JP2009502196A5 - - Google Patents
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- JP2009502196A5 JP2009502196A5 JP2008525040A JP2008525040A JP2009502196A5 JP 2009502196 A5 JP2009502196 A5 JP 2009502196A5 JP 2008525040 A JP2008525040 A JP 2008525040A JP 2008525040 A JP2008525040 A JP 2008525040A JP 2009502196 A5 JP2009502196 A5 JP 2009502196A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- complement
- oligonucleotides
- nucleotides
- oligonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 230000003321 amplification Effects 0.000 claims description 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 11
- 230000000295 complement effect Effects 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 241000829111 Human polyomavirus 1 Species 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 241000701460 JC polyomavirus Species 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 239000000523 sample Substances 0.000 description 4
- 238000003556 assay Methods 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70521705P | 2005-08-02 | 2005-08-02 | |
| US11/246,904 US7892795B2 (en) | 2005-08-02 | 2005-10-06 | Methods and compositions for detecting BK virus |
| PCT/US2006/029243 WO2007016275A2 (en) | 2005-08-02 | 2006-07-25 | Methods and compositions for detecting bk virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009502196A JP2009502196A (ja) | 2009-01-29 |
| JP2009502196A5 true JP2009502196A5 (2) | 2009-09-10 |
Family
ID=37709186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525040A Pending JP2009502196A (ja) | 2005-08-02 | 2006-07-25 | Bkウイルス検出のための方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US7892795B2 (2) |
| EP (2) | EP1910578B1 (2) |
| JP (1) | JP2009502196A (2) |
| CN (3) | CN110423844B (2) |
| AU (1) | AU2006275803B2 (2) |
| CA (1) | CA2617635C (2) |
| ES (1) | ES2552725T3 (2) |
| WO (1) | WO2007016275A2 (2) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7892795B2 (en) * | 2005-08-02 | 2011-02-22 | Focus Diagnostics, Inc. | Methods and compositions for detecting BK virus |
| US20090246754A1 (en) * | 2008-02-19 | 2009-10-01 | Intelligent Mdx | Optimized probes and primers and methods of using same for the detection and quantitation of bk virus |
| KR20110011600A (ko) * | 2008-02-20 | 2011-02-08 | 이와키, 코수케, 켄 | 폴리오마바이러스 검출 |
| US20090258342A1 (en) * | 2008-04-09 | 2009-10-15 | Intelligent Medical Devices, Inc. | Optimized probes and primers and methods of using same for the detection, quantification and grouping of hiv-1 |
| CN102344970B (zh) * | 2010-07-27 | 2013-01-23 | 温州医学院附属第一医院 | 同时检测人cmv和bk病毒dna的引物序列及定量检测试剂盒 |
| CN102154523B (zh) * | 2011-04-07 | 2013-01-02 | 温岭市第一人民医院 | 检测人bk病毒核酸的引物与荧光探针及其应用 |
| CN102690894B (zh) * | 2011-06-08 | 2013-05-01 | 中国人民解放军第三〇九医院 | 一种bk病毒的检测方法、其试剂盒及应用 |
| CN103093120A (zh) * | 2011-11-08 | 2013-05-08 | 北京健数通生物计算技术有限公司 | 高通量检测脊椎动物病原体基因芯片的探针设计方法 |
| CN104745723A (zh) * | 2015-01-30 | 2015-07-01 | 湖北永邦医疗科技有限公司 | 一种用于检测bk病毒的引物、探针和试剂盒 |
| US10793923B2 (en) * | 2016-11-09 | 2020-10-06 | Roche Molecular Systems, Inc. | Compositions and methods for detection of BK virus |
| JP7532257B2 (ja) * | 2018-03-02 | 2024-08-13 | アカデミシュ・ジークンホイス・ライデン・ハー・オー・デー・エン・ライドス・ユニヴェルシタイル・メディシュ・セントルム | ポリオーマウイルス複製の阻害 |
| FR3082524B1 (fr) * | 2018-06-18 | 2022-03-25 | Univ Paris Sud | Methode de stratification du risque de nephropathie a bk-virus apres transplantation renale |
| WO2020086546A1 (en) * | 2018-10-22 | 2020-04-30 | Gen-Probe Incorporated | Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus |
| KR102347899B1 (ko) * | 2019-06-21 | 2022-01-06 | 울산대학교 산학협력단 | 신장이식 후 bk 바이러스 신병증의 진단 또는 예후 예측을 위한 소변 엑소좀 바이오마커 |
| CN111733298B (zh) * | 2020-08-25 | 2020-11-20 | 圣湘生物科技股份有限公司 | 检测多瘤病毒并分型的组合物、试剂盒、方法及其用途 |
| TWI833069B (zh) | 2021-03-17 | 2024-02-21 | 國防醫學院 | 核酸探針組、核酸側流檢測套組以及該核酸側流檢測套組之用途 |
| CN114107571B (zh) * | 2022-01-18 | 2024-06-21 | 复旦大学附属中山医院 | 用于bk病毒lamp检测的试剂盒 |
| CN115029485A (zh) * | 2022-06-20 | 2022-09-09 | 广东永诺医疗科技有限公司 | 一种基于微滴式数字pcr的bkv病毒检测试剂盒 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4318846A (en) | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| US4605735A (en) | 1983-02-14 | 1986-08-12 | Wakunaga Seiyaku Kabushiki Kaisha | Oligonucleotide derivatives |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4757141A (en) | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US5541308A (en) * | 1986-11-24 | 1996-07-30 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| US5283174A (en) | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
| US5639604A (en) | 1987-09-21 | 1997-06-17 | Gen-Probe Incorporated | Homogeneous protection assay |
| US6004745A (en) | 1987-09-21 | 1999-12-21 | Gen-Probe Incorporated | Hybridization protection assay |
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US4914210A (en) | 1987-10-02 | 1990-04-03 | Cetus Corporation | Oligonucleotide functionalizing reagents |
| US5185439A (en) | 1987-10-05 | 1993-02-09 | Gen-Probe Incorporated | Acridinium ester labelling and purification of nucleotide probes |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| JP2650159B2 (ja) | 1988-02-24 | 1997-09-03 | アクゾ・ノベル・エヌ・ベー | 核酸増幅方法 |
| US5849481A (en) | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
| US5213796A (en) | 1991-05-06 | 1993-05-25 | Dana Farber Cancer Institute | Assay for polyomavirus in humans and uses thereof |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US6127121A (en) * | 1998-04-03 | 2000-10-03 | Epoch Pharmaceuticals, Inc. | Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
| WO2001066148A1 (en) | 2000-03-08 | 2001-09-13 | Neurosearch A/S | A method of sensitising endothelial cells to prodrugs |
| US6605602B1 (en) * | 2001-09-28 | 2003-08-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Method of treating BK virus nephropathy |
| BRPI0214741B1 (pt) * | 2001-12-08 | 2015-05-12 | Seegene Inc | Iniciador de controle de anelamento para melhorar a especificidade de anelamento na amplificação de ácido nucléico, Kit, Métodos para amplificar seqüências de ácido nucléico de um DNA e seqüência de ácido nucléico alvo ou uma mistura de ácidos nucléicos, para detectar a complementaridade de DNA ao mRNA diferencialmente expresso em duas ou mais amostras de ácido nucléico, para amplificar rapidamente um fragmento de CDNA alvo, para amplificar uma população de CDNAs de filamento duplo de comprimento completo complementar aos mRNAS, e CDNAs de filamento duplo enriquecidos em 5 complementares aos mRNAS, para amplificar mais do que uma seqüência de nucleotídeo alvo simultaneamente, para produzir uma impressão digital de DNA de gDNA, e de RNA de uma amostra de mRNA, para identificar segmentos de homologia conservada em uma família de multigene a partir de uma amostra de mRNA, para identificar uma variação de nucleotídeo em um ácido nucléico alvo, para a mutagênese em um ácido nucléico alvo, e, uso do iniciador |
| US7892795B2 (en) * | 2005-08-02 | 2011-02-22 | Focus Diagnostics, Inc. | Methods and compositions for detecting BK virus |
| WO2007127919A2 (en) * | 2006-04-28 | 2007-11-08 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a gene from the jc virus |
| US20080003565A1 (en) * | 2006-05-02 | 2008-01-03 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Viral nucleic acid microarray and method of use |
-
2005
- 2005-10-06 US US11/246,904 patent/US7892795B2/en active Active
-
2006
- 2006-07-25 AU AU2006275803A patent/AU2006275803B2/en active Active
- 2006-07-25 WO PCT/US2006/029243 patent/WO2007016275A2/en not_active Ceased
- 2006-07-25 EP EP06788689.5A patent/EP1910578B1/en active Active
- 2006-07-25 CN CN201910529553.9A patent/CN110423844B/zh active Active
- 2006-07-25 JP JP2008525040A patent/JP2009502196A/ja active Pending
- 2006-07-25 CN CN200680034771.6A patent/CN101511995B/zh active Active
- 2006-07-25 CA CA2617635A patent/CA2617635C/en active Active
- 2006-07-25 CN CN201510303094.4A patent/CN104862422B/zh active Active
- 2006-07-25 EP EP12196497.7A patent/EP2662456A1/en not_active Withdrawn
- 2006-07-25 ES ES06788689.5T patent/ES2552725T3/es active Active
-
2011
- 2011-01-12 US US13/005,490 patent/US8748092B2/en active Active
-
2014
- 2014-04-29 US US14/264,462 patent/US9745638B2/en not_active Expired - Lifetime
-
2017
- 2017-08-22 US US15/683,036 patent/US10801078B2/en not_active Expired - Lifetime
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