JP2017169559A5 - - Google Patents
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- JP2017169559A5 JP2017169559A5 JP2017037848A JP2017037848A JP2017169559A5 JP 2017169559 A5 JP2017169559 A5 JP 2017169559A5 JP 2017037848 A JP2017037848 A JP 2017037848A JP 2017037848 A JP2017037848 A JP 2017037848A JP 2017169559 A5 JP2017169559 A5 JP 2017169559A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- cell
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 101150074155 DHFR gene Proteins 0.000 claims 1
- 102100024746 Dihydrofolate reductase Human genes 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 108010022394 Threonine synthase Proteins 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 102000004419 dihydrofolate reductase Human genes 0.000 claims 1
- 108020001096 dihydrofolate reductase Proteins 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 108010068617 neonatal Fc receptor Proteins 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492617P | 2011-06-02 | 2011-06-02 | |
| US61/492,617 | 2011-06-02 | ||
| US201161498266P | 2011-06-17 | 2011-06-17 | |
| US61/498,266 | 2011-06-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513732A Division JP6104897B2 (ja) | 2011-06-02 | 2012-06-01 | Ｆｃレセプター結合タンパク質 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018085040A Division JP6638018B2 (ja) | 2011-06-02 | 2018-04-26 | Ｆｃレセプター結合タンパク質 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2017169559A JP2017169559A (ja) | 2017-09-28 |
| JP2017169559A5 true JP2017169559A5 (2) | 2017-12-07 |
| JP6334763B2 JP6334763B2 (ja) | 2018-05-30 |
| JP6334763B6 JP6334763B6 (ja) | 2018-07-11 |
Family
ID=47259886
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513732A Active JP6104897B2 (ja) | 2011-06-02 | 2012-06-01 | Ｆｃレセプター結合タンパク質 |
| JP2017037848A Active JP6334763B6 (ja) | 2011-06-02 | 2017-03-01 | Ｆｃレセプター結合タンパク質 |
| JP2018085040A Active JP6638018B2 (ja) | 2011-06-02 | 2018-04-26 | Ｆｃレセプター結合タンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513732A Active JP6104897B2 (ja) | 2011-06-02 | 2012-06-01 | Ｆｃレセプター結合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018085040A Active JP6638018B2 (ja) | 2011-06-02 | 2018-04-26 | Ｆｃレセプター結合タンパク質 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US9359438B2 (2) |
| EP (2) | EP2966089B1 (2) |
| JP (3) | JP6104897B2 (2) |
| KR (1) | KR102014554B1 (2) |
| CN (2) | CN103619353B (2) |
| AU (2) | AU2012262007B2 (2) |
| BR (1) | BR112013030352B1 (2) |
| CA (1) | CA2837527C (2) |
| ES (1) | ES2748583T3 (2) |
| IL (1) | IL229618B (2) |
| MX (1) | MX343659B (2) |
| PH (1) | PH12013502378A1 (2) |
| SG (2) | SG195025A1 (2) |
| WO (1) | WO2012167039A1 (2) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009131702A2 (en) * | 2008-04-25 | 2009-10-29 | Dyax Corp. | Antibodies against fcrn and use thereof |
| AU2012262007B2 (en) | 2011-06-02 | 2017-06-22 | Takeda Pharmaceutical Company Limited | Fc receptor binding proteins |
| GB201208370D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Antibodies |
| GB201320066D0 (en) | 2013-11-13 | 2013-12-25 | Ucb Pharma Sa | Biological products |
| WO2015081073A2 (en) * | 2013-11-26 | 2015-06-04 | The Brigham And Women's Hospital, Inc. | Compositions and methods for modulating an immune response |
| US10336825B2 (en) | 2014-04-30 | 2019-07-02 | Hanall Biopharma Co., Ltd. | Antibody binding to FcRn for treating autoimmune diseases |
| PL3137504T3 (pl) | 2014-04-30 | 2023-10-16 | Hanall Biopharma Co., Ltd. | Przeciwciało wiążące się z FcRn do leczenia chorób autoimmunologicznych |
| RS64768B1 (sr) * | 2015-01-30 | 2023-11-30 | Momenta Pharmaceuticals Inc | Fcrn antitela i načini njihove upotrebe |
| CN109641045A (zh) * | 2016-04-25 | 2019-04-16 | Synt免疫公司 | 人源化亲和力成熟的抗fcrn抗体 |
| SMT202400004T1 (it) * | 2016-07-29 | 2024-03-13 | Momenta Pharmaceuticals Inc | Anticorpi fcrn e loro metodi di utilizzo |
| EP3548320B1 (en) | 2016-12-01 | 2022-12-07 | SABIC Global Technologies B.V. | Hybrid composite tailgate |
| MA49378A (fr) * | 2017-06-15 | 2020-04-22 | UCB Biopharma SRL | Méthode de traitement de la thrombocytopénie immunitaire |
| CA3081144A1 (en) | 2017-12-08 | 2019-06-13 | Argenx Bvba | Use of fcrn antagonists for treatment of generalized myasthenia gravis |
| KR102904658B1 (ko) * | 2017-12-13 | 2025-12-29 | 모멘타 파머슈티컬스 인코포레이티드 | FcRn 항체 및 이의 사용 방법 |
| US12202900B2 (en) | 2018-06-08 | 2025-01-21 | argenx BV | Compositions and methods for treating immune thrombocytopenia |
| CN113518783A (zh) | 2018-07-20 | 2021-10-19 | 动量制药公司 | FcRn抗体组合物 |
| WO2021012176A1 (en) * | 2019-07-23 | 2021-01-28 | Shanghaitech University | Asic1 channel antagonist antibody |
| JP2023509195A (ja) | 2020-01-08 | 2023-03-07 | アルジェニクス ビーブイ | 天疱瘡症を治療する方法 |
| AU2021292200A1 (en) | 2020-06-17 | 2023-02-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of gene therapy patients |
| WO2022175217A1 (en) * | 2021-02-18 | 2022-08-25 | F. Hoffmann-La Roche Ag | Method for resolving complex, multistep antibody interactions |
| WO2022221236A1 (en) * | 2021-04-14 | 2022-10-20 | Genentech, Inc. | In vitro cell-based assay for predicting pharmacokinetics and brain penetration of biologics |
| US20230212316A1 (en) * | 2021-12-15 | 2023-07-06 | Wisconsin Alumni Research Foundation | IgG EPITOPE PEPTIDES THAT BIND RHEUMATOID FACTOR AND METHODS OF USE THEREOF |
| AU2023281650A1 (en) | 2022-05-30 | 2024-10-17 | Hanall Biopharma Co., Ltd. | Anti-fcrn antibody or antigen binding fragment thereof with improved stability |
| CN119698429A (zh) | 2022-06-15 | 2025-03-25 | 阿根思有限公司 | Fcrn结合分子及使用方法 |
| WO2025099576A1 (en) | 2023-11-06 | 2025-05-15 | Momenta Pharmaceuticals, Inc. | Compositions and methods for treating rheumatoid arthritis |
| WO2025163617A1 (en) | 2024-02-04 | 2025-08-07 | Momenta Pharmaceuticals, Inc. | Compositions and methods for treating sjögren's disease |
| WO2026083290A1 (en) | 2024-10-16 | 2026-04-23 | Momenta Pharmaceuticals, Inc. | Compositions and methods for treating sjögren's disease |
| CN119490588B (zh) * | 2024-10-17 | 2026-03-06 | 广州康盛生物科技股份有限公司 | 一种抗人FcRn的VHH抗体及其应用 |
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| AU2012262007B2 (en) | 2011-06-02 | 2017-06-22 | Takeda Pharmaceutical Company Limited | Fc receptor binding proteins |
| KR20200014379A (ko) | 2017-06-05 | 2020-02-10 | 얀센 바이오테크 인코포레이티드 | 비대칭 ch2-ch3 영역 돌연변이를 갖는 조작된 다중특이성 항체 및 다른 다량체 단백질 |
| US12202900B2 (en) | 2018-06-08 | 2025-01-21 | argenx BV | Compositions and methods for treating immune thrombocytopenia |
-
2012
- 2012-06-01 AU AU2012262007A patent/AU2012262007B2/en active Active
- 2012-06-01 BR BR112013030352-2A patent/BR112013030352B1/pt active IP Right Grant
- 2012-06-01 KR KR1020137034618A patent/KR102014554B1/ko active Active
- 2012-06-01 CN CN201280031902.0A patent/CN103619353B/zh active Active
- 2012-06-01 MX MX2013013832A patent/MX343659B/es active IP Right Grant
- 2012-06-01 WO PCT/US2012/040409 patent/WO2012167039A1/en not_active Ceased
- 2012-06-01 CA CA2837527A patent/CA2837527C/en active Active
- 2012-06-01 PH PH1/2013/502378A patent/PH12013502378A1/en unknown
- 2012-06-01 EP EP15167896.8A patent/EP2966089B1/en active Active
- 2012-06-01 JP JP2014513732A patent/JP6104897B2/ja active Active
- 2012-06-01 SG SG2013085204A patent/SG195025A1/en unknown
- 2012-06-01 CN CN201510926183.4A patent/CN105622754B/zh active Active
- 2012-06-01 US US14/122,880 patent/US9359438B2/en active Active
- 2012-06-01 EP EP12793948.6A patent/EP2714084B1/en active Active
- 2012-06-01 ES ES12793948T patent/ES2748583T3/es active Active
- 2012-06-01 SG SG10201604493TA patent/SG10201604493TA/en unknown
-
2013
- 2013-11-25 IL IL229618A patent/IL229618B/en active IP Right Grant
-
2016
- 2016-04-27 US US15/139,784 patent/US9862768B2/en active Active
-
2017
- 2017-03-01 JP JP2017037848A patent/JP6334763B6/ja active Active
- 2017-09-21 AU AU2017232160A patent/AU2017232160B2/en active Active
- 2017-12-04 US US15/830,998 patent/US10479834B2/en active Active
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2018
- 2018-04-26 JP JP2018085040A patent/JP6638018B2/ja active Active
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2019
- 2019-10-07 US US16/594,218 patent/US11014988B2/en active Active
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2021
- 2021-03-17 US US17/203,816 patent/US11739152B2/en active Active
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2023
- 2023-07-06 US US18/347,626 patent/US12454575B2/en active Active
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