JP2018519263A5 - - Google Patents
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- JP2018519263A5 JP2018519263A5 JP2017558407A JP2017558407A JP2018519263A5 JP 2018519263 A5 JP2018519263 A5 JP 2018519263A5 JP 2017558407 A JP2017558407 A JP 2017558407A JP 2017558407 A JP2017558407 A JP 2017558407A JP 2018519263 A5 JP2018519263 A5 JP 2018519263A5
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- 150000007523 nucleic acids Chemical class 0.000 claims description 22
- 239000013604 expression vector Substances 0.000 claims description 21
- 102000039446 nucleic acids Human genes 0.000 claims description 20
- 108020004707 nucleic acids Proteins 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 13
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 3
- 208000004736 B-Cell Leukemia Diseases 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010042971 T-cell lymphoma Diseases 0.000 claims 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
- 201000009277 hairy cell leukemia Diseases 0.000 claims 2
- 201000005787 hematologic cancer Diseases 0.000 claims 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000025324 B-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 201000011176 T-cell adult acute lymphocytic leukemia Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 239000000178 monomer Substances 0.000 description 33
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 9
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 9
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 6
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 6
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 description 6
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 description 6
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 238000006467 substitution reaction Methods 0.000 description 5
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 229960004641 rituximab Drugs 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020073781A JP7765171B2 (ja) | 2015-05-08 | 2020-04-17 | Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562159111P | 2015-05-08 | 2015-05-08 | |
| US62/159,111 | 2015-05-08 | ||
| US201562251005P | 2015-11-04 | 2015-11-04 | |
| US201562250971P | 2015-11-04 | 2015-11-04 | |
| US62/251,005 | 2015-11-04 | ||
| US62/250,971 | 2015-11-04 | ||
| PCT/US2015/062772 WO2016086189A2 (en) | 2014-11-26 | 2015-11-25 | Heterodimeric antibodies that bind cd3 and tumor antigens |
| USPCT/US2015/062772 | 2015-11-25 | ||
| US14/952,714 | 2015-11-25 | ||
| US14/952,714 US10889653B2 (en) | 2014-11-26 | 2015-11-25 | Heterodimeric antibodies that bind CD3 and tumor antigens |
| PCT/US2016/029797 WO2016182751A1 (en) | 2015-05-08 | 2016-04-28 | Heterodimeric antibodies that bind cd3 and tumor antigens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020073781A Division JP7765171B2 (ja) | 2015-05-08 | 2020-04-17 | Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018519263A JP2018519263A (ja) | 2018-07-19 |
| JP2018519263A5 true JP2018519263A5 (2) | 2019-06-13 |
| JP6694446B2 JP6694446B2 (ja) | 2020-05-13 |
Family
ID=57248331
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558407A Active JP6694446B2 (ja) | 2015-05-08 | 2016-04-28 | Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体 |
| JP2020073781A Active JP7765171B2 (ja) | 2015-05-08 | 2020-04-17 | Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体 |
| JP2023094234A Pending JP2023113868A (ja) | 2015-05-08 | 2023-06-07 | Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020073781A Active JP7765171B2 (ja) | 2015-05-08 | 2020-04-17 | Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体 |
| JP2023094234A Pending JP2023113868A (ja) | 2015-05-08 | 2023-06-07 | Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体 |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP4059514A1 (2) |
| JP (3) | JP6694446B2 (2) |
| KR (1) | KR20180018525A (2) |
| CN (2) | CN108025046B (2) |
| AU (3) | AU2016262368B2 (2) |
| BR (1) | BR112017023943A2 (2) |
| CA (1) | CA2984134A1 (2) |
| CL (1) | CL2017002752A1 (2) |
| CO (1) | CO2017011486A2 (2) |
| CR (1) | CR20170511A (2) |
| EA (1) | EA036156B1 (2) |
| EC (1) | ECSP17081420A (2) |
| IL (1) | IL255221A0 (2) |
| MA (1) | MA41279A (2) |
| MX (1) | MX390190B (2) |
| PE (1) | PE20180188A1 (2) |
| PH (1) | PH12017502019B1 (2) |
| SG (1) | SG11201708620QA (2) |
| TN (1) | TN2017000470A1 (2) |
| WO (1) | WO2016182751A1 (2) |
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| EP2839842A1 (en) * | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| EP3699195A3 (en) | 2014-03-28 | 2020-11-04 | Xencor, Inc. | Bispecific antibodies that bind to cd38 and cd3 |
| PE20171324A1 (es) * | 2014-11-26 | 2017-09-11 | Xencor Inc | Anticuerpos heterodimericos que se unen a cd3 y a antigenos tumorales |
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2016
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2019
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