JP2010509285A5 - - Google Patents
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- Publication number
- JP2010509285A5 JP2010509285A5 JP2009535729A JP2009535729A JP2010509285A5 JP 2010509285 A5 JP2010509285 A5 JP 2010509285A5 JP 2009535729 A JP2009535729 A JP 2009535729A JP 2009535729 A JP2009535729 A JP 2009535729A JP 2010509285 A5 JP2010509285 A5 JP 2010509285A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heterocyclyl
- heteroaryl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **(*)(C(N1)=N*)N(*)C1=* Chemical compound **(*)(C(N1)=N*)N(*)C1=* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86498806P | 2006-11-09 | 2006-11-09 | |
| US60/864,988 | 2006-11-09 | ||
| PCT/EP2007/062034 WO2008055947A1 (en) | 2006-11-09 | 2007-11-08 | Novel inhibitors of glutaminyl cyclase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010509285A JP2010509285A (ja) | 2010-03-25 |
| JP2010509285A5 true JP2010509285A5 (2) | 2011-02-17 |
| JP5456479B2 JP5456479B2 (ja) | 2014-03-26 |
Family
ID=39156601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535729A Expired - Fee Related JP5456479B2 (ja) | 2006-11-09 | 2007-11-08 | グルタミニルシクラーゼの新規阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2091945B1 (2) |
| JP (1) | JP5456479B2 (2) |
| DK (1) | DK2091945T3 (2) |
| ES (1) | ES2468546T3 (2) |
| WO (1) | WO2008055947A1 (2) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8889709B2 (en) | 2006-09-21 | 2014-11-18 | Probiodrug Ag | Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions |
| EA016584B1 (ru) | 2006-09-21 | 2012-06-29 | Пробиодруг Аг | Новые гены, родственные гену глутаминилциклазы |
| WO2010009987A2 (en) | 2008-07-21 | 2010-01-28 | Probiodrug Ag | Diagnostic antibody assay |
| CN102186475B (zh) * | 2008-09-04 | 2016-08-03 | 前体生物药物股份公司 | 新抑制剂 |
| JP5788320B2 (ja) * | 2008-09-04 | 2015-09-30 | プロビオドルグ エージー | イソｑｃ阻害剤の使用 |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| WO2011076854A1 (en) | 2009-12-22 | 2011-06-30 | Probiodrug Ag | CLEAVAGE OF β-AMYLOID PRECURSOR PROTEIN |
| WO2011101433A1 (en) | 2010-02-18 | 2011-08-25 | Probiodrug Ag | Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| JP5952816B2 (ja) | 2010-08-19 | 2016-07-13 | プロビオドルグ エージー | グルタミニルシクラーゼの結晶構造 |
| WO2012110946A1 (en) * | 2011-02-17 | 2012-08-23 | Glenmark Pharmaceuticals Sa | Pharmaceutical composition comprising the pde4 enzyme inhibitor revamilast and a disease modifying agent, preferably methotrexate |
| CA2828433C (en) | 2011-03-16 | 2020-08-04 | Probiodrug Ag | Diagnostic antibody assay |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| JP6156845B2 (ja) * | 2014-03-04 | 2017-07-05 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
| JP2018501482A (ja) | 2014-12-19 | 2018-01-18 | プロビオドルグ エージー | ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法 |
| ES2812698T3 (es) * | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| KR20240024948A (ko) | 2021-06-24 | 2024-02-26 | 인실리코 메디신 아이피 리미티드 | 질환의 치료를 위한 베타-락탐 유도체 |
| KR20260040085A (ko) * | 2023-07-21 | 2026-03-23 | 인실리코 메디신 아이피 리미티드 | 결정형 베타-락탐 유도체 및 이의 용도 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004098591A2 (en) * | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
| US8114887B2 (en) * | 2004-10-13 | 2012-02-14 | Merck, Sharp & Dohme Corp. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease |
| MX2008011216A (es) * | 2006-03-08 | 2008-09-11 | Hoffmann La Roche | 1,5-dihidro-imidazol-2-onas 4-amino-1,5-substituidas. |
-
2007
- 2007-11-08 WO PCT/EP2007/062034 patent/WO2008055947A1/en not_active Ceased
- 2007-11-08 EP EP07822338.5A patent/EP2091945B1/en active Active
- 2007-11-08 DK DK07822338.5T patent/DK2091945T3/da active
- 2007-11-08 ES ES07822338.5T patent/ES2468546T3/es active Active
- 2007-11-08 JP JP2009535729A patent/JP5456479B2/ja not_active Expired - Fee Related
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