JP2008530102A5 - - Google Patents

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Publication number: JP2008530102A5
Authority: JP; Japan
Prior art keywords: alkyl; cycloalkyl; hydrogen; nitrogen; aryl
Prior art date: 2006-02-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2007555195A

Other languages

English (en)

Japanese (ja)

Other versions

JP4988604B2 (ja

JP2008530102A (ja

Filing date

2006-02-09

Publication date

2009-03-26

2006-02-09 Application filed filed Critical

2006-02-09 Priority claimed from PCT/US2006/004461 external-priority patent/WO2006086488A2/en

2008-08-07 Publication of JP2008530102A publication Critical patent/JP2008530102A/ja

2009-03-26 Publication of JP2008530102A5 publication Critical patent/JP2008530102A5/ja

2012-08-01 Application granted granted Critical

2012-08-01 Publication of JP4988604B2 publication Critical patent/JP4988604B2/ja

2026-02-09 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 63
229910052739 hydrogen Inorganic materials 0.000 claims description 40
239000001257 hydrogen Substances 0.000 claims description 40
229910052757 nitrogen Inorganic materials 0.000 claims description 37
229910052736 halogen Inorganic materials 0.000 claims description 22
125000003545 alkoxy group Chemical group 0.000 claims description 21
150000002367 halogens Chemical class 0.000 claims description 14
125000003342 alkenyl group Chemical group 0.000 claims description 11
150000001875 compounds Chemical class 0.000 claims description 11
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 11
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
229910052799 carbon Inorganic materials 0.000 claims description 10
125000000392 cycloalkenyl group Chemical group 0.000 claims description 10
125000001475 halogen functional group Chemical group 0.000 claims description 8
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 8
125000004429 atom Chemical group 0.000 claims description 6
125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims description 3
125000004430 oxygen atom Chemical group O* 0.000 claims description 3
IPWGCHBBVBSTMX-UHFFFAOYSA-N 3-[[5-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenyl]sulfanyl-2,2-dimethylpropyl]thiophene-2-carbonyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(C)(C)C)C(C)=CC=1SC(C(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)S1 IPWGCHBBVBSTMX-UHFFFAOYSA-N 0.000 claims description 2
125000004093 cyano group Chemical group *C#N 0.000 claims 7
125000000217 alkyl group Chemical group 0.000 claims 6
125000001424 substituent group Chemical group 0.000 claims 4
-1 - nitro Chemical group 0.000 claims 3
125000000304 alkynyl group Chemical group 0.000 claims 1
125000000753 cycloalkyl group Chemical group 0.000 claims 1
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
238000006467 substitution reaction Methods 0.000 claims 1
150000002431 hydrogen Chemical class 0.000 description 4
125000006701 (C1-C7) alkyl group Chemical group 0.000 description 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 1

JP2007555195A 2005-02-11 2006-02-09 グルカゴン受容体アンタゴニストとしての置換チオフェン誘導体、その調製及び治療への使用 Expired - Fee Related JP4988604B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US65249205P	2005-02-11	2005-02-11
US60/652,492		2005-02-11
PCT/US2006/004461 WO2006086488A2 (en)	2005-02-11	2006-02-09	Substituted thiophene derivatives as glucagon receptor antagonists, preparation and therapeutic uses

Publications (3)

Publication Number	Publication Date
JP2008530102A JP2008530102A (ja)	2008-08-07
JP2008530102A5 true JP2008530102A5 (2)	2009-03-26
JP4988604B2 JP4988604B2 (ja)	2012-08-01

Family

ID=36694345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2007555195A Expired - Fee Related JP4988604B2 (ja)	2005-02-11	2006-02-09	グルカゴン受容体アンタゴニストとしての置換チオフェン誘導体、その調製及び治療への使用

Country Status (25)

Country	Link
US (1)	US8084489B2 (2)
EP (1)	EP1856090B1 (2)
JP (1)	JP4988604B2 (2)
KR (1)	KR20070104409A (2)
CN (1)	CN101115735B (2)
AT (1)	ATE445609T1 (2)
AU (1)	AU2006213894B2 (2)
BR (1)	BRPI0607015A2 (2)
CA (1)	CA2597073C (2)
CR (1)	CR9304A (2)
CY (1)	CY1109624T1 (2)
DE (1)	DE602006009773D1 (2)
DK (1)	DK1856090T3 (2)
EA (1)	EA200701705A1 (2)
ES (1)	ES2332470T3 (2)
IL (1)	IL184932A0 (2)
MA (1)	MA29432B1 (2)
MX (1)	MX2007009661A (2)
NO (1)	NO20074567L (2)
PL (1)	PL1856090T3 (2)
PT (1)	PT1856090E (2)
SI (1)	SI1856090T1 (2)
TN (1)	TNSN07313A1 (2)
WO (1)	WO2006086488A2 (2)
ZA (1)	ZA200706354B (2)

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CN1968921B (zh) *	2004-06-14	2011-11-23	伊莱利利公司	胰高血糖素受体拮抗剂、制备和治疗用途
KR20200123866A (ko)	2007-02-09	2020-10-30	메타베이시스 테라퓨틱스, 인크.	글루카곤 수용체의 길항제
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PT2799428T (pt)	2008-08-13	2017-02-17	Metabasis Therapeutics Inc	Antagonistas de glicagina
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
NZ611529A (en)	2010-12-23	2015-06-26	Pfizer	Glucagon receptor modulators
WO2012107850A1 (en)	2011-02-08	2012-08-16	Pfizer Inc.	Glucagon receptor modulator
EP2683699B1 (de)	2011-03-08	2015-06-24	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en)	2011-03-08	2014-09-09	Sanofi	Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683704B1 (de)	2011-03-08	2014-12-17	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de)	2011-03-08	2016-06-01	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8927577B2 (en)	2011-07-22	2015-01-06	Pfizer Inc.	Quinolinyl glucagon receptor modulators
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
TW201427658A (zh)	2012-12-10	2014-07-16	Merck Sharp & Dohme	藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法
EP3065736B1 (en)	2013-11-04	2018-11-14	Merck Sharp & Dohme Corp.	Glucagon receptor antagonist compounds, compositions thereof, and methods of use
WO2015191900A1 (en)	2014-06-12	2015-12-17	Ligand Pharmaceuticals, Inc.	Glucagon antagonists
EP3350200A4 (en)	2015-09-18	2019-03-27	Wake Forest University Health Services	ANGIOTENSIN (1 7) ANALOGUE AND ASSOCIATED PROCEDURES
US20180289859A1 (en)	2015-10-05	2018-10-11	Hettwer Holding Aps	Compositions and methods for treatment of bone defects
CA2914601A1 (en) *	2015-12-11	2017-06-11	Wake Forest University Health Sciences	Angiotensin-(1-7) analogs and methods relating thereto
NZ750953A (en)	2016-08-30	2026-02-27	Regeneron Pharma	Methods of treating severe insulin resistance by interfering with glucagon receptor signaling
US20190248888A1 (en)	2016-10-20	2019-08-15	Regeneron Pharmaceuticals, Inc.	Methods of lowering blood glucose levels
CA3071387A1 (en)	2017-08-22	2019-02-28	Regeneron Pharmaceuticals, Inc.	Methods of treating urea cycle disorders by interfering with glucagon receptor signaling
WO2019160940A1 (en)	2018-02-13	2019-08-22	Ligand Pharmaceuticals Incorporated	Glucagon receptor antagonists
CN118496197A (zh)	2019-12-20	2024-08-16	拜耳公司	取代的噻吩甲酰胺、噻吩甲酸及其衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005511683A (ja)	2001-12-03	2005-04-28	ノボ　ノルディスク　アクティーゼルスカブ	新規なグルカゴンアンタゴニスト
EP1519723A1 (en)	2002-06-27	2005-04-06	Novo Nordisk A/S	Novel glucagon antagonists/inverse agonists
US7989457B2 (en) *	2004-05-28	2011-08-02	Eli Lilly And Company	Glucagon receptor antagonists, preparation and therapeutic uses
CN1968921B (zh) *	2004-06-14	2011-11-23	伊莱利利公司	胰高血糖素受体拮抗剂、制备和治疗用途

2006
- 2006-02-09 ES ES06720513T patent/ES2332470T3/es not_active Expired - Lifetime
- 2006-02-09 DK DK06720513T patent/DK1856090T3/da active
- 2006-02-09 KR KR1020077018437A patent/KR20070104409A/ko not_active Ceased
- 2006-02-09 BR BRPI0607015-9A patent/BRPI0607015A2/pt not_active IP Right Cessation
- 2006-02-09 PT PT06720513T patent/PT1856090E/pt unknown
- 2006-02-09 EA EA200701705A patent/EA200701705A1/ru unknown
- 2006-02-09 DE DE602006009773T patent/DE602006009773D1/de not_active Expired - Lifetime
- 2006-02-09 AU AU2006213894A patent/AU2006213894B2/en not_active Ceased
- 2006-02-09 PL PL06720513T patent/PL1856090T3/pl unknown
- 2006-02-09 AT AT06720513T patent/ATE445609T1/de active
- 2006-02-09 US US11/815,987 patent/US8084489B2/en not_active Expired - Fee Related
- 2006-02-09 CA CA2597073A patent/CA2597073C/en not_active Expired - Fee Related
- 2006-02-09 JP JP2007555195A patent/JP4988604B2/ja not_active Expired - Fee Related
- 2006-02-09 EP EP06720513A patent/EP1856090B1/en not_active Expired - Lifetime
- 2006-02-09 MX MX2007009661A patent/MX2007009661A/es active IP Right Grant
- 2006-02-09 WO PCT/US2006/004461 patent/WO2006086488A2/en not_active Ceased
- 2006-02-09 CN CN2006800046189A patent/CN101115735B/zh not_active Expired - Fee Related
- 2006-02-09 SI SI200630534T patent/SI1856090T1/sl unknown
2007
- 2007-07-30 IL IL184932A patent/IL184932A0/en unknown
- 2007-07-31 ZA ZA200706354A patent/ZA200706354B/xx unknown
- 2007-08-10 TN TNP2007000313A patent/TNSN07313A1/en unknown
- 2007-08-10 CR CR9304A patent/CR9304A/es not_active Application Discontinuation
- 2007-09-10 NO NO20074567A patent/NO20074567L/no not_active Application Discontinuation
- 2007-09-11 MA MA30221A patent/MA29432B1/fr unknown
2009
- 2009-11-12 CY CY20091101192T patent/CY1109624T1/el unknown

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