JP2017506666A - 高インスリン血症に関連した症状の処置 - Google Patents

高インスリン血症に関連した症状の処置 Download PDF

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Publication number: JP2017506666A
Authority: JP; Japan
Prior art keywords: alkyl; alkylene; aryl; heteroaryl; heterocycloalkyl
Prior art date: 2014-02-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

JP2016554661A

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English (en)

Japanese (ja)

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JP2017506666A5 (2

Inventor

ランドー，スティーブン，ビー．

ケーギー，マイケル

Original Assignee

テンシャセラピューティクス，インコーポレイテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-02-28

Filing date

2015-02-27

Publication date

2017-03-09

2015-02-27 Application filed by テンシャセラピューティクス，インコーポレイテッド, テンシャセラピューティクス，インコーポレイテッド filed Critical テンシャセラピューティクス，インコーポレイテッド

2017-03-09 Publication of JP2017506666A publication Critical patent/JP2017506666A/ja

2018-02-22 Publication of JP2017506666A5 publication Critical patent/JP2017506666A5/ja

Status Withdrawn legal-status Critical Current

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MQIXMONQZBAABB-HNNXBMFYSA-N CC(C)(C)OC(C[C@@H](c1nnc(C(F)(F)F)[n]1-c1c2c(C)c(C)[s]1)N=C2c(cc1)ccc1Cl)=O Chemical compound CC(C)(C)OC(C[C@@H](c1nnc(C(F)(F)F)[n]1-c1c2c(C)c(C)[s]1)N=C2c(cc1)ccc1Cl)=O MQIXMONQZBAABB-HNNXBMFYSA-N 0.000 description 1
NEOVTYQDNTUFDO-SFHVURJKSA-N CC(C)(C)OC(C[C@@H](c1nnc(C)[n]1-c1c2c(C)c(C)[s]1)N=C2c1ccc(C)cc1)=O Chemical compound CC(C)(C)OC(C[C@@H](c1nnc(C)[n]1-c1c2c(C)c(C)[s]1)N=C2c1ccc(C)cc1)=O NEOVTYQDNTUFDO-SFHVURJKSA-N 0.000 description 1
ACFYVOWECVLYMP-KRWDZBQOSA-N CC(C)(C)OC(C[C@@H](c1nnc(C)[n]1-c1c2cc[s]1)N=C2c1ccc(C)cc1)=O Chemical compound CC(C)(C)OC(C[C@@H](c1nnc(C)[n]1-c1c2cc[s]1)N=C2c1ccc(C)cc1)=O ACFYVOWECVLYMP-KRWDZBQOSA-N 0.000 description 1
DNMKBLRJHYUGOG-SFHVURJKSA-N CC(C)(C)OC(C[C@@H](c1nnc(COC)[n]1-c1c2c(C)c(C)[s]1)N=C2c1ccc(C)cc1)=O Chemical compound CC(C)(C)OC(C[C@@H](c1nnc(COC)[n]1-c1c2c(C)c(C)[s]1)N=C2c1ccc(C)cc1)=O DNMKBLRJHYUGOG-SFHVURJKSA-N 0.000 description 1
RKJJOHJEISURKY-ZENAZSQFSA-N CCC1N2c([s]c(C)c3C)c3C(c(cc3)ccc3Cl)=N[C@@H](CC(OC(C)(C)C)=O)C2=NN1 Chemical compound CCC1N2c([s]c(C)c3C)c3C(c(cc3)ccc3Cl)=N[C@@H](CC(OC(C)(C)C)=O)C2=NN1 RKJJOHJEISURKY-ZENAZSQFSA-N 0.000 description 1
XOFSUERZLYLNTE-FQEVSTJZSA-N Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCCNCCNC)=O)c1nnc(C)[n]-21 Chemical compound Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCCNCCNC)=O)c1nnc(C)[n]-21 XOFSUERZLYLNTE-FQEVSTJZSA-N 0.000 description 1
CVPIVJUAWTWRAZ-NRFANRHFSA-N Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCN1CCN(C)CC1)=O)c1nnc(C)[n]-21 Chemical compound Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCN1CCN(C)CC1)=O)c1nnc(C)[n]-21 CVPIVJUAWTWRAZ-NRFANRHFSA-N 0.000 description 1
KULOTNHGHJGDQB-FQEVSTJZSA-N Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCN1CCOCC1)=O)c1nnc(C)[n]-21 Chemical compound Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCN1CCOCC1)=O)c1nnc(C)[n]-21 KULOTNHGHJGDQB-FQEVSTJZSA-N 0.000 description 1

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

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Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Physiology (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

JP2016554661A 2014-02-28 2015-02-27 高インスリン血症に関連した症状の処置 Withdrawn JP2017506666A (ja)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US201461946682P	2014-02-28	2014-02-28
US61/946,682		2014-02-28
US201462019777P	2014-07-01	2014-07-01
US62/019,777		2014-07-01
US201462054620P	2014-09-24	2014-09-24
US62/054,620		2014-09-24
PCT/US2015/018118 WO2015131113A1 (en)	2014-02-28	2015-02-27	Treatment of conditions associated with hyperinsulinaemia

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2018222642A Division JP6629947B2 (ja)	2014-02-28	2018-11-28	高インスリン血症に関連した症状の処置

Publications (2)

Publication Number	Publication Date
JP2017506666A true JP2017506666A (ja)	2017-03-09
JP2017506666A5 JP2017506666A5 (2)	2018-02-22

Family

ID=52693055

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
JP2016554661A Withdrawn JP2017506666A (ja)	2014-02-28	2015-02-27	高インスリン血症に関連した症状の処置
JP2018222642A Expired - Fee Related JP6629947B2 (ja)	2014-02-28	2018-11-28	高インスリン血症に関連した症状の処置

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
JP2018222642A Expired - Fee Related JP6629947B2 (ja)	2014-02-28	2018-11-28	高インスリン血症に関連した症状の処置

Country Status (12)

Country	Link
US (1)	US10925881B2 (2)
EP (1)	EP3110424A1 (2)
JP (2)	JP2017506666A (2)
KR (1)	KR20160130778A (2)
CN (1)	CN106456653A (2)
AU (1)	AU2015222805B2 (2)
CA (1)	CA2940472A1 (2)
IL (1)	IL247354B (2)
MX (1)	MX377534B (2)
RU (1)	RU2722179C2 (2)
SG (1)	SG11201607108XA (2)
WO (1)	WO2015131113A1 (2)

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JP2020533365A (ja) *	2017-09-14	2020-11-19	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	医薬の製造に有用な新規化合物
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IL247354B (en)	2020-06-30
US20170209461A1 (en)	2017-07-27
JP2019059751A (ja)	2019-04-18
CA2940472A1 (en)	2015-09-03
CN106456653A (zh)	2017-02-22
US10925881B2 (en)	2021-02-23
WO2015131113A1 (en)	2015-09-03
JP6629947B2 (ja)	2020-01-15
KR20160130778A (ko)	2016-11-14
EP3110424A1 (en)	2017-01-04
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