JP2012505221A5 - - Google Patents

Download PDF

Info

Publication number
JP2012505221A5
JP2012505221A5 JP2011531120A JP2011531120A JP2012505221A5 JP 2012505221 A5 JP2012505221 A5 JP 2012505221A5 JP 2011531120 A JP2011531120 A JP 2011531120A JP 2011531120 A JP2011531120 A JP 2011531120A JP 2012505221 A5 JP2012505221 A5 JP 2012505221A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011531120A
Other languages
English (en)
Other versions
JP2012505221A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/059730 external-priority patent/WO2010042543A2/en
Publication of JP2012505221A publication Critical patent/JP2012505221A/ja
Publication of JP2012505221A5 publication Critical patent/JP2012505221A5/ja
Pending legal-status Critical Current

Links

Description

Figure 2012505221

Figure 2012505221


Figure 2012505221
JP2011531120A 2008-10-06 2009-10-06 高コレステロール血症および高脂血症ならびにそれらに関連する疾患の予防および処置におけるトル様受容体の阻害剤の使用 Pending JP2012505221A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10297408P 2008-10-06 2008-10-06
US61/102,974 2008-10-06
PCT/US2009/059730 WO2010042543A2 (en) 2008-10-06 2009-10-06 Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto

Publications (2)

Publication Number Publication Date
JP2012505221A JP2012505221A (ja) 2012-03-01
JP2012505221A5 true JP2012505221A5 (ja) 2012-07-05

Family

ID=41472585

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011531120A Pending JP2012505221A (ja) 2008-10-06 2009-10-06 高コレステロール血症および高脂血症ならびにそれらに関連する疾患の予防および処置におけるトル様受容体の阻害剤の使用

Country Status (9)

Country Link
US (1) US8853177B2 (ja)
EP (2) EP3087988A3 (ja)
JP (1) JP2012505221A (ja)
KR (1) KR20110071108A (ja)
CN (1) CN102281880A (ja)
AU (1) AU2009302468A1 (ja)
CA (1) CA2738816A1 (ja)
MX (1) MX2011003625A (ja)
WO (1) WO2010042543A2 (ja)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2101819B1 (en) 2006-11-20 2013-01-09 President and Fellows of Harvard College Methods, compositions, and kits for treating pain and pruritis
AU2009313296B2 (en) * 2008-11-07 2015-07-23 National Jewish Health Diagnosis and treatment of autoimmune diseases by targeting autoimmune-related B cells ("ABCs")
WO2011005942A2 (en) * 2009-07-08 2011-01-13 Idera Pharmaceuticals, Inc. Oligonucleotide-based compounds as inhibitors of toll-like receptors
EP2995303A1 (en) 2009-07-10 2016-03-16 President and Fellows of Harvard College Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
JP5813778B2 (ja) 2010-11-19 2015-11-17 イデラ ファーマシューティカルズ インコーポレイテッドIdera Pharmaceuticals, Inc. トール様受容体に基づく免疫反応を調節するための免疫調節オリゴヌクレオチド(iro)化合物
WO2014085154A1 (en) 2012-11-27 2014-06-05 Beth Israel Deaconess Medical Center, Inc. Methods for treating renal disease
KR101898177B1 (ko) 2013-01-08 2018-09-12 이데라 파마슈티칼즈, 인코포레이티드 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고누클레오티드 (iro) 화합물
US9616057B2 (en) 2013-03-15 2017-04-11 The Board Of Trustees Of The Leland Stanford Junior University Desethylhydroxychloroquine for the treatment of diseases associated with inflammation
US10209996B2 (en) 2014-12-14 2019-02-19 Via Alliance Semiconductor Co., Ltd. Apparatus and method for programmable load replay preclusion
WO2016195194A2 (ko) * 2015-05-29 2016-12-08 아주대학교산학협력단 신규한 tlr2 길항제
KR101745524B1 (ko) 2015-05-29 2017-06-12 아주대학교산학협력단 신규한 tlr2 길항제
WO2017024037A1 (en) 2015-08-03 2017-02-09 President And Fellows Of Harvard College Charged ion channel blockers and methods for use
CN105506119A (zh) * 2016-01-08 2016-04-20 张君 大鼠网膜脂肪组织炎症通路关键因子表达水平的测定方法
CN105695625B (zh) * 2016-04-29 2021-12-17 宁波大学 一种用于辅助诊断原发性高血压的检测试剂盒及其应用
EP3468605A4 (en) 2016-06-08 2020-01-08 President and Fellows of Harvard College MANIPULATED VIRAL VECTOR TO REDUCE INDUCTION OF IGNITION AND IMMUNE REACTIONS
AU2018364542A1 (en) 2017-11-08 2020-04-16 President And Fellows Of Harvard College Compositions and methods for inhibiting viral vector-induced inflammatory responses
US12440536B2 (en) 2018-05-18 2025-10-14 The University Of Hong Kong Compositions of toll-like receptor 5 (TLR5) agonist and methods of use thereof
WO2020011869A2 (en) 2018-07-11 2020-01-16 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides targeting tlr2
CN109251956A (zh) * 2018-09-18 2019-01-22 青岛大学 糖尿病大鼠胰岛内MyD88 mRNA表达及黄芪的调节作用
EP3937945A4 (en) 2019-03-11 2023-01-04 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
MA55307A (fr) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueurs de canaux ioniques chargés et procédés d'utilisation
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
BR112021017809A2 (pt) 2019-03-11 2021-11-23 Nocion Therapeutics Inc Bloqueadores de canais iônicos substituídos por éster e métodos para uso
WO2021091585A1 (en) 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP7708777B2 (ja) 2020-03-11 2025-07-15 ノシオン セラピューティクス,インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO203996A0 (en) * 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
US6426334B1 (en) * 1997-04-30 2002-07-30 Hybridon, Inc. Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
EP2314693A3 (en) * 1999-08-13 2012-11-28 Idera Pharmaceuticals, Inc. Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
US6899891B2 (en) * 1999-12-16 2005-05-31 Harry J. Siskind Nutritional composition, methods of producing said composition and methods of using said composition
EP1252307B1 (en) * 2000-01-26 2008-01-02 Idera Pharmaceuticals, Inc. MODULATION OF OLIGONUCLEOTIDE CpG-MEDIATED IMMUNE STIMULATION BY POSITIONAL MODIFICATION OF NUCLEOSIDES
JP2003531915A (ja) 2000-05-01 2003-10-28 ハイブリドン・インコーポレイテッド ヌクレオシドの位置的修飾によるオリゴヌクレオチドCpG誘導性免疫刺激の調節
US7105495B2 (en) * 2001-04-30 2006-09-12 Idera Pharmaceuticals, Inc. Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
WO2003035836A2 (en) * 2001-10-24 2003-05-01 Hybridon Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
EP1495756A4 (en) * 2002-04-08 2009-10-28 Takeda Pharmaceutical THERAPEUTIC AGENT FOR SEVERE SEPTIC STATE PREVENTION
US20040009949A1 (en) * 2002-06-05 2004-01-15 Coley Pharmaceutical Group, Inc. Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory CpG nucleic acids
SE0201701D0 (sv) 2002-06-05 2002-06-05 Gotovax Ab Treatment of epithelial tumors and infections
EP1393745A1 (en) 2002-07-29 2004-03-03 Hybridon, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5'ends
WO2004094671A2 (en) 2003-04-22 2004-11-04 Coley Pharmaceutical Gmbh Methods and products for identification and assessment of tlr ligands
JP2007524615A (ja) 2003-06-20 2007-08-30 コーリー ファーマシューティカル ゲーエムベーハー 低分子トール様レセプター(tlr)アンタゴニスト
MXPA06000619A (es) * 2003-07-15 2006-04-11 Hybridon Inc Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion.
JP2007514648A (ja) * 2003-10-24 2007-06-07 エーザイ株式会社 Toll−likereceptor2に関連する疾患及び状態を治療するための化合物及び方法
US20050239733A1 (en) * 2003-10-31 2005-10-27 Coley Pharmaceutical Gmbh Sequence requirements for inhibitory oligonucleotides
GB0329146D0 (en) 2003-12-16 2004-01-21 Glaxosmithkline Biolog Sa Vaccine
US7959918B2 (en) * 2004-05-28 2011-06-14 Cedars-Sinai Medical Center Methods for treating vascular disease
PL1794174T3 (pl) * 2004-09-01 2012-11-30 Dynavax Tech Corp Sposoby i kompozycje do hamowania wrodzonych odpowiedzi immunologicznych i autoodporności
JP2008523076A (ja) 2004-12-08 2008-07-03 スリーエム イノベイティブ プロパティズ カンパニー 免疫調節性の組成物、合剤、および方法
AU2005316503A1 (en) * 2004-12-17 2006-06-22 Dynavax Technologies Corporation Methods and compositions for induction or promotion of immune tolerance
US20060257411A1 (en) * 2005-05-06 2006-11-16 Bruce Beutler Compositions and methods for modulating cells via CD14 and toll-like receptor 4 signaling pathway
CN101340931A (zh) 2005-09-27 2009-01-07 科利制药公司 使用连接寡核苷酸调节tlr介导的免疫应答
CN101287742B (zh) * 2005-10-12 2016-01-06 艾德拉药物股份有限公司 基于变异应答调制Toll样受体的免疫调节寡核苷酸(IRO)化合物
US8383598B2 (en) * 2005-10-12 2013-02-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8426375B2 (en) * 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8399423B2 (en) * 2005-10-12 2013-03-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8377898B2 (en) * 2006-10-12 2013-02-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
MX2010001785A (es) * 2007-08-15 2010-03-10 Idera Pharmaceuticals Inc Moduladores de receptores tipo larga distancia.
WO2009055076A2 (en) * 2007-10-26 2009-04-30 Dynavax Technologies Corporation Methods and compositions for inhibition of immune responses and autoimmunity
WO2009058361A1 (en) * 2007-10-31 2009-05-07 Dynavax Technologies Corp. Inhibition of type i ifn production
WO2009154609A1 (en) * 2008-06-17 2009-12-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
US11114308B2 (en) 2018-09-25 2021-09-07 International Business Machines Corporation Controlling of height of high-density interconnection structure on substrate
WO2020091561A1 (en) 2018-11-02 2020-05-07 Samsung Electronics Co., Ltd. Method and device for radio resource allocation in wireless communication system
TWI711225B (zh) 2019-07-01 2020-11-21 唐虞企業股份有限公司 連接器總成

Similar Documents

Publication Publication Date Title
JP2011510113A5 (ja)
JP2011528381A5 (ja)
JP2011051867A5 (ja)
JP2011117499A5 (ja)
JP2012511525A5 (ja)
JP2010049241A5 (ja)
JP2011026329A5 (ja)
JP2011006413A5 (ja)
JP2012031285A5 (ja)
JP2011052077A5 (ja)
JP2008188757A5 (ja)
JP2011214087A5 (ja)
JP2010233885A5 (ja)
JP2010037339A5 (ja)
JP2012011657A5 (ja)
JP2010166925A5 (ja)
JP2011208181A5 (ja)
JP2012042569A5 (ja)
JP2011207949A5 (ja)
JP2012011658A5 (ja)
JP2010246466A5 (ja)
JP2010211102A5 (ja)
JP2011146571A5 (ja)
JP2009507826A5 (ja)
JP2011106051A5 (ja)