JP2019094345A5 - - Google Patents
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- JP2019094345A5 JP2019094345A5 JP2019023478A JP2019023478A JP2019094345A5 JP 2019094345 A5 JP2019094345 A5 JP 2019094345A5 JP 2019023478 A JP2019023478 A JP 2019023478A JP 2019023478 A JP2019023478 A JP 2019023478A JP 2019094345 A5 JP2019094345 A5 JP 2019094345A5
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- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- compound
- independently
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DUJCVVIZCWSVIV-UHFFFAOYSA-N CCCCc1c(-c(c(Cl)ccc2)c2Cl)c(O)c(-c2nnc(Cc3n[o]c4c3cccc4)[o]2)c(O)n1 Chemical compound CCCCc1c(-c(c(Cl)ccc2)c2Cl)c(O)c(-c2nnc(Cc3n[o]c4c3cccc4)[o]2)c(O)n1 DUJCVVIZCWSVIV-UHFFFAOYSA-N 0.000 description 1
- RMUPKTGAGNBLFQ-UHFFFAOYSA-N CCCCc1c(-c(c(OC)ccc2)c2OC)c(O)c(-c2nnc(CN(C(CN3C)=O)C3=O)[o]2)c(O)n1 Chemical compound CCCCc1c(-c(c(OC)ccc2)c2OC)c(O)c(-c2nnc(CN(C(CN3C)=O)C3=O)[o]2)c(O)n1 RMUPKTGAGNBLFQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562170215P | 2015-06-03 | 2015-06-03 | |
| US62/170,215 | 2015-06-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562603A Division JP6483288B2 (ja) | 2015-06-03 | 2016-06-02 | 心臓血管障害の治療にて用いるための４−ヒドロキシ−３−（ヘテロアリール）ピリジン−２−オン ａｐｊアゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019094345A JP2019094345A (ja) | 2019-06-20 |
| JP2019094345A5 true JP2019094345A5 (2) | 2019-10-10 |
Family
ID=56131647
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562603A Active JP6483288B2 (ja) | 2015-06-03 | 2016-06-02 | 心臓血管障害の治療にて用いるための４−ヒドロキシ−３−（ヘテロアリール）ピリジン−２−オン ａｐｊアゴニスト |
| JP2019023478A Pending JP2019094345A (ja) | 2015-06-03 | 2019-02-13 | 心臓血管障害の治療にて用いるための４−ヒドロキシ−３−（ヘテロアリール）ピリジン−２−オン ａｐｊアゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562603A Active JP6483288B2 (ja) | 2015-06-03 | 2016-06-02 | 心臓血管障害の治療にて用いるための４−ヒドロキシ−３−（ヘテロアリール）ピリジン−２−オン ａｐｊアゴニスト |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US10011594B2 (2) |
| EP (2) | EP3530660A1 (2) |
| JP (2) | JP6483288B2 (2) |
| KR (1) | KR102066336B1 (2) |
| CN (1) | CN107922401B (2) |
| AR (1) | AR104884A1 (2) |
| AU (1) | AU2016270903B2 (2) |
| CA (1) | CA2988147C (2) |
| CL (1) | CL2017003055A1 (2) |
| CO (1) | CO2017013229A2 (2) |
| CY (1) | CY1121938T1 (2) |
| DK (1) | DK3303330T3 (2) |
| EA (1) | EA034912B1 (2) |
| ES (1) | ES2739526T3 (2) |
| HK (1) | HK1247915B (2) |
| HR (1) | HRP20191327T1 (2) |
| HU (1) | HUE045546T2 (2) |
| IL (1) | IL255951B (2) |
| LT (1) | LT3303330T (2) |
| MA (1) | MA41562B1 (2) |
| ME (1) | ME03474B (2) |
| MX (1) | MX378998B (2) |
| MY (1) | MY189453A (2) |
| NZ (1) | NZ738563A (2) |
| PE (1) | PE20180506A1 (2) |
| PH (1) | PH12017502158B1 (2) |
| PL (1) | PL3303330T3 (2) |
| PT (1) | PT3303330T (2) |
| RS (1) | RS59220B1 (2) |
| SI (1) | SI3303330T1 (2) |
| SM (1) | SMT201900427T1 (2) |
| TN (1) | TN2017000503A1 (2) |
| TW (1) | TWI672299B (2) |
| UY (1) | UY36705A (2) |
| WO (1) | WO2016196771A1 (2) |
| ZA (1) | ZA201708191B (2) |
Families Citing this family (27)
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| DK3300500T3 (da) | 2015-05-20 | 2020-05-18 | Amgen Inc | Triazolagonister af apj-receptoren |
| WO2016196771A1 (en) * | 2015-06-03 | 2016-12-08 | Bristol-Myers Squibb Company | 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders |
| KR102707502B1 (ko) | 2015-10-14 | 2024-09-13 | 브리스톨-마이어스 스큅 컴퍼니 | Apj 효능제로서의 2,4-디히드록시-니코틴아미드 |
| UY37005A (es) | 2015-12-04 | 2017-06-30 | Bristol-Myers Squibb Company Una Corporacion Del Estado De Delaware | Hidroxipirimidinonas sustituidas como agonistas del receptor de apelina y sus usos |
| BR112018012112A2 (pt) * | 2015-12-16 | 2018-12-04 | Bristol-Myers Squibb Company | heteroaril-hidroxipirimidinonas como agonistas do receptor apj |
| TWI744301B (zh) * | 2016-03-24 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 做為apj促效劑之6-羥基-4-側氧-1,4-二氫嘧啶-5-甲醯胺 |
| WO2017192485A1 (en) | 2016-05-03 | 2017-11-09 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the apj receptor |
| JP6962941B2 (ja) * | 2016-06-14 | 2021-11-05 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Ａｐｊ受容体アゴニストとしての４−ヒドロキシ−３−スルホニルピリジン−２（１ｈ）−オン |
| KR102384668B1 (ko) | 2016-06-14 | 2022-04-07 | 브리스톨-마이어스 스큅 컴퍼니 | Apj 효능제로서의 6-히드록시-5-(페닐/헤테로아릴술포닐)피리미딘-4(1h)-온 |
| JP7037558B2 (ja) * | 2016-10-14 | 2022-03-16 | ブリストル－マイヤーズ スクイブ カンパニー | ３－スルホニル－５－アミノピリジン－２，４－ジオール ａｐｊアゴニスト |
| EP3541792B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
| EP3541803B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| WO2018093579A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
| WO2018093576A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the apj receptor |
| US11020395B2 (en) | 2016-11-16 | 2021-06-01 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the APJ receptor |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| US11149040B2 (en) | 2017-11-03 | 2021-10-19 | Amgen Inc. | Fused triazole agonists of the APJ receptor |
| WO2019213006A1 (en) | 2018-05-01 | 2019-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
| CN109704980B (zh) * | 2019-02-16 | 2022-05-13 | 安徽大学 | 一种(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的制备方法 |
| CN109704981B (zh) * | 2019-02-16 | 2022-01-28 | 安徽诺全药业有限公司 | 取代合成(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的方法 |
| CN109734616B (zh) * | 2019-02-16 | 2022-05-13 | 安徽诺全药业有限公司 | 两步法合成(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的方法 |
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| IL316201A (en) | 2022-04-08 | 2024-12-01 | Eikonizo Therapeutics Inc | Oxadiazole HDAC6 inhibitors and their uses |
| WO2024148104A1 (en) | 2023-01-03 | 2024-07-11 | BioAge Labs, Inc. | Combination therapy of apelin receptor agonist and glp-1 receptor agonist for treating a disease or condition associated with weight gain |
| WO2025213190A1 (en) | 2024-04-05 | 2025-10-09 | BioAge Labs, Inc. | Methods of treating a disease or condition associated with weight gain |
| WO2025251084A1 (en) | 2024-05-31 | 2025-12-04 | BioAge Labs, Inc. | Methods of treating a disease or condition associated with weight gain |
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| TWI744301B (zh) | 2016-03-24 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 做為apj促效劑之6-羥基-4-側氧-1,4-二氫嘧啶-5-甲醯胺 |
| JP6962941B2 (ja) | 2016-06-14 | 2021-11-05 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Ａｐｊ受容体アゴニストとしての４−ヒドロキシ−３−スルホニルピリジン−２（１ｈ）−オン |
| KR102384668B1 (ko) | 2016-06-14 | 2022-04-07 | 브리스톨-마이어스 스큅 컴퍼니 | Apj 효능제로서의 6-히드록시-5-(페닐/헤테로아릴술포닐)피리미딘-4(1h)-온 |
| JP7037558B2 (ja) | 2016-10-14 | 2022-03-16 | ブリストル－マイヤーズ スクイブ カンパニー | ３－スルホニル－５－アミノピリジン－２，４－ジオール ａｐｊアゴニスト |
-
2016
- 2016-06-02 WO PCT/US2016/035482 patent/WO2016196771A1/en not_active Ceased
- 2016-06-02 EP EP19168724.3A patent/EP3530660A1/en not_active Withdrawn
- 2016-06-02 AR ARP160101639A patent/AR104884A1/es unknown
- 2016-06-02 SM SM20190427T patent/SMT201900427T1/it unknown
- 2016-06-02 LT LTEP16729454.5T patent/LT3303330T/lt unknown
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