JP2010509356A5 - - Google Patents

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Publication number: JP2010509356A5
Authority: JP; Japan
Prior art keywords: pyrrolo; pyridin; substituted; phenyl; benzamide
Prior art date: 2007-11-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2009536454A

Other languages

English (en)

Japanese (ja)

Other versions

JP5244118B2 (ja

JP2010509356A (ja

Filing date

2007-11-07

Publication date

2010-10-21

2007-11-07 Application filed filed Critical

2007-11-07 Priority claimed from PCT/US2007/083850 external-priority patent/WO2008060907A2/en

2010-03-25 Publication of JP2010509356A publication Critical patent/JP2010509356A/ja

2010-10-21 Publication of JP2010509356A5 publication Critical patent/JP2010509356A5/ja

2013-07-24 Application granted granted Critical

2013-07-24 Publication of JP5244118B2 publication Critical patent/JP5244118B2/ja

Status Expired - Fee Related legal-status Critical Current

2027-11-07 Anticipated expiration legal-status Critical

Links

150000001875 compounds Chemical class 0.000 claims 9
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 6
125000000623 heterocyclic group Chemical group 0.000 claims 5
229910052739 hydrogen Inorganic materials 0.000 claims 5
239000001257 hydrogen Substances 0.000 claims 5
150000002431 hydrogen Chemical class 0.000 claims 5
-1 1- (4-fluorophenylsulfonyl) piperidin-4-yl Chemical group 0.000 claims 4
125000003118 aryl group Chemical group 0.000 claims 4
239000003795 chemical substances by application Substances 0.000 claims 4
125000000753 cycloalkyl group Chemical group 0.000 claims 4
125000001072 heteroaryl group Chemical group 0.000 claims 4
125000003107 substituted aryl group Chemical group 0.000 claims 4
125000005346 substituted cycloalkyl group Chemical group 0.000 claims 4
102000009465 Growth Factor Receptors Human genes 0.000 claims 3
108010009202 Growth Factor Receptors Proteins 0.000 claims 3
125000000217 alkyl group Chemical group 0.000 claims 3
150000003839 salts Chemical class 0.000 claims 3
125000000547 substituted alkyl group Chemical group 0.000 claims 3
102000001253 Protein Kinase Human genes 0.000 claims 2
102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 2
108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 2
230000001772 anti-angiogenic effect Effects 0.000 claims 2
125000004104 aryloxy group Chemical group 0.000 claims 2
239000003937 drug carrier Substances 0.000 claims 2
230000000694 effects Effects 0.000 claims 2
125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
239000003112 inhibitor Substances 0.000 claims 2
230000002401 inhibitory effect Effects 0.000 claims 2
239000000203 mixture Substances 0.000 claims 2
239000008194 pharmaceutical composition Substances 0.000 claims 2
108060006633 protein kinase Proteins 0.000 claims 2
230000001603 reducing effect Effects 0.000 claims 2
230000008728 vascular permeability Effects 0.000 claims 2
YBTMCZUJPRZRLP-UHFFFAOYSA-N 2-phenyl-1h-pyrrolo[2,3-b]pyridine-5-carbonitrile Chemical compound C=1C2=CC(C#N)=CN=C2NC=1C1=CC=CC=C1 YBTMCZUJPRZRLP-UHFFFAOYSA-N 0.000 claims 1
ASCDTBKWWRNRIU-UHFFFAOYSA-N 3-[(4-aminopiperidin-1-yl)methyl]-2-phenyl-1h-pyrrolo[2,3-b]pyridine-5-carbonitrile Chemical compound C1CC(N)CCN1CC1=C(C=2C=CC=CC=2)NC2=NC=C(C#N)C=C12 ASCDTBKWWRNRIU-UHFFFAOYSA-N 0.000 claims 1
206010036790 Productive cough Diseases 0.000 claims 1
125000004093 cyano group Chemical group *C#N 0.000 claims 1
239000002254 cytotoxic agent Substances 0.000 claims 1
229940127089 cytotoxic agent Drugs 0.000 claims 1
231100000599 cytotoxic agent Toxicity 0.000 claims 1
201000010099 disease Diseases 0.000 claims 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
229910052736 halogen Inorganic materials 0.000 claims 1
150000002367 halogens Chemical class 0.000 claims 1
VZFPCRAXOIAVPR-UHFFFAOYSA-N n-[3-(cyclopropylcarbamoyl)phenyl]-2-phenyl-1h-pyrrolo[2,3-b]pyridine-5-carboxamide Chemical compound C=1C=CC(NC(=O)C=2C=C3C=C(NC3=NC=2)C=2C=CC=CC=2)=CC=1C(=O)NC1CC1 VZFPCRAXOIAVPR-UHFFFAOYSA-N 0.000 claims 1
YSQYCEMHQTZHHG-UHFFFAOYSA-N n-cyclopropyl-2,4-difluoro-5-[(2-phenyl-1h-pyrrolo[2,3-b]pyridin-5-yl)methylamino]benzamide Chemical compound FC1=CC(F)=C(C(=O)NC2CC2)C=C1NCC(C=C1C=2)=CN=C1NC=2C1=CC=CC=C1 YSQYCEMHQTZHHG-UHFFFAOYSA-N 0.000 claims 1
NPDNQMAHTBBMTM-UHFFFAOYSA-N n-cyclopropyl-3-[(2-cyclopropyl-1h-pyrrolo[2,3-b]pyridin-5-yl)methylamino]-4-fluorobenzamide Chemical compound FC1=CC=C(C(=O)NC2CC2)C=C1NCC(C=C1C=2)=CN=C1NC=2C1CC1 NPDNQMAHTBBMTM-UHFFFAOYSA-N 0.000 claims 1
NBUUNYHOCCNNIV-UHFFFAOYSA-N n-cyclopropyl-3-[[2-[3-[2-(dimethylamino)ethoxy]phenyl]-1h-pyrrolo[2,3-b]pyridin-5-yl]methylamino]-4-fluorobenzamide Chemical compound CN(C)CCOC1=CC=CC(C=2NC3=NC=C(CNC=4C(=CC=C(C=4)C(=O)NC4CC4)F)C=C3C=2)=C1 NBUUNYHOCCNNIV-UHFFFAOYSA-N 0.000 claims 1
ZFBNPNOJLQAKNS-UHFFFAOYSA-N n-cyclopropyl-4-fluoro-3-[(2-phenyl-1h-pyrrolo[2,3-b]pyridin-5-yl)methylamino]benzamide Chemical compound FC1=CC=C(C(=O)NC2CC2)C=C1NCC(C=C1C=2)=CN=C1NC=2C1=CC=CC=C1 ZFBNPNOJLQAKNS-UHFFFAOYSA-N 0.000 claims 1
ZGILBHDPGVMKEC-UHFFFAOYSA-N n-cyclopropyl-4-fluoro-3-[[2-(4-methoxyphenyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]methylamino]benzamide Chemical compound C1=CC(OC)=CC=C1C1=CC2=CC(CNC=3C(=CC=C(C=3)C(=O)NC3CC3)F)=CN=C2N1 ZGILBHDPGVMKEC-UHFFFAOYSA-N 0.000 claims 1
229910052757 nitrogen Inorganic materials 0.000 claims 1
125000004433 nitrogen atom Chemical group N* 0.000 claims 1
229940127084 other anti-cancer agent Drugs 0.000 claims 1
230000002062 proliferating effect Effects 0.000 claims 1
230000019491 signal transduction Effects 0.000 claims 1
210000003802 sputum Anatomy 0.000 claims 1
208000024794 sputum Diseases 0.000 claims 1
229940124597 therapeutic agent Drugs 0.000 claims 1
230000001225 therapeutic effect Effects 0.000 claims 1

JP2009536454A 2006-11-10 2007-11-07 新規キナーゼ阻害剤 Expired - Fee Related JP5244118B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US86518106P	2006-11-10	2006-11-10
US60/865,181		2006-11-10
PCT/US2007/083850 WO2008060907A2 (en)	2006-11-10	2007-11-07	Pyrrolo-pyridine kinase inhibitors

Publications (3)

Publication Number	Publication Date
JP2010509356A JP2010509356A (ja)	2010-03-25
JP2010509356A5 true JP2010509356A5 (2)	2010-10-21
JP5244118B2 JP5244118B2 (ja)	2013-07-24

Family

ID=39261598

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2009536454A Expired - Fee Related JP5244118B2 (ja)	2006-11-10	2007-11-07	新規キナーゼ阻害剤

Country Status (6)

Country	Link
US (1)	US8148361B2 (2)
EP (1)	EP2081928B1 (2)
JP (1)	JP5244118B2 (2)
CN (1)	CN101600714B (2)
NO (1)	NO20091708L (2)
WO (1)	WO2008060907A2 (2)

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2007
- 2007-11-07 WO PCT/US2007/083850 patent/WO2008060907A2/en not_active Ceased
- 2007-11-07 CN CN2007800496931A patent/CN101600714B/zh not_active Expired - Fee Related
- 2007-11-07 EP EP07844925.3A patent/EP2081928B1/en active Active
- 2007-11-07 JP JP2009536454A patent/JP5244118B2/ja not_active Expired - Fee Related
- 2007-11-07 US US12/513,928 patent/US8148361B2/en active Active
2009
- 2009-04-29 NO NO20091708A patent/NO20091708L/no not_active Application Discontinuation

Publication	Publication Date	Title
JP2010509356A5 (2)	2010-10-21
JP2007505877A5 (2)	2007-11-08
JP2007517807A5 (2)	2008-02-28
JP6021805B2 (ja)	2016-11-09	腫瘍治療剤
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