JP2016500251A - 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強 - Google Patents

免疫調節Ｆｃ融合タンパク質の抗癌活性の増強 Download PDF

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JP2016500251A
JP2016500251A JP2015545522A JP2015545522A JP2016500251A JP 2016500251 A JP2016500251 A JP 2016500251A JP 2015545522 A JP2015545522 A JP 2015545522A JP 2015545522 A JP2015545522 A JP 2015545522A JP 2016500251 A JP2016500251 A JP 2016500251A
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antibody
tumor
ctla
cells
cancer
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JP2016500251A5 (2
Inventor
ジョン・ジェイ・エンゲルハート
アラン・ジェイ・コーマン
マイケル・キグリー
マーク・ジェイ・セルビー
チャンユー・ワン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2015545522A 2012-12-03 2013-12-03 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強 Pending JP2016500251A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261732760P 2012-12-03 2012-12-03
US61/732,760 2012-12-03
US201361801187P 2013-03-15 2013-03-15
US61/801,187 2013-03-15
PCT/US2013/072918 WO2014089113A1 (en) 2012-12-03 2013-12-03 Enhancing anti-cancer activity of immunomodulatory fc fusion proteins

Related Child Applications (1)

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JP2019002712A Division JP7132858B2 (ja) 2012-12-03 2019-01-10 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強

Publications (2)

Publication Number Publication Date
JP2016500251A true JP2016500251A (ja) 2016-01-12
JP2016500251A5 JP2016500251A5 (2) 2017-01-19

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JP2015545522A Pending JP2016500251A (ja) 2012-12-03 2013-12-03 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強
JP2019002712A Active JP7132858B2 (ja) 2012-12-03 2019-01-10 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強
JP2021065226A Pending JP2021113197A (ja) 2012-12-03 2021-04-07 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強
JP2023045137A Pending JP2023078356A (ja) 2012-12-03 2023-03-22 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強

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JP2019002712A Active JP7132858B2 (ja) 2012-12-03 2019-01-10 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強
JP2021065226A Pending JP2021113197A (ja) 2012-12-03 2021-04-07 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強
JP2023045137A Pending JP2023078356A (ja) 2012-12-03 2023-03-22 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強

Country Status (16)

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US (5) US20150322119A1 (2)
EP (2) EP3508215A3 (2)
JP (4) JP2016500251A (2)
CN (2) CN104968364A (2)
CY (1) CY1121557T1 (2)
DK (1) DK2925350T3 (2)
ES (1) ES2715673T3 (2)
HR (1) HRP20190574T1 (2)
HU (1) HUE043903T2 (2)
LT (1) LT2925350T (2)
PL (1) PL2925350T3 (2)
PT (1) PT2925350T (2)
RS (1) RS58528B1 (2)
SI (1) SI2925350T1 (2)
SM (1) SMT201900242T1 (2)
WO (1) WO2014089113A1 (2)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020509037A (ja) * 2017-02-28 2020-03-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ワクチンに対する免疫応答を増強するための、ａｄｃｃが増強された抗ｃｔｌａ−４抗体の使用
JP2021508676A (ja) * 2017-12-30 2021-03-11 ベイジーン リミテッド 抗ｔｉｇｉｔ抗体並びに治療剤及び診断剤としてのその使用
JP2021512884A (ja) * 2018-02-02 2021-05-20 オンコイミューン， インコーポレイテッド 免疫療法効果が向上し副作用が軽減した変異抗ｃｔｌａ−４抗体

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