JP2019501191A5 - - Google Patents
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- JP2019501191A5 JP2019501191A5 JP2018535283A JP2018535283A JP2019501191A5 JP 2019501191 A5 JP2019501191 A5 JP 2019501191A5 JP 2018535283 A JP2018535283 A JP 2018535283A JP 2018535283 A JP2018535283 A JP 2018535283A JP 2019501191 A5 JP2019501191 A5 JP 2019501191A5
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- JP
- Japan
- Prior art keywords
- lyophilized formulation
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- Prior art date
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021068923A JP7201732B2 (ja) | 2016-01-08 | 2021-04-15 | ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドの製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276756P | 2016-01-08 | 2016-01-08 | |
| US62/276,756 | 2016-01-08 | ||
| PCT/US2017/012483 WO2017120437A1 (en) | 2016-01-08 | 2017-01-06 | Formulations of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021068923A Division JP7201732B2 (ja) | 2016-01-08 | 2021-04-15 | ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドの製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501191A JP2019501191A (ja) | 2019-01-17 |
| JP2019501191A5 true JP2019501191A5 (2) | 2020-06-25 |
| JP6871256B2 JP6871256B2 (ja) | 2021-05-12 |
Family
ID=59273934
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535283A Active JP6871256B2 (ja) | 2016-01-08 | 2017-01-06 | ２−（４−クロロフェニル）−ｎ−（（２−（２，６−ジオキソピペリジン−３−イル）−１−オキソイソインドリン−５−イル）メチル）−２，２−ジフルオロアセトアミドの製剤 |
| JP2021068923A Active JP7201732B2 (ja) | 2016-01-08 | 2021-04-15 | ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドの製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021068923A Active JP7201732B2 (ja) | 2016-01-08 | 2021-04-15 | ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドの製剤 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US10052315B2 (2) |
| EP (2) | EP3399979B9 (2) |
| JP (2) | JP6871256B2 (2) |
| KR (1) | KR20180100565A (2) |
| CN (2) | CN108601777B (2) |
| AU (2) | AU2017205167B2 (2) |
| BR (1) | BR112018013884A2 (2) |
| CA (1) | CA3010797C (2) |
| CL (1) | CL2018001830A1 (2) |
| CO (1) | CO2018008305A2 (2) |
| EA (1) | EA037508B1 (2) |
| EC (1) | ECSP18051143A (2) |
| ES (1) | ES2956767T3 (2) |
| IL (1) | IL260403B (2) |
| MX (1) | MX382150B (2) |
| SA (1) | SA518391983B1 (2) |
| SG (2) | SG11201805777QA (2) |
| WO (1) | WO2017120437A1 (2) |
| ZA (1) | ZA201804482B (2) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9499514B2 (en) | 2014-07-11 | 2016-11-22 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| CN108601777B (zh) | 2016-01-08 | 2021-08-03 | 细胞基因公司 | 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的制剂 |
| KR20180095094A (ko) * | 2016-01-08 | 2018-08-24 | 셀진 코포레이션 | 암을 치료하기 위한 방법 및 치료요법에 대한 임상 감수성의 예측변수로서 바이오마커의 용도 |
| US10245258B2 (en) | 2016-06-06 | 2019-04-02 | Celgene Corporation | Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| KR20200020899A (ko) * | 2017-06-30 | 2020-02-26 | 셀진 코포레이션 | 2-(4-클로로페닐)-n-((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-5-일)메틸)-2,2-디플루오로아세트아미드의 조성물 및 사용 방법 |
| CN113347974A (zh) * | 2018-12-31 | 2021-09-03 | 细胞基因公司 | 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合物和使用方法 |
| JP2022554346A (ja) | 2019-11-05 | 2022-12-28 | セルジーン コーポレーション | ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドとの併用療法 |
| MX2022006133A (es) | 2019-12-06 | 2022-06-17 | Celgene Corp | Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida. |
| AU2022207648A1 (en) | 2021-01-13 | 2023-07-27 | Monte Rosa Therapeutics Ag | Isoindolinone compounds |
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| US5391485A (en) | 1985-08-06 | 1995-02-21 | Immunex Corporation | DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues |
| JPS63500636A (ja) | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ |
| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5360352A (en) | 1992-12-24 | 1994-11-01 | The Whitaker Corporation | Wire retainer for current mode coupler |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US5855887A (en) | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5948893A (en) | 1996-01-17 | 1999-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Murine hybridoma and antibody binding to CD28 receptor secreted by the hybridoma and method of using the antibody |
| US6207157B1 (en) | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| EP1212422B1 (en) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| CA2466279A1 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| CN101899114A (zh) | 2002-12-23 | 2010-12-01 | 惠氏公司 | 抗pd-1抗体及其用途 |
| DK2439273T3 (da) | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| US8877780B2 (en) | 2006-08-30 | 2014-11-04 | Celgene Corporation | 5-substituted isoindoline compounds |
| CN100457098C (zh) * | 2006-12-20 | 2009-02-04 | 南京科源医药技术有限公司 | 甲磺酸萘莫司他冻干粉针剂及其制备方法 |
| BR122017025062B8 (pt) | 2007-06-18 | 2021-07-27 | Merck Sharp & Dohme | anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento |
| CN101224296A (zh) * | 2008-02-01 | 2008-07-23 | 山东先声麦得津生物制药有限公司 | 一种稳定的重组人血管内皮抑制素制剂及其制备工艺 |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| US8552154B2 (en) | 2008-09-26 | 2013-10-08 | Emory University | Anti-PD-L1 antibodies and uses therefor |
| PT2358697E (pt) * | 2008-10-29 | 2016-02-03 | Celgene Corp | Compostos de isoindolina para utilização no tratamento do cancro |
| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| JP5844159B2 (ja) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユＵｎｉｖｅｒｓｉｔｅ Ｄ’Ａｉｘ−Ｍａｒｓｅｉｌｌｅ | Ｐｄ−１抗体およびｐｄ−ｌ１抗体ならびにその使用 |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| WO2011082400A2 (en) | 2010-01-04 | 2011-07-07 | President And Fellows Of Harvard College | Modulators of immunoinhibitory receptor pd-1, and methods of use thereof |
| WO2011159877A2 (en) | 2010-06-18 | 2011-12-22 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| EP2699091B1 (en) * | 2011-03-28 | 2017-06-21 | DeuteRx, LLC | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
| US8974811B2 (en) * | 2013-03-14 | 2015-03-10 | Hikma Pharmaceuticals | Stabilized pharmaceutical formulations comprising antineoplastic compounds |
| EP2991651A1 (en) | 2013-05-03 | 2016-03-09 | Celgene Corporation | Methods for treating cancer using combination therapy |
| US9499514B2 (en) | 2014-07-11 | 2016-11-22 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| WO2017120415A1 (en) | 2016-01-08 | 2017-07-13 | Celgene Corporation | Solid forms of 2-(4-chlorophenyl)-n-((2-2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide, and their pharmaceutical compositions and uses |
| SG11201805779TA (en) | 2016-01-08 | 2018-08-30 | Celgene Corp | Antiproliferative compounds, and their pharmaceutical compositions and uses |
| CN108601777B (zh) * | 2016-01-08 | 2021-08-03 | 细胞基因公司 | 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的制剂 |
| JP2019011495A (ja) | 2017-06-30 | 2019-01-24 | 株式会社Ｕａｃｊ押出加工 | 熱交換器に配管部材を接続するためのアルミニウム合金製コネクタ及び該コネクタを備える熱交換器接続用配管部材、並びにこれらの製造方法 |
| CN113347974A (zh) | 2018-12-31 | 2021-09-03 | 细胞基因公司 | 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合物和使用方法 |
| JP2022554346A (ja) | 2019-11-05 | 2022-12-28 | セルジーン コーポレーション | ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドとの併用療法 |
-
2017
- 2017-01-06 CN CN201780005873.3A patent/CN108601777B/zh active Active
- 2017-01-06 CN CN202110818391.8A patent/CN113633634A/zh active Pending
- 2017-01-06 BR BR112018013884A patent/BR112018013884A2/pt not_active Application Discontinuation
- 2017-01-06 SG SG11201805777QA patent/SG11201805777QA/en unknown
- 2017-01-06 EA EA201891578A patent/EA037508B1/ru unknown
- 2017-01-06 KR KR1020187019190A patent/KR20180100565A/ko not_active Ceased
- 2017-01-06 SG SG10202007913WA patent/SG10202007913WA/en unknown
- 2017-01-06 JP JP2018535283A patent/JP6871256B2/ja active Active
- 2017-01-06 ES ES17736406T patent/ES2956767T3/es active Active
- 2017-01-06 EP EP17736406.4A patent/EP3399979B9/en active Active
- 2017-01-06 EP EP23181094.6A patent/EP4275707A3/en not_active Withdrawn
- 2017-01-06 US US15/400,791 patent/US10052315B2/en active Active
- 2017-01-06 WO PCT/US2017/012483 patent/WO2017120437A1/en not_active Ceased
- 2017-01-06 CA CA3010797A patent/CA3010797C/en active Active
- 2017-01-06 MX MX2018008429A patent/MX382150B/es unknown
- 2017-01-06 AU AU2017205167A patent/AU2017205167B2/en active Active
-
2018
- 2018-07-03 IL IL260403A patent/IL260403B/en unknown
- 2018-07-04 CL CL2018001830A patent/CL2018001830A1/es unknown
- 2018-07-04 ZA ZA201804482A patent/ZA201804482B/en unknown
- 2018-07-05 SA SA518391983A patent/SA518391983B1/ar unknown
- 2018-07-06 EC ECSENADI201851143A patent/ECSP18051143A/es unknown
- 2018-07-19 US US16/040,450 patent/US10449187B2/en active Active
- 2018-08-08 CO CONC2018/0008305A patent/CO2018008305A2/es unknown
-
2019
- 2019-09-09 US US16/565,346 patent/US11129821B2/en active Active
-
2021
- 2021-04-15 JP JP2021068923A patent/JP7201732B2/ja active Active
- 2021-08-25 US US17/412,187 patent/US11883389B2/en active Active
- 2021-09-29 AU AU2021240184A patent/AU2021240184A1/en not_active Abandoned
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