JP3210023B2 - ブロモ置換三環式化合物を調製する際に有用な中間体の合成 - Google Patents

ブロモ置換三環式化合物を調製する際に有用な中間体の合成

Info

Publication number: JP3210023B2
Authority: JP; Japan
Prior art keywords: formula; compound; hydrogen; alkyl; reacting
Prior art date: 1997-06-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP50447999A

Other languages

English (en)

Japanese (ja)

Other versions

JP2000513032A (ja

Inventor

キンチュン，

マークポイリアー，

イー−シンウォン，

ガン−ゾンウ，

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-16

Filing date

1998-06-15

Publication date

2001-09-17

1998-06-15 Application filed by Schering Corp filed Critical Schering Corp

2000-10-03 Publication of JP2000513032A publication Critical patent/JP2000513032A/ja

2001-09-17 Application granted granted Critical

2001-09-17 Publication of JP3210023B2 publication Critical patent/JP3210023B2/ja

2018-06-15 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

JP50447999A 1997-06-16 1998-06-15 ブロモ置換三環式化合物を調製する際に有用な中間体の合成 Expired - Fee Related JP3210023B2 (ja)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US08/882,753 US5760232A (en)	1997-06-16	1997-06-16	Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds
US882,753		1997-06-16
US08/882,753		1997-06-16
PCT/US1998/011403 WO1998057958A1 (en)	1997-06-16	1998-06-15	Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds

Publications (2)

Publication Number	Publication Date
JP2000513032A JP2000513032A (ja)	2000-10-03
JP3210023B2 true JP3210023B2 (ja)	2001-09-17

Family

ID=25381267

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP50447999A Expired - Fee Related JP3210023B2 (ja)	1997-06-16	1998-06-15	ブロモ置換三環式化合物を調製する際に有用な中間体の合成

Country Status (15)

Country	Link
US (1)	US5760232A (2)
EP (1)	EP0991640B1 (2)
JP (1)	JP3210023B2 (2)
AR (1)	AR015886A1 (2)
AT (1)	ATE214062T1 (2)
AU (1)	AU8056898A (2)
CA (1)	CA2293709C (2)
DE (1)	DE69804100T2 (2)
DK (1)	DK0991640T3 (2)
ES (1)	ES2169917T3 (2)
IN (1)	IN187755B (2)
MY (1)	MY133531A (2)
PT (1)	PT991640E (2)
WO (1)	WO1998057958A1 (2)
ZA (1)	ZA985207B (2)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5998620A (en) *	1997-03-25	1999-12-07	Schering Corporation	Synthesis of intermediates useful in preparing tricyclic compounds
WO2004031153A2 (en) *	2002-10-03	2004-04-15	Schering Corporation	Enantioselective alkylation of tricyclic compounds
HK1203412A1 (en)	2011-12-28	2015-10-30	Global Blood Therapeutics, Inc.	Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
ES2643403T3 (es)	2011-12-28	2017-11-22	Global Blood Therapeutics, Inc.	Compuestos de benzaldehído sustituidos y métodos para su uso en el aumento de la oxigenación tisular
CN105073728A (zh)	2013-03-15	2015-11-18	全球血液疗法股份有限公司	化合物及其用于调节血红蛋白的用途
US9422279B2 (en)	2013-03-15	2016-08-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en)	2013-03-15	2015-02-10	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
MX379235B (es)	2013-03-15	2025-03-11	Global Blood Therapeutics Inc	Compuestos y sus usos para modular la hemoglobina.
WO2014150258A1 (en)	2013-03-15	2014-09-25	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en)	2013-03-15	2019-04-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en)	2013-03-15	2014-09-18	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en)	2013-03-15	2018-10-16	Global Blood Therapeutics, Inc.	Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9604999B2 (en)	2013-03-15	2017-03-28	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en)	2013-03-15	2017-10-31	Global Blood Therapeutics, Inc.	Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en)	2013-03-15	2016-10-04	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru)	2013-11-18	2020-06-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
CN114181195A (zh)	2014-02-07	2022-03-15	全球血液疗法股份有限公司	一种化合物的结晶多晶型物
MA41841A (fr)	2015-03-30	2018-02-06	Global Blood Therapeutics Inc	Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
SG11201804647TA (en)	2015-12-04	2018-06-28	Global Blood Therapeutics Inc	Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI663160B (zh)	2016-05-12	2019-06-21	全球血液治療公司	用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TW202332423A (zh)	2016-10-12	2023-08-16	美商全球血液治療公司	包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
US11014884B2 (en)	2018-10-01	2021-05-25	Global Blood Therapeutics, Inc.	Modulators of hemoglobin
US12479816B2 (en)	2019-02-08	2025-11-25	University of Pittsburgh—of the Commonwealth System of Higher Education	20-HETE formation inhibitors
CN112341433A (zh) *	2020-11-16	2021-02-09	成都大学	一种氯雷他定的制备方法
AU2024286996A1 (en) *	2023-06-08	2026-01-08	Jiangsu Hengrui Pharmaceuticals Co., Ltd.	Preparation method for formamide compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5089496A (en) *	1986-10-31	1992-02-18	Schering Corporation	Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
SG48750A1 (en) *	1993-10-15	1998-05-18	Schering Corp	Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
SK86198A3 (en) *	1995-12-22	1999-02-11	Schering Corp	Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases

1997
- 1997-06-16 US US08/882,753 patent/US5760232A/en not_active Expired - Lifetime
1998
- 1998-06-12 AR ARP980102809A patent/AR015886A1/es unknown
- 1998-06-12 MY MYPI98002633A patent/MY133531A/en unknown
- 1998-06-15 PT PT98928873T patent/PT991640E/pt unknown
- 1998-06-15 JP JP50447999A patent/JP3210023B2/ja not_active Expired - Fee Related
- 1998-06-15 AU AU80568/98A patent/AU8056898A/en not_active Abandoned
- 1998-06-15 WO PCT/US1998/011403 patent/WO1998057958A1/en not_active Ceased
- 1998-06-15 ES ES98928873T patent/ES2169917T3/es not_active Expired - Lifetime
- 1998-06-15 DE DE69804100T patent/DE69804100T2/de not_active Expired - Lifetime
- 1998-06-15 IN IN1294MA1998 patent/IN187755B/en unknown
- 1998-06-15 AT AT98928873T patent/ATE214062T1/de not_active IP Right Cessation
- 1998-06-15 EP EP98928873A patent/EP0991640B1/en not_active Expired - Lifetime
- 1998-06-15 ZA ZA985207A patent/ZA985207B/xx unknown
- 1998-06-15 DK DK98928873T patent/DK0991640T3/da active
- 1998-06-15 CA CA002293709A patent/CA2293709C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AR015886A1 (es)	2001-05-30
IN187755B (2)	2002-06-15
JP2000513032A (ja)	2000-10-03
ES2169917T3 (es)	2002-07-16
AU8056898A (en)	1999-01-04
CA2293709A1 (en)	1998-12-23
MY133531A (en)	2007-11-30
PT991640E (pt)	2002-07-31
DK0991640T3 (da)	2002-05-27
EP0991640B1 (en)	2002-03-06
ZA985207B (en)	1999-04-07
DE69804100T2 (de)	2002-10-31
WO1998057958A1 (en)	1998-12-23
ATE214062T1 (de)	2002-03-15
CA2293709C (en)	2004-02-10
US5760232A (en)	1998-06-02
EP0991640A1 (en)	2000-04-12
DE69804100D1 (de)	2002-04-11

Legal Events

Date	Code	Title	Description
2004-07-13	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2005-07-05	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2006-07-04	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2007-06-28	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20070713 Year of fee payment: 6
2007-07-10	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20080713 Year of fee payment: 7
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2010-07-13	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20110713 Year of fee payment: 10
2011-07-13	LAPS	Cancellation because of no payment of annual fees

Publication	Publication Date	Title
JP3210023B2 (ja)	2001-09-17	ブロモ置換三環式化合物を調製する際に有用な中間体の合成
CA2150703C (en)	2002-01-08	Substituted pyrazoles
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US4978663A (en)	1990-12-18	5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility
JP2004532185A (ja)	2004-10-21	新規なカンナビミメティックリガンド
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RU2466126C2 (ru)	2012-11-10	Способ получения 2,3-дизамещенных индолов
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MXPA99011797A (en)	2001-05-17	Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds
US5112981A (en)	1992-05-12	5-(1-aminocyclohexyl)-2(1H)-pyridinone and related compounds
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