JP2020528082A5 - - Google Patents
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- JP2020528082A5 JP2020528082A5 JP2020524719A JP2020524719A JP2020528082A5 JP 2020528082 A5 JP2020528082 A5 JP 2020528082A5 JP 2020524719 A JP2020524719 A JP 2020524719A JP 2020524719 A JP2020524719 A JP 2020524719A JP 2020528082 A5 JP2020528082 A5 JP 2020528082A5
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- JP
- Japan
- Prior art keywords
- seq
- cpp
- sequence listing
- therapeutic agent
- rpe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 C*(C*(C)NC(N)=N)C(CC(C)=O)NC Chemical compound C*(C*(C)NC(N)=N)C(CC(C)=O)NC 0.000 description 5
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762533231P | 2017-07-17 | 2017-07-17 | |
| US62/533,231 | 2017-07-17 | ||
| PCT/US2018/042410 WO2019018350A1 (en) | 2017-07-17 | 2018-07-17 | TOPICAL ADMINISTRATION OF THERAPEUTIC AGENTS COMPRISING CELL PENETRATION PEPTIDES, FOR USE IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND OTHER OCULAR DISEASES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020528082A JP2020528082A (ja) | 2020-09-17 |
| JP2020528082A5 true JP2020528082A5 (2) | 2021-10-21 |
Family
ID=63104068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524719A Pending JP2020528082A (ja) | 2017-07-17 | 2018-07-17 | 加齢黄斑変性と他の眼疾患の治療用の細胞透過性ペプチドを使用する治療薬の局所送達 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10905770B2 (2) |
| EP (1) | EP3654941A1 (2) |
| JP (1) | JP2020528082A (2) |
| CN (1) | CN112996486A (2) |
| AU (1) | AU2018302022A1 (2) |
| CA (1) | CA3070241A1 (2) |
| IL (1) | IL272105A (2) |
| WO (1) | WO2019018350A1 (2) |
Families Citing this family (56)
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| WO2019195136A1 (en) | 2018-04-03 | 2019-10-10 | Ngm Biopharmaceuticals, Inc. | C3-binding agents and methods of use thereof |
| TW202009013A (zh) * | 2018-08-14 | 2020-03-01 | 優你康光學股份有限公司 | 具有功能性成分的隱形眼鏡及其產品 |
| GB201900728D0 (en) * | 2019-01-18 | 2019-03-06 | Univ Birmingham | Drug delivery system |
| US12115212B2 (en) * | 2019-01-18 | 2024-10-15 | L & J Bio Co., Ltd. | Methods of decreasing amyloid beta (Aβ) plaque deposition and hyperphosphorylated tau plaque deposition in Alzheimer's disease using a cystatin C fusion protein |
| EP3934675A2 (en) * | 2019-03-08 | 2022-01-12 | RA Pharmaceuticals, Inc. | Zilucoplan as deep tissue penetrating c5 inhibitor |
| JP7668227B2 (ja) * | 2019-04-08 | 2025-04-24 | バイオクライスト ファーマシューティカルズ， インコーポレイテッド | 血漿カリクレイン阻害剤および眼障害におけるその使用方法 |
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| WO2021087399A1 (en) * | 2019-10-30 | 2021-05-06 | Perfuse Therapeutics, Inc. | Treatment of ocular diseases using endothelin receptor antagonists |
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| CN115103842A (zh) | 2020-02-06 | 2022-09-23 | 珀弗斯治疗股份有限公司 | 用于治疗眼部疾病的组合物 |
| WO2021173999A1 (en) * | 2020-02-28 | 2021-09-02 | Northwestern University | Method of enhancing aqueous humor outflow and reducing intraocular pressure |
| US20230173024A1 (en) * | 2020-04-01 | 2023-06-08 | The Trustees Of The University Of Pennsylvania | Factor b inhibitors and uses thereof |
| US11754753B2 (en) * | 2020-04-27 | 2023-09-12 | Coopervision International Limited | Antioxidant contact lens |
| FR3111913A1 (fr) * | 2020-06-30 | 2021-12-31 | Eyevensys | Construction d’adn pour le traitement de pathologies oculaires |
| CN111671922B (zh) * | 2020-07-23 | 2023-03-21 | 四川大学华西医院 | 两亲性梳形嵌段接枝共聚物基超声造影剂及其制备方法 |
| CN114073774A (zh) * | 2020-08-17 | 2022-02-22 | 奥朗生物医药有限公司 | 药物和野生型穿膜肽衍生物的组合物 |
| CA3191819A1 (en) | 2020-09-09 | 2022-03-17 | Hazel Szeto | Methods and compositions for delivery of biotin to mitochondria |
| KR102556731B1 (ko) * | 2020-09-29 | 2023-07-21 | 주식회사 젠센 | 단백질 수송 도메인, 이를 포함하는 융합 화합물 및 이 융합 화합물을 포함하는 약학 조성물 |
| MX2023003877A (es) * | 2020-10-01 | 2023-04-18 | Abionyx Pharma Sa | Composiciones que comprenden complejos basados en proteina de union a lipidos para usarse en el tratamiento de enfermedades oculares. |
| MX2023004631A (es) * | 2020-10-22 | 2023-07-20 | Xequel Bio Inc | Formulaciones peptidicas y usos oftalmicos de las mismas. |
| US20230399378A1 (en) * | 2020-10-28 | 2023-12-14 | The Florey Institute Of Neuroscience And Mental Health | Peptide-based delivery of agents |
| CN114790225B (zh) * | 2021-01-26 | 2024-09-10 | 清华大学 | 一种新型内体逃逸肽及其应用 |
| US20220287968A1 (en) * | 2021-03-09 | 2022-09-15 | Florida State University Research Foundation, Inc. | Lipid vesicle-mediated delivery to cells |
| CN113057142B (zh) * | 2021-03-30 | 2022-12-09 | 四川大学华西医院 | 一种视网膜内和/或视网膜下纤维化动物模型的构建方法 |
| WO2022216785A1 (en) * | 2021-04-06 | 2022-10-13 | University Of South Florida | Peptide-small interfering rna-hyaluronic acid nanoparticles and methods of use thereof |
| AU2022264438A1 (en) * | 2021-04-30 | 2023-11-23 | Perfuse Therapeutics, Inc. | Treatment of ocular diseases using endothelin receptor antagonists |
| CA3218251A1 (en) * | 2021-04-30 | 2022-11-03 | Perfuse Therapeutics, Inc. | Pharmaceutical compositions and intravitreal drug delivery systems for the treatment of ocular diseases |
| CN113332450B (zh) * | 2021-05-11 | 2023-08-04 | 铜仁学院 | 一种眼部给药递释系统氧化锌纳米粒的制备方法及其使用方法和应用 |
| CA3220626A1 (en) * | 2021-05-28 | 2022-12-01 | Aleksandar SKUBAN | Use of complement factor d inhibitor for treatment of geographic atrophy secondary to age-related macular degeneration |
| CN113476587B (zh) * | 2021-07-19 | 2022-07-12 | 河南大学 | 一种脑靶向的神经保护剂ss31-ha-rt及其制备方法和应用 |
| CN113925966B (zh) * | 2021-09-17 | 2022-10-04 | 西安电子科技大学 | 快速响应型细胞核靶向纳米诊疗探针的制备方法 |
| CN114404429B (zh) * | 2021-11-30 | 2023-06-30 | 重庆医科大学附属第二医院 | 一种纳米银修饰的单宁酸-铁网络的载药纳米复合物及其制备方法和逆转肿瘤耐药应用 |
| KR102795182B1 (ko) * | 2022-02-18 | 2025-04-15 | (주)메디톡스 | 탈모 치료 또는 발모 촉진 활성을 갖는 폴리펩티드 및 그의 용도 |
| US20230310380A1 (en) * | 2022-04-05 | 2023-10-05 | Alan Neil Glazier | Methods, devices, and systems for treating lens protein aggregation diseases |
| AU2023250345A1 (en) | 2022-04-06 | 2024-11-14 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| CN116444678B (zh) * | 2022-10-18 | 2024-02-02 | 百葵锐(深圳)生物科技有限公司 | 一种具有真菌抗菌抑菌性能的新型多肽 |
| WO2024102746A1 (en) * | 2022-11-08 | 2024-05-16 | Microcures, Inc. | Methods and agents for treating neurotrophic keratitis |
| WO2024156871A1 (en) * | 2023-01-27 | 2024-08-02 | Glasspearl Oü | Mixtures of lipid nanoparticles and cell penetrating peptides |
| WO2024160819A1 (en) | 2023-01-30 | 2024-08-08 | Consorcio Centro De Investigación Biomédica En Red | Nanoparticles with antibodies for ocular treatment |
| WO2024178368A2 (en) * | 2023-02-23 | 2024-08-29 | Ohio State Innovation Foundation | Therapeutic protein combinations |
| CN116270974B (zh) * | 2023-03-09 | 2024-03-12 | 湖南大学 | 一种组合物、阿柏西普递送系统和制备方法 |
| TWI877652B (zh) * | 2023-06-14 | 2025-03-21 | 長庚大學 | 眼用藥物遞送載體及其應用 |
| WO2025093129A1 (en) * | 2023-11-01 | 2025-05-08 | Newamsterdam Pharma B.V. | Treatment and prevention of age-related macular degeneration using a cetp inhibitor |
| WO2025093436A1 (en) * | 2023-11-01 | 2025-05-08 | Newamsterdam Pharma B.V. | Treatment and prevention of age-related macular degeneration using a cetp inhibitor |
| WO2025117721A1 (en) * | 2023-11-27 | 2025-06-05 | Massachusetts Institute Of Technology | Reconstituted lipoprotein particles to rescue lipid defects in the alzheimer's brain |
| WO2025128821A1 (en) * | 2023-12-12 | 2025-06-19 | Juvena Therapeutics, Inc. | Compositions and methods for adp-ribosylation factor molecular trafficking |
| WO2025147589A1 (en) * | 2024-01-05 | 2025-07-10 | Osanni Bio, Inc. | Implants, compositions, and methods for treating retinal diseases and disorders |
| WO2025212745A1 (en) * | 2024-04-04 | 2025-10-09 | University Of Massachusetts | Engineered adeno-associated virus (aav) capsid protein and uses thereof |
| CN118290598B (zh) * | 2024-05-29 | 2024-09-27 | 深圳柏垠生物科技有限公司 | 重组纤连蛋白及其制备方法和应用 |
| WO2026033482A1 (en) * | 2024-08-08 | 2026-02-12 | Universita' Degli Studi Di Torino | Therapeutic contact lenses loaded with mucin-based nanoparticles |
| WO2025218146A1 (zh) * | 2024-08-09 | 2025-10-23 | 山西医科大学 | 一种抑制眼部病理性血管新生的滴眼剂及其制备方法 |
| CN118995345B (zh) * | 2024-08-09 | 2025-09-26 | 山西医科大学 | 一种抑制角膜缺氧损伤和角膜新生血管的隐形眼镜护理液及其制备方法 |
| WO2026034435A1 (ja) * | 2024-08-09 | 2026-02-12 | 東亞合成株式会社 | ペプチドフラグメント及びその利用 |
| CN119746027A (zh) * | 2025-01-10 | 2025-04-04 | 山东济肽生物科技有限公司 | 多肽组合物的应用及治疗衰老相关皮肤病的组合物 |
| CN119792574B (zh) * | 2025-01-10 | 2025-12-19 | 宁夏医科大学 | 一种仿生plga复合纳米材料及其制备方法与应用 |
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|---|---|---|---|---|
| DE19548114C2 (de) | 1995-12-21 | 2000-04-27 | Deutsches Krebsforsch | Konjugat, umfassend einen Wirkstoff, ein Polypeptid und einen Polyether |
| IL132941A0 (en) | 1997-05-21 | 2001-03-19 | Univ Leland Stanford Junior | Composition and method for enhancing transport across biological membranes |
| US7229961B2 (en) | 1999-08-24 | 2007-06-12 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into ocular tissues |
| ATE283013T1 (de) | 1999-10-21 | 2004-12-15 | Alcon Inc | Medikamentenzuführvorrichtung |
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| US6589948B1 (en) | 2000-11-28 | 2003-07-08 | Eukarion, Inc. | Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases |
| US7470659B2 (en) * | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
| SE0201863D0 (en) | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
| US20070269379A1 (en) | 2003-07-23 | 2007-11-22 | Samir Mitragotri | Penetration Enhancer Combinations for Transdermal Delivery |
| EP2279177A1 (en) | 2008-04-22 | 2011-02-02 | Merck Frosst Canada Ltd. | Novel substituted heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| US10272035B2 (en) * | 2008-11-13 | 2019-04-30 | Gholam A. Peyman | Ophthalmic drug delivery method |
| US20170157038A1 (en) * | 2008-11-13 | 2017-06-08 | Gholam A. Peyman | Ophthalmic drug delivery method |
| US8691580B2 (en) | 2010-04-09 | 2014-04-08 | Merck Sharp & Dohme Corp. | Single chemical entities and methods for delivery of oligonucleotides |
| EP2588127A4 (en) | 2010-06-24 | 2014-06-11 | Univ Indiana Res & Tech Corp | DIPEPTIDE-NETWORKED MEDICAL ACTIVE SUBSTANCES |
| MX2014004953A (es) | 2011-11-03 | 2014-05-28 | Bayer Ip Gmbh | Ligadores basados en tirosina para la conexion desprendible de peptidos. |
| US20140357563A1 (en) | 2011-12-09 | 2014-12-04 | The Children's Hospital Of Philadelphia | Compositions and Methods for the Generation of Activated Protein C and Methods of Use Thereof |
| EP2916827B1 (en) * | 2012-11-08 | 2020-06-10 | Clearside Biomedical Inc. | Methods for the treatment of ocular disease in human subjects |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| GB201401453D0 (en) | 2014-01-28 | 2014-03-12 | Univ Birmingham | Transmucosal and transepithelial drug delivery system |
| GB201403268D0 (en) | 2014-02-25 | 2014-04-09 | Univ Birmingham | Antimicrobial surface |
| CN117180445A (zh) | 2014-05-28 | 2023-12-08 | 梅德瑞斯糖尿病有限责任公司 | 针对胰岛素抵抗的改良肽药物 |
| CA3001661C (en) * | 2015-10-14 | 2025-05-06 | Massachusetts Eye And Ear Infirmary | HIGH-DOSE STATINS FOR AGE-RELATED MACULAR DEGENERATION |
| CN106668860B (zh) * | 2015-11-09 | 2019-11-22 | 烟台大学 | 靶向眼后段的递药系统及其制剂和制备方法 |
| WO2018161035A1 (en) * | 2017-03-03 | 2018-09-07 | Macregen, Inc. | Treatment of age-related macular degeneration and other eye diseases with one or more therapeutic agents |
-
2018
- 2018-07-17 EP EP18749975.1A patent/EP3654941A1/en not_active Withdrawn
- 2018-07-17 US US16/037,432 patent/US10905770B2/en not_active Expired - Fee Related
- 2018-07-17 CA CA3070241A patent/CA3070241A1/en not_active Abandoned
- 2018-07-17 JP JP2020524719A patent/JP2020528082A/ja active Pending
- 2018-07-17 AU AU2018302022A patent/AU2018302022A1/en not_active Abandoned
- 2018-07-17 CN CN201880059888.2A patent/CN112996486A/zh active Pending
- 2018-07-17 WO PCT/US2018/042410 patent/WO2019018350A1/en not_active Ceased
-
2020
- 2020-01-16 IL IL272105A patent/IL272105A/en unknown
- 2020-12-04 US US17/112,339 patent/US20210085797A1/en not_active Abandoned
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