JP2005010165A5 - - Google Patents
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- JP2005010165A5 JP2005010165A5 JP2004181332A JP2004181332A JP2005010165A5 JP 2005010165 A5 JP2005010165 A5 JP 2005010165A5 JP 2004181332 A JP2004181332 A JP 2004181332A JP 2004181332 A JP2004181332 A JP 2004181332A JP 2005010165 A5 JP2005010165 A5 JP 2005010165A5
- Authority
- JP
- Japan
- Prior art keywords
- fluid
- sample
- channel
- buffer
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012530 fluid Substances 0.000 claims description 261
- 239000000872 buffer Substances 0.000 claims description 47
- 239000003153 chemical reaction reagent Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 20
- 238000012360 testing method Methods 0.000 claims description 15
- 238000012545 processing Methods 0.000 claims description 13
- 239000008280 blood Substances 0.000 claims description 9
- 210000004369 blood Anatomy 0.000 claims description 8
- 210000003743 erythrocyte Anatomy 0.000 claims description 7
- 238000012546 transfer Methods 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 3
- 238000003018 immunoassay Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims 1
- 238000005303 weighing Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 description 36
- 239000003570 air Substances 0.000 description 31
- 239000000499 gel Substances 0.000 description 12
- 238000010790 dilution Methods 0.000 description 8
- 239000012895 dilution Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- -1 antibodies Proteins 0.000 description 6
- 239000012491 analyte Substances 0.000 description 5
- 238000011109 contamination Methods 0.000 description 5
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000010261 blood fractionation Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052752 metalloid Inorganic materials 0.000 description 1
- 150000002738 metalloids Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical compound CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/464,156 US7247487B2 (en) | 2003-06-18 | 2003-06-18 | Reducing working fluid dilution in liquid systems |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005010165A JP2005010165A (ja) | 2005-01-13 |
| JP2005010165A5 true JP2005010165A5 (2) | 2009-12-03 |
| JP4494877B2 JP4494877B2 (ja) | 2010-06-30 |
Family
ID=33418150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004181332A Expired - Fee Related JP4494877B2 (ja) | 2003-06-18 | 2004-06-18 | 液体システムにおける作動流体の希釈減少法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7247487B2 (2) |
| EP (1) | EP1489303B1 (2) |
| JP (1) | JP4494877B2 (2) |
| KR (1) | KR101140439B1 (2) |
| AU (1) | AU2004202662B2 (2) |
| CA (1) | CA2471686C (2) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524456B1 (en) * | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
| WO2003099407A2 (de) * | 2002-05-24 | 2003-12-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zum mischungsfreien übertragen von heterogenen flüssigkeiten in mikrokanälen |
| JP4698613B2 (ja) | 2004-01-26 | 2011-06-08 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 流体送達のシステムおよび方法 |
| EP1672674A1 (de) * | 2004-12-17 | 2006-06-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Untersuchungsverfahren und -system zur Hochdurchsatzmassenanalyse |
| CA2604323A1 (en) | 2005-04-19 | 2006-10-26 | President And Fellows Of Harvard College | Fluidic structures including meandering and wide channels |
| US20060280029A1 (en) * | 2005-06-13 | 2006-12-14 | President And Fellows Of Harvard College | Microfluidic mixer |
| WO2007024800A2 (en) * | 2005-08-22 | 2007-03-01 | Applera Corporation | Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other |
| JP4915690B2 (ja) * | 2006-05-23 | 2012-04-11 | 国立大学法人電気通信大学 | マイクロ化学チップ装置 |
| JP4968896B2 (ja) * | 2006-09-27 | 2012-07-04 | 富士フイルム株式会社 | 分散液製造装置及び分散液製造方法 |
| WO2008047533A1 (en) * | 2006-10-18 | 2008-04-24 | Konica Minolta Medical & Graphic, Inc. | Microchip reaction detection system, and method of reaction of microchip in flow path |
| US7803101B2 (en) * | 2007-01-30 | 2010-09-28 | Ortho-Clinical Diagnostics, Inc. | Random access multi-disc centrifuge |
| US7850917B2 (en) * | 2008-03-11 | 2010-12-14 | Ortho-Clinical Diagnostics, Inc. | Particle agglutination in a tip |
| FR2933315B1 (fr) * | 2008-07-07 | 2012-02-10 | Commissariat Energie Atomique | Dispositif microfluidique de deplacement de liquide |
| FR2934361B1 (fr) | 2008-07-22 | 2012-12-28 | Commissariat Energie Atomique | Dispositif de variation de pression d'un fluide pneumatique par deplacement de gouttes de liquide et pompe a chaleur utilisant un tel dispositif |
| JP4919119B2 (ja) * | 2010-01-19 | 2012-04-18 | 株式会社日立プラントテクノロジー | 試薬分注ノズルによる分取・分注方法および試薬分取・分注機構 |
| US8365616B1 (en) | 2010-09-16 | 2013-02-05 | Wolcott Duane K | Sampling probe for solutions containing soluble solids or high concentrations of dissolved solids |
| WO2013082273A1 (en) | 2011-11-30 | 2013-06-06 | Wellstat Diagnostics, Llc. | Filtration module |
| EP2623202B1 (de) * | 2012-01-31 | 2018-07-18 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zum erwärmen eines flüssigkeitsvolumens in einer beheizten pipettiernadel, pipettiervorrichtung und automatisches analysegerät |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
| US9081001B2 (en) | 2012-05-15 | 2015-07-14 | Wellstat Diagnostics, Llc | Diagnostic systems and instruments |
| ES2741001T3 (es) | 2013-03-13 | 2020-02-07 | Opko Diagnostics Llc | Mezcla de fluidos en sistemas fluídicos |
| EP3123148B1 (en) * | 2014-03-31 | 2020-05-27 | Redshift Systems Corporation | Fluid analyzer with modulation for liquids and gases |
| US10279345B2 (en) | 2014-12-12 | 2019-05-07 | Opko Diagnostics, Llc | Fluidic systems comprising an incubation channel, including fluidic systems formed by molding |
| WO2016130553A1 (en) | 2015-02-13 | 2016-08-18 | Siemens Healthcare Diagnostics Inc. | Methods and apparatus providing reduced carryover during pipetting operations |
| KR101779087B1 (ko) * | 2016-03-10 | 2017-09-18 | 조선대학교산학협력단 | Ｐｏｃｔ 기반 혈액생물성치 측정장치 및 측정방법 |
| CN110023950B (zh) | 2016-10-28 | 2023-08-08 | 拜克门寇尔特公司 | 物质准备评估系统 |
| EP4370933A4 (en) * | 2021-07-15 | 2025-05-21 | Techcyte, Inc. | Image analysis for classifying hemagglutination and quantifying presence of antibodies |
| US12498319B2 (en) | 2023-05-12 | 2025-12-16 | Redshift Bioanalytics, Inc. | Matched optical filter |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US482599A (en) * | 1892-09-13 | Traction-engine | ||
| US2797149A (en) | 1953-01-08 | 1957-06-25 | Technicon International Ltd | Methods of and apparatus for analyzing liquids containing crystalloid and non-crystalloid constituents |
| US2879141A (en) | 1955-11-16 | 1959-03-24 | Technicon Instr | Automatic analyzing apparatus |
| US3479141A (en) | 1967-05-17 | 1969-11-18 | Technicon Corp | Method and apparatus for analysis |
| US3992158A (en) | 1973-08-16 | 1976-11-16 | Eastman Kodak Company | Integral analytical element |
| US3991055A (en) * | 1975-05-30 | 1976-11-09 | Coulter Electronics, Inc. | Liquid transfer valve |
| US4121466A (en) * | 1977-04-19 | 1978-10-24 | Technicon Instruments Corporation | Liquid dispenser with an improved probe |
| US4259291A (en) | 1979-07-13 | 1981-03-31 | Technicon Instruments Corporation | Metering device |
| US4526754A (en) * | 1982-07-30 | 1985-07-02 | Technicon Instruments Corporation | Sample transport system |
| US4853336A (en) | 1982-11-15 | 1989-08-01 | Technicon Instruments Corporation | Single channel continuous flow system |
| US4574850A (en) * | 1985-01-17 | 1986-03-11 | E. I. Du Pont De Nemours And Company | Method of and apparatus for dispensing liquid |
| AU8326887A (en) | 1986-11-19 | 1988-06-16 | Technicon Instruments Corportion | Method and apparatus for conveying information in a liquid sample transport system |
| US4984475A (en) * | 1989-07-24 | 1991-01-15 | Tritech Partners | Ultra low carryover sample liquid analysis apparatus and method |
| US5399497A (en) * | 1992-02-26 | 1995-03-21 | Miles, Inc. | Capsule chemistry sample liquid analysis system and method |
| US5646049A (en) | 1992-03-27 | 1997-07-08 | Abbott Laboratories | Scheduling operation of an automated analytical system |
| US5552064A (en) | 1993-02-26 | 1996-09-03 | Ortho Diagnostic Systems, Inc. | Column agglutination assay and device using biphasic centrifugation |
| US5441895A (en) | 1993-12-07 | 1995-08-15 | Jakubowicz; Raymond F. | Reagent cup shape allowing stacking without dislodging reagent |
| JPH07159415A (ja) * | 1993-12-08 | 1995-06-23 | Hitachi Ltd | 自動試料導入方法 |
| KR100306951B1 (ko) | 1995-12-05 | 2001-11-15 | 테칸 보스턴, 인코포레이티드 | 내장된정보과학에의해미세유체공학시스템내의유체유동을구동시키기위해구심가속도를이용하는장치및방법 |
| WO1997039359A1 (en) * | 1996-04-15 | 1997-10-23 | Dade International Inc. | Apparatus and method for analysis |
| CN1329729C (zh) * | 1996-06-28 | 2007-08-01 | 卡钳生命科学股份有限公司 | 微流体系统 |
| US5992820A (en) | 1997-11-19 | 1999-11-30 | Sarnoff Corporation | Flow control in microfluidics devices by controlled bubble formation |
| US6348354B1 (en) * | 1998-07-06 | 2002-02-19 | Bayer Corporation | Method and apparatus for controlling a stream of liquid test packages in a capsule chemistry analysis system |
| US6524456B1 (en) * | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
| US6610499B1 (en) | 2000-08-31 | 2003-08-26 | The Regents Of The University Of California | Capillary array and related methods |
| US6453928B1 (en) | 2001-01-08 | 2002-09-24 | Nanolab Ltd. | Apparatus, and method for propelling fluids |
| US7077152B2 (en) * | 2001-07-07 | 2006-07-18 | Nanostream, Inc. | Microfluidic metering systems and methods |
| FR2829948B1 (fr) * | 2001-09-21 | 2004-07-09 | Commissariat Energie Atomique | Procede de deplacement d'un fluide d'interet dans un capillaire et microsysteme fluidique |
-
2003
- 2003-06-18 US US10/464,156 patent/US7247487B2/en not_active Expired - Fee Related
-
2004
- 2004-06-17 AU AU2004202662A patent/AU2004202662B2/en not_active Ceased
- 2004-06-17 KR KR1020040045130A patent/KR101140439B1/ko not_active Expired - Fee Related
- 2004-06-17 EP EP20040253624 patent/EP1489303B1/en not_active Expired - Lifetime
- 2004-06-18 JP JP2004181332A patent/JP4494877B2/ja not_active Expired - Fee Related
- 2004-06-18 CA CA 2471686 patent/CA2471686C/en not_active Expired - Fee Related
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