschung Gmbh | Neues Oberflächenprotein (SpsA-Protein) von Streptococcus pneumoniae etc. |
| FR2763244B1 (fr) * | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| AU739129B2 (en) | 1997-06-03 | 2001-10-04 | Connaught Laboratories Limited | Lactoferrin receptor genes of moraxella |
| EP0998557A2 (en) | 1997-07-21 | 2000-05-10 | North American Vaccine, Inc. | Modified immunogenic pneumolysin, compositions and their use as vaccines |
| AU9510598A (en) * | 1997-09-24 | 1999-04-12 | American Cyanamid Company | Human complement c3-degrading proteinase from (streptococcus pneumoniae) |
| US6224880B1 (en) * | 1997-09-24 | 2001-05-01 | Merck & Co., Inc. | Immunization against Streptococcus pneumoniae using conjugated and unconjugated pneumoccocal polysaccharide vaccines |
| EP0916726A1 (en) * | 1997-11-13 | 1999-05-19 | Rijksuniversiteit te Groningen | Attaching substances to micro-organisms |
| CA2312900A1 (en) | 1997-12-02 | 1999-06-10 | Powderject Vaccines, Inc. | Transdermal delivery of particulate vaccine compositions |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| US6709658B1 (en) * | 1998-02-12 | 2004-03-23 | Wyeth Holdings Corporation | Pneumococcal vaccines formulated with interleukin-12 |
| DE69942176D1 (de) | 1998-04-07 | 2010-05-06 | Medimmune Llc | Choline-bindende proteine derivate aus pneumokoken als impfstoff |
| IL138939A0 (en) * | 1998-04-07 | 2001-11-25 | St Jude Childrens Res Hospital | A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
| WO1999053940A1 (en) | 1998-04-23 | 1999-10-28 | Uab Research Foundation | PNEUMOCOCCAL SURFACE PROTEIN C(PspC), EPITOPIC REGIONS AND STRAIN SELECTION THEREOF, AND USES THEREFOR |
| GB9812613D0 (en) | 1998-06-11 | 1998-08-12 | Smithkline Beecham Biolog | Vaccine |
| EP1115875A1 (en) | 1998-09-24 | 2001-07-18 | Regents Of The University Of Minnesota | Human complement c3-degrading polypeptide from streptococcus pneumoniae |
| WO2000030299A1 (en) | 1998-11-17 | 2000-05-25 | Schlumberger Technology Corporation | Transmitting information over a communication link |
| WO2000029434A2 (en) | 1998-11-19 | 2000-05-25 | St. Jude Children's Research Hospital | PNEUMOCOCCAL CHOLINE BINDING PROTEINS, CbpG AND CbpD, DIAGNOSTIC AND THERAPEUTIC USES THEREOF |
| EP1140157B1 (en) * | 1998-12-21 | 2009-02-18 | MedImmune, Inc. | Streptococcus pneumoniae proteins and immunogenic fragments for vaccines |
| EP1034792A1 (en) * | 1999-03-11 | 2000-09-13 | Pasteur Merieux Serums Et Vaccins | Intranasal delivery of pneumococcal polysaccharide vaccines |
| ATE459373T1 (de) * | 1999-03-19 | 2010-03-15 | Glaxosmithkline Biolog Sa | Impfstoff gegen kapsulare polysaccharide von streptococcus pneumoniae |
| MXPA01012721A (es) * | 1999-06-10 | 2004-10-14 | Uab Research Foundation | Vacuna de combinacion de proteinas de superficie neumococcicas. |
| JP2003501110A (ja) | 1999-06-10 | 2003-01-14 | メディミューン，インコーポレーテッド | 肺炎連鎖球菌タンパク質とワクチン |
| US6319224B1 (en) | 1999-08-20 | 2001-11-20 | Bioject Medical Technologies Inc. | Intradermal injection system for injecting DNA-based injectables into humans |
| US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
-
2000
- 2000-09-15 GB GBGB0022742.1A patent/GB0022742D0/en not_active Ceased
-
2001
- 2001-09-12 EP EP09173889.8A patent/EP2140878B1/en not_active Expired - Lifetime
- 2001-09-12 HU HU0301043A patent/HUP0301043A3/hu not_active Application Discontinuation
- 2001-09-12 CN CNB018157483A patent/CN1253205C/zh not_active Expired - Fee Related
- 2001-09-12 SI SI200131001T patent/SI1317279T1/sl unknown
- 2001-09-12 US US10/380,575 patent/US20060051361A1/en not_active Abandoned
- 2001-09-12 PL PL361395A patent/PL209247B1/pl unknown
- 2001-09-12 CN CNB018157467A patent/CN100486642C/zh not_active Expired - Fee Related
- 2001-09-12 AU AU2002220548A patent/AU2002220548B2/en not_active Ceased
- 2001-09-12 MX MXPA03002265A patent/MXPA03002265A/es active IP Right Grant
- 2001-09-12 EP EP10179135A patent/EP2305298A1/en not_active Withdrawn
- 2001-09-12 KR KR1020117026231A patent/KR101268790B1/ko not_active Expired - Fee Related
- 2001-09-12 ES ES10178332.2T patent/ES2659400T3/es not_active Expired - Lifetime
- 2001-09-12 ES ES01984627.8T patent/ES2545876T3/es not_active Expired - Lifetime
- 2001-09-12 BR BR0113822-7A patent/BR0113822A/pt not_active IP Right Cessation
- 2001-09-12 BR BR0113821-9A patent/BR0113821A/pt not_active Application Discontinuation
- 2001-09-12 JP JP2002526416A patent/JP4903975B2/ja not_active Expired - Fee Related
- 2001-09-12 NZ NZ524286A patent/NZ524286A/en not_active IP Right Cessation
- 2001-09-12 EP EP01984626A patent/EP1317279B1/en not_active Revoked
- 2001-09-12 EP EP01984627.8A patent/EP1317280B1/en not_active Expired - Lifetime
- 2001-09-12 CA CA2421998A patent/CA2421998C/en not_active Expired - Fee Related
- 2001-09-12 AT AT01984626T patent/ATE516815T1/de active
- 2001-09-12 US US10/380,563 patent/US20040081662A1/en not_active Abandoned
- 2001-09-12 CZ CZ2003-757A patent/CZ305343B6/cs not_active IP Right Cessation
- 2001-09-12 KR KR1020107014638A patent/KR20100091241A/ko not_active Ceased
- 2001-09-12 KR KR10-2003-7003732A patent/KR20030031188A/ko not_active Ceased
- 2001-09-12 ES ES09173889.8T patent/ES2551097T3/es not_active Expired - Lifetime
- 2001-09-12 HU HU0301092A patent/HUP0301092A3/hu unknown
- 2001-09-12 CZ CZ2003-756A patent/CZ305324B6/cs not_active IP Right Cessation
- 2001-09-12 DK DK01984626.0T patent/DK1317279T3/da active
- 2001-09-12 ES ES01984626T patent/ES2368902T3/es not_active Expired - Lifetime
- 2001-09-12 AU AU2002238193A patent/AU2002238193B2/en not_active Ceased
- 2001-09-12 WO PCT/EP2001/010570 patent/WO2002022168A2/en not_active Ceased
- 2001-09-12 CN CN2009101285337A patent/CN101502648B/zh not_active Expired - Fee Related
- 2001-09-12 KR KR1020087020661A patent/KR100991916B1/ko not_active Expired - Fee Related
- 2001-09-12 JP JP2002526417A patent/JP4880184B2/ja not_active Expired - Fee Related
- 2001-09-12 AU AU3819302A patent/AU3819302A/xx active Pending
- 2001-09-12 MX MXPA03002264A patent/MXPA03002264A/es active IP Right Grant
- 2001-09-12 WO PCT/EP2001/010568 patent/WO2002022167A2/en not_active Ceased
- 2001-09-12 NZ NZ524287A patent/NZ524287A/en not_active IP Right Cessation
- 2001-09-12 IL IL15460801A patent/IL154608A0/xx unknown
- 2001-09-12 EP EP10179133A patent/EP2305297A1/en not_active Ceased
- 2001-09-12 KR KR1020037003731A patent/KR100805991B1/ko not_active Expired - Fee Related
- 2001-09-12 PL PL361401A patent/PL210198B1/pl unknown
- 2001-09-12 CA CA2422002A patent/CA2422002C/en not_active Expired - Fee Related
- 2001-09-12 AU AU2054802A patent/AU2054802A/xx active Pending
- 2001-09-12 PT PT01984626T patent/PT1317279E/pt unknown
- 2001-09-12 EP EP10178332.2A patent/EP2314313B1/en not_active Expired - Lifetime
- 2001-09-12 IL IL15460701A patent/IL154607A0/xx unknown
-
2003
- 2003-02-24 IL IL154607A patent/IL154607A/en not_active IP Right Cessation
- 2003-02-24 IL IL154608A patent/IL154608A/en not_active IP Right Cessation
- 2003-02-25 ZA ZA200301524A patent/ZA200301524B/en unknown
- 2003-02-25 ZA ZA200301526A patent/ZA200301526B/en unknown
- 2003-03-14 NO NO20031183A patent/NO336186B1/no not_active IP Right Cessation
- 2003-03-14 NO NO20031184A patent/NO337730B1/no not_active IP Right Cessation
-
2007
- 2007-05-07 US US11/745,006 patent/US20080081050A1/en not_active Abandoned
-
2010
- 2010-08-13 US US12/855,734 patent/US20110008419A1/en not_active Abandoned
-
2011
- 2011-09-12 JP JP2011198277A patent/JP2012006969A/ja active Pending
- 2011-10-06 CY CY20111100958T patent/CY1111915T1/el unknown
-
2013
- 2013-12-10 US US14/101,995 patent/US20140099339A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004508417A5 (2) | ||
| JP2009520761A5 (2) | ||
| JP2018531315A5 (2) | ||
| RU2004117775A (ru) | Вакцина steptococcus pneumoniae | |
| JP2009520760A5 (2) | ||
| KR102608081B1 (ko) | 폴리사카라이드-단백질 접합체를 포함하는 다가 폐렴구균 백신 조성물 | |
| JP2012006969A5 (2) | ||
| WO2002022167A3 (en) | Vaccine against streptococcus penumoniae | |
| CA2808919C (en) | Streptococcus pneumoniae capsular saccharide vaccine | |
| JP2004501618A5 (2) | ||
| JP2010260849A5 (2) | ||
| JP2015536312A5 (2) | ||
| JP2006506989A5 (2) | ||
| PL351893A1 (en) | Vaccines | |
| CA2504938A1 (en) | Compositions and methods for treating or preventing pneumococcal infection | |
| CA2413576A1 (en) | Streptococcus pyogenes antigens | |
| CN108524926B (zh) | 一种多价肺炎球菌结合疫苗的制剂组合及其应用 | |
| JP7334176B2 (ja) | 肺炎球菌表面タンパク質Ａ（ＰｓｐＡ）の発現 | |
| Klein et al. | Development and testing of Streptococcus pneumoniae conjugate vaccines | |
| Otczyk et al. | Vaccination for the control of childhood bacterial pneumonia—Haemophilus influenzae type b and pneumococcal vaccines | |
| CN222898668U (zh) | 一种护型功能枕 | |
| JP2003534250A5 (2) | ||
| Long et al. | Research progress of Streptococcus pneumoniae capsular polysaccharide-protein conjugate vaccines | |
| WO2004034981A3 (en) | Compositions and methods for inhibiting group b streptococcus-induced pulmonary hypertension in neonates | |
| MXPA00006324A (en) | Adjuvanted vaccine formulation |