|
SE0104140D0
(sv)
*
|
2001-12-07 |
2001-12-07 |
Astrazeneca Ab |
Novel Compounds
|
|
ATE482213T1
(de)
*
|
2004-11-04 |
2010-10-15 |
Vertex Pharma |
Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine
|
|
PT1853588E
(pt)
*
|
2005-02-16 |
2008-08-25 |
Astrazeneca Ab |
Compostos químicos
|
|
US20090156617A1
(en)
*
|
2005-05-12 |
2009-06-18 |
Northrup Alan B |
Tyrosine kinase inhibitors
|
|
EP1899323A2
(en)
*
|
2005-05-16 |
2008-03-19 |
AstraZeneca AB |
Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
|
|
WO2007046867A2
(en)
*
|
2005-05-19 |
2007-04-26 |
Xenon Pharmaceuticals Inc. |
Piperidine derivatives and their uses as therapeutic agents
|
|
WO2006127587A1
(en)
*
|
2005-05-20 |
2006-11-30 |
Vertex Pharmaceuticals Incorporated |
Pyrrolopyridines useful as inhibitors of protein kinase
|
|
WO2007049041A1
(en)
*
|
2005-10-28 |
2007-05-03 |
Astrazeneca Ab |
4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer
|
|
EP2455382B1
(en)
|
2005-12-13 |
2016-10-26 |
Incyte Holdings Corporation |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
|
|
GB0601638D0
(en)
*
|
2006-01-27 |
2006-03-08 |
Merck Sharp & Dohme |
Therapeutic treatment
|
|
PE20080403A1
(es)
*
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
|
US8198448B2
(en)
|
2006-07-14 |
2012-06-12 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
CA2668286C
(en)
|
2006-11-03 |
2014-09-16 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
|
CN101778825A
(zh)
*
|
2007-03-22 |
2010-07-14 |
沃泰克斯药物股份有限公司 |
适用作詹纳斯激酶抑制剂的n-杂环类化合物
|
|
WO2008129255A1
(en)
*
|
2007-04-18 |
2008-10-30 |
Astrazeneca Ab |
5-aminopyrazol-3-yl-3h-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer
|
|
UA99459C2
(en)
*
|
2007-05-04 |
2012-08-27 |
Астразенека Аб |
9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
|
|
US20100137398A1
(en)
*
|
2007-05-04 |
2010-06-03 |
Novartis Ag |
Use of hdac inhibitors for the treatment of gastrointestinal cancers
|
|
EP3070090B1
(en)
|
2007-06-13 |
2018-12-12 |
Incyte Holdings Corporation |
Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
|
|
CN101878217B
(zh)
*
|
2007-09-28 |
2014-01-15 |
协和发酵麒麟株式会社 |
皮肤疾病的预防和/或治疗剂
|
|
WO2009064835A1
(en)
*
|
2007-11-16 |
2009-05-22 |
Incyte Corporation |
4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
|
|
NZ586662A
(en)
*
|
2007-12-19 |
2012-08-31 |
Vertex Pharma |
PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JANUS KINASE 2 INHIBITORS
|
|
AU2008343813B2
(en)
*
|
2007-12-19 |
2012-04-12 |
Amgen Inc. |
Inhibitors of PI3 kinase
|
|
JP5638961B2
(ja)
*
|
2008-03-13 |
2014-12-10 |
ザ ジェネラル ホスピタル コーポレイション |
Ｂｍｐシグナル伝達経路のインヒビター
|
|
KR20110017445A
(ko)
*
|
2008-06-11 |
2011-02-21 |
아스트라제네카 아베 |
암 및 골수증식성 장애의 치료에 유용한 트리시클릭 2,4-디아미노-ｌ,3,5-트리아진 유도체
|
|
WO2010031816A1
(en)
*
|
2008-09-19 |
2010-03-25 |
Nerviano Medical Sciences S.R.L. |
3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES
|
|
PT2350075E
(pt)
|
2008-09-22 |
2014-06-09 |
Array Biopharma Inc |
Compostos imidazo[1,2b]piridazina substituídos como inibidores da trk cinase
|
|
CN102227422A
(zh)
*
|
2008-09-30 |
2011-10-26 |
阿斯利康(瑞典)有限公司 |
杂环jak激酶抑制剂
|
|
CN102271515B
(zh)
*
|
2008-10-31 |
2014-07-02 |
健泰科生物技术公司 |
吡唑并嘧啶jak抑制剂化合物和方法
|
|
GB0821913D0
(en)
|
2008-12-02 |
2009-01-07 |
Price & Co |
Antibacterial compounds
|
|
JP5775070B2
(ja)
*
|
2009-05-22 |
2015-09-09 |
インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ |
ヤヌスキナーゼ阻害剤としてのピラゾール−４−イル−ピロロ［２，３−ｄ］ピリミジンおよびピロール−３−イル−ピロロ［２，３−ｄ］ピリミジンのＮ−（ヘテロ）アリール−ピロリジン誘導体
|
|
SG176111A1
(en)
*
|
2009-05-22 |
2011-12-29 |
Incyte Corp |
3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
|
|
CN102448969A
(zh)
*
|
2009-05-28 |
2012-05-09 |
沃泰克斯药物股份有限公司 |
C-met蛋白激酶抑制剂
|
|
RS57869B1
(sr)
|
2009-06-17 |
2018-12-31 |
Vertex Pharma |
Inhibitori replikacije virusa gripa
|
|
UA110324C2
(en)
|
2009-07-02 |
2015-12-25 |
Genentech Inc |
Jak inhibitory compounds based on pyrazolo pyrimidine
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
AR078012A1
(es)
*
|
2009-09-01 |
2011-10-05 |
Incyte Corp |
Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
|
|
PT2473049T
(pt)
|
2009-09-04 |
2019-03-04 |
Sunesis Pharmaceuticals Inc |
Inibidores de tirosina quinase de bruton
|
|
PT3354652T
(pt)
|
2010-03-10 |
2020-07-20 |
Incyte Holdings Corp |
Derivados de piperidin-4-ilazetidina como inibidores de jak1
|
|
WO2011130515A1
(en)
*
|
2010-04-14 |
2011-10-20 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Arylthiazolyl piperidines and related compounds as modulators of survival motor neuron (smn) protein production
|
|
JP5960688B2
(ja)
|
2010-05-17 |
2016-08-02 |
インコゼン セラピューティクス プライベート リミテッド |
プロテインキナーゼ調節物質としての新規３，５−二置換−３ｈ−［１，２，３］トリアゾロ［４，５−ｂ］ピリジン化合物
|
|
NZ604708A
(en)
|
2010-05-20 |
2015-05-29 |
Array Biopharma Inc |
Macrocyclic compounds as trk kinase inhibitors
|
|
RS54824B1
(sr)
|
2010-05-21 |
2016-10-31 |
Incyte Holdings Corp |
Topikalna formulacija za inhibiciju jak-a
|
|
ES2568455T3
(es)
|
2010-06-01 |
2016-04-29 |
Summit Therapeutics Plc |
Compuestos para el tratamiento de enfermedad asociada a Clostridium difficile
|
|
GB2480814A
(en)
*
|
2010-06-01 |
2011-12-07 |
Summit Corp Plc |
Compounds for the treatment of clostridium difficile-associated disease
|
|
CA2818542A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
WO2012068440A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
|
AU2011343642A1
(en)
*
|
2010-12-16 |
2013-05-02 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
KR20180084153A
(ko)
*
|
2011-06-10 |
2018-07-24 |
메르크 파텐트 게엠베하 |
Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법
|
|
MY165963A
(en)
|
2011-06-20 |
2018-05-18 |
Incyte Holdings Corp |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
|
|
WO2012178125A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
UA118010C2
(uk)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
|
|
WO2013028263A1
(en)
*
|
2011-08-24 |
2013-02-28 |
Glaxosmithkline Llc |
Pyrazolopyrimidine derivatives as pi3 kinase inhibitors
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
EP2831073B1
(en)
|
2012-03-30 |
2020-12-09 |
Rhizen Pharmaceuticals S.A. |
Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b]pyridine compounds as modulators of c-met protein kinases
|
|
TW201406761A
(zh)
|
2012-05-18 |
2014-02-16 |
Incyte Corp |
做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
|
|
AR091273A1
(es)
*
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
EP2884978B1
(en)
*
|
2012-08-16 |
2019-07-17 |
The Scripps Research Institute |
Novel kappa opioid ligands
|
|
CN113384546A
(zh)
|
2012-11-15 |
2021-09-14 |
因赛特公司 |
鲁索利替尼的缓释剂型
|
|
WO2014081996A1
(en)
*
|
2012-11-23 |
2014-05-30 |
Glaxosmithkline Llc |
Novel compounds as diacylglycerol acyltransferase inhibitors
|
|
SI2941432T1
(en)
|
2012-12-07 |
2018-07-31 |
Vertex Pharmaceuticals Incorporated |
2-AMINO-6-FLUORO-N- (5-FLUORO-4- (4- (4- (OXETHAN-3-YL) PIPERAZIN-1-CARBONYL) PIPERIDIN-1-YLIPRIDIN-3-YL) 1,5 ALFA) PYRIMIDINE-3-CARBOXAMIDE AS ATR KINAZE INHIBITOR
|
|
TW201501713A
(zh)
*
|
2013-03-01 |
2015-01-16 |
Kyowa Hakko Kirin Co Ltd |
眼炎症性疾病之預防及／或治療劑
|
|
WO2014138168A1
(en)
|
2013-03-06 |
2014-09-12 |
Incyte Corporation |
Processes and intermediates for making a jak inhibitor
|
|
US9682983B2
(en)
|
2013-03-14 |
2017-06-20 |
The Brigham And Women's Hospital, Inc. |
BMP inhibitors and methods of use thereof
|
|
EP2970289A1
(en)
|
2013-03-15 |
2016-01-20 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
WO2014143242A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
JP2016512815A
(ja)
|
2013-03-15 |
2016-05-09 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
Ａｔｒキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体
|
|
WO2014175370A1
(ja)
*
|
2013-04-25 |
2014-10-30 |
塩野義製薬株式会社 |
ピロリジン誘導体およびそれらを含有する医薬組成物
|
|
SG10201801069QA
(en)
|
2013-08-07 |
2018-03-28 |
Incyte Corp |
Sustained release dosage forms for a jak1 inhibitor
|
|
HRP20181272T1
(hr)
|
2013-11-13 |
2018-10-05 |
Vertex Pharmaceuticals Incorporated |
Postupci priprave inhibitora replikacije virusa influence
|
|
RS59144B1
(sr)
|
2013-11-13 |
2019-09-30 |
Vertex Pharma |
Inhibitori replikacije virusa influence
|
|
WO2015073267A1
(en)
*
|
2013-11-15 |
2015-05-21 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
CN104650092B
(zh)
*
|
2013-11-16 |
2017-11-10 |
广东东阳光药业有限公司 |
取代的杂芳基化合物及其组合物和用途
|
|
DK3077397T3
(da)
|
2013-12-06 |
2019-12-16 |
Vertex Pharma |
2-amino-6-fluor-n-[5-fluor-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamidforbindelse anvendelig som atr-kinase-inhibitor, dens fremstilling, forskellige faste former og radiomarkerede derivater deraf
|
|
PE20211782A1
(es)
|
2014-05-23 |
2021-09-08 |
Hoffmann La Roche |
Compuestos de 5-cloro-2-difluorometoxifenil pirazolopirimidina, composiciones y metodos de uso de los mismos
|
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
|
PL3152212T3
(pl)
|
2014-06-05 |
2020-06-15 |
Vertex Pharmaceuticals Inc. |
Radioznakowane pochodne związku 2-amino-6-fluoro-n-[5-fluoro-piridyn-3-ylo]-pirazolo[1,5-a]pirymidino-3-karboksamidu przydatne jako inhibitor kinazy atr, wytwarzanie tego związku i jego różnych postaci stałych
|
|
LT3157566T
(lt)
|
2014-06-17 |
2019-08-12 |
Vertex Pharmaceuticals Incorporated |
Vėžio gydymo būdas, panaudojant chk1 ir atr inhibitorių derinį
|
|
WO2016011019A1
(en)
|
2014-07-15 |
2016-01-21 |
The Brigham And Women's Hospital, Inc. |
Compositions and methods for inhibiting bmp
|
|
HUE061448T2
(hu)
|
2014-11-16 |
2023-07-28 |
Array Biopharma Inc |
(S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-A]pirimidin-3-il) -3-hidroxipirrolidin-1-karboxamid-hidrogénszulfát kristályos formája
|
|
JP6704416B2
(ja)
|
2015-05-13 |
2020-06-03 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
インフルエンザウイルスの複製の阻害剤を調製する方法
|
|
JP6857617B2
(ja)
|
2015-05-13 |
2021-04-14 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
インフルエンザウイルスの複製の阻害剤
|
|
HK1258570A1
(zh)
|
2015-09-30 |
2019-11-15 |
Vertex Pharmaceuticals Inc. |
使用dna损伤剂及atr抑制剂的组合治疗癌症的方法
|
|
CN108697708A
(zh)
|
2015-10-26 |
2018-10-23 |
洛克索肿瘤学股份有限公司 |
Trk抑制剂抗性癌症中的点突变以及与此相关的方法
|
|
ES2987474T3
(es)
|
2016-04-04 |
2024-11-15 |
Loxo Oncology Inc |
Formulaciones líquidas de (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-IL)-pirazolo[1,5-A]pirimidin-3-IL)-3-hidroxipirrolidina-1-carboxamida
|
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
ES2836222T3
(es)
|
2016-05-18 |
2021-06-24 |
Loxo Oncology Inc |
Preparación de (S)-N-(5-((R)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
|
|
AU2017299850B2
(en)
|
2016-07-18 |
2021-05-27 |
University Health Network |
Solid forms of TTK inhibitor
|
|
JP7214632B2
(ja)
|
2016-07-21 |
2023-01-30 |
バイオジェン エムエー インク． |
ブルトン型チロシンキナーゼ阻害剤のコハク酸塩形態および組成物
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
WO2018200855A1
(en)
|
2017-04-27 |
2018-11-01 |
The Brigham And Women's Hospital, Inc. |
Novel alk2 inhibitors and methods for inhibiting bmp signaling
|
|
PL233595B1
(pl)
*
|
2017-05-12 |
2019-11-29 |
Celon Pharma Spolka Akcyjna |
Pochodne pirazolo[1,5-a]pirymidyny jako inhibitory kinazy JAK
|
|
WO2018215389A1
(en)
|
2017-05-22 |
2018-11-29 |
F. Hoffmann-La Roche Ag |
Therapeutic compounds and compositions, and methods of use thereof
|
|
AR113922A1
(es)
|
2017-12-08 |
2020-07-01 |
Incyte Corp |
Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
|
|
KR20200116481A
(ko)
*
|
2018-01-29 |
2020-10-12 |
메르크 파텐트 게엠베하 |
Gcn2 억제제 및 이의 용도
|
|
EP3746071A4
(en)
|
2018-01-29 |
2021-09-01 |
Merck Patent GmbH |
GCN2 INHIBITORS AND THEIR USES
|
|
EA202091830A1
(ru)
|
2018-01-30 |
2020-12-29 |
Инсайт Корпорейшн |
Способы и промежуточные соединения для получения ингибитора jak
|
|
MD3773593T2
(ro)
|
2018-03-30 |
2024-10-31 |
Incyte Corp |
Tratament hidradenitei supurative utilizând inhibitori ai JAK
|
|
JP7504880B2
(ja)
*
|
2018-10-26 |
2024-06-24 |
ケロス セラピューティクス インコーポレイテッド |
Ａｌｋ２阻害剤の結晶形
|
|
CA3124088A1
(en)
|
2018-12-20 |
2020-06-25 |
Incyte Corporation |
Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2
|
|
US12508262B2
(en)
|
2020-04-30 |
2025-12-30 |
Keros Therapeutics, Inc. |
Methods of using ALK2 inhibitors
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
WO2022098812A1
(en)
|
2020-11-04 |
2022-05-12 |
Keros Therapeutics, Inc. |
Methods of treating iron overload
|
|
US20250042873A1
(en)
*
|
2021-08-24 |
2025-02-06 |
The Johns Hopkins University |
Compositions and methods for treating proteotoxicity-associated diseases
|
|
CN116987083A
(zh)
*
|
2022-04-25 |
2023-11-03 |
杭州健崃生物科技有限公司 |
吡唑并[1,5-a]嘧啶衍生物及其制备方法和用途
|
|
KR102912267B1
(ko)
|
2023-04-20 |
2026-01-15 |
한국화학연구원 |
신규한 헤테로고리 화합물 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 포함하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물
|