JP4343272B2 - ポリオール組成物 - Google Patents

ポリオール組成物 Download PDF

Info

Publication number: JP4343272B2
Authority: JP; Japan
Prior art keywords: mannitol; sorbitol; polyols; weight; polyol
Prior art date: 1996-04-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP53767397A

Other languages

English (en)

Japanese (ja)

Other versions

JP2000508668A5 (2

JP2000508668A (ja

Inventor

シュヴァルツ，オイゲン

メーシュル，ゲルノット

マウル，カリン

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Patent GmbH

Original Assignee

Merck Patent GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-22

Filing date

1997-04-10

Publication date

2009-10-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7791693&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4343272(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-04-10 Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH

2000-07-11 Publication of JP2000508668A publication Critical patent/JP2000508668A/ja

2004-12-09 Publication of JP2000508668A5 publication Critical patent/JP2000508668A5/ja

2009-10-14 Application granted granted Critical

2009-10-14 Publication of JP4343272B2 publication Critical patent/JP4343272B2/ja

2017-04-10 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

229920005862 polyol Polymers 0.000 title claims abstract description 78
150000003077 polyols Chemical class 0.000 title claims abstract description 78
239000000203 mixture Substances 0.000 title claims abstract description 69
238000001694 spray drying Methods 0.000 claims abstract description 13
239000011230 binding agent Substances 0.000 claims abstract description 9
238000004519 manufacturing process Methods 0.000 claims abstract description 6
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 64
229930195725 Mannitol Natural products 0.000 claims description 64
239000000594 mannitol Substances 0.000 claims description 64
235000010355 mannitol Nutrition 0.000 claims description 64
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 41
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 41
239000000600 sorbitol Substances 0.000 claims description 41
235000010356 sorbitol Nutrition 0.000 claims description 41
VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 24
239000000832 lactitol Substances 0.000 claims description 19
235000010448 lactitol Nutrition 0.000 claims description 19
229960003451 lactitol Drugs 0.000 claims description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
150000001875 compounds Chemical class 0.000 claims description 10
239000000243 solution Substances 0.000 claims description 10
239000007864 aqueous solution Substances 0.000 claims description 8
238000005507 spraying Methods 0.000 claims description 6
239000013078 crystal Substances 0.000 claims description 4
238000000034 method Methods 0.000 claims description 4
238000005469 granulation Methods 0.000 claims description 3
230000003179 granulation Effects 0.000 claims description 3
238000003260 vortexing Methods 0.000 claims description 3
229960002920 sorbitol Drugs 0.000 claims 7
229960001855 mannitol Drugs 0.000 claims 3
238000001704 evaporation Methods 0.000 claims 2
239000003814 drug Substances 0.000 abstract 1
239000003826 tablet Substances 0.000 description 31
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
239000007921 spray Substances 0.000 description 9
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
238000007906 compression Methods 0.000 description 6
230000006835 compression Effects 0.000 description 6
238000009472 formulation Methods 0.000 description 6
238000000113 differential scanning calorimetry Methods 0.000 description 5
235000019359 magnesium stearate Nutrition 0.000 description 5
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 4
239000000654 additive Substances 0.000 description 4
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 4
239000003205 fragrance Substances 0.000 description 4
238000005259 measurement Methods 0.000 description 4
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
238000012916 structural analysis Methods 0.000 description 4
239000000811 xylitol Substances 0.000 description 4
235000010447 xylitol Nutrition 0.000 description 4
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 4
229960002675 xylitol Drugs 0.000 description 4
229920002799 BoPET Polymers 0.000 description 3
239000005041 Mylar™ Substances 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
238000010586 diagram Methods 0.000 description 3
238000011049 filling Methods 0.000 description 3
239000007787 solid Substances 0.000 description 3
150000005846 sugar alcohols Chemical class 0.000 description 3
ZEYHEAKUIGZSGI-UHFFFAOYSA-N 4-methoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C=C1 ZEYHEAKUIGZSGI-UHFFFAOYSA-N 0.000 description 2
SERLAGPUMNYUCK-YJOKQAJESA-N 6-O-alpha-D-glucopyranosyl-D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-YJOKQAJESA-N 0.000 description 2
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
238000002441 X-ray diffraction Methods 0.000 description 2
235000010323 ascorbic acid Nutrition 0.000 description 2
239000011668 ascorbic acid Substances 0.000 description 2
229960005070 ascorbic acid Drugs 0.000 description 2
229960001948 caffeine Drugs 0.000 description 2
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
239000000975 dye Substances 0.000 description 2
235000013305 food Nutrition 0.000 description 2
235000003599 food sweetener Nutrition 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
229940034008 mannitol / sorbitol Drugs 0.000 description 2
239000000463 material Substances 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
229920005903 polyol mixture Polymers 0.000 description 2
239000006190 sub-lingual tablet Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000003765 sweetening agent Substances 0.000 description 2
229930003231 vitamin Natural products 0.000 description 2
235000013343 vitamin Nutrition 0.000 description 2
239000011782 vitamin Substances 0.000 description 2
229940088594 vitamin Drugs 0.000 description 2
OIAQMFOKAXHPNH-UHFFFAOYSA-N 1,2-diphenylbenzene Chemical group C1=CC=CC=C1C1=CC=CC=C1C1=CC=CC=C1 OIAQMFOKAXHPNH-UHFFFAOYSA-N 0.000 description 1
WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
108010011485 Aspartame Proteins 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
239000004386 Erythritol Substances 0.000 description 1
UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
239000004376 Sucralose Substances 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
235000010358 acesulfame potassium Nutrition 0.000 description 1
239000000619 acesulfame-K Substances 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
239000000605 aspartame Substances 0.000 description 1
235000010357 aspartame Nutrition 0.000 description 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
229960003438 aspartame Drugs 0.000 description 1
238000005452 bending Methods 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
229940124827 caffeine tablet Drugs 0.000 description 1
238000007707 calorimetry Methods 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000001055 chewing effect Effects 0.000 description 1
229940112822 chewing gum Drugs 0.000 description 1
235000015218 chewing gum Nutrition 0.000 description 1
238000003181 co-melting Methods 0.000 description 1
235000009508 confectionery Nutrition 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
229940109275 cyclamate Drugs 0.000 description 1
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
125000006159 dianhydride group Chemical group 0.000 description 1
238000001938 differential scanning calorimetry curve Methods 0.000 description 1
238000007907 direct compression Methods 0.000 description 1
235000011869 dried fruits Nutrition 0.000 description 1
235000019414 erythritol Nutrition 0.000 description 1
UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
229940009714 erythritol Drugs 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000000227 grinding Methods 0.000 description 1
FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical compound OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 description 1
238000005984 hydrogenation reaction Methods 0.000 description 1
238000009776 industrial production Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000000320 mechanical mixture Substances 0.000 description 1
238000001000 micrograph Methods 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000011148 porous material Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000011084 recovery Methods 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
238000005070 sampling Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
229940098466 sublingual tablet Drugs 0.000 description 1
235000019408 sucralose Nutrition 0.000 description 1
BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
238000012982 x-ray structure analysis Methods 0.000 description 1

Images

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/18—Polyhydroxylic acyclic alcohols
- C07C31/26—Hexahydroxylic alcohols

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Zoology (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Medicinal Preparation (AREA)
Compositions Of Macromolecular Compounds (AREA)
Polyurethanes Or Polyureas (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Pulleys (AREA)

JP53767397A 1996-04-22 1997-04-10 ポリオール組成物 Expired - Lifetime JP4343272B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19615418A DE19615418A1 (de)	1996-04-22	1996-04-22	Polyol-Zusammensetzung
DE19615418.9		1996-04-22
PCT/EP1997/001787 WO1997039739A2 (de)	1996-04-22	1997-04-10	Polyol-zusammensetzung

Publications (3)

Publication Number	Publication Date
JP2000508668A JP2000508668A (ja)	2000-07-11
JP2000508668A5 JP2000508668A5 (2)	2004-12-09
JP4343272B2 true JP4343272B2 (ja)	2009-10-14

Family

ID=7791693

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP53767397A Expired - Lifetime JP4343272B2 (ja)	1996-04-22	1997-04-10	ポリオール組成物

Country Status (16)

Country	Link
US (1)	US6165511A (2)
EP (1)	EP0896528B1 (2)
JP (1)	JP4343272B2 (2)
CN (1)	CN1147290C (2)
AT (1)	ATE210971T1 (2)
CA (1)	CA2252609C (2)
CZ (1)	CZ291589B6 (2)
DE (2)	DE19615418A1 (2)
DK (1)	DK0896528T3 (2)
ES (1)	ES2169385T3 (2)
ID (1)	ID17384A (2)
MY (1)	MY116890A (2)
PT (1)	PT896528E (2)
RU (1)	RU2184535C2 (2)
TW (1)	TWI237567B (2)
WO (1)	WO1997039739A2 (2)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2271839A1 (en) *	1996-11-15	1998-05-28	Merck Patent Gesellschaft Mit Beschraenkter Haftung	Process for the production of shaped or unshaped polyol materials
US20030203036A1 (en)	2000-03-17	2003-10-30	Gordon Marc S.	Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
GB9716432D0 (en) *	1997-08-05	1997-10-08	Cerestar Holding Bv	Tableting of erythritol
FI107732B (fi)	1998-03-18	2001-09-28	Xyrofin Oy	Laktitolin kiteyttäminen, kiteinen laktitolituote ja sen käyttö
DE19943491B4 (de) *	1999-09-10	2010-04-01	Südzucker AG Mannheim/Ochsenfurt	Verbesserte Komprimate
US6872414B1 (en)	1999-09-20	2005-03-29	Xyrofin Oy	Anhydrous lactitol crystals, a product containing the same and a process for the preparation thereof as well as use thereof
US7575761B2 (en)	2000-06-30	2009-08-18	Novartis Pharma Ag	Spray drying process control of drying kinetics
WO2002015880A2 (en) *	2000-08-25	2002-02-28	Merck Patent Gmbh	Powdered mannitol and mannitol-containing compositions
KR20030042006A (ko) *	2000-10-16	2003-05-27	다이이찌 세이야꾸 가부시기가이샤	구강내 속붕괴성 의약 조성물 및 그의 제조방법
WO2003037303A1 (en) *	2001-11-01	2003-05-08	Nektar Therapeutics	Spray drying methods and compositions thereof
CA2363528A1 (en) *	2001-11-19	2003-05-19	Merck Patent Gesellschaft Mit Beschraenkter Haftung	Immediate release tablet containing naproxen sodium
EP1481211B1 (en) *	2001-11-29	2009-04-22	J. Rettenmaier & Söhne GmbH + Co. KG	Process for co-spray drying liquid herbal extracts with dry silicified mcc
DE10161402A1 (de) †	2001-12-13	2003-06-18	Merck Patent Gmbh	Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
US7118765B2 (en) *	2001-12-17	2006-10-10	Spi Pharma, Inc.	Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
FI20021312A7 (fi)	2002-07-03	2004-01-04	Danisco Sweeteners Oy	Polyolikoostumusten kiteyttäminen, kiteinen polyolikoostumustuote ja sen käyttö
DE10240778A1 (de) *	2002-08-30	2004-03-11	Merck Patent Gmbh	Verfahren zur Herstellung von direkt tablettierbarem a-Mannit
MXPA05005001A (es) *	2002-11-26	2005-08-03	Hecules Inc	Carboximetilcelulosa asociativa, soluble, metodo para obtenerla, y sus usos.
JP2004285052A (ja) *	2003-03-06	2004-10-14	Lion Corp	化粧料組成物
WO2004095942A2 (de) *	2003-04-30	2004-11-11	Ipc Prozess Center Gmbh & Co.	Coffein enthaltende tablette
CA2523475C (en) *	2003-05-28	2013-02-05	Nektar Therapeutics	Pharmaceutical formulation comprising a water-insoluble active agent
US20090208576A1 (en) *	2006-03-31	2009-08-20	Gandhi Anilkumar S	Orally Disintegrating Tablets
US20100092564A1 (en) *	2006-12-21	2010-04-15	Jae Han Park	Composition of and Method for Preparing Orally Disintegrating Tablets
DE102008014237A1 (de) *	2008-03-14	2009-09-17	J. Rettenmaier & Söhne Gmbh + Co. Kg	Direktverpressbares Tablettierhilfsmittel
EP2293774B1 (de) *	2008-06-20	2019-01-16	Merck Patent GmbH	Direkt verpressbare polyolkombination
TR201808694T4 (tr)	2008-06-20	2018-07-23	Merck Patent Gmbh	Doğrudan sıkıştırılabilen ve hızlı parçalanan tablet matrisi.
MX2011009053A (es) *	2009-03-09	2012-04-02	Spi Pharma Inc	Excipientes de compresion directa con alta capacidad de compactacion y durables y sistemas de excipiente.
DK2228175T3 (da)	2009-03-12	2013-09-08	Ferton Holding Sa	Anvendelse af pulver eller pulverblanding til fremstilling af et middel til pulverstrålerengøring af tandoverflader
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1996
- 1996-04-22 DE DE19615418A patent/DE19615418A1/de not_active Withdrawn
1997
- 1997-04-10 ES ES97920646T patent/ES2169385T3/es not_active Expired - Lifetime
- 1997-04-10 AT AT97920646T patent/ATE210971T1/de not_active IP Right Cessation
- 1997-04-10 PT PT97920646T patent/PT896528E/pt unknown
- 1997-04-10 CA CA002252609A patent/CA2252609C/en not_active Expired - Lifetime
- 1997-04-10 DK DK97920646T patent/DK0896528T3/da active
- 1997-04-10 RU RU98121204/14A patent/RU2184535C2/ru active
- 1997-04-10 US US09/171,536 patent/US6165511A/en not_active Expired - Lifetime
- 1997-04-10 CN CNB97194024XA patent/CN1147290C/zh not_active Expired - Lifetime
- 1997-04-10 EP EP97920646A patent/EP0896528B1/de not_active Revoked
- 1997-04-10 ID IDP971194A patent/ID17384A/id unknown
- 1997-04-10 DE DE59705894T patent/DE59705894D1/de not_active Revoked
- 1997-04-10 JP JP53767397A patent/JP4343272B2/ja not_active Expired - Lifetime
- 1997-04-10 CZ CZ19983385A patent/CZ291589B6/cs not_active IP Right Cessation
- 1997-04-10 WO PCT/EP1997/001787 patent/WO1997039739A2/de not_active Ceased
- 1997-04-17 MY MYPI97001672A patent/MY116890A/en unknown
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CA2252609C (en)	2007-01-30
CN1216466A (zh)	1999-05-12
ES2169385T3 (es)	2002-07-01
DE59705894D1 (de)	2002-01-31
ID17384A (id)	1997-12-24
RU2184535C2 (ru)	2002-07-10
CA2252609A1 (en)	1997-10-30
WO1997039739A3 (de)	1997-11-27
ATE210971T1 (de)	2002-01-15
PT896528E (pt)	2002-06-28
EP0896528A2 (de)	1999-02-17
US6165511A (en)	2000-12-26
CN1147290C (zh)	2004-04-28
WO1997039739A2 (de)	1997-10-30
DE19615418A1 (de)	1997-10-23
MY116890A (en)	2004-04-30
DK0896528T3 (da)	2002-04-08
CZ291589B6 (cs)	2003-04-16
TWI237567B (en)	2005-08-11
EP0896528B1 (de)	2001-12-19
JP2000508668A (ja)	2000-07-11
HK1019202A1 (en)	2000-01-28

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