JP2016510596A5 - - Google Patents
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- Publication number
- JP2016510596A5 JP2016510596A5 JP2015561737A JP2015561737A JP2016510596A5 JP 2016510596 A5 JP2016510596 A5 JP 2016510596A5 JP 2015561737 A JP2015561737 A JP 2015561737A JP 2015561737 A JP2015561737 A JP 2015561737A JP 2016510596 A5 JP2016510596 A5 JP 2016510596A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- seq
- acid sequence
- amino acid
- protein according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims 21
- 102000037865 fusion proteins Human genes 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 102100030608 Mothers against decapentaplegic homolog 7 Human genes 0.000 claims 5
- 101700026522 SMAD7 Proteins 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 230000004071 biological effect Effects 0.000 claims 5
- 230000004663 cell proliferation Effects 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 230000026683 transduction Effects 0.000 claims 3
- 238000010361 transduction Methods 0.000 claims 3
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 230000005778 DNA damage Effects 0.000 claims 1
- 231100000277 DNA damage Toxicity 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102100025751 Mothers against decapentaplegic homolog 2 Human genes 0.000 claims 1
- 101710143123 Mothers against decapentaplegic homolog 2 Proteins 0.000 claims 1
- 101710149951 Protein Tat Proteins 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000003172 anti-dna Effects 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000012292 cell migration Effects 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000010393 epithelial cell migration Effects 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005937 nuclear translocation Effects 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000037390 scarring Effects 0.000 claims 1
- 208000003265 stomatitis Diseases 0.000 claims 1
- 230000000451 tissue damage Effects 0.000 claims 1
- 231100000827 tissue damage Toxicity 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361775252P | 2013-03-08 | 2013-03-08 | |
| US61/775,252 | 2013-03-08 | ||
| PCT/US2014/022052 WO2014138670A1 (en) | 2013-03-08 | 2014-03-07 | Ptd-smad7 therapeutics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510596A JP2016510596A (ja) | 2016-04-11 |
| JP2016510596A5 true JP2016510596A5 (2) | 2017-03-30 |
| JP6576251B2 JP6576251B2 (ja) | 2019-09-18 |
Family
ID=51492023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561737A Active JP6576251B2 (ja) | 2013-03-08 | 2014-03-07 | ＰＴＤ−Ｓｍａｄ７薬物療法 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US10456448B2 (2) |
| EP (1) | EP2964774B1 (2) |
| JP (1) | JP6576251B2 (2) |
| CN (1) | CN105358704B (2) |
| CA (1) | CA2904329C (2) |
| IL (1) | IL241190B (2) |
| SG (1) | SG11201507045TA (2) |
| WO (1) | WO2014138670A1 (2) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3536337A1 (en) | 2010-09-22 | 2019-09-11 | The Regents of the University of Colorado, a body corporate | Therapeutic applications of smad7 |
| US10456448B2 (en) | 2013-03-08 | 2019-10-29 | The Regents Of The University Of Colorado, A Body Corporate | PTD-SMAD7 therapeutics |
| KR101853923B1 (ko) * | 2016-01-25 | 2018-05-02 | 연세대학교 산학협력단 | Smad 단백질을 포함하는 자가 면역 질환 치료용 조성물, Smad 단백질을 포함하는 융합 단백질, 이를 제조하기 위한 벡터, 및 이의 제조 방법 |
| US20200332302A1 (en) * | 2017-12-30 | 2020-10-22 | The Regents Of The University Of Colorado, A Body Corporate | Therapeutics of ptd-smad7 fusion proteins |
| JP7678483B2 (ja) * | 2021-03-10 | 2025-05-16 | 国立大学法人 熊本大学 | コロナウイルス感染を検出する方法 |
| WO2023044277A1 (en) * | 2021-09-15 | 2023-03-23 | The Regents Of The University Of Colorado, A Body Corporate | Smad7 polypeptide formulations |
| US20250269063A2 (en) * | 2022-02-07 | 2025-08-28 | Aavogen Inc. | Codon-optimized smad7 gene therapy to treat and prevent muscle wasting and to enhance muscle mass |
Family Cites Families (48)
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|---|---|---|---|---|
| NL8200523A (nl) | 1982-02-11 | 1983-09-01 | Univ Leiden | Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna. |
| US4879236A (en) | 1984-05-16 | 1989-11-07 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| US4952500A (en) | 1988-02-01 | 1990-08-28 | University Of Georgia Research Foundation, Inc. | Cloning systems for Rhodococcus and related bacteria |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
| JPH05505102A (ja) | 1989-12-21 | 1993-08-05 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 真核細胞の中に分子を配達する方法 |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
| JP2952041B2 (ja) | 1992-07-27 | 1999-09-20 | パイオニア ハイ−ブレッド インターナショナル，インコーポレイテッド | 培養ダイズ細胞のａｇｒｏｂａｃｔｅｒｉｕｍ媒介形質転換の改良法 |
| ES2123062T3 (es) | 1992-08-21 | 1999-01-01 | Biogen Inc | Polipeptidos de transporte derivados de la proteina tat. |
| GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
| US5436222A (en) | 1993-03-15 | 1995-07-25 | The Research Foundation Of State University Of New York | Use of platelet factor 4 to treat inflammatory diseases |
| US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
| US5871986A (en) | 1994-09-23 | 1999-02-16 | The General Hospital Corporation | Use of a baculovirus to express and exogenous gene in a mammalian cell |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| GB2320431B (en) * | 1996-12-20 | 2000-08-30 | Johnson & Johnson Medical | Compositions for the treatment of chronic wounds |
| WO1998053068A1 (en) * | 1997-05-20 | 1998-11-26 | Ludwig Institute For Cancer Research | Smad7 and uses thereof |
| US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
| AU3365299A (en) | 1998-03-27 | 1999-10-18 | Eli Lilly And Company | Treatment and prevention of vascular disease |
| US8466134B1 (en) | 1998-06-26 | 2013-06-18 | Athena Neurosciences, Inc. | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
| US6998240B2 (en) | 2001-06-11 | 2006-02-14 | Wisconsin Alumni Research Foundation | Screen for selective inhibitors or activators of Smad protein function |
| AUPR638101A0 (en) | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
| CA2496882C (en) | 2002-09-06 | 2011-11-01 | 3M Innovative Properties Company | Metering valve for a metered dose inhaler providing consistent delivery |
| KR100472938B1 (ko) | 2002-10-31 | 2005-03-11 | 학교법인 한림대학교 | 세포침투 효율을 향상시킨 수송도메인-목표단백질-수송도메인 융합단백질 및 그 용도 |
| KR20070030164A (ko) | 2003-10-16 | 2007-03-15 | 더 유니버시티 코트, 더 유니버시티 오브 에딘버러 | Ｅｓ 세포 자가 재생 및 계통 지정의 조절, 및 이를 위한배지 |
| US9757461B2 (en) | 2005-01-14 | 2017-09-12 | Camurus Ab | GnRH analogue formulations |
| MX2007012344A (es) * | 2005-04-05 | 2007-12-13 | Pioneer Hi Bred Int | Metodos y composiciones para disenar moleculas de acido nucleico para la expresion de polipeptido en plantas usando la desviacion de codon de virus de planta. |
| CA2999420A1 (en) | 2005-09-27 | 2007-04-05 | Tissuetech, Inc. | Amniotic membrane preparations and purified compositions and methods of use |
| WO2008105925A2 (en) | 2006-09-01 | 2008-09-04 | Oregon Health & Science University | COMPOUNDS AND METHODS FOR MODULATING β-CATENIN/SMAD-7 INTERACTIONS |
| US20080114287A1 (en) | 2006-11-14 | 2008-05-15 | Kar Neng Lai | Ultrasound Microbubble Mediated Genes Delivery System |
| MX2010010165A (es) | 2008-03-17 | 2010-11-25 | Scripps Research Inst | Procedimientos quimicos y geneticos combinados para generacion de celulas madre pluripotentes inducidas. |
| US8591961B2 (en) | 2008-09-04 | 2013-11-26 | Allergan, Inc. | Aesthetic treatment of scars and aging skin |
| WO2009151600A2 (en) | 2008-06-10 | 2009-12-17 | Tufts University | Smad proteins control drosha-mediated mirna maturation |
| US20100184033A1 (en) | 2008-07-16 | 2010-07-22 | West Michael D | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
| EP3536337A1 (en) | 2010-09-22 | 2019-09-11 | The Regents of the University of Colorado, a body corporate | Therapeutic applications of smad7 |
| WO2013151665A2 (en) * | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US10456448B2 (en) | 2013-03-08 | 2019-10-29 | The Regents Of The University Of Colorado, A Body Corporate | PTD-SMAD7 therapeutics |
-
2014
- 2014-03-07 US US14/773,167 patent/US10456448B2/en active Active
- 2014-03-07 SG SG11201507045TA patent/SG11201507045TA/en unknown
- 2014-03-07 CA CA2904329A patent/CA2904329C/en active Active
- 2014-03-07 CN CN201480025596.9A patent/CN105358704B/zh active Active
- 2014-03-07 WO PCT/US2014/022052 patent/WO2014138670A1/en not_active Ceased
- 2014-03-07 US US14/201,488 patent/US9422352B2/en active Active
- 2014-03-07 EP EP14761076.0A patent/EP2964774B1/en active Active
- 2014-03-07 JP JP2015561737A patent/JP6576251B2/ja active Active
-
2015
- 2015-09-06 IL IL241190A patent/IL241190B/en active IP Right Grant
-
2016
- 2016-07-12 US US15/208,424 patent/US20170000851A1/en not_active Abandoned
-
2019
- 2019-09-26 US US16/584,608 patent/US20200023037A1/en not_active Abandoned
-
2022
- 2022-04-22 US US17/727,579 patent/US20220370560A1/en not_active Abandoned
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