JP2017537629A5 - - Google Patents
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- JP2017537629A5 JP2017537629A5 JP2017529741A JP2017529741A JP2017537629A5 JP 2017537629 A5 JP2017537629 A5 JP 2017537629A5 JP 2017529741 A JP2017529741 A JP 2017529741A JP 2017529741 A JP2017529741 A JP 2017529741A JP 2017537629 A5 JP2017537629 A5 JP 2017537629A5
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- 150000001413 amino acids Chemical class 0.000 claims description 1158
- 230000004048 modification Effects 0.000 claims description 404
- 238000012986 modification Methods 0.000 claims description 404
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 220
- 239000000427 antigen Substances 0.000 claims description 172
- 102000036639 antigens Human genes 0.000 claims description 172
- 108091007433 antigens Proteins 0.000 claims description 172
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 80
- 229920001184 polypeptide Polymers 0.000 claims description 76
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 76
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 56
- 150000007523 nucleic acids Chemical class 0.000 claims description 48
- 108020004707 nucleic acids Proteins 0.000 claims description 46
- 102000039446 nucleic acids Human genes 0.000 claims description 46
- 210000004027 cell Anatomy 0.000 claims description 44
- 206010028980 Neoplasm Diseases 0.000 claims description 34
- 230000009826 neoplastic cell growth Effects 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 21
- 208000034578 Multiple myelomas Diseases 0.000 claims description 20
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 20
- 230000011664 signaling Effects 0.000 claims description 16
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 14
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 14
- 230000000139 costimulatory effect Effects 0.000 claims description 14
- 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 claims description 12
- 230000003834 intracellular effect Effects 0.000 claims description 12
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 10
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 10
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims description 9
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 102000004127 Cytokines Human genes 0.000 claims description 6
- 108090000695 Cytokines Proteins 0.000 claims description 6
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 6
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 6
- 239000003446 ligand Substances 0.000 claims description 6
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 4
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 4
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 4
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 4
- 101710174800 G-protein coupled receptor family C group 5 member D Proteins 0.000 claims description 4
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 3
- 210000004881 tumor cell Anatomy 0.000 claims description 3
- 108010082808 4-1BB Ligand Proteins 0.000 claims description 2
- 102100036008 CD48 antigen Human genes 0.000 claims description 2
- 102100025221 CD70 antigen Human genes 0.000 claims description 2
- -1 CD86 Proteins 0.000 claims description 2
- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 claims description 2
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims description 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 2
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims description 2
- 108090000177 Interleukin-11 Proteins 0.000 claims description 2
- 108010065805 Interleukin-12 Proteins 0.000 claims description 2
- 108090000172 Interleukin-15 Proteins 0.000 claims description 2
- 108050003558 Interleukin-17 Proteins 0.000 claims description 2
- 108010002350 Interleukin-2 Proteins 0.000 claims description 2
- 108010002386 Interleukin-3 Proteins 0.000 claims description 2
- 108090001005 Interleukin-6 Proteins 0.000 claims description 2
- 108010002586 Interleukin-7 Proteins 0.000 claims description 2
- 102000017578 LAG3 Human genes 0.000 claims description 2
- 101150030213 Lag3 gene Proteins 0.000 claims description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 108010042215 OX40 Ligand Proteins 0.000 claims description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 2
- 101100225046 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ecl2 gene Proteins 0.000 claims description 2
- 101100225047 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ecl3 gene Proteins 0.000 claims description 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 2
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims description 2
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims description 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 2
- 101150058725 ecl1 gene Proteins 0.000 claims description 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 108010074108 interleukin-21 Proteins 0.000 claims description 2
- 210000004698 lymphocyte Anatomy 0.000 claims description 2
- 210000003738 lymphoid progenitor cell Anatomy 0.000 claims description 2
- 210000004897 n-terminal region Anatomy 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 14
- 230000004043 responsiveness Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088286P | 2014-12-05 | 2014-12-05 | |
| US62/088,286 | 2014-12-05 | ||
| PCT/US2015/064102 WO2016090312A1 (en) | 2014-12-05 | 2015-12-04 | Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020198690A Division JP2021040652A (ja) | 2014-12-05 | 2020-11-30 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537629A JP2017537629A (ja) | 2017-12-21 |
| JP2017537629A5 true JP2017537629A5 (2) | 2019-01-17 |
| JP6919091B2 JP6919091B2 (ja) | 2021-08-18 |
Family
ID=56092565
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529741A Active JP6919091B2 (ja) | 2014-12-05 | 2015-12-04 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
| JP2020198690A Withdrawn JP2021040652A (ja) | 2014-12-05 | 2020-11-30 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
| JP2023079310A Withdrawn JP2023091037A (ja) | 2014-12-05 | 2023-05-12 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
| JP2025156538A Pending JP2025181929A (ja) | 2014-12-05 | 2025-09-19 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020198690A Withdrawn JP2021040652A (ja) | 2014-12-05 | 2020-11-30 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
| JP2023079310A Withdrawn JP2023091037A (ja) | 2014-12-05 | 2023-05-12 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
| JP2025156538A Pending JP2025181929A (ja) | 2014-12-05 | 2025-09-19 | Ｇタンパク質共役受容体を標的化するキメラ抗原受容体およびその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US10633426B2 (2) |
| EP (2) | EP4015534A1 (2) |
| JP (4) | JP6919091B2 (2) |
| KR (1) | KR102612367B1 (2) |
| CN (4) | CN118271463A (2) |
| AU (2) | AU2015357518B2 (2) |
| CA (1) | CA2969864A1 (2) |
| CY (1) | CY1125008T1 (2) |
| DK (1) | DK3227339T3 (2) |
| ES (1) | ES2899779T3 (2) |
| HR (1) | HRP20211978T1 (2) |
| HU (1) | HUE057777T2 (2) |
| IL (2) | IL252621B2 (2) |
| LT (1) | LT3227339T (2) |
| MX (2) | MX385156B (2) |
| MY (1) | MY192065A (2) |
| PH (1) | PH12017501044A1 (2) |
| PL (1) | PL3227339T3 (2) |
| PT (1) | PT3227339T (2) |
| RS (1) | RS62870B1 (2) |
| RU (1) | RU2762359C2 (2) |
| SA (1) | SA517381665B1 (2) |
| SG (2) | SG11201704547RA (2) |
| SI (1) | SI3227339T1 (2) |
| SM (1) | SMT202200040T1 (2) |
| WO (1) | WO2016090312A1 (2) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118271463A (zh) | 2014-12-05 | 2024-07-02 | 纪念斯隆-凯特琳癌症中心 | 靶向g-蛋白偶联受体的嵌合抗原受体及其用途 |
| BR112017011932A8 (pt) * | 2014-12-05 | 2022-11-08 | Memorial Sloan Kettering Cancer Center | Anticorpos direcionados a receptor acoplado a proteína g e métodos de uso |
| PL3298033T5 (pl) | 2015-05-18 | 2023-10-30 | TCR2 Therapeutics Inc. | Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych |
| US20190233533A1 (en) | 2016-06-28 | 2019-08-01 | Umc Utrecht Holding B.V. | Treatment Of IgE-Mediated Diseases With Antibodies That Specifically Bind CD38 |
| CA3032498A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| RU2721582C1 (ru) * | 2016-08-05 | 2020-05-20 | И-Байолоджикс Инк. | Антитела против лиганда-1 запрограммированной смерти (PD-L1) и их применение |
| WO2018067993A1 (en) | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| JP7291396B2 (ja) | 2016-11-22 | 2023-06-15 | ティーシーアール２ セラピューティクス インク． | 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 |
| EP3548055A4 (en) | 2016-12-02 | 2020-08-19 | University of Southern California | SYNTHETIC IMMUNE RECEPTORS AND THEIR PROCESSES FOR USE |
| CN110536693B (zh) | 2017-01-05 | 2023-12-22 | 卡尔医学有限公司 | Pd1-41bbl融合蛋白及使用其的方法 |
| US11299530B2 (en) | 2017-01-05 | 2022-04-12 | Kahr Medical Ltd. | SIRP alpha-CD70 fusion protein and methods of use thereof |
| US11566060B2 (en) | 2017-01-05 | 2023-01-31 | Kahr Medical Ltd. | PD1-CD70 fusion protein and methods of use thereof |
| RU2769769C2 (ru) | 2017-01-05 | 2022-04-05 | Кахр Медикал Лтд. | СЛИТЫЙ БЕЛОК SIRPα-4-1BBL И СПОСОБЫ ЕГО ПРИМЕНЕНИЯ |
| SG11201907321TA (en) * | 2017-02-07 | 2019-09-27 | Daiichi Sankyo Co Ltd | Anti-gprc5d antibody and molecule comprising the antibody |
| JP7538601B2 (ja) | 2017-04-26 | 2024-08-22 | ユーリカ セラピューティックス， インコーポレイテッド | キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用 |
| KR20250016455A (ko) | 2017-08-09 | 2025-02-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | 유전자 조작된 세포 조성물 및 관련 조성물의 제조 방법 |
| EP3664835B1 (en) | 2017-08-09 | 2024-10-23 | Juno Therapeutics, Inc. | Methods and compositions for preparing genetically engineered cells |
| MA50079A (fr) | 2017-09-07 | 2020-07-15 | Juno Therapeutics Inc | Procédés d'identification de caractéristiques cellulaires relatives à des réponses associées à une thérapie cellulaire |
| EP3704229B1 (en) | 2017-11-01 | 2023-12-20 | Juno Therapeutics, Inc. | Process for producing a t cell composition |
| PT3703750T (pt) | 2017-11-01 | 2025-01-17 | Memorial Sloan Kettering Cancer Center | Recetores de antigénio quimérico específicos para o antigénio de maturação das células b e polinucleótidos codificantes |
| WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| US12258580B2 (en) | 2017-11-01 | 2025-03-25 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| SG11202003501XA (en) | 2017-11-01 | 2020-05-28 | Juno Therapeutics Inc | Antibodies and chimeric antigen receptors specific for b-cell maturation antigen |
| US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| AU2018367452B2 (en) | 2017-11-14 | 2024-06-13 | Memorial Sloan-Kettering Cancer Center | IL-36 secreting immunoresponsive cells and uses thereof |
| MA51210A (fr) | 2017-12-01 | 2020-10-07 | Juno Therapeutics Inc | Procédés de dosage et de modulation de cellules génétiquement modifiées |
| MX2020005907A (es) | 2017-12-08 | 2020-10-19 | Juno Therapeutics Inc | Formulacion de medio libre de suero para cultivar celulas y metodos de uso de la misma. |
| CN119193493A (zh) | 2017-12-08 | 2024-12-27 | 朱诺治疗学股份有限公司 | 生产工程化t细胞组合物的过程 |
| US12161670B2 (en) | 2017-12-08 | 2024-12-10 | Juno Therapeutics, Inc. | Phenotypic markers for cell therapy and related methods |
| EP3774919A4 (en) * | 2018-03-30 | 2021-12-29 | Eureka Therapeutics, Inc. | Constructs targeting cd22 and uses thereof |
| UA130542C2 (uk) * | 2018-05-16 | 2026-03-18 | Янссен Байотек, Інк. | Антитіло до cd38 та терапевтичний засіб, який перенаправляє т-клітини, для лікування множинної мієломи у суб'єкта |
| KR102945860B1 (ko) | 2018-07-11 | 2026-03-31 | 카 메디컬 리미티드 | SIRPalpha-4-1BBL 변이체 융합 단백질 및 이의 사용 방법 |
| EP3820887A4 (en) | 2018-07-11 | 2022-04-20 | KAHR Medical Ltd. | Pd1-4-1bbl variant fusion protein and methods of use thereof |
| CN112805378A (zh) | 2018-08-09 | 2021-05-14 | 朱诺治疗学股份有限公司 | 用于评估整合核酸的方法 |
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| JP7672340B2 (ja) * | 2018-10-19 | 2025-05-07 | メモリアル スローン ケタリング キャンサー センター | シアリルルイスａを標的とするキメラ抗原受容体およびその使用 |
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| EP3873937A2 (en) * | 2018-11-01 | 2021-09-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for g protein-coupled receptor class c group 5 member d (gprc5d) |
| MA54078A (fr) | 2018-11-01 | 2021-09-15 | Juno Therapeutics Inc | Méthodes pour le traitement au moyen de récepteurs antigéniques chimériques spécifiques de l'antigene de maturation des lymphocytes b |
| PT3886875T (pt) | 2018-11-30 | 2024-06-27 | Juno Therapeutics Inc | Métodos para tratamento utilizando terapia celular adotiva |
| BR112021013824A2 (pt) * | 2019-01-18 | 2021-12-14 | Janssen Biotech Inc | Receptores de antígeno quiméricos gprc5d e células que expressam os mesmos |
| WO2020223535A1 (en) | 2019-05-01 | 2020-11-05 | Juno Therapeutics, Inc. | Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods |
| CA3136742A1 (en) | 2019-05-01 | 2020-11-05 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods |
| KR20220034782A (ko) | 2019-06-12 | 2022-03-18 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 매개 세포 독성 요법 및 친생존 ｂｃｌ2 패밀리 단백질 억제제의 병용 요법 |
| CN114555112A (zh) | 2019-08-22 | 2022-05-27 | 朱诺治疗学股份有限公司 | T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法 |
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| JP2023531531A (ja) | 2020-06-26 | 2023-07-24 | ジュノ セラピューティクス ゲーエムベーハー | 組換え受容体を条件付きで発現する操作されたｔ細胞、関連ポリヌクレオチド、および方法 |
| EP4240756A1 (en) | 2020-11-04 | 2023-09-13 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods |
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| CN117321200A (zh) | 2021-03-22 | 2023-12-29 | 朱诺治疗学股份有限公司 | 评估病毒载体颗粒效力的方法 |
| AU2022241654A1 (en) | 2021-03-22 | 2023-09-28 | Juno Therapeutics, Inc. | Methods of determining potency of a therapeutic cell composition |
| CN116964100A (zh) * | 2021-04-07 | 2023-10-27 | 株式会社Lg化学 | Gucy2c结合多肽及其用途 |
| JP2024517863A (ja) | 2021-05-06 | 2024-04-23 | ジュノ・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞を刺激し、形質導入する方法 |
| CN115386010B (zh) * | 2021-05-23 | 2026-02-06 | 上海邦耀生物科技有限公司 | 靶向gprc5d的嵌合抗原受体及其用途 |
| WO2023030272A1 (zh) | 2021-08-30 | 2023-03-09 | 原启生物科技(上海)有限责任公司 | 抗gprc5d抗原结合蛋白及其用途 |
| AU2022380155A1 (en) | 2021-11-03 | 2024-06-20 | Janssen Biotech, Inc. | Corticosteriod reduction in treatment with anti-cd38 antibodies |
| WO2023134718A1 (zh) | 2022-01-14 | 2023-07-20 | 原启生物科技(上海)有限责任公司 | 靶向gprc5d的嵌合抗原受体及其用途 |
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