|
US5300645A
(en)
|
1993-04-14 |
1994-04-05 |
Eli Lilly And Company |
Tetrahydro-pyrido-indole
|
|
US5858753A
(en)
|
1996-11-25 |
1999-01-12 |
Icos Corporation |
Lipid kinase
|
|
US5939421A
(en)
|
1997-07-01 |
1999-08-17 |
Signal Pharmaceuticals, Inc. |
Quinazoline analogs and related compounds and methods for treating inflammatory conditions
|
|
US6667300B2
(en)
|
2000-04-25 |
2003-12-23 |
Icos Corporation |
Inhibitors of human phosphatidylinositol 3-kinase delta
|
|
AU2001257571A1
(en)
|
2000-05-10 |
2001-11-20 |
Icos Corporation |
Phosphatidyl inositol 3-kinase delta binding partner
|
|
DE10043667A1
(de)
|
2000-09-05 |
2002-03-14 |
Merck Patent Gmbh |
2-Guanidino-4-aryl-chinazoline
|
|
AU2002221810B2
(en)
|
2000-11-07 |
2005-06-23 |
Novartis Ag |
Indolylmaleimide derivatives as protein kinase C inhibitors
|
|
EP1389617B1
(en)
|
2001-04-27 |
2007-01-03 |
Zenyaku Kogyo Kabushiki Kaisha |
Heterocyclic compound and antitumor agent containing the same as active ingredient
|
|
PE20040079A1
(es)
|
2002-04-03 |
2004-04-19 |
Novartis Ag |
Derivados de indolilmaleimida
|
|
JP2006514021A
(ja)
|
2002-12-09 |
2006-04-27 |
ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム |
Janusチロシンキナーゼ3(Jak3)を選択的に阻害するための方法
|
|
EP1578748B1
(en)
|
2002-12-27 |
2010-09-15 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors
|
|
US20050054614A1
(en)
|
2003-08-14 |
2005-03-10 |
Diacovo Thomas G. |
Methods of inhibiting leukocyte accumulation
|
|
WO2005016348A1
(en)
|
2003-08-14 |
2005-02-24 |
Icos Corporation |
Method of inhibiting immune responses stimulated by an endogenous factor
|
|
NZ546058A
(en)
|
2004-01-12 |
2010-09-30 |
Ym Biosciences Australia Pty |
Benzimidazole and other fused ring derivatives as selective janus kinase inhibitors
|
|
CA2553969A1
(en)
|
2004-01-23 |
2005-08-04 |
Amgen Inc. |
Vanilloid receptor ligands and their use in treatments
|
|
WO2005086814A2
(en)
*
|
2004-03-09 |
2005-09-22 |
The Uab Research Foundation |
Methods and compositions related to regulation of cytokine production by glycogen synthase kinase 3 (gsk-3)
|
|
CA2730540A1
(en)
|
2004-05-13 |
2005-12-01 |
Vanderbilt University |
Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis
|
|
SI2612862T1
(sl)
|
2004-05-13 |
2017-04-26 |
Icos Corporation |
Kinazolini kot inhibitorji humane fosfatidilinozitol 3-kinaze delta
|
|
AU2005252110B2
(en)
|
2004-06-11 |
2008-09-04 |
Shionogi & Co., Ltd. |
5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido[2,3-D] pyrimidine derivatives and related compounds for the treatment of cancer
|
|
GB0423653D0
(en)
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
US20060128710A1
(en)
|
2004-12-09 |
2006-06-15 |
Chih-Hung Lee |
Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
|
|
JP2008526734A
(ja)
|
2004-12-31 |
2008-07-24 |
エスケー ケミカルズ カンパニー リミテッド |
糖尿及び肥満治療予防に有効なキナゾリン誘導体
|
|
MX2007013595A
(es)
|
2005-05-04 |
2008-01-24 |
Renovis Inc |
Compuestos heterociclicos fusionados y composiciones y usos de estos.
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
AU2006283846B2
(en)
|
2005-08-26 |
2012-04-05 |
Merck Serono Sa |
Pyrazine derivatives and use as PI3K inhibitors
|
|
GB0520657D0
(en)
|
2005-10-11 |
2005-11-16 |
Ludwig Inst Cancer Res |
Pharmaceutical compounds
|
|
EP1968968A1
(en)
|
2005-12-21 |
2008-09-17 |
PainCeptor Pharma Corp. |
Compositions and methods for modulating gated ion channels
|
|
GB0612630D0
(en)
|
2006-06-26 |
2006-08-02 |
Novartis Ag |
Organic compounds
|
|
WO2008009077A2
(en)
|
2006-07-20 |
2008-01-24 |
Gilead Sciences, Inc. |
4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
|
|
EP2049502B1
(en)
*
|
2006-07-28 |
2012-01-04 |
Novartis AG |
2,4-substituted quinazolines as lipid kinase inhibitors
|
|
EP1891958A1
(en)
|
2006-08-03 |
2008-02-27 |
Universite Pierre Et Marie Curie (Paris Vi) |
Rho/Rock/PI3/Akt kinase inhibitors for the treatment of diseases associated with protozoan parasites.
|
|
KR20090087027A
(ko)
|
2006-11-13 |
2009-08-14 |
일라이 릴리 앤드 캄파니 |
염증 질환 및 암의 치료를 위한 티에노피리미디논
|
|
WO2008118454A2
(en)
|
2007-03-23 |
2008-10-02 |
Amgen Inc. |
Derivatives of quinoline or benzopyrazine and their uses for the treatment of (inter alia) inflammatory diseases, autoimmune diseases or various kinds of cancer
|
|
EA017389B1
(ru)
|
2007-03-23 |
2012-12-28 |
Амген Инк. |
Гетероциклические соединения и их применение
|
|
RS53151B
(sr)
|
2007-03-23 |
2014-06-30 |
Amgen Inc. |
3-supstituisani derivati hinolina ili hinoksalina i njihova upotreba kao inhibitora fosfatidilinozitol 3-kinaze (pi3k)
|
|
CA2682162C
(en)
|
2007-04-02 |
2016-05-10 |
Renovis, Inc. |
Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof
|
|
BRPI0810641A2
(pt)
|
2007-04-12 |
2019-09-24 |
Hoffmann La Roche |
"compostos farmacêuticos".
|
|
WO2008125833A1
(en)
|
2007-04-12 |
2008-10-23 |
Piramed Limited |
Pharmaceutical compounds
|
|
GB0707087D0
(en)
|
2007-04-12 |
2007-05-23 |
Piramed Ltd |
Pharmaceutical compounds
|
|
JP5498374B2
(ja)
|
2007-04-17 |
2014-05-21 |
エボテック・アーゲー |
2−シアノフェニル縮合複素環式化合物および組成物、ならびにその使用
|
|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
|
WO2008150827A1
(en)
|
2007-05-29 |
2008-12-11 |
Smithkline Beecham Corporation |
Naphthyridine, derivatives as p13 kinase inhibitors
|
|
US7893060B2
(en)
|
2007-06-12 |
2011-02-22 |
F. Hoffmann-La Roche Ag |
Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase
|
|
WO2008152394A1
(en)
|
2007-06-12 |
2008-12-18 |
F.Hoffmann-La Roche Ag |
Pharmaceutical compounds
|
|
WO2008152387A1
(en)
|
2007-06-12 |
2008-12-18 |
F.Hoffmann-La Roche Ag |
Quinazoline derivatives as pi3 kinase inhibitors
|
|
UY31137A1
(es)
*
|
2007-06-14 |
2009-01-05 |
Smithkline Beecham Corp |
Derivados de quinazolina como inhibidores de la pi3 quinasa
|
|
RU2341527C1
(ru)
|
2007-07-17 |
2008-12-20 |
Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" |
Аннелированные азагетероциклы, включающие пиримидиновый фрагмент, способ их получения и ингибиторы pi3k киназ
|
|
TW200908984A
(en)
|
2007-08-07 |
2009-03-01 |
Piramal Life Sciences Ltd |
Pyridyl derivatives, their preparation and use
|
|
WO2009036768A2
(en)
|
2007-09-19 |
2009-03-26 |
H. Lundbeck A/S |
Diagnosing potential weight gain in a subject
|
|
GB2467670B
(en)
|
2007-10-04 |
2012-08-01 |
Intellikine Inc |
Chemical entities and therapeutic uses thereof
|
|
EP2209775A1
(en)
|
2007-10-09 |
2010-07-28 |
UCB Pharma, S.A. |
Heterobicyclic compounds as histamine h4-receptor antagonists
|
|
WO2009058361A1
(en)
|
2007-10-31 |
2009-05-07 |
Dynavax Technologies Corp. |
Inhibition of type i ifn production
|
|
CA2716334A1
(en)
|
2007-11-13 |
2009-05-22 |
Icos Corporation |
Inhibitors of human phosphatidyl-inositol 3-kinase delta
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
EP3613743B1
(en)
|
2008-01-04 |
2022-03-16 |
Intellikine, LLC |
Processes for the preparation of 1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives
|
|
EP2276750A2
(en)
|
2008-03-27 |
2011-01-26 |
Auckland Uniservices Limited |
Substituted pyrimidines and triazines and their use in cancer therapy
|
|
US8436005B2
(en)
|
2008-04-03 |
2013-05-07 |
Abbott Laboratories |
Macrocyclic pyrimidine derivatives
|
|
US8658635B2
(en)
|
2008-06-05 |
2014-02-25 |
Glaxosmithkline Intellectual Property Development Limited |
Benzpyrazol derivatives as inhibitors of PI3 kinases
|
|
ES2383246T3
(es)
|
2008-06-05 |
2012-06-19 |
Glaxo Group Limited |
4-amino-indazoles
|
|
JP5502076B2
(ja)
|
2008-06-05 |
2014-05-28 |
グラクソ グループ リミテッド |
新規化合物
|
|
JP5596026B2
(ja)
|
2008-06-19 |
2014-09-24 |
ミレニアム ファーマシューティカルズ, インコーポレイテッド |
チオフェン又はチアゾール誘導体及びpi3k阻害剤としてのそれらの使用
|
|
JP2011527342A
(ja)
|
2008-07-07 |
2011-10-27 |
エックスカバリー ホールディング カンパニー エルエルシー |
Pi3kアイソフォーム選択的阻害剤
|
|
JP5788316B2
(ja)
|
2008-07-08 |
2015-09-30 |
インテリカイン, エルエルシー |
キナーゼインヒビターおよび使用方法
|
|
WO2010036908A1
(en)
*
|
2008-09-26 |
2010-04-01 |
Eisai R & D Management Co., Ltd. |
Use of benzoxazole compounds in the treatment of malaria
|
|
US8703778B2
(en)
|
2008-09-26 |
2014-04-22 |
Intellikine Llc |
Heterocyclic kinase inhibitors
|
|
CN102271683B
(zh)
|
2008-11-13 |
2014-07-09 |
吉里德卡利斯托加公司 |
恶性血液病的治疗
|
|
WO2010059593A1
(en)
|
2008-11-18 |
2010-05-27 |
Intellikine, Inc. |
Methods and compositions for treatment of ophthalmic conditions
|
|
AU2009322187B2
(en)
|
2008-12-04 |
2015-02-19 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Phosphatidylinositol-3-kinase p110 delta-targeted drugs in the treatment of CNS disorders
|
|
JP5656880B2
(ja)
|
2009-03-09 |
2015-01-21 |
グラクソ グループ リミテッドGlaxo Group Limited |
Pi3キナーゼの阻害剤としての4−オキサジアゾール−2−イル−インダゾール
|
|
CA2756347A1
(en)
|
2009-03-24 |
2010-09-30 |
Gilead Calistoga Llc |
Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
|
|
EP2411003A4
(en)
|
2009-03-24 |
2012-10-17 |
Univ Singapore |
USE OF ARTEMISININE DERIVATIVES IN THE TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE BRONCHO-PNEUMOPATHY (COPD)
|
|
WO2010120991A1
(en)
*
|
2009-04-17 |
2010-10-21 |
Wyeth Llc |
5, 6, 7, 8-tetrahydropyrido[4,3-d]pyrimidine compounds, their use as mtor, pi3, and hsmg-1 kinase inhibitors, and their syntheses
|
|
CN102458410A
(zh)
|
2009-04-20 |
2012-05-16 |
吉联亚·卡利斯托加有限责任公司 |
治疗实体瘤的方法
|
|
WO2010125082A1
(en)
|
2009-04-30 |
2010-11-04 |
Glaxo Group Limited |
Oxazole substituted indazoles as pi3-kinase inhibitors
|
|
EP2427195B1
(en)
|
2009-05-07 |
2019-05-01 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
CA2772371A1
(en)
|
2009-05-27 |
2010-12-02 |
F. Hoffmann-La Roche Ag |
Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
|
|
CN102459272B
(zh)
|
2009-05-27 |
2014-08-06 |
健泰科生物技术公司 |
对P110δ具有选择性的为PI3K抑制剂的二环嘧啶化合物和使用方法
|
|
WO2010151735A2
(en)
|
2009-06-25 |
2010-12-29 |
Amgen Inc. |
Heterocyclic compounds and their uses
|
|
EA201270013A1
(ru)
|
2009-06-25 |
2012-06-29 |
Амген Инк. |
Гетероциклические соединения и их применение
|
|
CN102625799A
(zh)
|
2009-06-25 |
2012-08-01 |
安姆根有限公司 |
杂环化合物及其用途
|
|
EP2445902A2
(en)
|
2009-06-25 |
2012-05-02 |
Amgen, Inc |
Heterocyclic compounds and their uses as inhibitors of pi3k activity
|
|
CN104945420A
(zh)
|
2009-06-29 |
2015-09-30 |
因塞特公司 |
作为pi3k抑制剂的嘧啶酮类
|
|
ES2627428T3
(es)
|
2009-07-02 |
2017-07-28 |
Sanofi |
Nuevos derivados de 2,3-dihidro-1H-imidazo{1,2-a}pirimidin-5-ona, su preparación y su utilización farmacéutica
|
|
BRPI1015943A8
(pt)
|
2009-07-02 |
2018-01-09 |
Sanofi Sa |
derivados de 1,2,3,4-tetra - hidro - pirimido {1,2-a} pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica.
|
|
EA201270184A1
(ru)
|
2009-07-21 |
2012-08-30 |
ГИЛИЭД КАЛИСТОГА ЭлЭлСи |
Лечение расстройств печени ингибиторами pi3k
|
|
IN2012DN01325A
(2)
|
2009-08-20 |
2015-06-05 |
Karus Therapeutics Ltd |
|
|
KR20120081164A
(ko)
|
2009-09-29 |
2012-07-18 |
엑스커버리 홀딩 컴퍼니 엘엘씨 |
Pi3k(델타) 선택적 억제제
|
|
GB0918249D0
(en)
|
2009-10-19 |
2009-12-02 |
Respivert Ltd |
Compounds
|
|
PH12012500901A1
(en)
|
2009-11-05 |
2016-08-05 |
Rhizen Pharmaceuticals Sa |
Novel benzopyran kinase modulators
|
|
US8741932B2
(en)
|
2009-11-06 |
2014-06-03 |
Piramal Enterprises Limited |
Imidazopyridine derivatives
|
|
KR20130049766A
(ko)
|
2009-11-13 |
2013-05-14 |
메르크 세로노 에스. 에이. |
트리사이클릭 피라졸 아민 유도체
|
|
EP2507231A1
(en)
|
2009-12-03 |
2012-10-10 |
Glaxo Group Limited |
Indazole derivatives as pi 3 - kinase inhibitors
|
|
US20120245171A1
(en)
|
2009-12-03 |
2012-09-27 |
Glaxo Group Limited |
Benzpyrazole derivatives as inhibitors of pi3 kinases
|
|
EP2507226A1
(en)
|
2009-12-03 |
2012-10-10 |
Glaxo Group Limited |
Novel compounds
|
|
US8633313B2
(en)
|
2009-12-18 |
2014-01-21 |
Amgen Inc. |
Heterocyclic compounds and their uses
|
|
WO2011075643A1
(en)
|
2009-12-18 |
2011-06-23 |
Incyte Corporation |
Substituted heteroaryl fused derivatives as pi3k inhibitors
|
|
US8680108B2
(en)
|
2009-12-18 |
2014-03-25 |
Incyte Corporation |
Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
|
|
MX2012009059A
(es)
|
2010-02-22 |
2012-09-07 |
Hoffmann La Roche |
Compuestos inhibidores de fosfoinositida 3-cinasa delta (pi3k) pirido [3,2-d]pirimidina y metodos de uso.
|
|
UY33304A
(es)
|
2010-04-02 |
2011-10-31 |
Amgen Inc |
Compuestos heterocíclicos y sus usos
|
|
AR081823A1
(es)
|
2010-04-14 |
2012-10-24 |
Incyte Corp |
DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
|
|
GB201007347D0
(en)
|
2010-04-30 |
2010-06-16 |
Karus Therapeutics Ltd |
Compounds
|
|
CA2799579A1
(en)
|
2010-05-21 |
2011-11-24 |
Intellikine, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
|
US9062055B2
(en)
|
2010-06-21 |
2015-06-23 |
Incyte Corporation |
Fused pyrrole derivatives as PI3K inhibitors
|
|
UA112517C2
(uk)
*
|
2010-07-06 |
2016-09-26 |
Новартіс Аг |
Тетрагідропіридопіримідинові похідні
|
|
JP5555378B2
(ja)
|
2010-07-14 |
2014-07-23 |
エフ.ホフマン−ラ ロシュ アーゲー |
Pi3kp110デルタに選択的なプリン化合物とその使用の方法
|
|
AR082986A1
(es)
|
2010-09-14 |
2013-01-23 |
Exelixis Inc |
DERIVADOS DE PURINA COMO INHIBIDORES DE PI3K-d, METODOS PARA SU PREPARACION, FORMULACIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS
|
|
EP2616442B8
(en)
|
2010-09-14 |
2018-10-17 |
Exelixis, Inc. |
Inhibitors of pi3k-delta and methods of their use and manufacture
|
|
TWI674262B
(zh)
|
2011-01-10 |
2019-10-11 |
美商英菲尼提製藥股份有限公司 |
製備異喹啉酮之方法及異喹啉酮之固體形式
|
|
US9108984B2
(en)
|
2011-03-14 |
2015-08-18 |
Incyte Corporation |
Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
|
|
WO2012126901A1
(en)
|
2011-03-21 |
2012-09-27 |
F. Hoffmann-La Roche Ag |
Benzoxazepin compounds selective for pi3k p110 delta and methods of use
|
|
WO2012135009A1
(en)
|
2011-03-25 |
2012-10-04 |
Incyte Corporation |
Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
|
|
JP2014509648A
(ja)
|
2011-03-28 |
2014-04-21 |
メイ プハルマ,インコーポレーテッド |
(α−置換シクロアルキルアミノ及びヘテロシクリルアミノ)ピリミジニル及び1,3,5−トリアジニルベンズイミダゾール、その医薬組成物、並びに増殖性疾患の治療におけるそれらの使用
|
|
UY34013A
(es)
|
2011-04-13 |
2012-11-30 |
Astrazeneca Ab |
?compuestos de cromenona con actividad anti-tumoral?.
|
|
EP2518070A1
(en)
|
2011-04-29 |
2012-10-31 |
Almirall, S.A. |
Pyrrolotriazinone derivatives as PI3K inhibitors
|
|
EP2518071A1
(en)
|
2011-04-29 |
2012-10-31 |
Almirall, S.A. |
Imidazopyridine derivatives as PI3K inhibitors
|
|
WO2013057711A1
(en)
*
|
2011-10-21 |
2013-04-25 |
Novartis Ag |
Quinazoline derivatives as pi3k modulators
|
|
DK2790705T3
(en)
|
2011-12-15 |
2018-03-12 |
Novartis Ag |
Use of inhibitors of the activity or function of PI3K
|