JP2016530213A5 - - Google Patents

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Publication number: JP2016530213A5
Authority: JP; Japan
Prior art keywords: optionally substituted; sulfonyl; tetrahydroquinolin; fluorophenyl; hexafluoro
Prior art date: 2014-09-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2016515522A

Other languages

English (en)

Japanese (ja)

Other versions

JP6397488B2 (ja

JP2016530213A (ja

Filing date

2014-09-18

Publication date

2017-10-26

2014-09-18 Application filed filed Critical

2014-09-18 Priority claimed from PCT/US2014/056197 external-priority patent/WO2015042212A1/en

2016-09-29 Publication of JP2016530213A publication Critical patent/JP2016530213A/ja

2017-10-26 Publication of JP2016530213A5 publication Critical patent/JP2016530213A5/ja

2018-09-26 Application granted granted Critical

2018-09-26 Publication of JP6397488B2 publication Critical patent/JP6397488B2/ja

Status Expired - Fee Related legal-status Critical Current

2034-09-18 Anticipated expiration legal-status Critical

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-1 1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl Chemical group 0.000 claims 9
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 8
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
125000001072 heteroaryl group Chemical group 0.000 claims 7
150000003839 salts Chemical class 0.000 claims 5
125000003118 aryl group Chemical group 0.000 claims 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
150000001875 compounds Chemical class 0.000 claims 3
125000005843 halogen group Chemical group 0.000 claims 3
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
125000003107 substituted aryl group Chemical group 0.000 claims 3
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
125000004104 aryloxy group Chemical group 0.000 claims 2
125000004093 cyano group Chemical group *C#N 0.000 claims 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
208000030159 metabolic disease Diseases 0.000 claims 2
239000008194 pharmaceutical composition Substances 0.000 claims 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
239000012453 solvate Substances 0.000 claims 2
229910052717 sulfur Inorganic materials 0.000 claims 2
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 claims 1
RBEJZPHWOONGBK-UHFFFAOYSA-N 1-benzyl-3-[[1-(4-fluorophenyl)sulfonyl-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3,4-dihydro-2H-quinolin-2-yl]methyl]urea Chemical compound OC(c1ccc2N(C(CNC(=O)NCc3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F RBEJZPHWOONGBK-UHFFFAOYSA-N 0.000 claims 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
208000023275 Autoimmune disease Diseases 0.000 claims 1
KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
MZFZBDFNAPJWGY-PIEWVDTRSA-N C(C)O\N=C(/C[C@H]1N(C2=CC=C(C=C2CC1)C(C(F)(F)F)(C(F)(F)F)O)S(=O)(=O)C1=CC=C(C=C1)F)\C Chemical compound C(C)O\N=C(/C[C@H]1N(C2=CC=C(C=C2CC1)C(C(F)(F)F)(C(F)(F)F)O)S(=O)(=O)C1=CC=C(C=C1)F)\C MZFZBDFNAPJWGY-PIEWVDTRSA-N 0.000 claims 1
MZFZBDFNAPJWGY-NLQLCTRYSA-N C(C)O\N=C(\C[C@H]1N(C2=CC=C(C=C2CC1)C(C(F)(F)F)(C(F)(F)F)O)S(=O)(=O)C1=CC=C(C=C1)F)/C Chemical compound C(C)O\N=C(\C[C@H]1N(C2=CC=C(C=C2CC1)C(C(F)(F)F)(C(F)(F)F)O)S(=O)(=O)C1=CC=C(C=C1)F)/C MZFZBDFNAPJWGY-NLQLCTRYSA-N 0.000 claims 1
JCAYOVKPNKUDOP-KQWLVTFDSA-N C1(=CC=CC=C1)O\N=C(\C[C@H]1N(C2=CC=C(C=C2CC1)C(C(F)(F)F)(C(F)(F)F)O)S(=O)(=O)C1=CC=C(C=C1)F)/C Chemical compound C1(=CC=CC=C1)O\N=C(\C[C@H]1N(C2=CC=C(C=C2CC1)C(C(F)(F)F)(C(F)(F)F)O)S(=O)(=O)C1=CC=C(C=C1)F)/C JCAYOVKPNKUDOP-KQWLVTFDSA-N 0.000 claims 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
125000000041 C6-C10 aryl group Chemical group 0.000 claims 1
YYLNNBFDGZYCLZ-KRWDZBQOSA-N CC(C)(N)Cc1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)o1 Chemical compound CC(C)(N)Cc1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)o1 YYLNNBFDGZYCLZ-KRWDZBQOSA-N 0.000 claims 1
LVYLRMXJXROXMH-INIZCTEOSA-N CC(C)(O)c1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)o1 Chemical compound CC(C)(O)c1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)o1 LVYLRMXJXROXMH-INIZCTEOSA-N 0.000 claims 1
QDZCCHJOVLZIEY-BJQOMGFOSA-N CC(O)(CO)c1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)o1 Chemical compound CC(O)(CO)c1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)o1 QDZCCHJOVLZIEY-BJQOMGFOSA-N 0.000 claims 1
QRVIJCNOXJMAQE-BGERDNNASA-N CCC(O)Cn1ccc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)n1 Chemical compound CCC(O)Cn1ccc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)n1 QRVIJCNOXJMAQE-BGERDNNASA-N 0.000 claims 1
KOVFYSOWRLIZNN-HNNXBMFYSA-N CSc1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)s1 Chemical compound CSc1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)s1 KOVFYSOWRLIZNN-HNNXBMFYSA-N 0.000 claims 1
ORUXJAJOWWWKDP-IBGZPJMESA-N FC(C(C(F)(F)F)(O)C=1C=C2CC[C@H](N(C2=CC=1)S(=O)(=O)C1=CC=C(C=C1)F)CC=1OC(=NN=1)C1=CC=NC=C1)(F)F Chemical compound FC(C(C(F)(F)F)(O)C=1C=C2CC[C@H](N(C2=CC=1)S(=O)(=O)C1=CC=C(C=C1)F)CC=1OC(=NN=1)C1=CC=NC=C1)(F)F ORUXJAJOWWWKDP-IBGZPJMESA-N 0.000 claims 1
LCTMAKMOTSGICZ-UHFFFAOYSA-N FC1=CC=C(C=C1)S(=O)(=O)N1C(CCC2=CC(=CC=C12)C(C(F)(F)F)(C(F)(F)F)O)CNC(=O)NC1=CC=CC=C1 Chemical compound FC1=CC=C(C=C1)S(=O)(=O)N1C(CCC2=CC(=CC=C12)C(C(F)(F)F)(C(F)(F)F)O)CNC(=O)NC1=CC=CC=C1 LCTMAKMOTSGICZ-UHFFFAOYSA-N 0.000 claims 1
QBLZQBOPZUOSEP-INIZCTEOSA-N FC1=CC=C(C=C1)S(=O)(=O)N1[C@@H](CCC2=CC(=CC=C12)C(C(F)(F)F)(C(F)(F)F)O)CC(=O)NNC(C(C)(C)O)=O Chemical compound FC1=CC=C(C=C1)S(=O)(=O)N1[C@@H](CCC2=CC(=CC=C12)C(C(F)(F)F)(C(F)(F)F)O)CC(=O)NNC(C(C)(C)O)=O QBLZQBOPZUOSEP-INIZCTEOSA-N 0.000 claims 1
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 1
150000001204 N-oxides Chemical class 0.000 claims 1
YVMCWBSJFQJLMS-INIZCTEOSA-N NC1(CC1)c1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)o1 Chemical compound NC1(CC1)c1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)o1 YVMCWBSJFQJLMS-INIZCTEOSA-N 0.000 claims 1
206010028980 Neoplasm Diseases 0.000 claims 1
GQGJVWYUFIORRZ-IBGZPJMESA-N OC(c1ccc2N([C@H](CC(=O)NNC(=O)c3ccncc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F Chemical compound OC(c1ccc2N([C@H](CC(=O)NNC(=O)c3ccncc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F GQGJVWYUFIORRZ-IBGZPJMESA-N 0.000 claims 1
GTDXVWUKRLIACM-NRFANRHFSA-N OC(c1ccc2N([C@H](CNCc3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F Chemical compound OC(c1ccc2N([C@H](CNCc3ccccc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F GTDXVWUKRLIACM-NRFANRHFSA-N 0.000 claims 1
MNHHBYVJYTWBGO-INIZCTEOSA-N OC(c1ccc2N([C@H](CNS(=O)(=O)C3CC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F Chemical compound OC(c1ccc2N([C@H](CNS(=O)(=O)C3CC3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F MNHHBYVJYTWBGO-INIZCTEOSA-N 0.000 claims 1
WPOUYVFYBNAPSI-DEOSSOPVSA-N OC(c1ccc2N([C@H](Cc3ccnn3Cc3ccc(F)cc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F Chemical compound OC(c1ccc2N([C@H](Cc3ccnn3Cc3ccc(F)cc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F WPOUYVFYBNAPSI-DEOSSOPVSA-N 0.000 claims 1
YYGNTJLVXLCHGQ-BHWOMJMDSA-N OCC(O)Cc1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)o1 Chemical compound OCC(O)Cc1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)o1 YYGNTJLVXLCHGQ-BHWOMJMDSA-N 0.000 claims 1
JJGIBUJPPDJWMM-XJDOXCRVSA-N OCC(O)Cn1ccc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)n1 Chemical compound OCC(O)Cn1ccc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)n1 JJGIBUJPPDJWMM-XJDOXCRVSA-N 0.000 claims 1
HBNJOSMGIAZNMX-XJDOXCRVSA-N OCC(O)Cn1nccc1C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F Chemical compound OCC(O)Cn1nccc1C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F HBNJOSMGIAZNMX-XJDOXCRVSA-N 0.000 claims 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
125000000217 alkyl group Chemical group 0.000 claims 1
208000026935 allergic disease Diseases 0.000 claims 1
208000006673 asthma Diseases 0.000 claims 1
125000002619 bicyclic group Chemical group 0.000 claims 1
125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
201000011510 cancer Diseases 0.000 claims 1
239000004202 carbamide Substances 0.000 claims 1
229910052799 carbon Inorganic materials 0.000 claims 1
125000004432 carbon atom Chemical group C* 0.000 claims 1
125000004122 cyclic group Chemical group 0.000 claims 1
239000003085 diluting agent Substances 0.000 claims 1
201000010099 disease Diseases 0.000 claims 1
208000016097 disease of metabolism Diseases 0.000 claims 1
208000035475 disorder Diseases 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
125000001188 haloalkyl group Chemical group 0.000 claims 1
229910052739 hydrogen Inorganic materials 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
125000002950 monocyclic group Chemical group 0.000 claims 1
125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
229910052757 nitrogen Inorganic materials 0.000 claims 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
125000004433 nitrogen atom Chemical group N* 0.000 claims 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
229910052760 oxygen Inorganic materials 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
230000002265 prevention Effects 0.000 claims 1
NKFLEFWUYAUDJV-UHFFFAOYSA-N pyridine-3-sulfonamide Chemical compound NS(=O)(=O)C1=CC=CN=C1 NKFLEFWUYAUDJV-UHFFFAOYSA-N 0.000 claims 1

JP2016515522A 2013-09-20 2014-09-18 ＲＯＲγ調節因子 Expired - Fee Related JP6397488B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201361880391P	2013-09-20	2013-09-20
US61/880,391		2013-09-20
PCT/US2014/056197 WO2015042212A1 (en)	2013-09-20	2014-09-18	RORγ MODULATORS

Publications (3)

Publication Number	Publication Date
JP2016530213A JP2016530213A (ja)	2016-09-29
JP2016530213A5 true JP2016530213A5 (2)	2017-10-26
JP6397488B2 JP6397488B2 (ja)	2018-09-26

Family

ID=51726859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2016515522A Expired - Fee Related JP6397488B2 (ja)	2013-09-20	2014-09-18	ＲＯＲγ調節因子

Country Status (5)

Country	Link
US (1)	US9725443B2 (2)
EP (1)	EP3046906B1 (2)
JP (1)	JP6397488B2 (2)
CN (1)	CN105555768B (2)
WO (1)	WO2015042212A1 (2)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6407285B2 (ja)	2013-09-09	2018-10-17	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ＲＯＲγ調節因子
JP6397488B2 (ja)	2013-09-20	2018-09-26	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ＲＯＲγ調節因子
AU2014365915C1 (en) *	2013-12-19	2019-04-04	Merck Patent Gmbh	Tetrahydro-tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors
ES2704460T3 (es)	2014-01-06	2019-03-18	Bristol Myers Squibb Co	Moduladores de ROR gamma de ciclohexilsulfona
JP6476205B2 (ja)	2014-01-06	2019-02-27	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ＲＯＲγ修飾因子としてのヘテロ環式スルホン
WO2015103508A1 (en)	2014-01-06	2015-07-09	Bristol-Myers Squibb Company	CARBOCYCLIC SULFONE RORγ MODULATORS
TWI705057B (zh)	2014-10-30	2020-09-21	比利時商健生藥品公司	用作ＲＯＲγｔ調節劑之三氟甲基醇
EP3212641B1 (en)	2014-10-30	2018-12-05	Janssen Pharmaceutica NV	Thiazoles as modulators of roryt
HRP20200016T1 (hr)	2014-10-30	2020-03-20	Janssen Pharmaceutica Nv	Amidno supstituirani tiazoli kao modulatori rorgamat
AR104555A1 (es) *	2015-05-07	2017-07-26	Bristol Myers Squibb Co	SULFONAS TRICÍCLICAS COMO MODULARES DE RORg
TW201803869A (zh)	2016-04-27	2018-02-01	健生藥品公司	作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑
WO2017213210A1 (ja) *	2016-06-10	2017-12-14	武田薬品工業株式会社	複素環化合物
KR102506326B1 (ko) *	2016-10-13	2023-03-03	브리스톨-마이어스 스큅 컴퍼니	Ror 감마 조정제로서의 헤테로시클릭 술폰
ES2929140T3 (es)	2018-06-18	2022-11-25	Janssen Pharmaceutica Nv	Imidazoles sustituidos con fenilo y piridinilo como moduladores de RORgammat
JP2021528398A (ja)	2018-06-18	2021-10-21	ヤンセンファーマシューティカエヌ．ベー．	ＲＯＲγＴのモジュレーターとしての６−アミノピリジン−３−イルピラゾール
JP2021528405A (ja)	2018-06-18	2021-10-21	ヤンセンファーマシューティカエヌ．ベー．	ＲＯＲγｔのモジュレータとしてのアミド置換チアゾール
EP3807261B1 (en)	2018-06-18	2022-07-13	Janssen Pharmaceutica NV	Pyridinyl pyrazoles as modulators of roryt
CN111635373B (zh) *	2019-03-01	2022-07-12	山东轩竹医药科技有限公司	多环磺酰胺类RORγ调节剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20012060A1 (it) *	2001-10-05	2003-04-05	Recordati Chem Pharm	Nuovi eterocilcli n-acilati
US7741317B2 (en) *	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
EP2368886A1 (en) *	2010-03-01	2011-09-28	Phenex Pharmaceuticals AG	Novel compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (ROR gamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune desease
WO2012064744A2 (en)	2010-11-08	2012-05-18	Lycera Corporation	Tetrahydroquinoline and related bicyclic compounds for inhibition of rorϒ activity and the treatment of disease
WO2013064231A1 (en) *	2011-10-31	2013-05-10	Phenex Pharmaceuticals Ag	SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3)
WO2014062938A1 (en)	2012-10-19	2014-04-24	Bristol-Myers Squibb Company	Rory modulators
JP6407285B2 (ja)	2013-09-09	2018-10-17	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ＲＯＲγ調節因子
JP6397488B2 (ja)	2013-09-20	2018-09-26	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ＲＯＲγ調節因子
KR101544975B1 (ko) *	2013-09-30	2015-08-18	주식회사 플라즈마트	임피던스 매칭 방법 및 임피던스 매칭 시스템
JP6476205B2 (ja)	2014-01-06	2019-02-27	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ＲＯＲγ修飾因子としてのヘテロ環式スルホン
WO2015103508A1 (en)	2014-01-06	2015-07-09	Bristol-Myers Squibb Company	CARBOCYCLIC SULFONE RORγ MODULATORS
EA030849B1 (ru)	2014-01-06	2018-10-31	Бристол-Маерс Сквибб Компани	ПИРРОЛИДИНИЛСУЛЬФОНОВЫЕ МОДУЛЯТОРЫ RORγ
ES2704460T3 (es)	2014-01-06	2019-03-18	Bristol Myers Squibb Co	Moduladores de ROR gamma de ciclohexilsulfona

2014
- 2014-09-18 JP JP2016515522A patent/JP6397488B2/ja not_active Expired - Fee Related
- 2014-09-18 EP EP14784387.4A patent/EP3046906B1/en not_active Not-in-force
- 2014-09-18 US US15/022,673 patent/US9725443B2/en active Active
- 2014-09-18 WO PCT/US2014/056197 patent/WO2015042212A1/en not_active Ceased
- 2014-09-18 CN CN201480051836.2A patent/CN105555768B/zh not_active Expired - Fee Related

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