|
EP2023940B1
(en)
|
2006-05-05 |
2011-06-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of sglt2
|
|
WO2008049085A1
(en)
*
|
2006-10-18 |
2008-04-24 |
Isis Pharmaceuticals, Inc. |
Antisense compounds
|
|
WO2008113832A2
(en)
*
|
2007-03-22 |
2008-09-25 |
Santaris Pharma A/S |
SHORT RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF TARGET mRNA
|
|
US8318496B2
(en)
*
|
2007-10-04 |
2012-11-27 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for improving cellular uptake of oligomeric compounds
|
|
US8846639B2
(en)
|
2008-04-04 |
2014-09-30 |
Isis Pharmaceutical, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
|
MX2011004097A
(es)
|
2008-10-15 |
2011-07-28 |
Isis Pharmaceuticals Inc |
Modulacion de la expresion del factor 11.
|
|
RU2572826C2
(ru)
|
2008-12-02 |
2016-01-20 |
Чиралджен, Лтд. |
Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
|
|
CA2767253A1
(en)
|
2009-07-06 |
2011-01-13 |
Ontorii, Inc. |
Novel nucleic acid prodrugs and methods of use thereof
|
|
WO2011097643A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
EP3628750A1
(en)
|
2010-02-08 |
2020-04-01 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
WO2012012467A2
(en)
|
2010-07-19 |
2012-01-26 |
Isis Pharmaceuticals, Inc. |
Modulation of nuclear-retained rna
|
|
US8648053B2
(en)
|
2010-10-20 |
2014-02-11 |
Rosalind Franklin University Of Medicine And Science |
Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for Usher syndrome
|
|
US9920317B2
(en)
|
2010-11-12 |
2018-03-20 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
|
EP3260540A1
(en)
|
2010-11-12 |
2017-12-27 |
The General Hospital Corporation |
Polycomb-associated non-coding rnas
|
|
CA3077910A1
(en)
|
2010-11-17 |
2012-05-24 |
Ionis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
|
US10017764B2
(en)
|
2011-02-08 |
2018-07-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
WO2012161806A1
(en)
*
|
2011-02-25 |
2012-11-29 |
Isis Pharmaceuticals, Inc. |
Modulation of stat3 expression
|
|
PH12019502377A1
(en)
|
2011-04-21 |
2022-11-14 |
Isis Pharmaceuticals Inc |
Modulation of hepatitis b virus (hbv) expression
|
|
WO2012151324A1
(en)
|
2011-05-02 |
2012-11-08 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
|
AU2012284265B2
(en)
|
2011-07-19 |
2017-08-17 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
ES2651514T3
(es)
|
2011-08-11 |
2018-01-26 |
Ionis Pharmaceuticals, Inc. |
Compuestos oligoméricos gapados que comprenden deoxirribonucleósidos modificados en 5 ' -en la brecha y usos de ellos
|
|
HK1200484A1
(zh)
|
2011-09-14 |
2015-08-07 |
Translate Bio Ma, Inc. |
多聚寡核苷酸化合物
|
|
US9243291B1
(en)
*
|
2011-12-01 |
2016-01-26 |
Isis Pharmaceuticals, Inc. |
Methods of predicting toxicity
|
|
JP2015511821A
(ja)
*
|
2012-03-12 |
2015-04-23 |
ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S |
Atxn3発現の調節のための組成物および方法
|
|
WO2013159108A2
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
|
AU2013262709A1
(en)
|
2012-05-16 |
2015-01-22 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
WO2013173605A1
(en)
*
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating pten expression
|
|
CA2873766A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating atp2a2 expression
|
|
BR112014028634A2
(pt)
|
2012-05-16 |
2017-06-27 |
Rana Therapeutics Inc |
composições e métodos para modulação da expressão de utrn
|
|
CA2873769A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating hemoglobin gene family expression
|
|
JP2015523854A
(ja)
|
2012-05-16 |
2015-08-20 |
ラナ セラピューティクス インコーポレイテッド |
Smn遺伝子ファミリー発現を調節するための組成物及び方法
|
|
US9574193B2
(en)
|
2012-05-17 |
2017-02-21 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for modulating apolipoprotein (a) expression
|
|
US20160002624A1
(en)
|
2012-05-17 |
2016-01-07 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide compositions
|
|
RU2748495C2
(ru)
|
2012-05-24 |
2021-05-26 |
Ионис Фармасьютикалз, Инк. |
Способы и композиции для модулирования экспрессии аполипопротеина (а)
|
|
US9828602B2
(en)
|
2012-06-01 |
2017-11-28 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
|
WO2013181666A2
(en)
|
2012-06-01 |
2013-12-05 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
|
CN104684923B
(zh)
|
2012-07-13 |
2018-09-28 |
株式会社新日本科学 |
手性核酸佐剂
|
|
SG11201500239VA
(en)
|
2012-07-13 |
2015-03-30 |
Wave Life Sciences Japan |
Asymmetric auxiliary group
|
|
JP6453212B2
(ja)
|
2012-07-13 |
2019-01-16 |
ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. |
キラル制御
|
|
EP2895200B1
(en)
|
2012-09-14 |
2019-11-06 |
Translate Bio MA, Inc. |
Multimeric oligonucleotide compounds
|
|
WO2014059353A2
(en)
|
2012-10-11 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
|
US20160138014A1
(en)
*
|
2012-10-12 |
2016-05-19 |
Isis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
|
US10125369B2
(en)
*
|
2012-12-05 |
2018-11-13 |
Alnylam Pharmaceuticals, Inc. |
PCSK9 iRNA compositions and methods of use thereof
|
|
CA2901983A1
(en)
|
2013-03-01 |
2014-09-04 |
National University Corporation Tokyo Medical And Dental University |
Chimeric single-stranded antisense polynucleotides and double-stranded antisense agent
|
|
CA3216595A1
(en)
*
|
2013-03-14 |
2014-10-02 |
Kevin Fitzgerald |
Complement component c5 irna compositions and methods of use thereof
|
|
DK2991656T3
(da)
|
2013-05-01 |
2020-03-23 |
Ionis Pharmaceuticals Inc |
Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
ES2797679T3
(es)
|
2013-12-02 |
2020-12-03 |
Ionis Pharmaceuticals Inc |
Compuestos antisentido y usos de los mismos
|
|
WO2015108048A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
|
|
WO2015108047A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
|
|
JPWO2015108046A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
|
ES2917473T3
(es)
|
2014-01-16 |
2022-07-08 |
Wave Life Sciences Ltd |
Diseño quiral
|
|
CN106103717A
(zh)
|
2014-03-19 |
2016-11-09 |
Ionis制药公司 |
用于调节共济失调蛋白2表达的组合物
|
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
|
RS60707B1
(sr)
|
2014-04-01 |
2020-09-30 |
Biogen Ma Inc |
Kompozicije za modulaciju ekspresije sod-1
|
|
SG11201608502TA
(en)
|
2014-05-01 |
2016-11-29 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulating complement factor b expression
|
|
US10472634B2
(en)
|
2014-06-04 |
2019-11-12 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting apolipoprotein E receptor 2
|
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
|
US10301624B2
(en)
|
2014-06-25 |
2019-05-28 |
The General Hospital Corporation |
Targeting human satellite II (HSATII)
|
|
BR112017004056A2
(pt)
|
2014-09-12 |
2017-12-05 |
Biogen Ma Inc |
composições e métodos para detecção da proteína smn em um indivíduo e tratamento de um indivíduo
|
|
WO2016041058A1
(en)
|
2014-09-18 |
2016-03-24 |
The University Of British Columbia |
Allele-specific therapy for huntington disease haplotypes
|
|
CN107109411B
(zh)
|
2014-10-03 |
2022-07-01 |
冷泉港实验室 |
核基因输出的定向增加
|
|
CA2966044A1
(en)
|
2014-10-30 |
2016-05-06 |
The General Hospital Corporation |
Methods for modulating atrx-dependent gene repression
|
|
JP2017536366A
(ja)
*
|
2014-11-19 |
2017-12-07 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Lnaキラルホスホロチオエート
|
|
CN107208092B
(zh)
*
|
2014-12-16 |
2021-09-10 |
罗氏创新中心哥本哈根有限公司 |
手性毒性筛选方法
|
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
AU2016215155A1
(en)
*
|
2015-02-04 |
2017-08-17 |
F. Hoffmann-La Roche Ag |
Tau antisense oligomers and uses thereof
|
|
EP3254104B1
(en)
|
2015-02-04 |
2021-08-25 |
Bristol-Myers Squibb Company |
Methods of selecting therapeutic molecules
|
|
WO2016130943A1
(en)
|
2015-02-13 |
2016-08-18 |
Rana Therapeutics, Inc. |
Hybrid oligonucleotides and uses thereof
|
|
EP3256592A4
(en)
*
|
2015-02-13 |
2018-09-12 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating rna
|
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
WO2016149455A2
(en)
|
2015-03-17 |
2016-09-22 |
The General Hospital Corporation |
The rna interactome of polycomb repressive complex 1 (prc1)
|
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
CN108135921B
(zh)
|
2015-07-22 |
2023-10-17 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
US10533175B2
(en)
|
2015-09-25 |
2020-01-14 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating Ataxin 3 expression
|
|
EP3359685B1
(en)
|
2015-10-09 |
2026-01-28 |
University Of Southampton |
Modulation of gene expression for deregulated protein expression
|
|
US11058709B1
(en)
|
2015-12-04 |
2021-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
|
EP3933041B1
(en)
|
2015-12-14 |
2024-01-31 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of autosomal dominant retardation
|
|
US20190002887A1
(en)
|
2015-12-31 |
2019-01-03 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing ataxin-2 expression
|
|
CA3006599A1
(en)
|
2016-01-05 |
2017-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing lrrk2 expression
|
|
WO2017142054A1
(ja)
|
2016-02-17 |
2017-08-24 |
国立大学法人東京工業大学 |
人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド
|
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
|
AU2017234678A1
(en)
|
2016-03-16 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating KEAP1
|
|
JP2019516680A
(ja)
|
2016-05-04 |
2019-06-20 |
ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. |
オリゴヌクレオチド組成物およびその方法
|
|
CN109414448B
(zh)
|
2016-06-17 |
2021-10-26 |
豪夫迈·罗氏有限公司 |
用于减少PAPD5或PAPD7 mRNA治疗乙型肝炎感染的核酸分子
|
|
EP3471781A4
(en)
|
2016-06-17 |
2020-05-06 |
Ionis Pharmaceuticals, Inc. |
MODULATION OF GYS1 EXPRESSION
|
|
CA3029772A1
(en)
|
2016-07-05 |
2018-01-11 |
Biomarin Technologies B.V. |
Pre-mrna splice switching or modulating oligonucleotides comprising bicyclic scaffold moieties, with improved characteristics for the treatment of genetic disorders
|
|
US11118179B2
(en)
|
2016-09-23 |
2021-09-14 |
Synthena Ag |
Mixed tricyclo-DNA, 2′-modified RNA oligonucleotide compositions and uses thereof
|
|
WO2018055577A1
(en)
*
|
2016-09-23 |
2018-03-29 |
Synthena Ag |
Mixed tricyclo-dna, 2'-modified rna oligonucleotide compositions and uses thereof
|
|
EP3517610A4
(en)
|
2016-09-23 |
2020-05-27 |
National University Corporation Tokyo Medical and Dental University |
THROUGH HETERODUPLEX NUCLEIC ACID THROUGH BLOOD BRAIN CABINET
|
|
US11260134B2
(en)
|
2016-09-29 |
2022-03-01 |
National University Corporation Tokyo Medical And Dental University |
Double-stranded nucleic acid complex having overhang
|
|
EP3522898A4
(en)
|
2016-10-06 |
2020-05-27 |
Ionis Pharmaceuticals, Inc. |
METHOD FOR CONJUGATING OLIGOMERIC COMPOUNDS
|
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
|
EP4035659A1
(en)
|
2016-11-29 |
2022-08-03 |
PureTech LYT, Inc. |
Exosomes for delivery of therapeutic agents
|
|
WO2018102745A1
(en)
|
2016-12-02 |
2018-06-07 |
Cold Spring Harbor Laboratory |
Modulation of lnc05 expression
|
|
CN110337495B
(zh)
|
2017-02-06 |
2024-03-29 |
日产化学株式会社 |
单链寡核苷酸
|
|
WO2018155450A1
(ja)
|
2017-02-21 |
2018-08-30 |
国立大学法人大阪大学 |
アンチセンスオリゴ核酸
|
|
JOP20190215A1
(ar)
|
2017-03-24 |
2019-09-19 |
Ionis Pharmaceuticals Inc |
مُعدّلات التعبير الوراثي عن pcsk9
|
|
WO2019004420A1
(ja)
|
2017-06-30 |
2019-01-03 |
国立大学法人東京医科歯科大学 |
ヘテロ二本鎖型antimiR
|
|
TW201920672A
(zh)
*
|
2017-08-08 |
2019-06-01 |
新加坡商波濤生命科學有限公司 |
寡核苷酸組合物及其使用方法
|
|
US11197884B2
(en)
|
2017-08-18 |
2021-12-14 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
|
SG11202001590RA
(en)
|
2017-08-25 |
2020-03-30 |
Stoke Therapeutics Inc |
Antisense oligomers for treatment of conditions and diseases
|
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
|
CN111226114A
(zh)
|
2017-10-13 |
2020-06-02 |
罗氏创新中心哥本哈根有限公司 |
用部分立体限定的寡核苷酸子文库鉴定反义寡核苷酸改进的立体限定硫代磷酸酯寡核苷酸变体的方法
|
|
UA126931C2
(uk)
|
2017-10-16 |
2023-02-22 |
Ф. Хоффманн-Ля Рош Аг |
МОЛЕКУЛИ НУКЛЕЇНОВИХ КИСЛОТ ДЛЯ ЗМЕНШЕННЯ РІВНЯ мРНК PAPD5 І PAPD7 ДЛЯ ЛІКУВАННЯ ІНФЕКЦІЙНОГО ГЕПАТИТУ B
|
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
|
US20200385714A1
(en)
|
2017-12-11 |
2020-12-10 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating fndc3b expression
|
|
WO2019115417A2
(en)
|
2017-12-12 |
2019-06-20 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating rb1 expression
|
|
US11459564B2
(en)
|
2017-12-21 |
2022-10-04 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
|
JP2021507253A
(ja)
|
2017-12-21 |
2021-02-22 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
Htra1 rnaアンタゴニストについてのコンパニオン診断
|
|
CN111448316B
(zh)
|
2017-12-22 |
2025-02-14 |
罗氏创新中心哥本哈根有限公司 |
新的硫代亚磷酰胺
|
|
WO2019122282A1
(en)
|
2017-12-22 |
2019-06-27 |
Roche Innovation Center Copenhagen A/S |
Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
|
|
WO2019122279A1
(en)
|
2017-12-22 |
2019-06-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorodithioate internucleoside linkage
|
|
US20210095274A1
(en)
|
2018-01-10 |
2021-04-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating pias4 expression
|
|
US20210095275A1
(en)
|
2018-01-12 |
2021-04-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating gsk3b expression
|
|
BR112020014425A2
(pt)
|
2018-01-15 |
2020-12-29 |
Ionis Pharmaceuticals, Inc. |
Moduladores de expressão de dnm2
|
|
CN111615558A
(zh)
|
2018-01-17 |
2020-09-01 |
罗氏创新中心哥本哈根有限公司 |
用于调节erc1表达的寡核苷酸
|
|
WO2019141723A1
(en)
|
2018-01-18 |
2019-07-25 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting srebp1
|
|
WO2019145386A1
(en)
|
2018-01-26 |
2019-08-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating csnk1d expression
|
|
CA3088071A1
(en)
|
2018-02-09 |
2019-08-15 |
Genentech, Inc. |
Oligonucleotides for modulating tmem106b expression
|
|
AU2019218987B2
(en)
|
2018-02-12 |
2025-04-24 |
Ionis Pharmaceuticals, Inc. |
Modified compounds and uses thereof
|
|
JP7360170B2
(ja)
|
2018-02-28 |
2023-10-12 |
国立大学法人 東京医科歯科大学 |
虚血病変部位特異的な遺伝子治療法
|
|
EP3759127A4
(en)
|
2018-03-02 |
2022-03-30 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN
|
|
TWI840345B
(zh)
|
2018-03-02 |
2024-05-01 |
美商Ionis製藥公司 |
Irf4表現之調節劑
|
|
EP3766972B1
(en)
|
2018-03-14 |
2025-04-23 |
Institute of Science Tokyo |
Nucleic acid complex
|
|
US11851654B2
(en)
|
2018-03-19 |
2023-12-26 |
National University Corporation Tokyo Medical And Dental University |
Nucleic acid with reduced toxicity
|
|
MX2020009765A
(es)
|
2018-03-20 |
2021-01-08 |
Tokyo Inst Tech |
Oligonucleotido antisentido reducido en toxicidad.
|
|
US11661601B2
(en)
|
2018-03-22 |
2023-05-30 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating FMR1 expression
|
|
JP7262816B2
(ja)
|
2018-03-22 |
2023-04-24 |
国立大学法人 東京医科歯科大学 |
ヘテロ核酸のbbb通過脂質リガンド
|
|
WO2019199720A1
(en)
*
|
2018-04-09 |
2019-10-17 |
The Trustees Of Princeton University |
Compositions comprising immune system activators and method of using same
|
|
CA3094020A1
(en)
|
2018-04-11 |
2019-10-17 |
Ionis Pharmaceuticals, Inc. |
Modulators of ezh2 expression
|
|
US12060558B2
(en)
|
2018-05-04 |
2024-08-13 |
Stoke Therapeutics, Inc. |
Methods and compositions for treatment of cholesteryl ester storage disease
|
|
US20210371860A1
(en)
|
2018-05-08 |
2021-12-02 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating myh7 expression
|
|
JP7438135B2
(ja)
|
2018-05-09 |
2024-02-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Fxiの発現を低下させるための化合物及び方法
|
|
SG11202010215TA
(en)
|
2018-05-09 |
2020-11-27 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing atxn3 expression
|
|
WO2019233922A1
(en)
|
2018-06-05 |
2019-12-12 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating atxn2 expression
|
|
CA3103429A1
(en)
*
|
2018-06-14 |
2019-12-19 |
Don W. Cleveland |
Compounds and methods for increasing stmn2 expression
|
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
|
WO2020007702A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting bcl2l11
|
|
WO2020007700A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting spi1
|
|
WO2020007772A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting gbp-1
|
|
SG11202012759XA
(en)
|
2018-07-03 |
2021-01-28 |
Hoffmann La Roche |
Oligonucleotides for modulating tau expression
|
|
WO2020007826A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mbtps1
|
|
WO2020007889A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting stat1
|
|
WO2020011743A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mafb
|
|
WO2020011653A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting kynu
|
|
WO2020011745A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers6
|
|
WO2020011869A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting tlr2
|
|
WO2020011744A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers5
|
|
EP4512407A3
(en)
|
2018-07-13 |
2025-09-24 |
F. Hoffmann-La Roche AG |
Oligonucleotides for modulating rtel1 expression
|
|
EP3823725A4
(en)
|
2018-07-17 |
2023-05-10 |
Aronora, Inc. |
METHODS FOR SAFELY REDUCING THROMBOPOIETIN
|
|
BR112021000308A2
(pt)
|
2018-07-25 |
2021-04-13 |
Ionis Pharmaceuticals, Inc. |
Compostos e métodos para redução da expressão de atxn2
|
|
US20210308170A1
(en)
|
2018-07-27 |
2021-10-07 |
Osaka University |
Composition for suppression of aging, prevention, amelioration, or treatment of an age-related disease or symptom, or extension of lifespan
|
|
US20210292358A1
(en)
|
2018-07-31 |
2021-09-23 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
|
|
EP3830101B1
(en)
|
2018-07-31 |
2025-11-19 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
|
|
US12370264B1
(en)
|
2018-08-02 |
2025-07-29 |
Dyne Therapeutics, Inc. |
Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject
|
|
US12097263B2
(en)
|
2018-08-02 |
2024-09-24 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
US12018087B2
(en)
|
2018-08-02 |
2024-06-25 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
|
|
US20220193250A1
(en)
|
2018-08-02 |
2022-06-23 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
US11911484B2
(en)
|
2018-08-02 |
2024-02-27 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
WO2020038976A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting usp8
|
|
WO2020038971A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting vcan
|
|
WO2020038973A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting sptlc1
|
|
EP3620519A1
(en)
|
2018-09-04 |
2020-03-11 |
F. Hoffmann-La Roche AG |
Use of isolated milk extracellular vesicles for delivering oligonucleotides orally
|
|
EP3873920A1
(en)
|
2018-11-01 |
2021-09-08 |
F. Hoffmann-La Roche AG |
Antisense oligonucleotides targeting tia1
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
BR112021008967A2
(pt)
|
2018-11-15 |
2021-08-17 |
Ionis Pharmaceuticals, Inc. |
moduladores da expressão de irf5
|
|
SG11202103794QA
(en)
|
2018-11-21 |
2021-05-28 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing prion expression
|
|
WO2020117706A1
(en)
*
|
2018-12-03 |
2020-06-11 |
Triplet Therapeutics, Inc. |
Methods for the treatment of trinucleotide repeat expansion disorders associated with mlh3 activity
|
|
US20220042011A1
(en)
|
2018-12-21 |
2022-02-10 |
Hoffmann-La Roche Inc. |
Antisense oligonucleotides targeting card9
|
|
EP3914232A1
(en)
|
2019-01-25 |
2021-12-01 |
F. Hoffmann-La Roche AG |
Lipid vesicle for oral drug delivery
|
|
SG11202107399WA
(en)
|
2019-01-31 |
2021-08-30 |
Ionis Pharmaceuticals Inc |
Modulators of yap1 expression
|
|
WO2020169696A1
(en)
|
2019-02-20 |
2020-08-27 |
Roche Innovation Center Copenhagen A/S |
Novel phosphoramidites
|
|
CA3130431A1
(en)
|
2019-02-20 |
2020-08-27 |
Roche Innovation Center Copenhagen A/S |
Phosphonoacetate gapmer oligonucleotides
|
|
CN113474633A
(zh)
|
2019-02-26 |
2021-10-01 |
罗氏创新中心哥本哈根有限公司 |
寡核苷酸配制方法
|
|
KR20210134003A
(ko)
|
2019-02-27 |
2021-11-08 |
스톡 테라퓨틱스, 인크. |
병태 및 질환의 치료를 위한 안티센스 올리고머
|
|
TW202540426A
(zh)
|
2019-02-27 |
2025-10-16 |
美商Ionis製藥公司 |
Malat1表現之調節劑
|
|
JP7530106B2
(ja)
|
2019-03-14 |
2024-08-07 |
レナセラピューティクス株式会社 |
Ihh発現を調節するための核酸複合体
|
|
FI3947684T3
(fi)
|
2019-03-29 |
2025-05-27 |
Ionis Pharmaceuticals Inc |
Yhdisteitä ja menetelmiä ube3a-ats:n moduloimiseksi
|
|
US11286485B2
(en)
|
2019-04-04 |
2022-03-29 |
Hoffmann-La Roche Inc. |
Oligonucleotides for modulating ATXN2 expression
|
|
EP3954395A4
(en)
|
2019-04-08 |
2023-06-28 |
National University Corporation Tokyo Medical and Dental University |
Pharmaceutical composition for muscle disease treatment
|
|
EP3980539A1
(en)
|
2019-06-06 |
2022-04-13 |
F. Hoffmann-La Roche AG |
Antisense oligonucleotides targeting atxn3
|
|
EP3956450B1
(en)
*
|
2019-07-26 |
2025-08-13 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating gfap
|
|
US20220370491A1
(en)
|
2019-09-18 |
2022-11-24 |
National University Corporation Tokyo Medical And Dental University |
Nucleic acid complex
|
|
US12509483B2
(en)
|
2019-10-11 |
2025-12-30 |
Sumitomo Chemical Company, Limited |
Method for producing nucleic acid oligomers
|
|
JP7793144B2
(ja)
|
2019-10-11 |
2026-01-05 |
国立大学法人東京科学大学 |
修飾ヘテロ核酸
|
|
US20220251557A1
(en)
*
|
2019-11-27 |
2022-08-11 |
Tokyo Institute Of Technology |
Method for reducing toxicity of antisense nucleic acids
|
|
US20230020092A1
(en)
|
2019-12-19 |
2023-01-19 |
Entrada Therapeutics, Inc. |
Compositions for delivery of antisense compounds
|
|
EP4081639A1
(en)
|
2019-12-24 |
2022-11-02 |
F. Hoffmann-La Roche AG |
Pharmaceutical combination of a therapeutic oligonucleotide targeting hbv and a tlr7 agonist for treatment of hbv
|
|
CN114828852A
(zh)
|
2019-12-24 |
2022-07-29 |
豪夫迈·罗氏有限公司 |
用于治疗hbv的靶向hbv的抗病毒药剂和/或免疫调节剂的药物组合
|
|
EP4097234A1
(en)
|
2020-01-28 |
2022-12-07 |
Université de Strasbourg |
Antisense oligonucleotide targeting linc00518 for treating melanoma
|
|
US20230312635A1
(en)
|
2020-01-29 |
2023-10-05 |
Sumitomo Chemical Company, Limited |
Method for producing nucleic acid oligomer
|
|
WO2021153770A1
(en)
|
2020-01-29 |
2021-08-05 |
Sumitomo Chemical Company, Limited |
Process of preparing nucleic acid oligomer
|
|
EP4098747A4
(en)
|
2020-01-31 |
2025-03-26 |
Sanwa Kagaku Kenkyusho Co., Ltd. |
ATN1 ANTISENSE OLIGONUCLEOTIDE
|
|
CR20220485A
(es)
|
2020-02-28 |
2022-11-10 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular smn2
|
|
JPWO2021177418A1
(2)
|
2020-03-04 |
2021-09-10 |
|
|
|
WO2021178374A2
(en)
*
|
2020-03-05 |
2021-09-10 |
Synerk Inc. |
Compounds and methods for reducing apoe expression
|
|
US20230174981A1
(en)
|
2020-03-16 |
2023-06-08 |
National University Corporation Tokyo Medical And Dental University |
Heteronucleic acid containing morpholino nucleic acid
|
|
US12522629B2
(en)
|
2020-03-27 |
2026-01-13 |
Sumitomo Chemical Company, Limited |
Method for producing nucleic acid oligomer
|
|
CA3175691A1
(en)
*
|
2020-04-17 |
2021-10-21 |
Neil R. Cashman |
Compositions and methods for inhibiting tdp-43 and fus aggregation
|
|
MX2022013707A
(es)
|
2020-05-01 |
2022-12-07 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para modular atxn1.
|
|
BR112022022889A2
(pt)
|
2020-05-11 |
2023-04-04 |
Stoke Therapeutics Inc |
Oligômeros antissentido de opa1 para tratamento de condições e doenças
|
|
BR112022024206A2
(pt)
|
2020-06-29 |
2023-01-03 |
Ionis Pharmaceuticals Inc |
Compostos e métodos para modular plp1
|
|
US20230242570A1
(en)
|
2020-07-09 |
2023-08-03 |
Sumitomo Chemical Company, Limited |
Method for producing nucleic acid oligomer
|
|
AU2021315992A1
(en)
|
2020-07-28 |
2023-02-09 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing app expression
|
|
IL300258A
(en)
|
2020-08-07 |
2023-03-01 |
Ionis Pharmaceuticals Inc |
Compounds and methods for modulating SCN2A
|
|
JP7719788B2
(ja)
|
2020-09-24 |
2025-08-06 |
住友化学株式会社 |
核酸オリゴマーの製造方法
|
|
EP4136092B1
(en)
|
2020-11-18 |
2024-07-31 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating angiotensinogen expression
|
|
WO2022117747A2
(en)
|
2020-12-03 |
2022-06-09 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting atxn3
|
|
TW202237842A
(zh)
|
2020-12-03 |
2022-10-01 |
瑞士商赫孚孟拉羅股份公司 |
靶向atxn3之反義寡核苷酸
|
|
JP2023554346A
(ja)
|
2020-12-18 |
2023-12-27 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
第xii因子を調節するための化合物及び方法
|
|
US20240117356A1
(en)
|
2020-12-31 |
2024-04-11 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
US20240083990A1
(en)
|
2021-01-26 |
2024-03-14 |
Universite Brest Bretagne Occidentale |
Novel stim1 splicing variants and uses thereof
|
|
CA3211396A1
(en)
*
|
2021-02-17 |
2022-08-25 |
Q-State Biosciences, Inc. |
Ube3a antisense therapeutics
|
|
US20240358845A1
(en)
|
2021-05-10 |
2024-10-31 |
Entrada Therapeutics, Inc. |
Compositions and methods for intracellular therapeutics
|
|
CA3219942A1
(en)
*
|
2021-05-10 |
2022-11-17 |
Q-State Biosciences, Inc. |
Compositions targeting sodium channel 1.6
|
|
US20240240183A1
(en)
|
2021-05-25 |
2024-07-18 |
National University Corporation Tokyo Medical And Dental University |
Heteronucleic acid containing scpBNA or AmNA
|
|
CA3222167A1
(en)
|
2021-05-31 |
2022-12-08 |
Rena Therapeutics Inc. |
Ligand-binding nucleic acid complex
|
|
KR20240023602A
(ko)
|
2021-06-18 |
2024-02-22 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Ifnar1 발현을 감소시키기 위한 화합물 및 방법
|
|
PE20242357A1
(es)
|
2021-06-23 |
2024-12-16 |
Entrada Therapeutics Inc |
Compuestos antisentido y metodos para dirigirse a repeticiones cug
|
|
US11633498B2
(en)
|
2021-07-09 |
2023-04-25 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
US11638761B2
(en)
|
2021-07-09 |
2023-05-02 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
|
|
US11969475B2
(en)
|
2021-07-09 |
2024-04-30 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
US20250339459A1
(en)
|
2021-08-19 |
2025-11-06 |
National University Corporation Tokyo Medical And Dental University |
Modified heteronucleic acid containing morpholino nucleic acid
|
|
US20240390508A1
(en)
|
2021-08-21 |
2024-11-28 |
Takeda Pharmaceutical Company Limited |
Human transferrin receptor binding peptide-drug conjugate
|
|
EP4396352A4
(en)
|
2021-09-01 |
2025-10-01 |
Ionis Pharmaceuticals Inc |
COMPOUNDS AND METHODS FOR REDUCING DMPK EXPRESSION
|
|
WO2023042876A1
(ja)
|
2021-09-15 |
2023-03-23 |
国立大学法人東京医科歯科大学 |
2'-修飾ヌクレオシドを含むヘテロ核酸
|
|
KR20240082343A
(ko)
|
2021-09-28 |
2024-06-10 |
스미또모 가가꾸 가부시끼가이샤 |
정제 디클로로아세트산의 제조 방법
|
|
JPWO2023080159A1
(2)
|
2021-11-02 |
2023-05-11 |
|
|
|
EP4426833A1
(en)
|
2021-11-03 |
2024-09-11 |
F. Hoffmann-La Roche AG |
Oligonucleotides for modulating apolipoprotein e4 expression
|
|
CA3234478A1
(en)
|
2021-11-11 |
2023-05-19 |
Souphalone LUANGSAY |
Pharmaceutical combinations for treatment of hbv
|
|
JP2024547071A
(ja)
|
2021-12-20 |
2024-12-26 |
エフ. ホフマン-ラ ロシュ アーゲー |
トレオース核酸アンチセンスオリゴヌクレオチドおよびその方法
|
|
WO2023131926A2
(en)
|
2022-01-10 |
2023-07-13 |
Ausper Biopharma Co., Ltd. |
Modulation of hepatitis b virus (hbv) expression
|
|
EP4465994A1
(en)
|
2022-01-20 |
2024-11-27 |
Genentech, Inc. |
Antisense oligonucleotides for modulating tmem106b expression
|
|
EP4493570A2
(en)
|
2022-03-16 |
2025-01-22 |
Empirico Inc. |
Galnac compositions for improving sirna bioavailability
|
|
KR20240162536A
(ko)
|
2022-03-23 |
2024-11-15 |
스미또모 가가꾸 가부시끼가이샤 |
핵산 올리고머의 제조 방법
|
|
KR20240163743A
(ko)
|
2022-03-28 |
2024-11-19 |
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|
|
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|
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|
|
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|
|
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|
|
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|
|
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|
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|
|
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|
|
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|
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|
|
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|
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|
|
|
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|
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|
|
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|
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|
|
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|
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|
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|
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|
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|
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|
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|
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