JP2019502425A - Laser-assisted wound healing protocol and system - Google Patents

Abstract

Method of healing a wound and treating diseased tissue using a diode laser that generates a light beam having a wavelength in the visible region (400 nm to 700 nm) of the electromagnetic spectrum with a laser power of 0.001 to 1.2 watts A method wherein a diode laser is used with intermittent stops to control tissue temperature and biostimulate epithelial regeneration when used with or without a substrate. A method of treating a diseased tissue using laser light in a green wavelength region (520 to 570 nm) with a laser output of 0.001 W to 5 W. A method of treating a diseased tissue using laser light in the IR wavelength region (700 nm to 1400 nm) with a laser output of 0.001 W to 5 W.

Description

Cross-reference This application is an international application claiming priority to partially continued patent application No. 15 / 348,793 filed on November 10, 2016, which is filed on November 10, 2015 US Patent Application No. 14 / 937,858 of US Patent Application No. 14 / 937,858, which claims the benefit of priority under US Patent Act 120, which is now published as US Pat. No. 9,180,319. Claiming the benefit of priority from U.S. Patent Application No. 13 / 864,226, filed on May 16, which is now abandoned, U.S. Patent Application No. 13/078, filed Apr. 4, 2011. , 757, all of which are hereby incorporated by reference.

  The present invention relates generally to a method of treating gingival disease using a diode laser that produces a light beam having a wavelength in the visible region (400 nm to 700 nm) of the electromagnetic spectrum. Optionally, the laser light utilizes a green wavelength range (520-570 nm) with a laser power of 0.001 W to 5 W to treat the wound. Also described is a method for treating diseased tissue using a diode laser. Optionally, the laser light is. The wound is treated using the IR wavelength range (700 nm to 1400 nm) with a laser power of 001 W to 5 W. Optionally, the LED light utilizes the IR wavelength range to treat the wound.

  Laser-assisted periodontal tissue and bone regeneration (LAPOR) is a laser-assisted protocol that involves the use of substrates such as, but not limited to, LAPOR periodontal solutions, LAPOR periodontal gels and LAPOR substrates Causes cell attachment of epithelial cells, gingival fibroblasts, PDL fibroblasts and increased adhesion of osteogenic cells. By using PDL fibroblasts, gingival fibroblasts, and osteoblast-like cells, it is believed that the rate of wound filling is accelerated in vitro by enhancing cell migration and proliferation.

  Substrates such as the LAPOR periodontal solution, LAPOR periodontal gel, and LAPOR substrate used in the LAPOR protocol stimulate overall protein synthesis and the synthesis of specific extracellular matrix molecules. Studies evaluating bone remodeling regulatory systems have shown that proteins influence this regulatory system and thus show an indirect involvement in the bone remodeling process. When used in combination with three specially formulated periodontal and wound healing substrates and LAPOR gel root preparations, LAPOR stimulates the overall synthesis of tissue and bone, resulting in gingival adhesion, gingival It has been shown to increase height, bone density, and bone height, which indicates that the speed at which the wound fills is accelerated in vivo.

  The diode laser used produces a light beam having a wavelength in the visible region (400 nm to 700 nm) of the electromagnetic spectrum. Optionally, a light beam having a wavelength in the green wavelength range (520-570 nm) with a laser power of 0.5 to 1.2 W is used for the LAPOR protocol. It has been shown by the LAPOR protocol to biostimulate the process of periodontal tissue healing and regeneration, including biostimulation of new bone and its supporting factors. The diode laser used in the LAPOR protocol non-surgically biostimulates the healing response of the periodontal tissue, non-surgically biostimulates the tissue regeneration of the periodontal tissue, and the long junctional epithelium passes through the groove. Prevents downward migration (a biomechanical aspect of tissue healing), thereby maintaining tissue height. Diode lasers used in the LAPOR protocol help non-surgical stimulation of substrates such as, but not limited to, proteins overall synthesis and synthesis of extracellular matrix molecules.

  Alternatively, the LAPOR protocol is green with an alternative wattage of 0.001 W to 5 W, preferably 0.002 W to 4 W, more preferably 0.003 W to 4 W, most preferably 0.005 W to 2 W. You may use the light beam which has a wavelength of a wavelength range (520-570 nm), a red wavelength range (620-750 nm), or a yellow wavelength range (570-590 nm). The diode laser used helps the substrate stimulate the entire tissue and bone synthesis by biostimulating the wound healing response and bone / tissue regeneration and its supporting factors.

  It is further envisioned that the present invention may be used to treat tissue damage and wounds. That is, laser-assisted tissue and bone regeneration (LATOR) using solutions, LATOR gels, and LATOR substrates enhances cell migration and proliferation and accelerates the rate of wound filling. The protocol is used in combination with six specially formulated tissue and wound healing matrices and gel conditioning agents to stimulate the overall tissue and bone synthesis, including tissue attachment, tissue height, bone density, It is shown that increasing the height of the bone and thereby accelerating the speed of wound filling as in the LAPOR protocol.

  In an exemplary embodiment of the present invention, disclosed is a gingival disease and scaling / root using a diode laser that generates a light beam having a wavelength in the visible region (400 nm to 700 nm) of the electromagnetic spectrum. A method of treating a wound including gingival tissue after planing. Optionally, a light beam having a wavelength in the green range (520-570 nm) with a laser output of 0.5 watts to 1.2 watts is used to purify the gingival tissue and to biostimulate the healing and tooth Regenerate the surrounding tissue (including the cementum on the root surface), thus preventing the long junctional epithelium from migrating down in the groove, thereby preserving the height of the tissue. Alternatively, it has a green wavelength range (520-570 nm), a red wavelength range (620-750 nm), or a yellow wavelength range (570-590 nm) with an alternative wattage of 0.001 W to 5 W. A light beam may be used to biostimulate healing and regenerate the wound site, its tissue and bone. In a preferred embodiment, the wattage is in the region of 0.002W to 4W, more preferably in the region of 0.003 to 3W, and most preferably in the region of 0.005W to 2W. The diode laser also biostimulates the healing and regeneration responses induced by the substrates, ie, LAPOR periodontal and wound healing solution, LAPOR periodontal gel, and LAPOR periodontal and wound healing substrate, the method is 1) Placing the laser inside the groove, 2) spreading the laser beam across the groove by intermittently moving it longitudinally and laterally, and 3) forming a clot (then cell attachment) Placing the substrate in the groove before adhesion, migration, and proliferation are increased). In a preferred embodiment, the LATOR protocol may treat the entire wound site using a diode laser according to the parameters described above. Optionally, the laser light is. The wound is treated using the IR wavelength range (700 nm to 1400 nm) with a laser power of 001 W to 5 W.

  In an alternative embodiment, the LAPOR protocol may use LED light to biostimulate healing and regenerate periodontal and whole wound tissue (LATOR protocol). LED light is used on wounds at 10W or less to assist in organizing new cells and thereby regenerating tissue. Optionally, the LED light utilizes the IR wavelength range to treat the wound. Optionally, the laser light has an IR wavelength range (700 nm to 1400 nm). Treat wounds with 001W to 5W laser power.

  In an alternative embodiment, the LAPOR and LATOR protocols may use radio frequency (RF) waves to purify gingival tissue, biostimulate healing, and regenerate periodontal tissue. An RF beam is used on the wound at 10 W or less to assist in organizing new cells and thereby regenerating tissue. A carrier wave (sine wave) transfers the non-sinusoidal waveform to the treatment location. The carrier frequency may be in the range of 0.1 MHz to 20 MHz, while the non-sinusoidal waveform may be in the range of 0 to 40 KHz, or alternatively 0-24 GHz. In a preferred embodiment, the carrier frequency is in the region of 0.2 MHz to 10 MHz, preferably 0.3 MHz to 5 MHz. Optionally, a width of 0.001 W to 10 watts, preferably a width of 0.001 W to 3 W, is utilized for a hertz width of 40 Hz to 24 GHz. In a further alternative embodiment, the RF wave is a single sine wave. In a further alternative embodiment, the RF wave is more than one sine wave, where more than one indicates a harmonic pattern. In a preferred embodiment, the LATOR protocol may treat the entire wound site using RF waves according to the parameters described above. Optionally, the non-sinusoidal waveform may be in the region of the above parameters in the absence of a carrier wave.

  In another embodiment of the present invention, disclosed is a tooth root comprising 15% EDTA, 20% calcium gluconate, methylparaben, propylparaben, ethanolamine as a buffer, carboxymethylcellulose, and an edible green colorant, sterile water / Bone / cartilage regulator.

  In yet another embodiment of the invention, disclosed is a combination of monosodium phosphate or disodium phosphate and sodium hydroxide in a solution with a sodium content of 11 mg / 100 g; 60% water; 9% 9% proline; 9% all other essential amino acids selected from the group consisting of isoleucine, leucine, methionine, phenylalanine, threonine, tryptophan, valine, histidine, asparagine, and selenocysteine; alanine, arginine, 2% of all other non-essential amino acids selected from the group consisting of aspartic acid, cysteine, glutamic acid, glutamine, glycine, serine, tyrosine, and pyrrolysine; selected from the group consisting of adenosine, uridine, guanosine, iridine, and cytidine 6.9% Releasing bases; ADP, selected ATP, and from the group consisting of acetylcholine, 2% phosphoric acid ester; and consisting of 1% benzoic acid, which is the first substrate.

  In yet another embodiment of the present invention, disclosed is a second substrate composed of tricalcium phosphate precipitated with calcium hydroxide / claw oil and hydroxyapatite crystals.

  In yet another embodiment of the invention, disclosed is 5.1% hyaluronic acid; 8% fatty acid selected from the group consisting of linoleic acid (LA), alpha-linoleic acid (ALA); mannose 4.4% of a sugar selected from the group consisting of galactose, N-acetylgalactosamine, N-acetylglucosamine, N-acetylneuraminic acid, fucose (L configuration without 6-position carboxyl group), and xylose; A mixture of 2.2% glucose and fucose (L configuration without 6-carboxyl group); vitamin A, vitamin D2, D3, vitamin E, vitamin K1, K2, vitamin B12 (methylcobalamin, hydroxocobalamin), 3% lipid selected from the group consisting of cholesterol and diaglycerol; vitamin B1, Vita 2.7% vitamins selected from the group consisting of vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin B9, vitamin C, and pantothenic acid; calcium chloride, choline chloride, magnesium sulfate, potassium chloride, 4.5% electrolyte source selected from the group consisting of potassium phosphate (monobasic), sodium bicarbonate, sodium chloride, and sodium iodide; selected from the group consisting of Ag nanoparticles and Au nanoparticles, 6 3.9% ionic metal selected from the group consisting of copper, zinc, selenium, iron, manganese, cobalt, chromium, boron, and molybdenum; and the group consisting of boron, silicon, nickel, and vanadium A third substrate composed of 4% of other ionic metals selected from

In another embodiment of the invention, disclosed are carbomer, potassium chloride, chloride, sodium, potassium, manganese, tricalcium phosphate, sulfate, carbonate, snail serum, snail secretion filtrate, HA , Au, Ag, Cu, Fe, Pt, collagen, glycine HCl, and fucose.

  In another embodiment of the invention, disclosed is a fifth substrate composed of tricalcium phosphate and / or calcified collagen and / or non-calcified collagen.

  In another embodiment of the invention, disclosed is tricalcium phosphate and / or calcified collagen, and / or non-calcified collagen, and / or HCl, and / or NaCl, and / or metal. A sixth substrate constructed, wherein the metal is selected from the group consisting of copper, Au, Ag, iron, and platinum, or any combination thereof.

  Further important features of the invention are therefore outlined so that the more detailed description that follows may be better understood and the contribution here to the art will be better appreciated. Additional features of the invention will be described later in this specification and will form the subject matter of the following claims.

  Before describing at least one embodiment of the present invention in detail, the present invention is not limited in this application to the details of the constitution and arrangement of the components set forth in the following description or illustrated in the drawings. It will be understood. The present invention can be practiced in other embodiments and practiced and implemented in various ways. It will also be understood that the language and terminology employed herein are for the purpose of description and are not to be considered limiting.

  As such, those skilled in the art may readily utilize the concepts based on this disclosure as a basis for the design of other structures, methods, and systems for carrying out the multiple objectives of the present invention. You will recognize that. It is important, therefore, that the claims be regarded as including such equivalent constructions insofar as they do not depart from the spirit and scope of the present invention.

  The foregoing has outlined rather broadly the preferred features of the invention so that those skilled in the art may better understand the detailed description of the invention that follows. Additional features of the invention will be described hereinafter that form the subject of the claims of the invention. The disclosed concepts and specific embodiments can be readily used as a basis for designing or modifying other structures to carry out the same purposes of the present invention, and such other structures Those skilled in the art should recognize that they do not depart from the spirit and scope of the present invention in its broad form.

  Other aspects, features, and advantages of the present invention will become more fully apparent from the following detailed description, the appended claims, and the accompanying drawings. In the drawings, similar elements are given similar reference numerals.

FIG. 1 shows an X-ray image of a patient's teeth before treatment with a diode laser before applying a substrate. 2-7 are X-ray images of the lower tooth of FIG. 1 after treatment with a substrate followed by treatment with a diode laser. FIG. 8 shows an X-ray image of the upper tooth after treatment with a substrate and before treatment with a diode laser. FIG. 9 is an X-ray image of the upper tooth of FIG. 8 after treatment with a substrate followed by treatment with a diode laser. FIG. 10 is a flow diagram of a method of treating a gingival disease using a diode laser in accordance with the principles of the present invention. FIG. 11 is a diagram showing the measurement values of bone density over time for 12 teeth of a patient after treatment with a diode laser and a substrate. FIG. 12 shows the bone density measurements at 17 locations on a patient's teeth 28 after treatment with a diode laser and substrate over time. FIG. 13 is a graph showing, over time, bone density measurements at three locations on a patient's teeth 2, 3 and 15 after treatment with a diode laser and substrate. 14a and 14b are diagrams showing X-rays of the patient's teeth 15 that have collected the measurement values shown in FIG. 11, wherein (a) shows the teeth 15 before treatment, and (b) shows 3 The tooth 15 at the time of the measurement in October 2011 after the treatment is shown. 15a and 15b are diagrams showing X-rays of the patient's teeth 28, in which the measurement values shown in FIG. 12 are collected, and (a) is a diagram showing X-rays of the patient's teeth 28 before treatment. Yes, (b) shows tooth 28 as measured in January 2011 after four treatments. FIGS. 16a and 16b show the pre-treatment teeth, showing panoramic x-rays of the patient's teeth 2, 3 and 15 with the measurements shown in FIG. 13 collected, (a) treatment. The front tooth is shown, and (b) shows the tooth at the time of measurement in July 2011. 17a to 17f are various views of the first embodiment of the diode laser of the present invention, in which (a) is a right side view, (b) is a rear side view, and (c) is a left side. (D) is a front side view, (e) is a top view, and (f) is a clean-up of the laser housing. 18a to 18c are three-dimensional exploded views of the diode laser of FIG. 17, in which (a) is a three-dimensional exploded view, (b) is an assembly drawing, and (c) is a bottom view. 19a-19g are various views of a second embodiment of the diode laser of the present invention, (a) is a top perspective view, (b) is a rear view, and (c) is Left side view, (d) is a top view, (e) is a front perspective view, (f) is a right side view, and (g) is a bottom view. 20a and 20b are three-dimensional exploded views of the diode laser of FIG. 19, where (a) shows an exploded view and (b) shows a close-up of the laser housing. 21a-21c are various views of a third embodiment of a diode laser of the present invention, where (a) is a side perspective view, (b) is an exploded view, and (c) is a laser A close-up of the housing is shown. 22a to 22c are diagrams showing a laser of an optical fiber according to the present invention, where (a) is an assembly drawing, (b) is a three-dimensional exploded view, and (c) is a fully assembled laser. . FIG. 23 is a flow chart of a protocol for using the laser of the present invention. FIG. 24 is a diagram showing measured values of the jaw profile before and after the treatment. FIG. 25 is a diagram showing measured values of toe wrinkle length before and after treatment. Figures 26a-26c show measurements of gingival wound healing and tissue regeneration before and after treatment, (a) shows the wound before treatment, and (b) shows the post-treatment wound. (C) shows the measured value of the height of the tissue before and after the treatment. FIG. 27 is a diagram showing measured values of the length of the hand wrinkle before and after the treatment. FIG. 28 shows the measurement of new skin growth of the wound before and after treatment. FIG. 29 shows measurements of the reduction in (anal) scar width before and after treatment. FIG. 30 shows measurements of the reduction in (anal) scar length before and after treatment. FIG. 31 is a diagram showing measured values of swallowing strength before and after treatment. FIG. 32 is a diagram showing measured values of breast hardness before and after treatment. 33a to 33e are various views of the RF handpiece of the present invention, where (a) is a top view, (b) is a side view, (c) is a perspective view of the RF chip, and (d). Is a three-dimensional exploded side perspective view, and (e) shows an alternative side perspective view of the RF handpiece of the present invention. Figures 34a-f are various views of a fourth alternative diode laser of the present invention, where (a) is a right side view, (b) is a front view, and (c) is a left side view. (D) is a left side perspective view, (e) is a top view, and (f) is a right side perspective view. FIGS. 35a-f are various views of a laser source for use with fiber optic handpieces and interchangeable chips. 36a-36f are various views of the portable RF transmitter of the present invention, wherein (a) is a top view, (b) is a side view, (c) is a bottom view, and (d) is a bottom view. The left side view, (e) is a left front perspective view, and (f) is a right front perspective view. FIGS. 37a and 37b show alternative fiber optic lasers of the present invention, where (a) a flat tip and (b) a glass dispersion tip. FIG. 38 shows regeneration of epithelial wounds before and after treatment. FIG. 39 is a diagram showing regeneration of an Achilles tendon wound before and after treatment. FIG. 40 is a diagram showing regeneration of an ankle epithelial wound before and after treatment. FIG. 41 shows a reduction in the size of an ankle wound before and after treatment. FIG. 42 is a diagram showing the regeneration of the oral wound before and after the treatment. FIG. 43a is a view showing regeneration of a venous wound before and after the treatment, and FIG. 43b is a view showing a flashlight infrared laser.

Detailed Description of the Invention

Definitions As used herein, the term “gingival disease” means a periodontal disease that can cause tooth loss and / or other health problems. Examples of periodontal diseases include gingivitis, invasive periodontitis, chronic periodontitis, periodontitis as a sign of systemic disease, and necrotizing periodontal disease.

  As used herein, the term “tissue disease” refers to tissue and / or epithelial loss resulting from injury and / or wounds that can cause other health problems such as amputation of the limb. means.

  As used herein, the term “patient” means any individual suffering from a gingival disease and in need of treatment for said gingival disease.

  As used herein, the term “location” means the exact point of measurement within the groove or in the immediate surrounding range.

  As used herein, the term “substrate mixture” refers to the first substrate and / or the first substrate disclosed herein for treating gingival and / or tissue diseases and / or wounds. It means a mixture of two substrates and / or a third substrate and / or a fourth substrate and / or a fifth substrate and / or a sixth substrate.

  As used herein, the term “bone regeneration” means that the density of calcium increases at specific locations in or around the groove.

  As used herein, the term “calcium density” means a measure of the amount of calcium around a given site.

  As used herein, the term “wound” means any range that has lost any native tissue or bone or any other structure that is not named, In non-wound, undamaged and unaged forms are lost.

  The LAPOR protocol can be used in the treatment of gingival diseases and wounds by combining with the most effective treatment methods involving the use of specialized lasers. Approximately 66% of the US population has some form of gingival disease. However, many avoid trying to get treatment, often because of the discomfort as a result of gingival surgery. LAPOR offers new options. The LAPOR protocol is a more effective treatment for traditional periodontal surgery and is much more beneficial to patients both in the short term and in the long term. The LATOR protocol can be used similarly for the treatment of tissue diseases and wounds.

  The LAPOR protocol requires only about 1 hour and only 2 short follow-up visits. The patient takes only 24 hours to recover without downtime. This makes it possible to return to work quickly and comfortably.

  After performing the LAPOR protocol, gingival retraction is zero compared to most cases after normal periodontal surgery. This is combined with the formation of new cementum on the root, without previously impaired bone formation, periodontal ligament formation, and tooth loss. After performing the LATOR protocol, wound fibrosis is zero compared to most cases after normal treatment, new tissue formation occurs in multiple directions, and the wound closes without implantation.

  Using the LAPOR protocol of the present invention, wound sites can be healed by combining the most effective methods of treatment with lasers, LEDs, radio frequency energy, and substrates, or separately. After performing the treatment protocol, no tissue regression from the wound site was observed. In a preferred embodiment, the RF energy wave may be up to 10W. The carrier frequency may be in the range of 0.1 MHz to 20 MHz, while the non-sinusoidal waveform may be in the range of 0 to 40 KHz, or 0 to 24 GHz. In a preferred embodiment, the carrier frequency is in the region of 0.2 MHz to 10 MHz, preferably 0.3 MHz to 5 MHz. Optionally, RF energy in the region of 0.001 W to 10 W, preferably in the region of 0.001 W to 3 W, is utilized with a hertz width of 40 Hz to 24 GHz. In a further alternative embodiment, the RF wave is more than one sine wave, where more than one exhibits a harmonic pattern.

  A special type of laser used in the LAPOR and LATOR protocols is the semiconductor coherent light beam used for the diode, s. The laser light used has a wavelength between 400 nm and 700 nm, which is the wavelength in the visible region of the electromagnetic spectrum. Optionally, the green region of the visible spectrum (520-570 nm) is utilized with a laser power of 0.5 to 1.2 watts, which sterilizes the site and frees the gingival tissue from bacteria. The healing is stimulated. In combination with treatment with a substrate, the laser biostimulates the regeneration of periodontal tissue. Traditional periodontal treatment reduces the depth of the pocket by removing the height of the tooth tissue. The LAPOR protocol is a regeneration technique. The patient does not lose tissue volume. The tissue volume is increased and the bone is regenerated. For general tissue diseases, the laser biostimulates tissue regeneration, where traditional treatment removes tissue height to reduce disease. Optionally, the laser light has an IR wavelength range (700 nm to 1400 nm). Utilize 001W to 5W laser power to treat wounds. Optionally, LED light is used at 10W or less.

  The use of a diode laser in combination with routine scaling and root planing is more effective than scaling and root planing alone. It increases the speed and extent of the patient's gingival healing and post-operative comfort. This is achieved through laser reduction of bacteria and biological stimulation using laser light having a wavelength in the visible region of the electromagnetic spectrum, i.e., a wavelength between 400 nm and 700 nm. Optionally, the green region of the visible spectrum (520-570 nm) is utilized with a laser power of 0.5 to 1.2 watts. Alternatively, the laser output wattage may be in the region of 0.001 W to 5 W, preferably 0.002 W to 4 W, more preferably 0.003 W to 3 W, and most preferably 0.005 W to 2 W. .

  Referring to FIG. 10, disclosed is a method 10 using a diode laser that produces a light beam, which is used intermittently and has a wavelength in the visible region of the electromagnetic spectrum, i.e., from 400 nm. It has a wavelength of 700 nm. Optionally, the green region of the visible spectrum (520-570 nm) is used with a laser power of 0.5 to 1.2 watts to treat gingival diseases. Beginning at block 12, the perioprobe determines the extent of excess pocket depth and therefore helps the dentist better identify the extent of the diseased tissue and bacterial infection. The dentist removes tartar from the root surface using an ultrasonic scaler and hand instrument, block 14. This action by the dentist helps stimulate the healing response in the groove by opening capillaries when scaling. Proceeding to block 18, the laser tip is placed inside the groove and the tip is moved longitudinally and laterally across the groove to produce a continuous light beam that stops intermittently for tissue temperature control, It becomes possible to spread the entire groove. The laser chip is cut out at a 45 degree angle between the first paths. The laser is cut away at an inverse 45 degree angle between the second path. This allows the laser beam to spread over the existing periodontal tissue, and the heat of the target laser light kills the bacteria so that the tissue can be purified. This also makes it possible to biostimulate the contents of the groove. At block 20, the dentist once again scales the groove area and root surface to induce a healing response through the restored blood flow. Proceeding to block 22, then at least one substrate, such as but not limited to matrix protein, is placed in the tooth groove prior to clot formation, and in block 24 the patient opens his mouth for 5 minutes. By gently helping, the clot is formed slowly, keeping the substrate intact. Optionally, the laser light is used to treat the wound. An IR wavelength region (700 nm to 1400 nm) is used with a laser output of 001 W to 5 W.

  Alternatively, the laser chip is a specially designed chip that distributes light energy across the wound groove. Thereby, the laser beam is spread over the existing tissue, and the bacteria are killed by the heat of the target laser light, so that the tissue can be purified. As a result, the block 20 is excluded and the process proceeds directly to the block 22.

  The LAPOR protocol is much less invasive than traditional surgery and provides advantages and benefits over its counterparts. Recovery time is much faster because most, if not all, healthy tissue damage is avoided through the use of this more advanced technique. Since the LAPOR protocol leaves healthy tissue intact, the gingival height itself increases around the teeth and is better retained. The LAPOR protocol prevents long mating epithelium from migrating down in the groove, thereby preserving tissue height and allowing periodontal tissue regeneration.

  Referring to FIGS. 17a-17f, shown are various angle images of a first embodiment of the device 100 for use in conjunction with the substrates and methods of the present invention. 18a and 18b show perspective views of the device 100 in the first embodiment. Specifically, FIG. 18 a shows a three-dimensional exploded view of the device 100 including a cord 101 integrally connected to the handle 109 and a handle 109 further connected to the heat sink 102. The housing 103 is firmly connected to the heat sink 102, thereby creating a cavity between the housing 103 and the heat sink 102. The laser 104 is disposed in a cavity between the housing 103 and the heat sink 102. A male connector 105 connects the RF source 108 to the housing 103, where a threaded insert 106 covers the connection therebetween. The cap 107 is disposed so as to cover the housing 103 and fixes the handle 109. FIG. 18c shows a detailed view of the heat sink 102, laser 104, housing 103, and male connector 105 in association with one another. In a preferred embodiment, the device 100 may have a plurality of RF sources 108, where a plurality is defined as at least two chips (ie, bipolar). For ease of use depending on the location of the wound undergoing treatment, the housing 103 can be moved so that the RF source 108 is adjusted 45 degrees up and down relative to the x-axis.

  The laser energy may have a wavelength in the green wavelength range (520-570 nm), red wavelength range (620-750 nm), or yellow wavelength range (570-590 nm) with a wattage of 0.001 W to 5 W. In a preferred embodiment, the laser energy is. It has a wattage of 001 W to 5 W. The wattage is in the region of 0.001W to 4W, more preferably in the region of 0.003 to 3W, and most preferably in the region of 0.005W to 2W. The RF energy may have an output of 10 watts or less. The carrier frequency may be in the range of 0.1 MHz to 20 MHz, while the non-sinusoidal waveform may be in the range of 0 to 40 KHz, or 0 to 24 GHz. In a preferred embodiment, the carrier frequency is in the region of 0.2 MHz to 10 MHz, preferably 0.3 MHz to 5 MHz. Optionally, RF energy in the 0.001 W to 10 W region, preferably in the 0.001 W to 3 W region, is utilized for the 40 Hz to 24 GHz Hertz region. In a further alternative embodiment, the RF wave is more than one sine wave, where the more than one sine wave exhibits a harmonic pattern. Optionally, a non-sinusoidal waveform may be in the region of the above parameters in the absence of a carrier wave.

  Referring to FIGS. 19a-19g, shown are various angle images of a second embodiment of the device 200 for use in conjunction with the substrates and methods of the present invention. FIG. 20a shows a perspective view of the device 200 of the second embodiment. Specifically, FIG. 20 a shows a three-dimensional exploded view of the device 200 including a handle 209 that further includes a wire grommet 201 and a heat sink 202 that are integrally connected to the handle 209. The housing 203 is firmly connected to the heat sink 202, thereby creating a cavity between the housing 203 and the heat sink 202. The laser 204 is disposed in a cavity between the housing 203 and the heat radiating plate 202. A male connector 205 connects the RF source 208 to the housing 203, where a threaded insert 206 covers the connection therebetween. FIG. 20b shows a detailed view of laser 204 and housing 203 in association with each other.

  Referring to FIGS. 21a-21c, shown is a third embodiment of a device 300 for use in conjunction with the substrates and methods of the present invention. FIG. 21a shows a perspective view of the device 300 of the second embodiment. Specifically, FIG. 21 b shows a three-dimensional exploded view of the device 300 including a housing 303 further including a wire grommet 301 and a heat sink 302 that are integrally connected to the housing 303. The housing 303 is firmly connected to the heat sink 302, thereby creating a cavity between the housing 303 and the heat sink 302. The laser 304 is disposed in a cavity between the housing 303 and the heat sink 302. A male connector 305 connects the RF source 308 to the housing 303, where a threaded insert 306 covers the connection therebetween. FIG. 21c shows a detailed view of laser 304 and housing 303 in association with each other. By way of example only, a device may have 5 or 6 chips.

  Referring to FIGS. 22a and 22b, shown is a fiber optic device 400 for use in conjunction with the substrates and methods of the present invention. The fiber optic device 400 includes a hand grip assembly 401 disposed between a first end and a second end. The first end further includes a protrusion insert 402 disposed between the hand grip assembly 401 and the removable protrusion assembly 404. A bent fiber tube 405 extends from the removable protrusion assembly 405. The second end further includes a base insert 406 located between the hand grip assembly 401 and the rubber covering 407. Extending from the rubber coating 407 is a sheathed fiber 408 having a SMA connector 409 at the opposite end of the rubber coating 407. FIG. 22c shows the fully assembled fiber optic device 400 further having a barrel for housing the laser source.

  First, a conditioning agent is applied to the root or bone surface. The tooth root adjuster includes the following in Table 1.

  The conditioning agent is optionally removed with a rinse prior to applying additional substrate or laser light. Alternatively, the conditioning agent is left on the root or bone surface during application of laser light prior to application of any substrate. In an alternative embodiment, the conditioning agent is left in with only one substrate applied before optionally applying the laser light. Optionally, the modifier is left in the groove and the substrate is added prior to the optional application of laser light.

  By arranging a substrate containing blood that emits cold light in the groove, blood that emits cold light can be coagulated on the substrate.

  Optionally, the liquid substrate or substrate 1 is composed of the following in Table 2 per liter of solution.

  Optionally, the total constituents of sterile water are adjusted up or down by 20% depending on the desired reached viscosity.

  In an alternative embodiment, the liquid substrate or substrate 1 consists of the following in Table 3.

  In an alternative embodiment, an additional substrate may be applied and the additional substrate, Substrate 2, is composed of tricalcium phosphate precipitated with calcium hydroxide / claw oil and hydroxyapatite crystals. Is done.

  In an alternative embodiment, an additional substrate may be applied, and the additional substrate, Substrate 3, is composed of the following in Table 4.

  Optionally, depending on the desired reached viscosity, the total components of sterile water are adjusted up or down by 20%.

  In an alternative embodiment, an additional substrate may be applied and the additional substrate, Substrate 4, consists of the following in Table 5:

  Metal may be increased by 50% for chronic wounds (see FIG. 40).

  Optionally, depending on the desired reached viscosity, the total components of sterile water are adjusted up or down by 20%.

  Substrates 1, 2 and 3 may have different delivery modes, such as dripping, spraying, injection or intravenous with the same ingredients, and sublingual, anal, foam, And ointment formulations, or drinkable liquids.

In an alternative embodiment, an additional substrate may be applied and the additional substrate, Substrate 5, consists of:
1. 1. Collagen, calcified and / or 2. Collagen that is not calcified and / or Collagen supplemented with porous tricalcium phosphate crystals of one size or various sizes: 4-50 μm, 50-150 μm, 100-300 μm, 500-1000 μm, 1-3 mm, and 3-6 mm thing. Tricalcium phosphate crystals may be dense or porous. Optionally, substrate 5 may be used in the absence of other substrates.

In an alternative embodiment, an additional substrate may be applied and the additional substrate, Substrate 6, consists of:
1. 1. Collagen, calcified and / or 2. Collagen that is not calcified and / or HCl and / or 4. 4. NaCl and / or 5. Cu, Ag, Fe, Au, Pt, or any combination thereof and / or Collagen supplemented with porous tricalcium phosphate crystals of one size or various sizes: 4-50 μm, 50-150 μm, 100-300 μm, 500-1000 μm, 1-3 mm, and 3-6 mm thing. Tricalcium phosphate crystals may be dense or porous. Optionally, substrate 6 may be used in the absence of other substrates.

  Additional substrates may be applied, the additional substrate being composed of the following: a mixture of tricalcium phosphate and hydroxyapatite crystals. Tricalcium phosphate is precipitated in a preferred embodiment using CaOH / Devil's claw oil. Optionally, the additional substrate comprises 50% tricalcium phosphate / devils claw oil precipitated with 50% porous hydroxyapatite crystals. The tricalcium phosphate crystals used are granules of the following sizes: 4-50 μm, 50-150 μm, 100-300 μm, 500-1000 μm, 1-3 mm, and 3-6 mm. Tricalcium phosphate crystals may be dense or porous.

  The additional substrate may be composed of granules of hydroxyapatite crystals, which have the following sizes: 10-50 μm, 50-150 μm, 100-300 μm, 500-1000 μm, 1-3 mm, and 3-6 mm Containing. Hydroxyapatite crystals may be dense or porous.

  In the following examples, a conditioning agent is applied and then rinsed off. Optionally, the conditioner is left in the groove so that the conditioner leaves micropores in the tooth structure open.

  After applying the conditioner, the groove is biostimulated using laser light. After this happens, a liquid substrate is applied. Optionally, additional substrate is applied. For non-oral cavities, the diluted substrate assists in the treatment when beneficial, although not required to be ingested or taken via IV.

  In an alternative embodiment, an optional spray substrate, Spray 1, may be applied, the spray being composed of the following: Au, Ag, Cu, Fe, Pt, and sterile water.

  In an alternative embodiment, an optional spray substrate, Spray 2, may be applied, the spray being: Cl, Na, K, Mg, phosphate, sulfate, bicarbonate, and Consists of sterile water.

  The fiber optic device of the present invention is the only device placed inside the groove for treatment. The grooves are also treated with a laser, RF, or a laser with RF. The remaining device embodiments disclosed may be used for wound treatment in conjunction with a substrate, depending on the wound site and the severity of the wound. Substrates disclosed herein may be in forms including, but not limited to, liquids, tablets, enemas, gels, injections, or foams.

Alternative RF and / or laser assisted wound tissue regeneration :
1. Perform scaling / root planing,
2. Etching the roots,
3. Rinse with saline,
4). Place the laser tip in the groove wound, turn on the laser for 5 seconds,
5. Step 4 is repeated circumferentially around the teeth in the longitudinal and transverse directions until the entire groove wound is saturated with laser energy,
6). Placing substrate 1 and / or 2, and / or 3, and / or 4, and / or 5 in a glass dappen dish;
7). Mixing a desired amount of substrate 1, and / or 2, and / or 3, and / or 4, and / or 5 in a dappen dish;
8). Place the desired mixture in the wound of the groove where bone / tissue loss has occurred,
9. Wait a few seconds,
10. Place more mixture in the wound of the groove where bone / tissue damage is occurring,
11. Wait a few seconds,
12 Repeat step 8 until all defects are filled
13. Wait one minute,
14 Handpiece with RF chip and / or LED chip and with or without laser is placed perpendicular to the wound, turned on and kept in place for 1 minute,
15. Wait 10 seconds,
16. Repeat RF step 14 until the entire wound is covered with RF energy, with or without a laser.

Alternative RF and / or laser assisted wound tissue repair:
1. Clean the wound with saline,
2. Placing substrate 1 and / or 3 on the wound;
3. Direct RF / laser, RF or laser energy to the wound for 1 minute,
4). Placing another layer of substrate 1, and / or 2, and / or 3, and / or 4, and / or 5, or any combination thereof on the wound;
5. Wait 10 seconds,
6). Repeat steps 2-5 until the wound bed is covered,
7). Alternatively, wait one week between steps 2-6 and gradually cover the wound bed.

  Oral, head / neck, tongue, anal, vaginal and deeper areas of treatment involve the substrate (apply substrate or drink with water), substrate, while they are being treated No RF, with substrate (apply substrate or drink with water) RF and laser add, RF without substrate add substrate and laser, and with substrate (apply substrate or with water It is carried out using a laser (drinking) and a laser without a substrate. The described procedure may be utilized throughout the gastrointestinal tract, head / neck, and anus. Treatment with a laser, RF or LED applied to the oral cavity and surrounding structures, the anal cavity and surrounding structures, the head and neck region and surrounding structures, benefits the deeper scope of those structures. Those deeper ranges of corresponding structures are therefore part of the treatment site. Surrounding structures include, but are not limited to, all bones, cartilage, muscles, tendons, nerves, blood vessels, epithelium, and fascia.

RF and / or laser assisted head and neck wound tissue repair:
1. Drink 4 ounces of diluted substrate 1,
2. Wait 15 minutes,
3. Drink 4 ounces of diluted substrate 3,
4. Wait 15 minutes,
5. Directing RF / laser, RF or laser energy to the wounded head and neck location and surrounding structures,
6). Keep the energy in place or move it over the desired range until the desired effect is achieved,
7). Moving to the next site until the desired result is achieved. Surrounding structures include, but are not limited to, all bones, cartilage, muscles, tendons, nerves, blood vessels, and epithelia.

  The head and neck includes, but is not limited to, the entire structure of the head and neck including the esophagus and surrounding structures; the tongue (the full range of the tongue, including but not limited to the anterior, posterior, dorsal, ventral) Mouth, including all structures inside the mouth, including but not limited to: arterial and neural beds, white line, buccal mucosa, buccal wings, lingual wings; The nose; the interior of the nose (including but not limited to the epithelial lining), all muscles and other structures around the tongue and tongue; all muscles and other structures around the eye and around the eye; All arterial beds, venous beds, and nerve beds are included. All muscles, nerves, veins, all glands and tissues of the head and neck, and any other structure of the head and neck.

RF and / or laser assisted vaginal wound repair:
1. Drink 4 ounces of diluted substrate 1,
2. Wait 15 minutes,
3. Drink 4 ounces of diluted substrate 2
4. Wait 15 minutes,
5. Directing RF / laser, RF or laser energy to the vagina and surrounding structures,
6. Keep energy in place for 10-20 minutes or until the desired effect is achieved,
7). Rotate the handpiece
8). Repeat steps 5-7 until the desired result is achieved.
Surrounding structures include, but are not limited to, all bones, cartilage, muscles, tendons, nerves, blood vessels, and epithelia.

RF and / or laser and / or LED assisted wound / tissue repair-external anal sphincter:
1. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5
2. Wait 15 minutes,
3. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5
4. Wait 15 minutes,
5. Directing RF / laser, RF or laser energy to the vagina and surrounding structures,
6. Keep energy in place for 10-20 minutes or until the desired effect is achieved,
7). Rotate the handpiece
8). Repeat steps 5-7 until the desired result is achieved.
Surrounding structures include, but are not limited to, all bone, cartilage, muscle, tendon, nerve, blood vessel, and epithelium, and any other anal cavity structure.

RF and / or laser assisted wound / tissue repair-breast:
1. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5
2. Wait 15 minutes,
3. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5
4. Wait 15 minutes,
5. Directing RF / laser, RF or laser energy to the breast and breast-related structures,
6. Keep energy in place for 10-20 minutes or until the desired effect is achieved,
7). Rotate the handpiece
8). Repeat steps 5-7 until the desired result is achieved.
Related structures include, but are not limited to, all bone, cartilage, muscle, tendon, nerve, blood vessel, lymph node, and epithelium.

RF and / or laser assisted wound / tissue repair-tongue and its supporting structure in the swallowing mechanism:
1. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5
2. Wait 15 minutes,
3. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5
4. Wait 15 minutes,
5. Directing RF / laser, RF or laser energy to the tongue and surrounding structures,
6. Keep energy in place for 10-20 minutes or until the desired effect is achieved,
7). Rotate the handpiece
8). Repeat steps 5-7 until the desired result is achieved.
Surrounding structures include, but are not limited to, all bones, cartilage, muscles, tendons, nerves, blood vessels, and epithelia.

RF and / or laser assisted wound regeneration:
1. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5, and / or 6
2. Wait 15 minutes,
3. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5, and / or 6
4. Wait 15 minutes,
5. Directing RF / laser, RF or laser energy to the wound and surrounding structures,
6). Applying diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5, and / or 6;
7). Directing RF / laser, RF or laser energy to the wound and surrounding structures,
8. Keep energy in place for 10-20 minutes or until the desired effect is achieved,
9. If necessary, rotate the energy source,
10. Repeat steps 5-9 until the desired result is achieved.
11. Alternatively, wait one week between steps 5-9 and gradually cover the wound bed.
Surrounding structures include, but are not limited to, all bones, cartilage, muscles, tendons, nerves, blood vessels, and epithelia.

RF and / or laser assisted hole repair:
1. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5
2. Wait 15 minutes,
3. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5
4. Wait 15 minutes,
5. Directing RF / laser, RF or laser energy to the holes and surrounding structures,
6. Keep energy in place for 10-20 minutes or until the desired effect is achieved,
7). Rotate the handpiece
8). Repeat steps 5-7 until the desired result is achieved.
Surrounding structures include, but are not limited to, all bones, cartilage, muscles, tendons, nerves, blood vessels, and epithelia.

RF and / or laser and / or LED assisted oral wound repair:
1. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5, and / or 6
2. Wait 15 minutes,
3. 4 ounces of diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5, and / or 6
4. Wait 15 minutes,
5. Directing RF / laser, RF or laser energy to the oral cavity and surrounding structures,
6). Applying diluted substrate 1, and / or 2, and / or 3, and / or 4, and / or 5, and / or 6;
7). Directing RF / laser, RF or laser energy to the wound and surrounding structures,
8. Keep energy in place for 10-20 minutes or until the desired effect is achieved,
9. Rotate the energy source,
8). Repeat steps 5-9 until the desired result is achieved.
Surrounding structures include, but are not limited to, all bones, cartilage, muscles, tendons, nerves, blood vessels, and epithelia.

  In addition, wound treatment may be utilized for additional conditions, including but not limited to vaginal wound repair, breast wound repair / regeneration / generation, anal Wound repair, age-related stain repair, pore repair, skin and tissue repair, and systemic wound repair.

  Referring to FIGS. 33a-33e, shown is a fourth embodiment of a device 500 for use in conjunction with the substrates and methods of the present invention. FIG. 33a shows a top view of the device 500 of the fourth embodiment. FIG. 33 b shows a side view and FIG. 33 c shows a close-up of the chip of device 500. In particular, FIG. 33d shows a three-dimensional exploded view of the device 500 including a housing 503, a chip 505, and an energy source 507. The energy source 507 provides RF energy to the housing 503 when connected. FIG. 33e shows a side perspective view of the assembled device 500. FIG. Optionally, device 500 may be used in the absence of a substrate.

  With reference to FIGS. 34a-34f, shown is a fifth embodiment of a device 600 for use in conjunction with the substrates and methods of the present invention. 34d and 34f show side perspective views of the device 600. FIG. FIG. 34a shows a side view of device 600, where device 600 has a hemispherical shape and further includes a flat surface opposite the hemispherical surface. The flat surface further includes a plurality of mini lasers 605 for delivering diode laser energy for the treatment of acute wounds. The mini laser 605 is built in the device 600. In a preferred embodiment, the laser power used for the procedure may be approximately 6-24 mW.

  With reference to FIGS. 35a-35f, it is shown that an output device 700 for an optical fiber has a piece for use with the substrates and methods of the present invention. FIG. 35 a shows the components of the pocket output device 700, which further includes a base 701, a battery base 702, a rechargeable battery 703, a handle for the fiber optic laser 704, and an upper portion 705. . FIGS. 35b-35f show various views of the pocket output device 700. The handle 704 is a self-contained unit with a fiber optic line 706 attached to which a fiber optic laser head (not shown) is connected. ing. In addition, a diode laser module is housed in the pocket output device 700.

  Referring to FIGS. 36a-36f, shown is a portable RF transmitter 800 for use in conjunction with the substrates and methods of the present invention. 36e and 36f show side perspective views of the RF transmitter 800. FIG. 36a shows a top view, FIG. 36b shows a front view, FIG. 36c shows a bottom view, and FIG. 36d shows a left side view. Optionally, the RF transmitter 800 may be used in the absence of a substrate.

  Referring to FIGS. 37a-37b, shown is an alternative embodiment of a replaceable fiber optic chip for use in a laser for use in conjunction with the substrates and methods of the present invention. FIG. 37a shows a replaceable fiber optic chip for a laser having a protruding piece 900 and a flat tip 901. FIG. FIG. 37b shows a replaceable fiber optic chip for a laser having a protruding piece 900 and a glass dispersion tip 902. FIG.

I. Analysis of Teeth # 15 at 12 Specific Sites The depth of the pocket at the patient's tooth 15 was measured at 12 separate locations. The root was then scaled and planed to remove tartar stuck to the root surface. After scaling and planing, bleeding occurs in the groove. The groove was allowed to air dry, and then the conditioner was immediately applied to the groove and allowed to stand for 30 seconds before rinsing with saline. The teeth were then rescaled and planed to restore blood flow. A 45 ° laser chip was placed in the groove while blood was stored in the groove. The used laser light has a wavelength between 400 nm and 700 nm, which is a wavelength in the visible region of the electromagnetic spectrum. The laser was fired continuously, only intermittently, to control tissue temperature. The laser was spread throughout the groove by moving the tip in the longitudinal and lateral directions across the groove for 30 seconds. In order to allow the laser beans to spread over the existing periodontal tissue to cleanse and biostimulate the contents of the groove, the laser chip is 45 ° at the opposite angle with respect to the second path in the groove. On the third road, it was cut out at 90 °.

  Meanwhile, the first substrate and the second substrate were mixed in a glass dish. Some blood from the patient being treated in the groove using laser light was also mixed into the glass dish. The mixture was then placed in the groove immediately after mixing. Enough mixture was placed in the groove to fill the groove while ensuring that the mixture remained 3 mm below the top of the gingival margin and remained immersed in the blood. The patient's mouth is kept open for 5 minutes to ensure a new clot containing the intact substrate mixture is formed.

  The treatment was repeated four times thereafter on the teeth 15, with the pocket depth at each location being measured before the treatment. The measured values are shown in FIG. The data shows that the calcium density has increased at specific locations.

II. Analysis of Teeth # 12 at 17 Specific Sites The depth of the pocket at the patient's tooth 28 was measured at 17 separate locations. The treatment disclosed in the present specification was performed five times thereafter, and the depth of the pocket at each point was measured before the treatment. The measured values are shown in FIG. The data shows that the calcium density increased across all points.

III. Analysis of teeth # 2, # 3, and # 15 at three unique locations per tooth Measure the depth of the pockets on the patient's teeth 2, 3, and 15 at three separate locations per tooth did. The treatment disclosed herein was performed 3 months after the first treatment, with the pocket depth at each location being measured before the treatment. The measured values are shown in FIG. The data shows that bone regeneration has progressed.

IV. Analysis of jaw profile The patient's jaw profile was measured. After the first measurement, the treatment disclosed herein was performed once and the measurement was repeated after the treatment. The measured values are shown in FIG. The data shows that the jaw profile has increased overall after a single treatment.

V. Toe Wrinkle Analysis The patient's toe wrinkle length was measured. The treatment disclosed herein was performed after obtaining the first measurement, and the measurement was repeated after the treatment. The measured values are shown in FIG. The data shows an overall 71% reduction in wrinkle size after treatment.

VI. Analysis of gingival wound tissue The patient's gingival wound was measured from the gingival line to the gingival crest. The treatment disclosed herein was performed and measurements were repeated after treatment. Images of gingival wounds are shown in FIGS. 26a and 26b before and after treatment. The measured values are shown in FIG. The data shows that after a single treatment the wound was reduced by more than 50%.

VII. Analysis of hand wrinkles The length of the patient's hand wrinkles was measured. The treatment disclosed herein was performed after the first measurement and the measurement was repeated after the treatment. The measured values are shown in FIG. The data shows that the wrinkle length has decreased overall after treatment.

VIII. Analysis of new skin growth The patient's skin leg wound was measured. The treatment disclosed herein was performed after the first measurement and the measurement was repeated after the treatment. The measured values are shown in FIG. The data show that overall new skin growth increased after treatment. In a preferred embodiment, a chronic wound of the limb may be treated using a three-sided LED system. Here, the treatment unit is placed around the limb on three sides and applies LED energy to a larger surface area. LED systems use energy sources of less than 60 mW.

IX. Anal scar reduction analysis The patient's anal scar tissue was measured. The treatment disclosed herein was performed after the first measurement and the measurement was repeated after the treatment. The measured values are shown in FIGS. The data shows that both length and width of scar tissue were reduced after treatment.

X. Analysis of tongue strength Tongue strength and swallowing were evaluated for three patients. After the initial assessment, the treatment disclosed herein was performed and tongue strength and swallowing were again assessed after the treatment. The measured values are shown in FIG. The data shows that each patient experienced an increase in tongue strength after treatment.

XI. Breast stiffness analysis Breast stiffness was recorded for two patients. After the initial assessment, the treatment disclosed herein was performed and breast stiffness was assessed again after the treatment. Comparison of hardness is shown in FIG. The data show that patients experienced an increase in hardness of 75% and 66.7%, respectively, after treatment.

XII. Analysis of epithelial wound regeneration The regeneration of epithelial wounds in patients was evaluated. After the initial wound measurement, the treatment disclosed herein was performed and the wound size was measured again after the treatment. A comparison of measured values is shown in FIG. Epithelial regeneration was found to increase to 170% one day after treatment.

XIII. Analysis of radial tendon wound regeneration The patient's radial tendon wound regeneration was evaluated. A comparison of measurements obtained after performing the treatment disclosed herein after the initial wound measurement and again measuring the wound size after the treatment is shown in FIG. Tendon arch size increased 4-fold from the first measurement to the third and last measurement.

XIII. Analysis of ankle epithelial wound regeneration The patient's ankle epithelial wound regeneration was assessed. After the initial wound measurement, the treatment disclosed herein was performed and the wound size was measured again after the treatment. A comparison of the measurements for the two treatment ranges is shown in FIG. Epithelial regeneration was found to increase in area to 264% 5 months after treatment.

XIV. Analysis of decrease in ankle wound size The decrease in ankle epithelial wound size in patients was evaluated. After the initial wound measurement, the treatment disclosed herein was performed and the wound size was measured again after the treatment. A comparison of measured values for the two treatment ranges is shown in FIG. The epithelial wound size was found to decrease in area to 72% 5 months after treatment.

XV. Analysis of Oral Wound Regeneration The patient's oral epithelial wound regeneration was evaluated. After the initial wound measurement, the treatment disclosed herein was performed and the wound size was measured again after the treatment. A comparison of the measured values is shown in FIG. The size of epithelial regeneration increased by 1.34 cm ² from the first measurement to the fourth and last measurement.

XVI. Analysis of venous wound regeneration The venous wound regeneration of patients was evaluated. After the initial wound measurement, the treatment disclosed herein was performed and the wound size was measured again after the treatment. A comparison of the measured values is shown in FIG. 43a. The size of epithelial regeneration increased by 2.9 cm ² from the first measurement to the last measurement. The procedure was performed using a flashlight infrared laser as shown in FIG. 43b. Here, the LED beam is a concentrated flat light beam applied to the skin and veins. This flashlight laser is a self-contained, modular laser that allows the skin around the wound to be handled successfully during the procedure. Alternatively, an LED panel may be used.

  One embodiment of the present invention provides a device for treating a wound according to the methods described herein, the device comprising a green wavelength range (520-570 nm), a red wavelength range (620-750 nm), Or a laser having a wavelength in the yellow wavelength range (570 to 590 nm), a light beam is emitted, and the wavelength is 0.001 W to 5 W, preferably 0.002 W to 4 W, more preferably 0.003 W to 3 W, most preferably It has an alternative wattage of 0.005W to 2W. Optionally, the laser light is. The wound is treated using the IR wavelength range (700 nm to 1400 nm) with a laser power of 001 W to 5 W. Optionally, the LED light utilizes the IR wavelength range to treat the wound.

  Another embodiment of the present invention provides a device for treating a wound according to the methods described herein, the device comprising a carrier frequency in the range of 0.1 MHz to 20 MHz, and a range of 0 to 40 KHz. Emits up to 10 W of RF beam including a non-sinusoidal waveform. In a preferred embodiment, the carrier frequency is in the region of 0.2 MHz to 10 MHz, preferably 0.3 MHz to 5 MHz. Optionally, RF energy in the range of 0.001 W to 10 W, preferably in the range of 0.001 W to 3 W, is utilized in the hertz range of 40 Hz to 24 GHz. In a further alternative embodiment, the RF wave is more than one sine wave, where the more than one indicates a harmonic pattern. Optionally, the non-sinusoidal waveform may be in the region of the above parameters in the absence of a carrier wave.

  Yet another embodiment of the invention provides a device for the treatment of a wound according to the methods described herein, wherein the device emits a laser beam, an RF beam, or a combination thereof.

  Yet another embodiment of the present invention provides a device for treatment of a wound in the oral cavity according to the methods described herein, which emits a fiber optic laser beam. In a preferred embodiment, the fiber optic device may be used in conjunction with lasers and RF devices to treat entire and oral wounds. Optionally, the device emits LED light.

  While applied to the preferred embodiment, the fundamental novel features of the invention have been shown, described and pointed out, while the foregoing is considered as illustrative only of the principles of the invention and is exhaustive. It will be understood that it is not intended to be limiting or to limit the invention to the precise form disclosed.

Obvious modifications and variations are possible in view of the above teachings. The discussed embodiments have been chosen and described to provide the best illustration of the principles of the invention and its practical application so that those skilled in the art will find the invention suitable for the specific use envisioned. It can be used in various embodiments and with various modifications. All such modifications and variations are within the scope of the invention as defined by the following claims, when interpreted according to the entitled scope of the appended claims.

Claims (19)

(A) providing an instrument including a handpiece and further including at least one aperture through which the diode laser is disposed, the diode laser having a wavelength from about 400 nm to about 700 nm; Generating a light beam, the light beam exiting the instrument through the at least one aperture;
(B) providing a power source for manipulating the instrument; and (c) placing the at least one opening from the handpiece of the instrument directly or proximate to tissue damage of an individual. Treating tissue damage in the form of a wound.   The method of claim 1, wherein the light beam has a wavelength from about 520 nm to about 570 nm, and the power source delivers an output with a width of about 0.5 W to about 1.2 W to the instrument.   The method of claim 2, wherein the damaged tissue is gingival tissue.   The light beam has a wavelength selected from the group consisting of about 520 nm to about 570 nm, such as about 620 nm to about 750 nm, and about 570 nm to about 590 nm, and the power source is about. The method of claim 1, wherein an output with a width from 0001 W to about 5 W is transmitted to the instrument.   The power source is approximately. From 002W to about 4W, about. 003W to about 3W, and about. 5. The method of claim 4, wherein an output of a width selected from the group consisting of 005W to about 2W is transmitted to the instrument. A system for use in repairing soft tissue damage after an acute or chronic individual injury,
(A) providing an instrument comprising a handpiece having at least one aperture through which a light source emits through the light beam, the instrument further being connected to a power source;
(B) providing at least one substrate, the substrate being capable of inducing a biostimulation response when applied to the soft tissue injury;
(C) applying the handpiece directly or proximate to the soft tissue injury;
(D) moving the handpiece longitudinally and laterally across the soft tissue, and (e) applying the at least one substrate directly onto the soft tissue injury.   7. The system of claim 6, wherein the soft tissue damage from the acute or chronic injury is located on the skin surface of the individual.   The system of claim 6, wherein the soft tissue damage from the acute or chronic injury is located directly below the skin surface of the individual.   The system of claim 6, wherein the light source is selected from the group consisting of a diode laser or a light emitting diode (LED).   The system of claim 9, wherein the power source transmits an output of 10 W or less to the LED light, and the light beam of the LED has a wavelength from about 700 nm to about 1400 nm. (A) providing an instrument comprising a handpiece having at least one aperture through which radio frequency (RF) waves are transmitted;
(B) providing a power source for operating the instrument;
(C) for use in purifying and healing soft tissue comprising placing the at least one opening from the handpiece of the instrument directly or in close proximity to an individual's soft tissue damage System.   The system of claim 11, wherein the power source uses 10 W or less to output to the instrument.   The system of claim 11, wherein a carrier is used in conjunction with the RF wave.   14. The system of claim 13, wherein the carrier is a sine wave and transfers a non-sinusoidal waveform to the soft tissue of an individual.   The system of claim 14, wherein the carrier frequency is from about 0.1 MHz to about 20 MHz and the non-sinusoidal waveform frequency is from about 0 KHz to about 40 KHz to about 24 GHz.   The system of claim 11, wherein the RF wave is a single sine wave.   The system of claim 11, wherein the RF wave is more than one sine wave, and wherein the more than one sine wave is transmitted in a harmonic pattern. (A) an effective amount of tricalcium phosphate,
(B) at least one of calcified collagen and non-calcified collagen,
(C) A substrate for use in treating soft tissue injury comprising an effective amount of HCl or NaCl and at least one metal. The substrate of claim 18, wherein the at least one metal is selected from the group consisting of copper, gold, silver, iron, and platinum, or any combination thereof.

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