JP2008520740A - Ｖｅｇｆ産生を阻害する活性因子としての置換されたフェノール - Google Patents

Ｖｅｇｆ産生を阻害する活性因子としての置換されたフェノール Download PDF

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JP2008520740A
JP2008520740A JP2007543448A JP2007543448A JP2008520740A JP 2008520740 A JP2008520740 A JP 2008520740A JP 2007543448 A JP2007543448 A JP 2007543448A JP 2007543448 A JP2007543448 A JP 2007543448A JP 2008520740 A JP2008520740 A JP 2008520740A
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スーンキュ チョウイ，
ヤン−チューン ムーン，
ナダラジャン タミララス，
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ピーティーシー セラピューティクス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2007543448A 2004-11-23 2005-11-23 Ｖｅｇｆ産生を阻害する活性因子としての置換されたフェノール Pending JP2008520740A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62988904P 2004-11-23 2004-11-23
US63373804P 2004-12-06 2004-12-06
US63928304P 2004-12-27 2004-12-27
PCT/US2005/042482 WO2006065479A2 (en) 2004-11-23 2005-11-23 Substituted phenols as active agents inhibiting vegf production

Publications (1)

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JP2008520740A true JP2008520740A (ja) 2008-06-19

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007543448A Pending JP2008520740A (ja) 2004-11-23 2005-11-23 Ｖｅｇｆ産生を阻害する活性因子としての置換されたフェノール
JP2007543450A Pending JP2008520742A (ja) 2004-11-23 2005-11-23 Ｖｅｇｆ産生の阻害に有用なカルバゾール誘導体、カルボリン誘導体およびインドール誘導体
JP2007543449A Pending JP2008520741A (ja) 2004-11-23 2005-11-23 翻訳制御によるｖｅｇｆ生成を阻害するための活性因子としてのテトラヒドロカルバゾール

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Application Number Title Priority Date Filing Date
JP2007543450A Pending JP2008520742A (ja) 2004-11-23 2005-11-23 Ｖｅｇｆ産生の阻害に有用なカルバゾール誘導体、カルボリン誘導体およびインドール誘導体
JP2007543449A Pending JP2008520741A (ja) 2004-11-23 2005-11-23 翻訳制御によるｖｅｇｆ生成を阻害するための活性因子としてのテトラヒドロカルバゾール

Country Status (6)

Country Link
US (3) US8946444B2 (2)
EP (3) EP1824821A2 (2)
JP (3) JP2008520740A (2)
CA (3) CA2588389A1 (2)
MX (3) MX2007006180A (2)
WO (3) WO2006058088A2 (2)

Cited By (2)

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WO2012105610A1 (ja) * 2011-02-02 2012-08-09 公立大学法人名古屋市立大学 眼内血管新生及び／又は眼内血管透過性亢進を伴う疾患の予防又は治療のための医薬
JP2013509442A (ja) * 2009-10-29 2013-03-14 サートリス ファーマシューティカルズ， インコーポレイテッド サーチュイン調節因子としての二環式ピリジンおよび類似体

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US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
UA92317C2 (ru) 2004-03-15 2010-10-25 Пи-Ти-Си ТЕРАПЬЮТИКС, ИНК. Производные карболина, пригодные для ингибирования развития кровеносных сосудов
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
EP1831225A2 (en) 2004-11-19 2007-09-12 The Regents of the University of California Anti-inflammatory pyrazolopyrimidines
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
CA2612723A1 (en) 2005-06-24 2007-01-04 Eli Lilly And Company Tetrahydrocarbazole derivatives useful as androgen receptor modulators
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WO2007114926A2 (en) 2006-04-04 2007-10-11 The Regents Of The University Of California Kinase antagonists
CA2656357C (en) 2006-07-19 2014-05-06 E.I. Du Pont De Nemours And Company Process for making 3-substituted 2-amino-5-halobenzamides
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UA98777C2 (en) 2006-11-20 2012-06-25 Эли Лилли Энд Компани Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators
DE102007009235A1 (de) * 2007-02-22 2008-09-18 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
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GB2467670B (en) 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
WO2009078423A1 (ja) * 2007-12-18 2009-06-25 National University Corporation University Of Toyama アルドース還元酵素阻害活性を有する縮合三環化合物
MX2010007419A (es) 2008-01-04 2010-11-12 Intellikine Inc Ciertas entidades quimicas, composiciones y metodos.
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP2252293B1 (en) 2008-03-14 2018-06-27 Intellikine, LLC Kinase inhibitors and methods of use
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
ATE537143T1 (de) 2008-03-27 2011-12-15 Gruenenthal Gmbh Spiro(5.5)undecan derivate
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WO2009118174A1 (de) 2008-03-27 2009-10-01 Grünenthal GmbH Substituierte cyclohexyldiamine
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JPN6011052041; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052042; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052044; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052046; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052049; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052052; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052055; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052056; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052058; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052061; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052062; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052065; ＲＥＧＩＳＴＲＹ（ＳＴＮ）［ｏｎｌｉｎｅ］ *
JPN6011052068; ＹＯＯＮ，Ｋ．Ｊ．Ｐ．　ｅｔ　ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ　ａｎｄ　ｅｖａｌｕａｔｉｏｎ　ｏｆ　ｅｓｔｅｒｓ　ａｎｄ　ｃａｒｂａｍａｔｅｓ　ｔｏ　ｉｄｅｎｔｉｆｙ　ｃｒｉｔｉｃａｌ　ｆｕｎｃｔｉｏｎａｌ　ｇｒｏｕｐｓ　ｆｏｒ　ｅｓｔｅｒａｓ' Ｂｉｏｏｒｇａｎｉｃ　ａｎｄ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１１，　Ｎｏ．１５, 2003, ｐ．３２３７-３２４４ *
JPN6011052071; ＢＡＴＥＹ，Ｒ．Ａ．　ｅｔ　ａｌ．: 'Ａ　ｎｅｗ　ｐｒｏｔｏｃｏｌ　ｆｏｒ　ｔｈｅ　ｆｏｒｍａｔｉｏｎ　ｏｆ　ｃａｒｂａｍａｔｅｓ　ａｎｄ　ｔｈｉｏｃａｒｂａｍａｔｅｓ　ｕｓｉｎｇ　ｃａｒｂａｍｏｙｌ　ｉｍｉｄａｚｏｌｉｕｍ　ｓａｌｔｓ' Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ Ｖｏｌ．４０，　Ｎｏ．１４, 1999, ｐ．２６６９-２６７２ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509442A (ja) * 2009-10-29 2013-03-14 サートリス ファーマシューティカルズ， インコーポレイテッド サーチュイン調節因子としての二環式ピリジンおよび類似体
WO2012105610A1 (ja) * 2011-02-02 2012-08-09 公立大学法人名古屋市立大学 眼内血管新生及び／又は眼内血管透過性亢進を伴う疾患の予防又は治療のための医薬

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JP2008520741A (ja) 2008-06-19
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MX2007006179A (es) 2007-06-20
US8143257B2 (en) 2012-03-27
US20080261956A1 (en) 2008-10-23
MX2007006178A (es) 2007-06-20
CA2588389A1 (en) 2006-06-22
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CA2588607A1 (en) 2006-06-01
MX2007006180A (es) 2007-06-20
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WO2006065479A3 (en) 2006-08-03
US8946444B2 (en) 2015-02-03
US20150141418A1 (en) 2015-05-21
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US20090042866A1 (en) 2009-02-12

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