JP2007508360A5 - - Google Patents

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Publication number: JP2007508360A5
Authority: JP; Japan
Prior art keywords: compound; group; pharmaceutically acceptable; solvate; hydrate
Prior art date: 2004-10-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2006534799A

Other languages

English (en)

Japanese (ja)

Other versions

JP4754494B2 (ja

JP2007508360A (ja

Filing date

2004-10-15

Publication date

2011-05-26

2003-10-17 Priority claimed from FR0312141A external-priority patent/FR2861071B1/fr

2004-10-15 Application filed filed Critical

2007-04-05 Publication of JP2007508360A publication Critical patent/JP2007508360A/ja

2011-05-26 Publication of JP2007508360A5 publication Critical patent/JP2007508360A5/ja

2011-08-24 Application granted granted Critical

2011-08-24 Publication of JP4754494B2 publication Critical patent/JP4754494B2/ja

2024-10-15 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 claims 22
150000003839 salts Chemical class 0.000 claims 7
239000012453 solvate Substances 0.000 claims 7
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 6
239000002253 acid Substances 0.000 claims 6
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
239000003814 drug Substances 0.000 claims 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 2
208000018737 Parkinson disease Diseases 0.000 claims 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
208000035475 disorder Diseases 0.000 claims 2
206010015037 epilepsy Diseases 0.000 claims 2
125000005843 halogen group Chemical group 0.000 claims 2
238000004519 manufacturing process Methods 0.000 claims 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
125000001424 substituent group Chemical group 0.000 claims 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
206010001605 Alcohol poisoning Diseases 0.000 claims 1
208000019901 Anxiety disease Diseases 0.000 claims 1
206010012289 Dementia Diseases 0.000 claims 1
208000030814 Eating disease Diseases 0.000 claims 1
208000024658 Epilepsy syndrome Diseases 0.000 claims 1
208000002877 Epileptic Syndromes Diseases 0.000 claims 1
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
208000019454 Feeding and Eating disease Diseases 0.000 claims 1
208000019695 Migraine disease Diseases 0.000 claims 1
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 1
206010062575 Muscle contracture Diseases 0.000 claims 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
208000002193 Pain Diseases 0.000 claims 1
206010033664 Panic attack Diseases 0.000 claims 1
208000028017 Psychotic disease Diseases 0.000 claims 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
125000003342 alkenyl group Chemical group 0.000 claims 1
125000000304 alkynyl group Chemical group 0.000 claims 1
230000003542 behavioural effect Effects 0.000 claims 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
208000006111 contracture Diseases 0.000 claims 1
125000004093 cyano group Chemical group *C#N 0.000 claims 1
201000010099 disease Diseases 0.000 claims 1
235000014632 disordered eating Nutrition 0.000 claims 1
125000001153 fluoro group Chemical group F* 0.000 claims 1
206010027599 migraine Diseases 0.000 claims 1
230000004112 neuroprotection Effects 0.000 claims 1
229910052757 nitrogen Inorganic materials 0.000 claims 1
125000004433 nitrogen atom Chemical group N* 0.000 claims 1
208000019906 panic disease Diseases 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
208000019899 phobic disease Diseases 0.000 claims 1
208000020016 psychiatric disease Diseases 0.000 claims 1
230000009329 sexual behaviour Effects 0.000 claims 1
201000002859 sleep apnea Diseases 0.000 claims 1
208000024891 symptom Diseases 0.000 claims 1
125000004001 thioalkyl group Chemical group 0.000 claims 1

JP2006534799A 2003-10-17 2004-10-15 Ｎ−［フェニル（アルキルピペリジン−２−イル）メチル］ベンズアミド誘導体、この調製方法およびこの治療法における使用 Expired - Fee Related JP4754494B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0312141		2003-10-17
FR0312141A FR2861071B1 (fr)	2003-10-17	2003-10-17	Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
PCT/FR2004/002642 WO2005037782A2 (fr)	2003-10-17	2004-10-15	Derives de n-[phenyl(alkylpiperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique

Publications (3)

Publication Number	Publication Date
JP2007508360A JP2007508360A (ja)	2007-04-05
JP2007508360A5 true JP2007508360A5 (2)	2011-05-26
JP4754494B2 JP4754494B2 (ja)	2011-08-24

Family

ID=34385234

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2006534799A Expired - Fee Related JP4754494B2 (ja)	2003-10-17	2004-10-15	Ｎ−［フェニル（アルキルピペリジン−２−イル）メチル］ベンズアミド誘導体、この調製方法およびこの治療法における使用

Country Status (26)

Country	Link
US (1)	US7790753B2 (2)
EP (1)	EP1682503B1 (2)
JP (1)	JP4754494B2 (2)
CN (1)	CN1882541B (2)
AT (1)	ATE359268T1 (2)
AU (1)	AU2004281216B2 (2)
BR (1)	BRPI0415433A (2)
CA (1)	CA2542925A1 (2)
CY (1)	CY1106653T1 (2)
DE (1)	DE602004005886T2 (2)
DK (1)	DK1682503T3 (2)
ES (1)	ES2282916T3 (2)
FR (1)	FR2861071B1 (2)
HR (1)	HRP20070203T3 (2)
IL (1)	IL174936A (2)
MA (1)	MA28100A1 (2)
ME (1)	MEP12708A (2)
NO (1)	NO20062031L (2)
NZ (1)	NZ547166A (2)
PL (1)	PL1682503T3 (2)
PT (1)	PT1682503E (2)
RS (1)	RS20060317A (2)
RU (1)	RU2351589C2 (2)
SI (1)	SI1682503T1 (2)
WO (1)	WO2005037782A2 (2)
ZA (1)	ZA200603942B (2)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2842804B1 (fr)	2002-07-29	2004-09-03	Sanofi Synthelabo	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) *	2003-10-17	2006-04-07	Sanofi Synthelabo	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
PE20061156A1 (es)	2004-12-23	2006-12-16	Glaxo Group Ltd	Derivados de benzamida como agentes inhibidores del transportador de glicina
GB0600427D0 (en)	2006-01-10	2006-02-15	Glaxo Group Ltd	Compounds
JP2009535301A (ja) *	2006-04-05	2009-10-01	グラクソグループリミテッド	グリシントランスポーターを阻害する化合物およびその使用
GB0612416D0 (en) *	2006-06-22	2006-08-02	Glaxo Group Ltd	Compounds
KR20090117950A (ko)	2007-03-08	2009-11-16	더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티	미토콘드리아 알데히드 탈수소효소-2 조절자 및 그것의 사용 방법
TW200911808A (en) *	2007-07-23	2009-03-16	Astrazeneca Ab	Novel compounds
MX2009014235A (es)	2007-08-22	2010-04-27	Abbott Gmbh & Co Kg	4-bencilaminoquinolonas, composiciones farmaceuticas que las contiene y su uso.
MX2010010773A (es)	2008-04-01	2011-04-11	Abbott Gmbh & Co Kg	Tetrahidroisoquinolinas, composiciones farmaceuticas que las contienen y su uso en terapia.
EP2337563B1 (en)	2008-09-08	2014-04-09	The Board of Trustees of The Leland Stanford Junior University	Modulators of aldehyde dehydrogenase activity and methods of use thereof
KR20110082180A (ko)	2008-10-28	2011-07-18	더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티	알데히드 탈수소효소의 조절자 및 그것의 사용방법
UA104611C2 (en) *	2009-01-27	2014-02-25	Ф. Хоффманн-Ля Рош Аг	Aroylamino- and heteroaroylamino-substituted piperidines as glyt-1 inhibitors
WO2010087761A1 (en) *	2009-01-28	2010-08-05	Astrazeneca Ab	2-aza-bicyclo[2.2.2]octane compounds and uses thereof
TW201038569A (en)	2009-02-16	2010-11-01	Abbott Gmbh & Co Kg	Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
AR075442A1 (es)	2009-02-16	2011-03-30	Abbott Gmbh & Co Kg	Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
FR2943056A1 (fr) *	2009-03-16	2010-09-17	Sanofi Aventis	Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
CA2755526A1 (fr) *	2009-03-16	2010-09-23	Sanofi	Derives de n-[(2-aza-bicyclo[2.1.1]hex-1-yl)-aryl-methyl]-heterobenzamide, leur preparation et leur application en therapeutique
JP5618047B2 (ja) *	2010-01-29	2014-11-05	国立大学法人千葉大学	ポジトロン断層撮影法およびポジトロン放出化合物
US9051280B2 (en)	2010-08-13	2015-06-09	AbbVie Deutschland GmbH & Co. KG	Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en)	2010-08-13	2014-11-11	Abbott Laboratories	Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en)	2010-08-13	2014-11-04	Abbott Laboratories	Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en)	2010-08-13	2014-09-30	Abbott Laboratories	Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en)	2010-08-13	2015-06-02	AbbVie Deutschland GmbH & Co. KG	Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2012149106A1 (en)	2011-04-29	2012-11-01	The Board Of Trustees Of The Leland Stanford Junior University	Compositions and methods for increasing proliferation of adult salivary stem cells
US9309200B2 (en)	2011-05-12	2016-04-12	AbbVie Deutschland GmbH & Co. KG	Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
CA2844275A1 (en)	2011-08-05	2013-02-14	AbbVie Deutschland GmbH & Co. KG	Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2014006004A (es)	2011-11-18	2015-04-16	Abbvie Deutschland	Derivados de aminobenzociclohepteno, aminotetralina, aminoindano y fenalcilamina n-sustituidas, composiciones farmaceuticas que los contienen, y su uso en terapia.
US9365512B2 (en)	2012-02-13	2016-06-14	AbbVie Deutschland GmbH & Co. KG	Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
JP6410790B2 (ja)	2013-03-14	2018-10-24	ザボードオブトラスティーズオブザレランドスタンフォードジュニアユニバーシティー	ミトコンドリアアルデヒドデヒドロゲナーゼ−２調節因子およびその使用方法
US9656955B2 (en)	2013-03-15	2017-05-23	Abbvie Inc.	Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en)	2013-03-15	2017-05-16	Abbvie Inc.	Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
CA2924689A1 (en)	2013-10-17	2015-04-23	AbbVie Deutschland GmbH & Co. KG	Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2016004934A (es)	2013-10-17	2016-12-20	Abbvie Deutschland	Derivados de aminotetralina y aminoindano, composiciones farmaceuticas que los contienen, y su uso en terapia.
US9550754B2 (en)	2014-09-11	2017-01-24	AbbVie Deutschland GmbH & Co. KG	4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3801636A (en) *	1971-08-13	1974-04-02	Abbott Lab	3,4,5-tri-substituted cinnamides
US5254569A (en) *	1991-01-14	1993-10-19	The Du Pont Merck Pharmaceutical Company	(Amidomethyl)nitrogen heterocyclic analgesics
JP3026845B2 (ja) *	1991-02-20	2000-03-27	日清製粉株式会社	ピペリジン誘導体
CZ284456B6 (cs) *	1992-02-15	1998-12-16	Hoechst Aktiengesellschaft	Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
EP1058684A1 (en) *	1998-03-06	2000-12-13	Janssen Pharmaceutica N.V.	Glycine transport inhibitors
FR2838739B1 (fr) *	2002-04-19	2004-05-28	Sanofi Synthelabo	Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique
FR2842804B1 (fr) *	2002-07-29	2004-09-03	Sanofi Synthelabo	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
BR0317324A (pt) *	2002-12-18	2005-11-16	Fmc Corp	N-(arilmetil substituìdo)-4-(metil dissubstituìdo) piperidinas e piridinas
FR2861073B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
FR2861070B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
WO2005080367A1 (en) *	2004-02-12	2005-09-01	Pharmagene Laboratories Limited	Ep2 receptor agonists
CA2602626A1 (en) *	2005-04-11	2006-10-19	Yale University	Method of treating schizophrenia prodrome

2003
- 2003-10-17 FR FR0312141A patent/FR2861071B1/fr not_active Expired - Fee Related
2004
- 2004-10-15 RU RU2006116886/04A patent/RU2351589C2/ru not_active IP Right Cessation
- 2004-10-15 SI SI200430307T patent/SI1682503T1/sl unknown
- 2004-10-15 DE DE602004005886T patent/DE602004005886T2/de not_active Expired - Lifetime
- 2004-10-15 WO PCT/FR2004/002642 patent/WO2005037782A2/fr not_active Ceased
- 2004-10-15 CN CN200480033878XA patent/CN1882541B/zh not_active Expired - Fee Related
- 2004-10-15 EP EP04791553A patent/EP1682503B1/fr not_active Expired - Lifetime
- 2004-10-15 AT AT04791553T patent/ATE359268T1/de active
- 2004-10-15 PT PT04791553T patent/PT1682503E/pt unknown
- 2004-10-15 ME MEP-127/08A patent/MEP12708A/xx unknown
- 2004-10-15 ES ES04791553T patent/ES2282916T3/es not_active Expired - Lifetime
- 2004-10-15 BR BRPI0415433-9A patent/BRPI0415433A/pt not_active IP Right Cessation
- 2004-10-15 HR HR20070203T patent/HRP20070203T3/xx unknown
- 2004-10-15 DK DK04791553T patent/DK1682503T3/da active
- 2004-10-15 CA CA002542925A patent/CA2542925A1/fr not_active Abandoned
- 2004-10-15 PL PL04791553T patent/PL1682503T3/pl unknown
- 2004-10-15 NZ NZ547166A patent/NZ547166A/en not_active IP Right Cessation
- 2004-10-15 JP JP2006534799A patent/JP4754494B2/ja not_active Expired - Fee Related
- 2004-10-15 AU AU2004281216A patent/AU2004281216B2/en not_active Ceased
2006
- 2006-04-11 IL IL174936A patent/IL174936A/en not_active IP Right Cessation
- 2006-04-17 MA MA28945A patent/MA28100A1/fr unknown
- 2006-04-17 US US11/405,285 patent/US7790753B2/en not_active Expired - Fee Related
- 2006-05-05 NO NO20062031A patent/NO20062031L/no not_active Application Discontinuation
- 2006-05-16 ZA ZA200603942A patent/ZA200603942B/en unknown
- 2006-10-15 RS RSP-2006/0317A patent/RS20060317A/sr unknown
2007
- 2007-06-11 CY CY20071100778T patent/CY1106653T1/el unknown

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