JP4494877B2 - 液体システムにおける作動流体の希釈減少法 - Google Patents

液体システムにおける作動流体の希釈減少法 Download PDF

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Publication number: JP4494877B2
Authority: JP; Japan
Prior art keywords: fluid; sample; reagent; gel; buffer
Prior art date: 2003-06-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2004181332A

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English (en)

Japanese (ja)

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JP2005010165A (ja

JP2005010165A5 (2

Inventor

ジェイコブスメリット

ディンゾン

Original Assignee

オルソ−クリニカルダイアグノスティクス，インコーポレイティド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-18

Filing date

2004-06-18

Publication date

2010-06-30

2004-06-18 Application filed by オルソ−クリニカルダイアグノスティクス，インコーポレイティド filed Critical オルソ−クリニカルダイアグノスティクス，インコーポレイティド

2005-01-13 Publication of JP2005010165A publication Critical patent/JP2005010165A/ja

2009-12-03 Publication of JP2005010165A5 publication Critical patent/JP2005010165A5/ja

2010-06-30 Application granted granted Critical

2010-06-30 Publication of JP4494877B2 publication Critical patent/JP4494877B2/ja

2024-06-18 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

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Images

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/0318—Processes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
- Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer

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Engineering & Computer Science (AREA)
Mechanical Engineering (AREA)
General Engineering & Computer Science (AREA)
Physics & Mathematics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Pathology (AREA)
Automatic Analysis And Handling Materials Therefor (AREA)
Sampling And Sample Adjustment (AREA)

JP2004181332A 2003-06-18 2004-06-18 液体システムにおける作動流体の希釈減少法 Expired - Fee Related JP4494877B2 (ja)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/464,156 US7247487B2 (en)	2003-06-18	2003-06-18	Reducing working fluid dilution in liquid systems

Publications (3)

Publication Number	Publication Date
JP2005010165A JP2005010165A (ja)	2005-01-13
JP2005010165A5 JP2005010165A5 (2)	2009-12-03
JP4494877B2 true JP4494877B2 (ja)	2010-06-30

Family

ID=33418150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2004181332A Expired - Fee Related JP4494877B2 (ja)	2003-06-18	2004-06-18	液体システムにおける作動流体の希釈減少法

Country Status (6)

Country	Link
US (1)	US7247487B2 (2)
EP (1)	EP1489303B1 (2)
JP (1)	JP4494877B2 (2)
KR (1)	KR101140439B1 (2)
AU (1)	AU2004202662B2 (2)
CA (1)	CA2471686C (2)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6524456B1 (en) *	1999-08-12	2003-02-25	Ut-Battelle, Llc	Microfluidic devices for the controlled manipulation of small volumes
WO2003099407A2 (de) *	2002-05-24	2003-12-04	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Verfahren zum mischungsfreien übertragen von heterogenen flüssigkeiten in mikrokanälen
JP4698613B2 (ja)	2004-01-26	2011-06-08	プレジデントアンドフェロウズオブハーバードカレッジ	流体送達のシステムおよび方法
EP1672674A1 (de) *	2004-12-17	2006-06-21	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Untersuchungsverfahren und -system zur Hochdurchsatzmassenanalyse
CA2604323A1 (en)	2005-04-19	2006-10-26	President And Fellows Of Harvard College	Fluidic structures including meandering and wide channels
US20060280029A1 (en) *	2005-06-13	2006-12-14	President And Fellows Of Harvard College	Microfluidic mixer
WO2007024800A2 (en) *	2005-08-22	2007-03-01	Applera Corporation	Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other
JP4915690B2 (ja) *	2006-05-23	2012-04-11	国立大学法人電気通信大学	マイクロ化学チップ装置
JP4968896B2 (ja) *	2006-09-27	2012-07-04	富士フイルム株式会社	分散液製造装置及び分散液製造方法
WO2008047533A1 (en) *	2006-10-18	2008-04-24	Konica Minolta Medical & Graphic, Inc.	Microchip reaction detection system, and method of reaction of microchip in flow path
US7803101B2 (en) *	2007-01-30	2010-09-28	Ortho-Clinical Diagnostics, Inc.	Random access multi-disc centrifuge
US7850917B2 (en) *	2008-03-11	2010-12-14	Ortho-Clinical Diagnostics, Inc.	Particle agglutination in a tip
FR2933315B1 (fr) *	2008-07-07	2012-02-10	Commissariat Energie Atomique	Dispositif microfluidique de deplacement de liquide
FR2934361B1 (fr)	2008-07-22	2012-12-28	Commissariat Energie Atomique	Dispositif de variation de pression d'un fluide pneumatique par deplacement de gouttes de liquide et pompe a chaleur utilisant un tel dispositif
JP4919119B2 (ja) *	2010-01-19	2012-04-18	株式会社日立プラントテクノロジー	試薬分注ノズルによる分取・分注方法および試薬分取・分注機構
US8365616B1 (en)	2010-09-16	2013-02-05	Wolcott Duane K	Sampling probe for solutions containing soluble solids or high concentrations of dissolved solids
WO2013082273A1 (en)	2011-11-30	2013-06-06	Wellstat Diagnostics, Llc.	Filtration module
EP2623202B1 (de) *	2012-01-31	2018-07-18	Siemens Healthcare Diagnostics Products GmbH	Verfahren zum erwärmen eines flüssigkeitsvolumens in einer beheizten pipettiernadel, pipettiervorrichtung und automatisches analysegerät
US9213043B2 (en)	2012-05-15	2015-12-15	Wellstat Diagnostics, Llc	Clinical diagnostic system including instrument and cartridge
US9625465B2 (en)	2012-05-15	2017-04-18	Defined Diagnostics, Llc	Clinical diagnostic systems
US9081001B2 (en)	2012-05-15	2015-07-14	Wellstat Diagnostics, Llc	Diagnostic systems and instruments
ES2741001T3 (es)	2013-03-13	2020-02-07	Opko Diagnostics Llc	Mezcla de fluidos en sistemas fluídicos
EP3123148B1 (en) *	2014-03-31	2020-05-27	Redshift Systems Corporation	Fluid analyzer with modulation for liquids and gases
US10279345B2 (en)	2014-12-12	2019-05-07	Opko Diagnostics, Llc	Fluidic systems comprising an incubation channel, including fluidic systems formed by molding
WO2016130553A1 (en)	2015-02-13	2016-08-18	Siemens Healthcare Diagnostics Inc.	Methods and apparatus providing reduced carryover during pipetting operations
KR101779087B1 (ko) *	2016-03-10	2017-09-18	조선대학교산학협력단	Ｐｏｃｔ 기반 혈액생물성치 측정장치 및 측정방법
CN110023950B (zh)	2016-10-28	2023-08-08	拜克门寇尔特公司	物质准备评估系统
EP4370933A4 (en) *	2021-07-15	2025-05-21	Techcyte, Inc.	Image analysis for classifying hemagglutination and quantifying presence of antibodies
US12498319B2 (en)	2023-05-12	2025-12-16	Redshift Bioanalytics, Inc.	Matched optical filter

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US482599A (en) *		1892-09-13		Traction-engine
US2797149A (en)	1953-01-08	1957-06-25	Technicon International Ltd	Methods of and apparatus for analyzing liquids containing crystalloid and non-crystalloid constituents
US2879141A (en)	1955-11-16	1959-03-24	Technicon Instr	Automatic analyzing apparatus
US3479141A (en)	1967-05-17	1969-11-18	Technicon Corp	Method and apparatus for analysis
US3992158A (en)	1973-08-16	1976-11-16	Eastman Kodak Company	Integral analytical element
US3991055A (en) *	1975-05-30	1976-11-09	Coulter Electronics, Inc.	Liquid transfer valve
US4121466A (en) *	1977-04-19	1978-10-24	Technicon Instruments Corporation	Liquid dispenser with an improved probe
US4259291A (en)	1979-07-13	1981-03-31	Technicon Instruments Corporation	Metering device
US4526754A (en) *	1982-07-30	1985-07-02	Technicon Instruments Corporation	Sample transport system
US4853336A (en)	1982-11-15	1989-08-01	Technicon Instruments Corporation	Single channel continuous flow system
US4574850A (en) *	1985-01-17	1986-03-11	E. I. Du Pont De Nemours And Company	Method of and apparatus for dispensing liquid
AU8326887A (en)	1986-11-19	1988-06-16	Technicon Instruments Corportion	Method and apparatus for conveying information in a liquid sample transport system
US4984475A (en) *	1989-07-24	1991-01-15	Tritech Partners	Ultra low carryover sample liquid analysis apparatus and method
US5399497A (en) *	1992-02-26	1995-03-21	Miles, Inc.	Capsule chemistry sample liquid analysis system and method
US5646049A (en)	1992-03-27	1997-07-08	Abbott Laboratories	Scheduling operation of an automated analytical system
US5552064A (en)	1993-02-26	1996-09-03	Ortho Diagnostic Systems, Inc.	Column agglutination assay and device using biphasic centrifugation
US5441895A (en)	1993-12-07	1995-08-15	Jakubowicz; Raymond F.	Reagent cup shape allowing stacking without dislodging reagent
JPH07159415A (ja) *	1993-12-08	1995-06-23	Hitachi Ltd	自動試料導入方法
KR100306951B1 (ko)	1995-12-05	2001-11-15	테칸 보스턴, 인코포레이티드	내장된정보과학에의해미세유체공학시스템내의유체유동을구동시키기위해구심가속도를이용하는장치및방법
WO1997039359A1 (en) *	1996-04-15	1997-10-23	Dade International Inc.	Apparatus and method for analysis
CN1329729C (zh) *	1996-06-28	2007-08-01	卡钳生命科学股份有限公司	微流体系统
US5992820A (en)	1997-11-19	1999-11-30	Sarnoff Corporation	Flow control in microfluidics devices by controlled bubble formation
US6348354B1 (en) *	1998-07-06	2002-02-19	Bayer Corporation	Method and apparatus for controlling a stream of liquid test packages in a capsule chemistry analysis system
US6524456B1 (en) *	1999-08-12	2003-02-25	Ut-Battelle, Llc	Microfluidic devices for the controlled manipulation of small volumes
US6610499B1 (en)	2000-08-31	2003-08-26	The Regents Of The University Of California	Capillary array and related methods
US6453928B1 (en)	2001-01-08	2002-09-24	Nanolab Ltd.	Apparatus, and method for propelling fluids
US7077152B2 (en) *	2001-07-07	2006-07-18	Nanostream, Inc.	Microfluidic metering systems and methods
FR2829948B1 (fr) *	2001-09-21	2004-07-09	Commissariat Energie Atomique	Procede de deplacement d'un fluide d'interet dans un capillaire et microsysteme fluidique

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KR20040111119A (ko)	2004-12-31
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US7247487B2 (en)	2007-07-24
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KR101140439B1 (ko)	2012-04-30
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