JP2021515565A5 - - Google Patents

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Publication number
JP2021515565A5
JP2021515565A5 JP2020547331A JP2020547331A JP2021515565A5 JP 2021515565 A5 JP2021515565 A5 JP 2021515565A5 JP 2020547331 A JP2020547331 A JP 2020547331A JP 2020547331 A JP2020547331 A JP 2020547331A JP 2021515565 A5 JP2021515565 A5 JP 2021515565A5
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JP
Japan
Prior art keywords
antibody
antigen
binding fragment
seq
amino acid
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JP2020547331A
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English (en)
Japanese (ja)
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JP7563979B2 (ja
JP2021515565A (ja
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Priority claimed from GBGB1804028.7A external-priority patent/GB201804028D0/en
Priority claimed from GBGB1804029.5A external-priority patent/GB201804029D0/en
Priority claimed from GBGB1804027.9A external-priority patent/GB201804027D0/en
Priority claimed from PCT/EP2018/056312 external-priority patent/WO2018167104A1/en
Application filed filed Critical
Priority claimed from PCT/EP2019/056252 external-priority patent/WO2019175220A1/en
Publication of JP2021515565A publication Critical patent/JP2021515565A/ja
Publication of JP2021515565A5 publication Critical patent/JP2021515565A5/ja
Application granted granted Critical
Publication of JP7563979B2 publication Critical patent/JP7563979B2/ja
Active legal-status Critical Current
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JP2020547331A 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25 Active JP7563979B2 (ja)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US201862642218P 2018-03-13 2018-03-13
US201862642248P 2018-03-13 2018-03-13
US201862642232P 2018-03-13 2018-03-13
US201862642230P 2018-03-13 2018-03-13
US201862642243P 2018-03-13 2018-03-13
US62/642,248 2018-03-13
GBGB1804028.7A GB201804028D0 (en) 2018-03-13 2018-03-13 Anti-CD25 antibody agents
US62/642,243 2018-03-13
GBGB1804029.5A GB201804029D0 (en) 2018-03-13 2018-03-13 Anti-CD25 antibody agents
GB1804027.9 2018-03-13
GB1804028.7 2018-03-13
US62/642,232 2018-03-13
EPPCT/EP2018/056312 2018-03-13
US62/642,230 2018-03-13
US62/642,218 2018-03-13
GBGB1804027.9A GB201804027D0 (en) 2018-03-13 2018-03-13 Anti-CD25 antibody agents
GB1804029.5 2018-03-13
PCT/EP2018/056312 WO2018167104A1 (en) 2017-03-17 2018-03-13 Fc-optimized anti-cd25 for tumour specific cell depletion
PCT/EP2019/056252 WO2019175220A1 (en) 2018-03-13 2019-03-13 Anti-cd25 for tumour specific cell depletion

Publications (3)

Publication Number Publication Date
JP2021515565A JP2021515565A (ja) 2021-06-24
JP2021515565A5 true JP2021515565A5 (2) 2022-03-18
JP7563979B2 JP7563979B2 (ja) 2024-10-08

Family

ID=67903878

Family Applications (8)

Application Number Title Priority Date Filing Date
JP2020547399A Active JP7451415B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25
JP2020547415A Pending JP2021515568A (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25
JP2020547332A Active JP7565797B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25
JP2020547363A Active JP7451414B2 (ja) 2018-03-13 2019-03-13 抗cd25抗体剤
JP2020547333A Active JP7510348B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25
JP2020547331A Active JP7563979B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25
JP2020547326A Active JP7563978B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25
JP2020547371A Active JP7474701B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25抗体

Family Applications Before (5)

Application Number Title Priority Date Filing Date
JP2020547399A Active JP7451415B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25
JP2020547415A Pending JP2021515568A (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25
JP2020547332A Active JP7565797B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25
JP2020547363A Active JP7451414B2 (ja) 2018-03-13 2019-03-13 抗cd25抗体剤
JP2020547333A Active JP7510348B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020547326A Active JP7563978B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25
JP2020547371A Active JP7474701B2 (ja) 2018-03-13 2019-03-13 腫瘍特異的細胞枯渇のための抗cd25抗体

Country Status (14)

Country Link
US (11) US11802161B2 (2)
EP (8) EP3765504B1 (2)
JP (8) JP7451415B2 (2)
KR (3) KR102909650B1 (2)
CN (8) CN112041345B (2)
AU (3) AU2019233576A1 (2)
BR (3) BR112020016501A2 (2)
CA (3) CA3088659A1 (2)
CR (3) CR20200466A (2)
MA (1) MA51993A (2)
PE (3) PE20210289A1 (2)
SG (3) SG11202008733YA (2)
TW (3) TW201940515A (2)
WO (8) WO2019175222A1 (2)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
KR20220032642A (ko) * 2016-04-07 2022-03-15 캔써 리서치 테크놀로지 리미티드 종양 특이적 세포 고갈을 위한 항 cd25 fc 감마 수용체 이중특이적 항체
CN108795858A (zh) * 2017-04-28 2018-11-13 深圳宾德生物技术有限公司 高抗癌活性t细胞的筛选方法和应用
AU2019233576A1 (en) 2018-03-13 2020-09-17 Cancer Research Technology Limited Anti-CD25 for tumour specific cell depletion
US20220251232A1 (en) * 2019-05-20 2022-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Novel anti-cd25 antibodies
TWI877278B (zh) 2019-12-30 2025-03-21 美商思進公司 以非海藻糖苷化抗-cd70抗體治療癌症之方法
US20230174670A1 (en) * 2020-05-14 2023-06-08 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Anti-cd25 antibodies, antigen-binding fragments thereof, and medical uses thereof
US11124568B1 (en) * 2020-08-19 2021-09-21 Vitruviae LLC CD3/CD25 antibodies for neuro-immune diseases
AU2021378308B2 (en) * 2020-11-13 2026-01-08 Ibio, Inc. Cd25 antibodies
EP4247496A1 (en) * 2020-11-20 2023-09-27 Institut National de la Santé et de la Recherche Médicale (INSERM) Anti-cd25 antibodies
CN116917318A (zh) * 2020-11-20 2023-10-20 法国国家健康和医学研究院 抗cd25抗体
EP4255929A2 (en) 2020-12-02 2023-10-11 Vib Vzw An ltbr agonist in combination therapy against cancer
JP2024505556A (ja) 2021-02-02 2024-02-06 ラクテン・メディカル,インコーポレイテッド がん、腫瘍および腫瘍細胞の局所および全身処置のための方法
EP4302092A1 (en) * 2021-03-01 2024-01-10 F. Hoffmann-La Roche AG Novel biomarkers and uses thereof
JP2024532790A (ja) 2021-08-09 2024-09-10 南京▲諾▼艾新生物技▲術▼有限公司 組換え抗ヒトcd25抗体及びその使用
EP4392455A4 (en) * 2021-08-25 2025-08-20 Ibio Inc ANTI-CD-25 ANTIBODIES
EP4396230A1 (en) 2021-09-02 2024-07-10 F. Hoffmann-La Roche AG Antibodies for the treatment of aml
EP4395823A4 (en) * 2021-09-03 2025-07-16 Novarock Biotherapeutics Ltd BISPECIFIC BINDING PROTEINS THAT BIND TO CD137 AND A TUMOR-ASSOCIATED ANTIGEN
US20250154268A1 (en) 2022-01-17 2025-05-15 Nona Biosciences (Suzhou) Co., Ltd. Antibody targeting cd25, and preparation method therefor and use thereof
CN119095621A (zh) 2022-04-26 2024-12-06 弗哈夫曼拉罗切有限公司 用于治疗癌症的包括Fas轴拮抗剂和T-reg细胞消耗剂拮抗剂的联合疗法
CN115197321B (zh) * 2022-06-02 2023-08-18 四川大学 靶向cd25的抗体及其用途
CN115181182B (zh) * 2022-06-13 2024-03-29 南京融捷康生物科技有限公司 一种人源化的抗cd25的单域抗体及其应用
CN115181181B (zh) * 2022-06-13 2024-03-29 南京融捷康生物科技有限公司 一种抗cd25的单域抗体及其应用
JP2025525451A (ja) * 2022-06-30 2025-08-05 ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ Cd25特異的抗体およびその使用
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
WO2024088987A1 (en) 2022-10-26 2024-05-02 F. Hoffmann-La Roche Ag Combination therapy for the treatment of cancer
CN118240080A (zh) * 2022-12-22 2024-06-25 深圳市福元生物科技有限公司 一种cd25单域抗体、人源化抗体、及制备方法
CN116004636B (zh) * 2023-01-10 2024-03-12 广西师范大学 一种不结合红细胞的差异化cd47核酸适体及其应用
EP4662238A1 (en) 2023-02-06 2025-12-17 F. Hoffmann-La Roche AG Combination therapy and uses thereof
IL323035A (en) * 2023-03-14 2025-10-01 Odyssey Therapeutics Inc Anti-CD25 antigen-binding proteins and their uses
CN120917143A (zh) 2023-03-29 2025-11-07 第一三共株式会社 抗cd25抗体及抗cd25抗体-药物偶联物
TW202509067A (zh) * 2023-04-11 2025-03-01 大陸商蘇州創勝醫藥集團有限公司 抗cd25抗體及其用途
AU2024279278A1 (en) 2023-05-31 2025-12-18 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
IL327045A (en) 2023-10-05 2026-05-01 Capstan Therapeutics Inc Structure-restricted ionizable cationic lipids and lipid nanoparticles
WO2025145207A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg-depleting agent
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
US20250302763A1 (en) 2024-02-22 2025-10-02 Capstan Therapeutics, Inc. Immune engineering amplification
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2026006708A2 (en) * 2024-06-27 2026-01-02 Odyssey Therapeutics, Inc. Anti-cd25 antigen-binding proteins and uses thereof
CN121226552A (zh) * 2024-06-28 2025-12-30 百奥泰生物制药股份有限公司 抗cd25抗体及其应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
US4578335A (en) * 1984-05-21 1986-03-25 Immunex Corporation Interleukin 2 receptor
EP1578397B1 (en) 2002-11-15 2012-12-26 Genmab A/S Human monoclonal antibodies against cd25
US20050181375A1 (en) 2003-01-10 2005-08-18 Natasha Aziz Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer
WO2004074437A2 (en) 2003-02-14 2004-09-02 University Of Southern California Compositions and methods for cancer immunotherapy
WO2005123780A2 (en) 2004-04-09 2005-12-29 Protein Design Labs, Inc. Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
GB0409799D0 (en) * 2004-04-30 2004-06-09 Isis Innovation Method of generating improved immune response
AU2005302459A1 (en) 2004-10-29 2006-05-11 University Of Southern California Combination cancer immunotherapy with co-stimulatory molecules
GB0507696D0 (en) 2005-04-15 2005-05-25 Novartis Ag Organic compounds
WO2008003473A2 (en) 2006-07-06 2008-01-10 Merck Patent Gmbh Compositions and methods for enhancing the efficacy of il-2 mediated immune responses
EP3018144A1 (en) * 2006-08-18 2016-05-11 XOMA Technology Ltd. Prlr-specific antibody and uses thereof
EP1997832A1 (en) * 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Monoclonal antibodies against Claudin-18 for treatment of cancer
RU2391401C2 (ru) 2008-02-12 2010-06-10 Общество с ограниченной ответственностью "Лаборатория клеточного мониторинга" СПОСОБ ПОЛУЧЕНИЯ ПОПУЛЯЦИИ CD4+CD25+Foxp3+ Т-ЛИМФОЦИТОВ ЧЕЛОВЕКА ex vivo, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ
WO2010054007A1 (en) 2008-11-07 2010-05-14 Fabrus Llc Combinatorial antibody libraries and uses thereof
BR112012006388B1 (pt) 2009-09-22 2022-01-04 Probiogen Ag Método para produzir uma molécula, e, método para produzir uma proteína
WO2011077245A2 (en) 2009-12-23 2011-06-30 Fondazione Centro San Raffaele Del Monte Tabor Compositions
TWI513466B (zh) 2010-01-20 2015-12-21 Boehringer Ingelheim Int 抗凝血劑解毒劑
EP2378287A1 (en) * 2010-04-15 2011-10-19 TXCell New method for isolating Tr1 cells
WO2012012759A2 (en) 2010-07-22 2012-01-26 The Regents Of The University Of California Anti-tumor antigen antibodies and methods of use
US9682143B2 (en) 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
JP2016515524A (ja) * 2013-03-15 2016-05-30 アッヴィ バイオテクノロジー リミテッド 抗cd25抗体およびそれらの使用
EP2970486B1 (en) * 2013-03-15 2018-05-16 Xencor, Inc. Modulation of t cells with bispecific antibodies and fc fusions
US20150010538A1 (en) * 2013-03-15 2015-01-08 Abbvie Biotherapeutics Inc. Anti-cd25 antibodies and their uses
SG10201708143QA (en) * 2013-06-06 2017-11-29 Pf Medicament Anti-c10orf54 antibodies and uses thereof
WO2015109212A1 (en) * 2014-01-17 2015-07-23 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
CA2935423C (en) 2014-01-24 2023-11-07 Dana-Farber Cancer Institute, Inc. Antibody molecules to pd-1 and uses thereof
GB201403775D0 (en) * 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
PE20170140A1 (es) 2014-07-16 2017-03-30 Genentech Inc Metodos para tratar el cancer con inhibidores de tigit y agentes contra el cancer
MX388181B (es) * 2014-07-22 2025-03-19 Cb Therapeutics Inc Anticuerpos anti-pd-1.
KR101940430B1 (ko) 2014-08-07 2019-01-18 가꼬우호우징 효고 이카다이가쿠 Il-18과 분자 표적 항체를 병용하는 암 치료약
US11147652B2 (en) 2014-11-13 2021-10-19 Align Technology, Inc. Method for tracking, predicting, and proactively correcting malocclusion and related issues
FI4141032T3 (fi) * 2014-11-20 2024-07-31 Hoffmann La Roche T-solua aktivoivien bispesifisten antigeeniä sitovien molekyylien ja pd-1-akselia sitovien antagonistien yhdistelmähoito
TWI711630B (zh) * 2014-11-21 2020-12-01 美商必治妥美雅史谷比公司 抗cd73抗體及其用途
MY187045A (en) * 2014-12-23 2021-08-27 Bristol Myers Squibb Co Antibodies to tigit
SG11201706583PA (en) 2015-02-19 2017-09-28 Compugen Ltd Anti-pvrig antibodies and methods of use
HUE048111T2 (hu) * 2015-03-23 2020-05-28 Bayer Pharma AG Anti-CEACAM6 ellenanyagok és alkalmazásuk
WO2017070561A1 (en) * 2015-10-23 2017-04-27 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
CA3016187A1 (en) * 2016-03-04 2017-09-08 Bristol-Myers Squibb Company Combination therapy with anti-cd73 antibodies
EP3309177B1 (en) * 2016-03-04 2020-05-13 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Pdl-1 antibody, pharmaceutical composition thereof, and uses thereof
KR20220032642A (ko) 2016-04-07 2022-03-15 캔써 리서치 테크놀로지 리미티드 종양 특이적 세포 고갈을 위한 항 cd25 fc 감마 수용체 이중특이적 항체
IL263273B2 (en) * 2016-06-10 2025-10-01 Regeneron Pharma Antibodies against GITR and their uses
JP6831651B2 (ja) 2016-07-04 2021-02-17 川崎重工業株式会社 ワークの袋詰め装置
SG11201903882VA (en) 2016-11-08 2019-05-30 Delinia Inc Il-2 variants for the treatment of autoimmune diseases
US11879014B2 (en) * 2017-03-17 2024-01-23 Tusk Therapeutics Ltd. Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody
WO2019005922A1 (en) 2017-06-28 2019-01-03 North Carolina State University PHOTONIC PROHIBITED BAND RESONATOR FOR MAGNETIC RESONANCE APPLICATIONS
EP3649153B8 (en) 2017-07-06 2025-07-16 Tusk Therapeutics Ltd Fc optimised anti-cd25 antibodies for tumor specific cell depletion
UA129536C2 (uk) 2018-03-13 2025-05-28 Туск Терап'Ютікс Лтд Анти-cd25 для виснаження пухлиноспецифічних клітин
AU2019233576A1 (en) 2018-03-13 2020-09-17 Cancer Research Technology Limited Anti-CD25 for tumour specific cell depletion
KR20200003558A (ko) 2018-07-02 2020-01-10 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. 용지 슬립을 방지하기 위한 급지장치 및 이를 포함하는 화상형성장치
KR102080909B1 (ko) 2018-07-06 2020-02-24 한국수력원자력 주식회사 원자로의 해체 시스템

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