JP2010536767A5 - - Google Patents
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- JP2010536767A5 JP2010536767A5 JP2010521081A JP2010521081A JP2010536767A5 JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5 JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- ring
- independently
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96511507P | 2007-08-17 | 2007-08-17 | |
| US60/965,115 | 2007-08-17 | ||
| US4345908P | 2008-04-09 | 2008-04-09 | |
| US61/043,459 | 2008-04-09 | ||
| US8045408P | 2008-07-14 | 2008-07-14 | |
| US61/080,454 | 2008-07-14 | ||
| PCT/US2008/072074 WO2009025983A2 (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125041A Division JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | ５−ハロアルキル−４，５−ジヒドロイソキサゾール誘導体を調製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536767A JP2010536767A (ja) | 2010-12-02 |
| JP2010536767A5 true JP2010536767A5 (2) | 2011-09-15 |
| JP5965102B2 JP5965102B2 (ja) | 2016-08-03 |
Family
ID=40350174
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521081A Active JP5965102B2 (ja) | 2007-08-17 | 2008-08-04 | ５−ハロアルキル−４，５−ジヒドロイソキサゾール誘導体を調製する方法 |
| JP2014125041A Pending JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | ５−ハロアルキル−４，５−ジヒドロイソキサゾール誘導体を調製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125041A Pending JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | ５−ハロアルキル−４，５−ジヒドロイソキサゾール誘導体を調製する方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8217180B2 (2) |
| EP (1) | EP2176244B1 (2) |
| JP (2) | JP5965102B2 (2) |
| KR (2) | KR101597839B1 (2) |
| CN (2) | CN105693646A (2) |
| AR (1) | AR067948A1 (2) |
| AU (1) | AU2008289321B2 (2) |
| BR (1) | BRPI0814153B8 (2) |
| CA (1) | CA2693067C (2) |
| CO (1) | CO6260136A2 (2) |
| ES (1) | ES2587386T3 (2) |
| IL (1) | IL203174A (2) |
| MX (2) | MX2010001773A (2) |
| MY (2) | MY150980A (2) |
| PT (1) | PT2176244T (2) |
| RU (1) | RU2536039C2 (2) |
| TW (3) | TWI600639B (2) |
| WO (1) | WO2009025983A2 (2) |
| ZA (1) | ZA201000214B (2) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768129B (zh) | 2004-03-05 | 2012-05-23 | 日产化学工业株式会社 | 异*唑啉取代苯甲酰胺化合物的制备中间体 |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| WO2008154528A2 (en) | 2007-06-13 | 2008-12-18 | E. I. Du Pont De Nemours And Company | Isoxazoline insecticides |
| TWI430995B (zh) * | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| KR101769728B1 (ko) | 2007-06-27 | 2017-08-18 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 동물 해충 방제 방법 |
| JP5349303B2 (ja) * | 2007-06-27 | 2013-11-20 | 日産化学工業株式会社 | ３−ヒドロキシプロパン−１−オン化合物、２−プロペン−１−オン化合物およびイソキサゾリン化合物の製造方法 |
| TWI600639B (zh) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | 製備５-鹵烷基-４，５-二氫異唑衍生物之化合物 |
| MX2010003557A (es) * | 2007-10-03 | 2010-04-12 | Du Pont | Compuestos de isoxazolina de naftaleno para el control de plagas de invertebrados. |
| TWI518076B (zh) * | 2008-04-09 | 2016-01-21 | 杜邦股份有限公司 | 製備雜環化合物之方法 |
| BRPI0915818A2 (pt) | 2008-07-09 | 2015-08-04 | Basf Se | Mistura pesticida, composição pesticida, método para controlar fungos nocivos fitopatogênicos, para proteger plantas de fungos nocivos fitopatogênicos, para controlar insetos, aracnídeos ou nematódeos, para proteger plantas do ataque ou infestação por insetos, acarídeos ou nematódeos, e para a proteção de semente, semente, e, uso de uma mistura. |
| CN102088856B (zh) | 2008-07-09 | 2015-11-25 | 巴斯夫欧洲公司 | 包含异*唑啉化合物的杀虫活性混合物i |
| EP2331536B1 (en) | 2008-08-22 | 2013-08-21 | Syngenta Participations AG | Insecticidal compounds |
| JP2012500782A (ja) | 2008-08-22 | 2012-01-12 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | 殺虫化合物類 |
| JP2012501989A (ja) | 2008-09-04 | 2012-01-26 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | 殺虫化合物 |
| EA201100980A1 (ru) | 2008-12-23 | 2012-01-30 | Басф Се | Замещенные амидиновые соединения для подавления животных-вредителей |
| TW201029997A (en) | 2008-12-23 | 2010-08-16 | Basf Se | Imine compounds for combating invertebrate pests |
| EP2414353A1 (en) * | 2009-04-01 | 2012-02-08 | Basf Se | Isoxazoline compounds for combating invertebrate pests |
| RS54772B1 (sr) | 2009-12-17 | 2016-10-31 | Merial Sas | Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže |
| US8999889B2 (en) | 2010-02-01 | 2015-04-07 | Basf Se | Substituted ketonic isoxazoline compounds and derivatives for combating animal pests |
| UA108881C2 (xx) | 2010-05-27 | 2015-06-25 | Кристалічна форма 4-$5-$3-хлор-5-(трифторметил)феніл]-4,5-дигідро-5-(трифторметил)-3-ізоксазоліл]-n-$2-оксо-2-$(2,2,2-трифторетил)аміно]етил]-1-нафталінкарбоксаміду | |
| UY33403A (es) | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
| BR112013006686A2 (pt) | 2010-09-24 | 2017-11-14 | Zoetis Llc | isoxazolina oximas como agentes antiparasitários |
| KR101901466B1 (ko) * | 2010-09-27 | 2018-09-21 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 2-아미노-n-(2,2,2-트라이플루오로에틸)아세트아미드의 제조 방법 |
| JP2014505089A (ja) | 2011-02-10 | 2014-02-27 | ノバルティス アーゲー | 無脊椎有害動物を防除するためのイソオキサゾリン誘導体 |
| WO2012120135A1 (en) | 2011-03-10 | 2012-09-13 | Novartis Ag | Isoxazole derivatives |
| JP6075563B2 (ja) | 2011-11-08 | 2017-02-08 | 日産化学工業株式会社 | 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物 |
| CA2858766A1 (en) | 2011-12-23 | 2013-06-27 | Basf Se | Isothiazoline compounds for combating invertebrate pests |
| NZ723198A (en) | 2012-11-20 | 2018-11-30 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic compounds and compositions and methods of using thereof |
| WO2015066277A1 (en) | 2013-11-01 | 2015-05-07 | Merial Limited | Antiparisitic and pesticidal isoxazoline compounds |
| ES2842592T3 (es) | 2014-05-19 | 2021-07-14 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelmínticos |
| US10864193B2 (en) | 2014-10-31 | 2020-12-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising fipronil at high concentrations |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| ES2903286T3 (es) | 2016-04-06 | 2022-03-31 | Boehringer Ingelheim Animal Health Usa Inc | Proceso de preparación de compuestos de isoxazolina enriquecidos enantioméricamente y de solvato de tolueno cristalino de (S)-afoxolaner |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| WO2018187623A1 (en) * | 2017-04-05 | 2018-10-11 | Merial, Inc. | Crystalline forms of (s)-afoxolaner |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| BR112020003217A2 (pt) | 2017-08-14 | 2020-10-06 | Boehringer Ingelheim Animal Health USA Inc. | compostos pesticidas e parasiticidas de pirazolisoxazolina |
| TWI707849B (zh) | 2018-02-13 | 2020-10-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP3789382B1 (en) | 2018-04-27 | 2023-07-05 | Kumiai Chemical Industry Co., Ltd. | Production method for 5,5-di-substituted-4,5-dihydroisoxazole |
| EP3820572B1 (en) | 2018-07-13 | 2023-08-16 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| CN114828979B (zh) | 2019-10-08 | 2024-09-17 | 唐纳森公司 | 包括细纤维层的过滤器介质 |
| EP4077286A1 (en) | 2019-12-18 | 2022-10-26 | Elanco Tiergesundheit AG | Isoxazoline derivatives as pesticides |
| WO2021203066A1 (en) | 2020-04-03 | 2021-10-07 | Donaldson Company, Inc. | Filtration media |
| JP2023527792A (ja) | 2020-05-27 | 2023-06-30 | アキシャル セラピューティクス，インク． | Ｔｌｒ２調節剤化合物、医薬組成物、及びそれらの使用 |
| IL303195A (en) | 2020-11-25 | 2023-07-01 | Akagera Medicines Inc | Lipid nanoparticles for delivery of nucleic acids and related methods of use |
| WO2023012821A1 (en) * | 2021-08-01 | 2023-02-09 | Zenfold Sustainable Technologies Private Limited | A process for the preparation of carbamoyl benzamide phenyl isoxazoline class drug/s and its intermediates |
| CN115710185B (zh) * | 2021-08-23 | 2024-05-03 | 中国石油化工股份有限公司 | 利用金属碳化物催化剂生产甲胺的方法 |
| EP4531819A2 (en) | 2022-05-25 | 2025-04-09 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| CN116253658B (zh) * | 2022-11-25 | 2023-08-11 | 济南久隆医药科技有限公司 | 一种阿福拉纳中间体合成方法 |
| CN115772091B (zh) * | 2023-01-05 | 2023-06-23 | 济南久隆医药科技有限公司 | 一种2-氨基-n-(2,2,2-三氟乙基)乙酰胺的合成方法 |
| CN119899156A (zh) * | 2023-10-27 | 2025-04-29 | 华北制药集团动物保健品有限责任公司 | 一种阿福拉纳的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3879532A (en) * | 1974-01-18 | 1975-04-22 | Shell Oil Co | Control by isoxazoles of endoparasitic nematodes |
| US4129568A (en) * | 1977-05-12 | 1978-12-12 | Monsanto Company | 2-[3-Aryl-2-isoxazolin-5-yl]benzoates |
| US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| GB9505651D0 (en) | 1995-03-21 | 1995-05-10 | Agrevo Uk Ltd | AgrEvo UK Limited |
| BR9708828A (pt) | 1996-04-26 | 1999-08-03 | Nippon Soda Co | Composto e composição herbicida |
| AR007292A1 (es) | 1996-06-06 | 1999-10-27 | Rohm & Haas | Compuestos aromaticos benciloxi sustituidos, una composicion fungicida, un metodo para controlar hongos fitopatogenicos y un metodo para controlarinsectos. |
| GB2351081A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
| DE10114597A1 (de) * | 2001-03-23 | 2002-10-02 | Bayer Cropscience Gmbh | Arylisoxazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| WO2004018410A1 (ja) | 2002-08-26 | 2004-03-04 | Nissan Chemical Industries, Ltd. | 置換ベンズアニリド化合物及び有害生物防除剤 |
| DE10320782A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Cropscience Ag | Substituierte Oxyarene |
| JP2005272452A (ja) | 2004-02-23 | 2005-10-06 | Nissan Chem Ind Ltd | 置換ベンズアニリド化合物及び有害生物防除剤 |
| CN101768129B (zh) | 2004-03-05 | 2012-05-23 | 日产化学工业株式会社 | 异*唑啉取代苯甲酰胺化合物的制备中间体 |
| US20050250826A1 (en) | 2004-03-26 | 2005-11-10 | Thais Sielecki-Dzurdz | Compounds, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor |
| JP5051340B2 (ja) * | 2005-06-06 | 2012-10-17 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| MY146795A (en) | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
| GB0514071D0 (en) | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
| KR100546831B1 (ko) | 2005-08-31 | 2006-01-25 | (주) 마이크로프랜드 | 프로브 카드의 탐침팁 공정 방법 |
| BRPI0617076B1 (pt) * | 2005-09-02 | 2021-07-06 | Nissan Chemical Corporation | Composto benzamida substituída por isoxazolina da fórmula (1) ou sal do mesmo; composto benzamida substituido por 4-hidroxiiminametila da fórmula (2) ou sal do mesmo; pesticida; agente agroquímico; parasiticida interno ou externo para mamíferos ou aves; inseticida ou acaricida |
| JP2007106756A (ja) | 2005-09-14 | 2007-04-26 | Nissan Chem Ind Ltd | 置換イソキサゾリン化合物及び有害生物防除剤 |
| TWI266597B (en) * | 2005-09-27 | 2006-11-11 | Delta Electronics Inc | Electronic apparatus capable of dissipating heat uniformly |
| JP2009519937A (ja) * | 2005-12-14 | 2009-05-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 無脊椎有害生物防除用イソオキサゾリン |
| TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| JP5304981B2 (ja) | 2005-12-26 | 2013-10-02 | 日産化学工業株式会社 | １，３−ビス（置換フェニル）−３−ヒドロキシプロパン−１−オンおよび２−プロペン−１−オン化合物およびその塩 |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| WO2007105814A1 (ja) | 2006-03-10 | 2007-09-20 | Nissan Chemical Industries, Ltd. | 置換イソキサゾリン化合物及び有害生物防除剤 |
| MX2008013307A (es) | 2006-04-20 | 2008-10-27 | Du Pont | Pirazolinas para controlar plagas de invertebrados. |
| JPWO2007125984A1 (ja) | 2006-04-28 | 2009-09-10 | 日本農薬株式会社 | イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法 |
| JP2008044880A (ja) | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | 殺虫性イソオキサゾリン類 |
| WO2008108448A1 (ja) | 2007-03-07 | 2008-09-12 | Nissan Chemical Industries, Ltd. | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| MY146638A (en) * | 2007-04-10 | 2012-09-14 | Bayer Cropscience Ag | Insecticidal aryl isoxazoline derivatives |
| WO2008154528A2 (en) | 2007-06-13 | 2008-12-18 | E. I. Du Pont De Nemours And Company | Isoxazoline insecticides |
| TWI430995B (zh) * | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| JP5349303B2 (ja) * | 2007-06-27 | 2013-11-20 | 日産化学工業株式会社 | ３−ヒドロキシプロパン−１−オン化合物、２−プロペン−１−オン化合物およびイソキサゾリン化合物の製造方法 |
| KR101769728B1 (ko) | 2007-06-27 | 2017-08-18 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 동물 해충 방제 방법 |
| TWI600639B (zh) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | 製備５-鹵烷基-４，５-二氫異唑衍生物之化合物 |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| JP5365806B2 (ja) | 2007-09-10 | 2013-12-11 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| MX2010003557A (es) * | 2007-10-03 | 2010-04-12 | Du Pont | Compuestos de isoxazolina de naftaleno para el control de plagas de invertebrados. |
-
2008
- 2008-07-31 TW TW103118216A patent/TWI600639B/zh active
- 2008-07-31 TW TW106102361A patent/TWI649303B/zh active
- 2008-07-31 TW TW97129034A patent/TWI461411B/zh active
- 2008-08-04 RU RU2010109881/04A patent/RU2536039C2/ru active
- 2008-08-04 BR BRPI0814153A patent/BRPI0814153B8/pt active IP Right Grant
- 2008-08-04 KR KR1020107005776A patent/KR101597839B1/ko active Active
- 2008-08-04 ES ES08797091.9T patent/ES2587386T3/es active Active
- 2008-08-04 KR KR1020157017534A patent/KR20150082693A/ko not_active Ceased
- 2008-08-04 CN CN201610091532.XA patent/CN105693646A/zh active Pending
- 2008-08-04 EP EP08797091.9A patent/EP2176244B1/en active Active
- 2008-08-04 CN CN200880103362A patent/CN101855215A/zh active Pending
- 2008-08-04 WO PCT/US2008/072074 patent/WO2009025983A2/en not_active Ceased
- 2008-08-04 MX MX2010001773A patent/MX2010001773A/es active IP Right Grant
- 2008-08-04 MX MX2013011829A patent/MX337588B/es unknown
- 2008-08-04 AU AU2008289321A patent/AU2008289321B2/en active Active
- 2008-08-04 PT PT87970919T patent/PT2176244T/pt unknown
- 2008-08-04 MY MYPI20100137 patent/MY150980A/en unknown
- 2008-08-04 MY MYPI2014000219A patent/MY176115A/en unknown
- 2008-08-04 CA CA2693067A patent/CA2693067C/en active Active
- 2008-08-04 JP JP2010521081A patent/JP5965102B2/ja active Active
- 2008-08-04 US US12/679,382 patent/US8217180B2/en active Active
- 2008-08-15 AR ARP080103565 patent/AR067948A1/es active IP Right Grant
-
2010
- 2010-01-06 IL IL203174A patent/IL203174A/en active IP Right Grant
- 2010-01-12 ZA ZA2010/00214A patent/ZA201000214B/en unknown
- 2010-02-17 CO CO10018337A patent/CO6260136A2/es active IP Right Grant
-
2012
- 2012-07-09 US US13/544,113 patent/US8513431B2/en active Active
-
2014
- 2014-06-18 JP JP2014125041A patent/JP2014221775A/ja active Pending
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