JP4444565B2 - 新規ナノエマルション - Google Patents

新規ナノエマルション Download PDF

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Publication number: JP4444565B2
Authority: JP; Japan
Prior art keywords: surfactant; nanoemulsion; oil; phase; alkyl
Prior art date: 2001-03-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2002578903A

Other languages

English (en)

Japanese (ja)

Other versions

JP2004532214A (ja

Inventor

ジョージ，リリアナ

タドロック，チャールズ，シー．

ソリス，ピーター，ジェー．

バリアン，ラッフィー，ジェー．

Original Assignee

カラーアクセス，インコーポレイティド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-30

Filing date

2002-03-29

Publication date

2010-03-31

2002-03-29 Application filed by カラーアクセス，インコーポレイティド filed Critical カラーアクセス，インコーポレイティド

2004-10-21 Publication of JP2004532214A publication Critical patent/JP2004532214A/ja

2010-03-31 Application granted granted Critical

2010-03-31 Publication of JP4444565B2 publication Critical patent/JP4444565B2/ja

2022-03-29 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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239000007908 nanoemulsion Substances 0.000 title claims description 31
239000004094 surface-active agent Substances 0.000 claims description 35
239000000203 mixture Substances 0.000 claims description 27
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
239000003945 anionic surfactant Substances 0.000 claims description 10
239000002537 cosmetic Substances 0.000 claims description 10
KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 9
KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 9
229960003237 betaine Drugs 0.000 claims description 9
239000003093 cationic surfactant Substances 0.000 claims description 9
239000000516 sunscreening agent Substances 0.000 claims description 9
230000000475 sunscreen effect Effects 0.000 claims description 8
238000004132 cross linking Methods 0.000 claims description 7
229940045898 sodium stearoyl glutamate Drugs 0.000 claims description 7
KDHFCTLPQJQDQI-BDQAORGHSA-M sodium;(4s)-4-amino-5-octadecanoyloxy-5-oxopentanoate Chemical group [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O KDHFCTLPQJQDQI-BDQAORGHSA-M 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 4
230000007935 neutral effect Effects 0.000 claims description 3
150000005846 sugar alcohols Polymers 0.000 claims description 3
MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 claims description 2
229940075468 lauramidopropyl betaine Drugs 0.000 claims description 2
108700004121 sarkosyl Proteins 0.000 claims description 2
239000002904 solvent Substances 0.000 claims description 2
150000001805 chlorine compounds Chemical group 0.000 claims 1
KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims 1
229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims 1
-1 jojoba oil Substances 0.000 description 35
239000012071 phase Substances 0.000 description 26
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
239000003921 oil Substances 0.000 description 16
239000000047 product Substances 0.000 description 16
235000019198 oils Nutrition 0.000 description 15
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 14
239000003795 chemical substances by application Substances 0.000 description 12
239000004615 ingredient Substances 0.000 description 12
239000000839 emulsion Substances 0.000 description 11
150000003467 sulfuric acid derivatives Chemical class 0.000 description 10
150000001412 amines Chemical class 0.000 description 8
239000008346 aqueous phase Substances 0.000 description 8
239000013543 active substance Substances 0.000 description 7
235000011187 glycerol Nutrition 0.000 description 7
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
ISRLGZXSKRDKID-JXBDSQKUSA-N [3-bis[3-[dimethyl-[3-[[(9z,12z)-octadeca-9,12-dienoyl]amino]propyl]azaniumyl]-2-hydroxypropoxy]phosphoryloxy-2-hydroxypropyl]-dimethyl-[3-[[(9z,12z)-octadeca-9,12-dienoyl]amino]propyl]azanium;trichloride Chemical compound [Cl-].[Cl-].[Cl-].CCCCC\C=C/C\C=C/CCCCCCCC(=O)NCCC[N+](C)(C)CC(O)COP(=O)(OCC(O)C[N+](C)(C)CCCNC(=O)CCCCCCC\C=C/C\C=C/CCCCC)OCC(O)C[N+](C)(C)CCCNC(=O)CCCCCCC\C=C/C\C=C/CCCCC ISRLGZXSKRDKID-JXBDSQKUSA-N 0.000 description 6
125000000217 alkyl group Chemical group 0.000 description 6
239000002280 amphoteric surfactant Substances 0.000 description 6
238000009472 formulation Methods 0.000 description 6
239000003995 emulsifying agent Substances 0.000 description 5
229940075529 glyceryl stearate Drugs 0.000 description 5
239000000463 material Substances 0.000 description 5
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 5
FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical class C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 5
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 5
239000004166 Lanolin Substances 0.000 description 4
239000004480 active ingredient Substances 0.000 description 4
150000001298 alcohols Chemical class 0.000 description 4
239000002585 base Substances 0.000 description 4
125000004432 carbon atom Chemical group C* 0.000 description 4
125000002091 cationic group Chemical group 0.000 description 4
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
235000014113 dietary fatty acids Nutrition 0.000 description 4
229930195729 fatty acid Natural products 0.000 description 4
239000000194 fatty acid Substances 0.000 description 4
239000012467 final product Substances 0.000 description 4
229940075507 glyceryl monostearate Drugs 0.000 description 4
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
229940039717 lanolin Drugs 0.000 description 4
235000019388 lanolin Nutrition 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 3
229940008099 dimethicone Drugs 0.000 description 3
239000004205 dimethyl polysiloxane Substances 0.000 description 3
235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
229910052736 halogen Inorganic materials 0.000 description 3
229930195733 hydrocarbon Natural products 0.000 description 3
150000002430 hydrocarbons Chemical class 0.000 description 3
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 3
239000002736 nonionic surfactant Substances 0.000 description 3
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
150000003242 quaternary ammonium salts Chemical class 0.000 description 3
229910052710 silicon Inorganic materials 0.000 description 3
239000010703 silicon Substances 0.000 description 3
239000000344 soap Substances 0.000 description 3
XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 3
PUNFIBHMZSHFKF-KTKRTIGZSA-N (z)-henicos-12-ene-1,2,3-triol Chemical compound CCCCCCCC\C=C/CCCCCCCCC(O)C(O)CO PUNFIBHMZSHFKF-KTKRTIGZSA-N 0.000 description 2
XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 description 2
DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
235000019482 Palm oil Nutrition 0.000 description 2
VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
108010077895 Sarcosine Proteins 0.000 description 2
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000000654 additive Substances 0.000 description 2
150000008051 alkyl sulfates Chemical class 0.000 description 2
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 2
229960005193 avobenzone Drugs 0.000 description 2
150000007942 carboxylates Chemical class 0.000 description 2
229960000541 cetyl alcohol Drugs 0.000 description 2
WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 2
235000012000 cholesterol Nutrition 0.000 description 2
239000006071 cream Substances 0.000 description 2
229940086555 cyclomethicone Drugs 0.000 description 2
DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
239000007854 depigmenting agent Substances 0.000 description 2
ILRSCQWREDREME-UHFFFAOYSA-N dodecanamide Chemical compound CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 description 2
SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
230000001804 emulsifying effect Effects 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
239000003205 fragrance Substances 0.000 description 2
239000000499 gel Substances 0.000 description 2
150000002367 halogens Chemical group 0.000 description 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
125000002768 hydroxyalkyl group Chemical group 0.000 description 2
MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 2
SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical class OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000006210 lotion Substances 0.000 description 2
239000000693 micelle Substances 0.000 description 2
239000004530 micro-emulsion Substances 0.000 description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
OQILCOQZDHPEAZ-UHFFFAOYSA-N octyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 2
JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
239000002540 palm oil Substances 0.000 description 2
229940100460 peg-100 stearate Drugs 0.000 description 2
235000021317 phosphate Nutrition 0.000 description 2
239000008213 purified water Substances 0.000 description 2
ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
229940043230 sarcosine Drugs 0.000 description 2
230000035807 sensation Effects 0.000 description 2
235000019615 sensations Nutrition 0.000 description 2
239000002195 soluble material Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 2
150000003871 sulfonates Chemical class 0.000 description 2
239000003760 tallow Substances 0.000 description 2
BGHCVCJVXZWKCC-UHFFFAOYSA-N tetradecane Chemical compound CCCCCCCCCCCCCC BGHCVCJVXZWKCC-UHFFFAOYSA-N 0.000 description 2
ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
IIYFAKIEWZDVMP-UHFFFAOYSA-N tridecane Chemical compound CCCCCCCCCCCCC IIYFAKIEWZDVMP-UHFFFAOYSA-N 0.000 description 2
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
DRAWQKGUORNASA-UHFFFAOYSA-N (2-hydroxy-3-octadec-9-enoyloxypropyl) octadec-9-enoate Chemical compound CCCCCCCCC=CCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCC=CCCCCCCCC DRAWQKGUORNASA-UHFFFAOYSA-N 0.000 description 1
XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 description 1
ZPFAVCIQZKRBGF-UHFFFAOYSA-N 1,3,2-dioxathiolane 2,2-dioxide Chemical compound O=S1(=O)OCCO1 ZPFAVCIQZKRBGF-UHFFFAOYSA-N 0.000 description 1
QPRQGBZSPPWULZ-UHFFFAOYSA-N 1-(18-methylnonadecyl)-4,5-dihydroimidazole Chemical compound CC(C)CCCCCCCCCCCCCCCCCN1CCN=C1 QPRQGBZSPPWULZ-UHFFFAOYSA-N 0.000 description 1
WECGLUPZRHILCT-GSNKCQISSA-N 1-linoleoyl-sn-glycerol Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](O)CO WECGLUPZRHILCT-GSNKCQISSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
JSOVGYMVTPPEND-UHFFFAOYSA-N 16-methylheptadecyl 2,2-dimethylpropanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)C(C)(C)C JSOVGYMVTPPEND-UHFFFAOYSA-N 0.000 description 1
239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 description 1
QJEBJKXTNSYBGE-UHFFFAOYSA-N 2-(2-heptadecyl-4,5-dihydroimidazol-1-yl)ethanol Chemical compound CCCCCCCCCCCCCCCCCC1=NCCN1CCO QJEBJKXTNSYBGE-UHFFFAOYSA-N 0.000 description 1
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
IZHSCDOXRKNGBC-UHFFFAOYSA-M 2-[1-benzyl-2-(15-methylhexadecyl)-4,5-dihydroimidazol-1-ium-1-yl]ethanol;chloride Chemical compound [Cl-].CC(C)CCCCCCCCCCCCCCC1=NCC[N+]1(CCO)CC1=CC=CC=C1 IZHSCDOXRKNGBC-UHFFFAOYSA-M 0.000 description 1
MGYUQZIGNZFZJS-KTKRTIGZSA-N 2-[2-[(z)-octadec-9-enoxy]ethoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCOCCO MGYUQZIGNZFZJS-KTKRTIGZSA-N 0.000 description 1
SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 description 1
TZGPACAKMCUCKX-UHFFFAOYSA-N 2-hydroxyacetamide Chemical compound NC(=O)CO TZGPACAKMCUCKX-UHFFFAOYSA-N 0.000 description 1
BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 description 1
OHUWJIVNYZYXDZ-UHFFFAOYSA-N 2-oxo-2-tetradecoxyethanesulfonic acid Chemical compound CCCCCCCCCCCCCCOC(=O)CS(O)(=O)=O OHUWJIVNYZYXDZ-UHFFFAOYSA-N 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
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Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Dispersion Chemistry (AREA)
Dermatology (AREA)
Nanotechnology (AREA)
Biophysics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Medical Informatics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Cosmetics (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

JP2002578903A 2001-03-30 2002-03-29 新規ナノエマルション Expired - Fee Related JP4444565B2 (ja)

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US28070001P	2001-03-30	2001-03-30
PCT/US2002/009630 WO2002080864A1 (en)	2001-03-30	2002-03-29	Novel nanoemulsions

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JP4444565B2 true JP4444565B2 (ja)	2010-03-31

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EP (1)	EP1377255A4 (de)
JP (1)	JP4444565B2 (de)
AU (1)	AU2002258644B2 (de)
CA (1)	CA2442660A1 (de)
WO (1)	WO2002080864A1 (de)

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KR101837433B1 (ko) *	2017-05-26	2018-03-12	주식회사 스타프랜즈	유용성 성분을 함유하는 나노에멀젼, 이의 제조방법 및 이를 포함하는 화장료 조성물

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US9486408B2 (en)	2005-12-01	2016-11-08	University Of Massachusetts Lowell	Botulinum nanoemulsions
DE102006004353A1 (de) *	2006-01-30	2007-08-02	Goldschmidt Gmbh	Kaltherstellbare, niedrigviskose und langzeitstabile kosmetische Emulsionen
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WO2008137747A1 (en)	2007-05-02	2008-11-13	The Regents Of The University Of Michigan	Nanoemulsion therapeutic compositions and methods of using the same
CN101765423B (zh)	2007-05-31	2014-08-06	安特里奥公司	核酸纳米粒子和其用途
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2002
- 2002-03-29 EP EP02728600A patent/EP1377255A4/de not_active Withdrawn
- 2002-03-29 JP JP2002578903A patent/JP4444565B2/ja not_active Expired - Fee Related
- 2002-03-29 CA CA002442660A patent/CA2442660A1/en not_active Abandoned
- 2002-03-29 AU AU2002258644A patent/AU2002258644B2/en not_active Ceased
- 2002-03-29 WO PCT/US2002/009630 patent/WO2002080864A1/en not_active Ceased

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Publication number	Publication date
EP1377255A1 (de)	2004-01-07
WO2002080864A1 (en)	2002-10-17
EP1377255A4 (de)	2008-11-19
AU2002258644B2 (en)	2006-12-14
CA2442660A1 (en)	2002-10-17
JP2004532214A (ja)	2004-10-21

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Publication	Publication Date	Title
JP4444565B2 (ja)	2010-03-31	新規ナノエマルション
US20040115159A1 (en)	2004-06-17	Novel nanoemulsions
AU2002258644A1 (en)	2003-04-10	Novel nanoemulsions
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EP0717978A2 (de)	1996-06-26	Wasser-in-Öl-in-Wasser Spülmittel
JPH0665596A (ja)	1994-03-08	新規複合体及び乳化組成物
JPH08245371A (ja)	1996-09-24	流動性非イオン性両親媒性脂質をベースとする透明なナノエマルション及び化粧品もしくは皮膚用製薬におけるその使用
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JP2026020358A (ja)	2026-02-06	水中油型乳化組成物

JP4444565B2 - 新規ナノエマルション - Google Patents

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