JP2004531270A5 - - Google Patents
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- Publication number
- JP2004531270A5 JP2004531270A5 JP2003507235A JP2003507235A JP2004531270A5 JP 2004531270 A5 JP2004531270 A5 JP 2004531270A5 JP 2003507235 A JP2003507235 A JP 2003507235A JP 2003507235 A JP2003507235 A JP 2003507235A JP 2004531270 A5 JP2004531270 A5 JP 2004531270A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- antibody
- kda
- antigen
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30053501P | 2001-06-22 | 2001-06-22 | |
| PCT/US2002/019646 WO2003000848A2 (en) | 2001-06-22 | 2002-06-21 | Liver engrafting cells, assays, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009090608A Division JP2009183299A (ja) | 2001-06-22 | 2009-04-03 | 肝移植細胞、アッセイ法、およびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004531270A JP2004531270A (ja) | 2004-10-14 |
| JP2004531270A5 true JP2004531270A5 (2) | 2006-01-05 |
| JP4455876B2 JP4455876B2 (ja) | 2010-04-21 |
Family
ID=23159503
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003507235A Expired - Fee Related JP4455876B2 (ja) | 2001-06-22 | 2002-06-21 | 肝移植細胞、アッセイ法、およびその使用法 |
| JP2009090608A Withdrawn JP2009183299A (ja) | 2001-06-22 | 2009-04-03 | 肝移植細胞、アッセイ法、およびその使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009090608A Withdrawn JP2009183299A (ja) | 2001-06-22 | 2009-04-03 | 肝移植細胞、アッセイ法、およびその使用法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7211404B2 (2) |
| EP (3) | EP2388330B1 (2) |
| JP (2) | JP4455876B2 (2) |
| CN (2) | CN1665920A (2) |
| AT (1) | ATE371018T1 (2) |
| AU (1) | AU2002315392B2 (2) |
| CA (1) | CA2451637C (2) |
| DE (1) | DE60221987T2 (2) |
| DK (1) | DK1406998T3 (2) |
| ES (1) | ES2292772T3 (2) |
| WO (1) | WO2003000848A2 (2) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8044259B2 (en) * | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US7838292B1 (en) * | 2001-03-29 | 2010-11-23 | University Of Louisville Research Foundation, Inc. | Methods for obtaining adult human olfactory progenitor cells |
| ATE371018T1 (de) * | 2001-06-22 | 2007-09-15 | Stemcells Inc | Le-zellen (liver engrafting cells), assays und verwendungen davon |
| US20040136972A1 (en) * | 2001-09-07 | 2004-07-15 | Yeda Research And Development Co. Ltd. | Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues |
| US7780993B2 (en) * | 2001-09-07 | 2010-08-24 | Yeda Research And Development Co. Ltd. | Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts |
| AU2002364537A1 (en) * | 2001-12-07 | 2003-06-23 | Regents Of The University Of Michigan | Prospective identification and characterization of breast cancer stem cells |
| IL165425A0 (en) * | 2004-11-28 | 2006-01-15 | Yeda Res & Dev | Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues |
| US20060019256A1 (en) * | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US20050014217A1 (en) * | 2003-07-18 | 2005-01-20 | Cytokinetics, Inc. | Predicting hepatotoxicity using cell based assays |
| WO2005074633A2 (en) * | 2004-02-03 | 2005-08-18 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
| EP1801582B1 (en) * | 2004-08-20 | 2010-03-17 | Sekisui Medical Co., Ltd. | Method of predicting the metabolism of drug in human liver and liver function |
| US20060252073A1 (en) * | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
| US20070099209A1 (en) * | 2005-06-13 | 2007-05-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| AU2006259583A1 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| CA2628255C (en) * | 2005-10-31 | 2016-04-19 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| CA2628221A1 (en) | 2005-10-31 | 2007-05-10 | Oncomed Pharmaceuticals, Inc. | Anti-frizzled receptor antibodies for treating cancer |
| US8673635B2 (en) * | 2005-12-21 | 2014-03-18 | Universite Catholique De Louvain | Isolated liver stem cells |
| US20080019961A1 (en) * | 2006-02-21 | 2008-01-24 | Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
| WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| US8569573B2 (en) * | 2007-06-05 | 2013-10-29 | Oregon Health & Science University | Method of expanding human hepatocytes in vivo |
| JP2010534065A (ja) * | 2007-07-20 | 2010-11-04 | セルアーティス アーベー | ヒト胚盤胞幹細胞に、胚体内胚葉（ＤＥ‐ｈｅｐ）を介して由来する新規な肝細胞の集団 |
| US8241898B2 (en) * | 2007-12-10 | 2012-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Regenerative dot cells |
| US9125891B2 (en) * | 2008-03-07 | 2015-09-08 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Lymph nodes as a site for regeneration |
| SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
| US20100227393A1 (en) * | 2009-03-06 | 2010-09-09 | Eric Lagasse | Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| JPWO2011102532A1 (ja) * | 2010-02-16 | 2013-06-17 | 国立大学法人九州大学 | 誘導肝細胞 |
| CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| AU2013334790A1 (en) | 2012-10-23 | 2015-04-30 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using Wnt pathway-binding agents |
| AU2014212081A1 (en) | 2013-02-04 | 2015-08-13 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| ES2759228T3 (es) | 2013-07-05 | 2020-05-08 | Univ Catholique Louvain | Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado |
| JP6672603B2 (ja) * | 2015-03-27 | 2020-03-25 | 株式会社豊田中央研究所 | 物質と細胞との間の作用の評価方法 |
| HK1255123A1 (zh) | 2015-06-23 | 2019-08-02 | The Jackson Laboratory | 具有患者衍生异种移植物的非hla匹配的人源化nsg小鼠模型 |
| KR102762505B1 (ko) | 2017-02-17 | 2025-02-03 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 이식, 조직 재생, 장기형성 및 다중 조직 기능을 위한 부위로서의 지방-부속 림프 클러스터 |
| EP3784224A4 (en) * | 2018-04-27 | 2022-08-03 | The Regents of the University of California | DE NOVO FORMATION OF THE BILIARY SYSTEM BY HEPATOCYTE TRANSDIFFERENTIATION |
| AU2021256473A1 (en) * | 2020-04-17 | 2022-12-22 | The Council Of The Queensland Institute Of Medical Research | Immune cells with enhanced function |
| US20250102522A1 (en) * | 2021-10-07 | 2025-03-27 | Hepatx Corporation | Methods of tracking donor cells in a recipient |
| WO2023132371A1 (ja) | 2022-01-07 | 2023-07-13 | インテグリカルチャー株式会社 | 肝臓由来の細胞の培養方法および肝臓由来の細胞を含む培養系 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| WO1993003142A1 (en) * | 1991-08-07 | 1993-02-18 | Albert Einstein College Of Medicine | Proliferation of hepatocyte precursors |
| US6069005A (en) | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
| ES2157225T3 (es) * | 1992-10-09 | 2001-08-16 | Advanced Tissue Sciences Inc | Celulas hepaticas de reserva. |
| US5459037A (en) | 1993-11-12 | 1995-10-17 | The Scripps Research Institute | Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations |
| ES2260759T3 (es) * | 1993-11-19 | 2006-11-01 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Hepatoblastos y metodo de aislamiento de los mismos. |
| US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| EP0833893A1 (en) | 1995-06-06 | 1998-04-08 | Whitehead Institute For Biomedical Research | Isolation of mammalian hematopoietic stem cells |
| WO1996040875A1 (en) * | 1995-06-07 | 1996-12-19 | Novartis Ag | Methods for obtaining compositions enriched for hematopoietic stem cells and antibodies for use therein |
| US5776683A (en) | 1996-07-11 | 1998-07-07 | California Pacific Medical Center | Methods for identifying genes amplified in cancer cells |
| AU5195398A (en) * | 1996-10-25 | 1998-05-15 | Advanced Research And Technology Institute, Inc. | Dna sequences encoding fusions of dna repair proteins and uses thereof |
| US6129911A (en) * | 1998-07-10 | 2000-10-10 | Rhode Island Hospital, A Lifespan Partner | Liver stem cell |
| US6242666B1 (en) * | 1998-12-16 | 2001-06-05 | The Scripps Research Institute | Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells |
| US6468794B1 (en) | 1999-02-12 | 2002-10-22 | Stemcells, Inc. | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
| ES2351170T3 (es) | 1999-02-12 | 2011-02-01 | Stemcells California, Inc. | Poblaciones enriquecidas de células del sistema nervioso central. |
| CN1258589C (zh) | 2000-10-03 | 2006-06-07 | 北卡罗来纳大学 | 分离双能肝祖细胞的方法 |
| JPWO2002088332A1 (ja) * | 2001-04-24 | 2004-08-19 | 北海道ティー・エル・オー株式会社 | 小型肝細胞高含有コロニー、その調製方法、その肝組織への成熟化方法、成熟化した小型肝細胞高含有コロニーを用いた薬物機能の推定方法 |
| ATE371018T1 (de) | 2001-06-22 | 2007-09-15 | Stemcells Inc | Le-zellen (liver engrafting cells), assays und verwendungen davon |
| US8707400B2 (en) | 2007-01-22 | 2014-04-22 | Apple Inc. | System and method for implementing an extended authentication and authorization credential store |
-
2002
- 2002-06-21 AT AT02742240T patent/ATE371018T1/de not_active IP Right Cessation
- 2002-06-21 ES ES02742240T patent/ES2292772T3/es not_active Expired - Lifetime
- 2002-06-21 EP EP20100178898 patent/EP2388330B1/en not_active Revoked
- 2002-06-21 US US10/177,178 patent/US7211404B2/en not_active Expired - Lifetime
- 2002-06-21 AU AU2002315392A patent/AU2002315392B2/en not_active Expired
- 2002-06-21 EP EP02742240A patent/EP1406998B1/en not_active Expired - Lifetime
- 2002-06-21 EP EP07016341A patent/EP1956078A3/en not_active Withdrawn
- 2002-06-21 CN CN028165284A patent/CN1665920A/zh active Pending
- 2002-06-21 CN CN2010101654480A patent/CN101974480A/zh active Pending
- 2002-06-21 DE DE60221987T patent/DE60221987T2/de not_active Expired - Lifetime
- 2002-06-21 WO PCT/US2002/019646 patent/WO2003000848A2/en not_active Ceased
- 2002-06-21 JP JP2003507235A patent/JP4455876B2/ja not_active Expired - Fee Related
- 2002-06-21 DK DK02742240T patent/DK1406998T3/da active
- 2002-06-21 CA CA2451637A patent/CA2451637C/en not_active Expired - Lifetime
-
2006
- 2006-08-09 US US11/502,210 patent/US7811818B2/en not_active Expired - Fee Related
-
2009
- 2009-04-03 JP JP2009090608A patent/JP2009183299A/ja not_active Withdrawn
-
2010
- 2010-08-10 US US12/853,477 patent/US8283164B2/en not_active Expired - Fee Related
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