JP2017532302A5 - - Google Patents
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- JP2017532302A5 JP2017532302A5 JP2017512684A JP2017512684A JP2017532302A5 JP 2017532302 A5 JP2017532302 A5 JP 2017532302A5 JP 2017512684 A JP2017512684 A JP 2017512684A JP 2017512684 A JP2017512684 A JP 2017512684A JP 2017532302 A5 JP2017532302 A5 JP 2017532302A5
- Authority
- JP
- Japan
- Prior art keywords
- tev
- utr
- sequence
- human
- gaopt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 108020004705 Codon Proteins 0.000 description 2
- 241000723792 Tobacco etch virus Species 0.000 description 2
- 108020005345 3' Untranslated Regions Proteins 0.000 description 1
- 108020003589 5' Untranslated Regions Proteins 0.000 description 1
- 101000899111 Homo sapiens Hemoglobin subunit beta Proteins 0.000 description 1
- 101001063991 Homo sapiens Leptin Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 102000049953 human LEP Human genes 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462046487P | 2014-09-05 | 2014-09-05 | |
| US62/046,487 | 2014-09-05 | ||
| PCT/US2015/048535 WO2016037053A1 (en) | 2014-09-05 | 2015-09-04 | Lipids and lipid compositions for the delivery of active agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532302A JP2017532302A (ja) | 2017-11-02 |
| JP2017532302A5 true JP2017532302A5 (2) | 2018-10-18 |
| JP6731912B2 JP6731912B2 (ja) | 2020-07-29 |
Family
ID=54256820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512684A Active JP6731912B2 (ja) | 2014-09-05 | 2015-09-04 | 活性物質の送達用の脂質および脂質組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10125092B2 (2) |
| EP (1) | EP3188760B1 (2) |
| JP (1) | JP6731912B2 (2) |
| CN (1) | CN107072946B (2) |
| ES (1) | ES2969956T3 (2) |
| WO (1) | WO2016037053A1 (2) |
Families Citing this family (86)
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| HK1221912A1 (zh) | 2013-10-04 | 2017-06-16 | Novartis Ag | 用於治疗乙肝病毒的有机化合物 |
| WO2015051366A2 (en) | 2013-10-04 | 2015-04-09 | Novartis Ag | Novel formats for organic compounds for use in rna interference |
| EP3052464B1 (en) | 2013-10-04 | 2020-04-15 | Novartis AG | 3'end caps for rna-interferring agents for use in rna interference |
| PL4023249T3 (pl) | 2014-04-23 | 2025-03-10 | Modernatx, Inc. | Szczepionki z kwasem nukleinowym |
| US10125092B2 (en) * | 2014-09-05 | 2018-11-13 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| EP3342777B1 (en) * | 2015-08-28 | 2023-01-11 | Sekisui Medical Co., Ltd. | Benzyl compound |
| AU2016342045A1 (en) | 2015-10-22 | 2018-06-07 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| LT3436077T (lt) * | 2016-03-30 | 2025-06-25 | Intellia Therapeutics, Inc. | Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams |
| BE1024796B9 (fr) | 2016-06-02 | 2019-01-08 | Glaxosmithkline Biologicals Sa | Constructions antigeniques du virus zika |
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| CN109260174B (zh) * | 2018-09-04 | 2021-10-15 | 中山大学 | 一种治疗性蛋白纳米颗粒的高通量制备方法 |
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| EP3886901A1 (en) | 2018-11-29 | 2021-10-06 | GlaxoSmithKline Biologicals S.A. | Methods for manufacturing an adjuvant |
| BR112021010853A2 (pt) | 2018-12-05 | 2021-08-31 | Intellia Therapeutics, Inc. | Lipídios de amina modificados |
| BR112021010611A2 (pt) | 2018-12-14 | 2021-08-24 | Glaxosmithkline Biologicals S.A. | Composições e métodos de vacina de reforço (prime boost) heterólogo |
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| EP4059515A4 (en) * | 2019-11-15 | 2024-02-14 | Daiichi Sankyo Company, Limited | Nucleic acid lipid particle vaccine encapsulating hpv mrna |
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| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
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| EP4032546A1 (en) | 2021-01-20 | 2022-07-27 | GlaxoSmithKline Biologicals S.A. | Therapeutic viral vaccine |
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| CN116761888A (zh) * | 2021-01-20 | 2023-09-15 | 比姆医疗股份有限公司 | 纳米材料 |
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| CN112961065B (zh) * | 2021-02-05 | 2023-03-14 | 嘉晨西海(杭州)生物技术有限公司 | 一种可电离脂质分子及其制备方法及其在制备脂质纳米颗粒的应用 |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| CA3212653A1 (en) | 2021-03-26 | 2022-09-29 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
| WO2022244815A1 (ja) * | 2021-05-19 | 2022-11-24 | 第一三共株式会社 | Ｈｐｖ感染症ワクチン |
| WO2022251191A1 (en) * | 2021-05-24 | 2022-12-01 | The Trustees Of The University Of Pennsylvania | One-component delivery system for nucleic acids |
| WO2022248353A1 (en) | 2021-05-24 | 2022-12-01 | Glaxosmithkline Biologicals Sa | Adjuvants |
| EP4352247A1 (en) | 2021-06-09 | 2024-04-17 | GlaxoSmithKline Biologicals s.a. | Release assay for determining potency of self-amplifying rna drug product and methods for using |
| US20240350410A1 (en) | 2021-08-16 | 2024-10-24 | Glaxosmithkline Biologicals Sa | Freeze-drying of lipid nanoparticles (lnps) encapsulating rna and formulations thereof |
| WO2023020992A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| EP4387596A1 (en) | 2021-08-16 | 2024-06-26 | GlaxoSmithKline Biologicals SA | Low-dose lyophilized rna vaccines and methods for preparing and using the same |
| WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
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| CA3240127A1 (en) * | 2021-12-07 | 2023-06-15 | Zihao Wang | Rna formulations and lipids |
| WO2023109961A1 (en) * | 2021-12-17 | 2023-06-22 | Immorna (hangzhou) Biotechnology Co., Ltd. | Interleukin-12 self-replicating rna and methods |
| JP2023130120A (ja) * | 2022-03-07 | 2023-09-20 | スペラファーマ株式会社 | ペプチド合成方法 |
| KR20240166554A (ko) * | 2022-03-25 | 2024-11-26 | 세일 바이오메디슨스, 인크. | 신규한 이온화 가능 지질 및 지질 나노입자, 및 이를 사용하는 방법 |
| JP2023181989A (ja) * | 2022-06-13 | 2023-12-25 | 上海臻上医薬科技有限公司 | マイクロニードル注射製剤およびその使用 |
| WO2023242817A2 (en) | 2022-06-18 | 2023-12-21 | Glaxosmithkline Biologicals Sa | Recombinant rna molecules comprising untranslated regions or segments encoding spike protein from the omicron strain of severe acute respiratory coronavirus-2 |
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| WO2024160936A1 (en) | 2023-02-03 | 2024-08-08 | Glaxosmithkline Biologicals Sa | Rna formulation |
| GB202302092D0 (en) | 2023-02-14 | 2023-03-29 | Glaxosmithkline Biologicals Sa | Analytical method |
| WO2024187158A1 (en) * | 2023-03-08 | 2024-09-12 | The Regents Of The University Of California | Benzaldehyde acetal acid-degradable amphiphilic lipid and self-assembling peptides |
| WO2024223724A1 (en) | 2023-04-27 | 2024-10-31 | Glaxosmithkline Biologicals Sa | Influenza virus vaccines |
| AU2024260120A1 (en) | 2023-04-27 | 2025-11-06 | Glaxosmithkline Biologicals Sa | Influenza virus vaccines |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025011529A2 (en) | 2023-07-07 | 2025-01-16 | Shanghai Circode Biomed Co., Ltd. | Circular rna vaccines for seasonal flu and methods of uses |
| WO2025045142A1 (en) | 2023-08-29 | 2025-03-06 | Shanghai Circode Biomed Co., Ltd. | Circular rna encoding vegf polypeptides, formulations, and methods of uses |
| WO2025067389A1 (en) * | 2023-09-28 | 2025-04-03 | Immorna (hangzhou) Biotechnology Co., Ltd. | Lipid complex nanoparticle for lung-targeted delivery of nucleic acid therapeutic agent |
| WO2025132839A1 (en) | 2023-12-21 | 2025-06-26 | Glaxosmithkline Biologicals Sa | Influenza virus vaccines |
| CN120227354A (zh) * | 2023-12-29 | 2025-07-01 | 康希诺(上海)生物研发有限公司 | 一种用于递送核酸的脂质纳米颗粒及其制备方法和用途 |
| TW202602853A (zh) * | 2024-03-21 | 2026-01-16 | 日商日東電工股份有限公司 | ｐＨ—敏感性陽離子脂質、包含其之脂質奈米顆粒及傳遞核酸之方法 |
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| WO2025229572A1 (en) | 2024-05-01 | 2025-11-06 | Glaxosmithkline Biologicals Sa | Epstein-barr virus antigen-encoding messenger ribonucleic acid and antigen protein vaccines |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
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-
2015
- 2015-09-04 US US15/505,282 patent/US10125092B2/en active Active
- 2015-09-04 WO PCT/US2015/048535 patent/WO2016037053A1/en not_active Ceased
- 2015-09-04 EP EP15775528.1A patent/EP3188760B1/en active Active
- 2015-09-04 JP JP2017512684A patent/JP6731912B2/ja active Active
- 2015-09-04 ES ES15775528T patent/ES2969956T3/es active Active
- 2015-09-04 CN CN201580060043.1A patent/CN107072946B/zh active Active
-
2018
- 2018-09-19 US US16/135,116 patent/US10844002B2/en active Active
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