JP4009671B2 - 不連続向流クロマトグラフィーの方法および装置 - Google Patents

不連続向流クロマトグラフィーの方法および装置 Download PDF

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Publication number: JP4009671B2
Authority: JP; Japan
Prior art keywords: pump; sample; chromatography; solvent; cycle
Prior art date: 1995-11-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP52010597A

Other languages

English (en)

Japanese (ja)

Other versions

JP2000503112A (ja

JP2000503112A5 (2

Inventor

グリル，エム．チャールズ

ハンプトン，ダブリュ．トーマス

Original Assignee

ノヴァセップ

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-30

Filing date

1996-11-12

Publication date

2007-11-21

1996-11-12 Application filed by ノヴァセップ filed Critical ノヴァセップ

2000-03-14 Publication of JP2000503112A publication Critical patent/JP2000503112A/ja

2004-10-28 Publication of JP2000503112A5 publication Critical patent/JP2000503112A5/ja

2007-11-21 Application granted granted Critical

2007-11-21 Publication of JP4009671B2 publication Critical patent/JP4009671B2/ja

2016-11-12 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims description 39
238000004185 countercurrent chromatography Methods 0.000 title 1
238000004587 chromatography analysis Methods 0.000 claims description 42
238000002347 injection Methods 0.000 claims description 39
239000007924 injection Substances 0.000 claims description 39
239000002904 solvent Substances 0.000 claims description 31
238000004237 preparative chromatography Methods 0.000 claims description 8
125000004122 cyclic group Chemical group 0.000 claims description 2
239000000523 sample Substances 0.000 description 52
238000000926 separation method Methods 0.000 description 25
238000001802 infusion Methods 0.000 description 24
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 14
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 14
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 14
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 14
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 13
239000007788 liquid Substances 0.000 description 12
239000002699 waste material Substances 0.000 description 12
238000004064 recycling Methods 0.000 description 9
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 7
238000000605 extraction Methods 0.000 description 6
238000004128 high performance liquid chromatography Methods 0.000 description 6
230000000630 rising effect Effects 0.000 description 5
238000005516 engineering process Methods 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
238000002835 absorbance Methods 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
238000013459 approach Methods 0.000 description 3
238000013461 design Methods 0.000 description 3
238000001514 detection method Methods 0.000 description 3
238000005194 fractionation Methods 0.000 description 3
239000000463 material Substances 0.000 description 3
230000008569 process Effects 0.000 description 3
239000012488 sample solution Substances 0.000 description 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
238000013375 chromatographic separation Methods 0.000 description 2
238000012864 cross contamination Methods 0.000 description 2
238000011161 development Methods 0.000 description 2
238000010586 diagram Methods 0.000 description 2
239000000203 mixture Substances 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
239000002245 particle Substances 0.000 description 2
230000000737 periodic effect Effects 0.000 description 2
238000002953 preparative HPLC Methods 0.000 description 2
239000000047 product Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
238000012546 transfer Methods 0.000 description 2
230000005526 G1 to G0 transition Effects 0.000 description 1
101000610640 Homo sapiens U4/U6 small nuclear ribonucleoprotein Prp3 Proteins 0.000 description 1
235000009421 Myristica fragrans Nutrition 0.000 description 1
101001110823 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 60S ribosomal protein L6-A Proteins 0.000 description 1
101000712176 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 60S ribosomal protein L6-B Proteins 0.000 description 1
102100040374 U4/U6 small nuclear ribonucleoprotein Prp3 Human genes 0.000 description 1
238000001042 affinity chromatography Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
238000011109 contamination Methods 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
238000003821 enantio-separation Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
239000001115 mace Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000005086 pumping Methods 0.000 description 1
239000013014 purified material Substances 0.000 description 1
239000012264 purified product Substances 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000004366 reverse phase liquid chromatography Methods 0.000 description 1
238000005070 sampling Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
238000001542 size-exclusion chromatography Methods 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
230000000007 visual effect Effects 0.000 description 1

Images

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Recycling of the fraction to be distributed
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/44—Flow patterns using recycling of the fraction to be distributed
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Recycling of the fraction to be distributed
- B01D15/1857—Reactive simulated moving beds

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Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Sustainable Development (AREA)
Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Pathology (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)

JP52010597A 1995-11-30 1996-11-12 不連続向流クロマトグラフィーの方法および装置 Expired - Fee Related JP4009671B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/566,425 US5630943A (en)	1995-11-30	1995-11-30	Discontinuous countercurrent chromatographic process and apparatus
US08/566,425		1995-11-30
PCT/EP1996/004937 WO1997020206A1 (en)	1995-11-30	1996-11-12	Discontinuous countercurrent chromatographic process and apparatus

Publications (3)

Publication Number	Publication Date
JP2000503112A JP2000503112A (ja)	2000-03-14
JP2000503112A5 JP2000503112A5 (2)	2004-10-28
JP4009671B2 true JP4009671B2 (ja)	2007-11-21

Family

ID=24262836

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP52010597A Expired - Fee Related JP4009671B2 (ja)	1995-11-30	1996-11-12	不連続向流クロマトグラフィーの方法および装置

Country Status (6)

Country	Link
US (1)	US5630943A (2)
EP (1)	EP0877936B1 (2)
JP (1)	JP4009671B2 (2)
CA (1)	CA2238954A1 (2)
DE (1)	DE69631903T2 (2)
WO (1)	WO1997020206A1 (2)

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1995
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1996
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- 1996-11-12 CA CA002238954A patent/CA2238954A1/en not_active Abandoned
- 1996-11-12 WO PCT/EP1996/004937 patent/WO1997020206A1/en not_active Ceased
- 1996-11-12 JP JP52010597A patent/JP4009671B2/ja not_active Expired - Fee Related
- 1996-11-12 DE DE69631903T patent/DE69631903T2/de not_active Expired - Lifetime

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JP2000503112A (ja)	2000-03-14
DE69631903T2 (de)	2004-08-19
US5630943A (en)	1997-05-20
EP0877936A1 (en)	1998-11-18
EP0877936B1 (en)	2004-03-17
WO1997020206A1 (en)	1997-06-05
DE69631903D1 (de)	2004-04-22
CA2238954A1 (en)	1997-06-05

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