JP4531990B2 - 間質性肺炎・肺線維症の予防・治療薬 - Google Patents

間質性肺炎・肺線維症の予防・治療薬 Download PDF

Info

Publication number: JP4531990B2
Authority: JP; Japan
Prior art keywords: trans; pyridylcarbamoyl; interstitial pneumonia; pulmonary fibrosis; aminoethyl
Prior art date: 1999-03-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2000607663A

Other languages

English (en)

Japanese (ja)

Other versions

JPWO2000057913A1 (ja

Inventor

邦彦飯塚

邦生土橋

雅義上畑

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Tanabe Pharma Corp

Original Assignee

Mitsubishi Tanabe Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-25

Filing date

2000-03-21

Publication date

2010-08-25

2000-03-21 Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp

2002-07-09 Publication of JPWO2000057913A1 publication Critical patent/JPWO2000057913A1/ja

2010-08-25 Application granted granted Critical

2010-08-25 Publication of JP4531990B2 publication Critical patent/JP4531990B2/ja

2020-03-21 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

0 CC1CCC(*N(*)*)CC1 Chemical compound CC1CCC(*N(*)*)CC1 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1

Images

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system

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Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pyridine Compounds (AREA)

JP2000607663A 1999-03-25 2000-03-21 間質性肺炎・肺線維症の予防・治療薬 Expired - Fee Related JP4531990B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP11-81072		1999-03-25
JP8107299		1999-03-25
PCT/JP2000/001728 WO2000057913A1 (fr)	1999-03-25	2000-03-21	Prophylaxies/remedes pour la pneumonie interstitielle et la fibrose pulmonaire

Publications (2)

Publication Number	Publication Date
JPWO2000057913A1 JPWO2000057913A1 (ja)	2002-07-09
JP4531990B2 true JP4531990B2 (ja)	2010-08-25

Family

ID=13736199

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2000607663A Expired - Fee Related JP4531990B2 (ja)	1999-03-25	2000-03-21	間質性肺炎・肺線維症の予防・治療薬

Country Status (12)

Country	Link
US (1)	US6844354B1 (fr)
EP (1)	EP1163910B1 (fr)
JP (1)	JP4531990B2 (fr)
KR (1)	KR100704704B1 (fr)
CN (1)	CN1187090C (fr)
AT (1)	ATE374026T1 (fr)
AU (1)	AU3196900A (fr)
CA (1)	CA2368675C (fr)
DE (1)	DE60036540T2 (fr)
ES (1)	ES2295009T3 (fr)
HK (1)	HK1042656A1 (fr)
WO (1)	WO2000057913A1 (fr)

Families Citing this family (31)

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JP2004509876A (ja)	2000-09-20	2004-04-02	メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング	４−アミノ−キナゾリン
US7829566B2 (en)	2001-09-17	2010-11-09	Werner Mederski	4-amino-quinazolines
JP4505228B2 (ja)	2002-01-10	2010-07-21	バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト	Ｒｈｏ−キナーゼ阻害剤
EP1470121B1 (fr)	2002-01-23	2012-07-11	Bayer HealthCare LLC	Derives pyrimidine en tant qu'inhibiteurs de kinase rho
MXPA04007196A (es)	2002-01-23	2005-06-08	Bayer Pharmaceuticals Corp	Inhibidores de rho-quinasa.
US7645878B2 (en)	2002-03-22	2010-01-12	Bayer Healthcare Llc	Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
WO2005007110A2 (fr) *	2003-07-11	2005-01-27	Pro-Pharmaceuticals, Inc.	Compositions et procedes d'administration de medicaments hydrophobes
US20050053664A1 (en) *	2003-09-08	2005-03-10	Eliezer Zomer	Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
EP1718146A2 (fr) *	2004-02-13	2006-11-08	Pro-Pharmaceuticals, Inc.	Compositions et procedes utilises pour traiter l'acne et la candida
FR2868310A1 (fr) *	2004-04-02	2005-10-07	Oreal	Utilisation cosmetique d'au moins un inhibiteur de la production et/ou de l'activation des rhoa kinases comme agent destine a detendre les traits et/ou decontracter la peau
US20080286251A1 (en) *	2004-08-02	2008-11-20	Propharmaceuticals, Inc.	Compositions and Methods for the Enhancement of Chemotherapy with Microbial Cytotoxins
US20120269886A1 (en)	2004-12-22	2012-10-25	Nitto Denko Corporation	Therapeutic agent for pulmonary fibrosis
JP2009221164A (ja)	2008-03-17	2009-10-01	Nitto Denko Corp	肺線維症処置剤
WO2008011216A2 (fr)	2006-05-16	2008-01-24	Pro-Pharmaceuticals, Inc.	Polysaccharides à dents de galactose dans une formulation pour des thérapies antifibrotiques
WO2007136790A2 (fr) *	2006-05-18	2007-11-29	Mannkind Corporation	Inhibiteurs de kinases intracellulaires
WO2009158587A1 (fr) *	2008-06-26	2009-12-30	Inspire Pharmaceuticals, Inc.	Procédé permettant de traiter des maladies pulmonaires par des composés inhibiteurs de rho kinase
US8273900B2 (en)	2008-08-07	2012-09-25	Novartis Ag	Organic compounds
WO2010096746A1 (fr)	2009-02-20	2010-08-26	Cellular Dynamics International, Inc.	Procédés et compositions pour la différenciation de cellules souches
KR101720961B1 (ko)	2009-02-27	2017-03-29	셀룰러 다이내믹스 인터내셔널, 인코포레이티드	다능성 세포의 분화
WO2011021221A2 (fr)	2009-08-17	2011-02-24	Reliance Life Sciences Pvt. Ltd.	Compositions destinées aux lésions de la moelle épinière
GB201107176D0 (en)	2011-04-28	2011-06-15	Cxr Biosciences Ltd	Pyrrolnitrin derivatives
EP2628482A1 (fr)	2012-02-17	2013-08-21	Academisch Medisch Centrum	Inhibiteurs du rho kinase pour l'utilisation dans le traitement du neuroblastome
WO2013163171A1 (fr)	2012-04-24	2013-10-31	Kaufman Dan S	Procédé de développement de cellules tueuses naturelles à partir de cellules souches
US9339515B2 (en)	2013-02-20	2016-05-17	Galectin Therapeutics, Inc.	Method for treatment of pulmonary fibrosis
CA2899507A1 (fr)	2013-03-14	2014-09-25	The Regents Of The University Of California	Production in vitro de cellules de precurseurs d'eminence ganglionnaire mediane
WO2016085765A1 (fr)	2014-11-25	2016-06-02	President And Fellows Of Harvard College	Procédés de génération de podocytes à partir de cellules souches pluripotentes et cellules obtenues selon ces procédés
US11739326B2 (en)	2017-11-14	2023-08-29	Massachusetts Eye And Ear Infirmary	RUNX1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition
CN110833559A (zh) *	2018-08-15	2020-02-25	广西梧州制药（集团）股份有限公司	吡唑并嘧啶衍生物在治疗急性肺损伤致肺纤维化的用途
CA3110661A1 (fr)	2018-08-29	2020-03-05	University Of Massachusetts	Inhibition de proteines kinases pour traiter la maladie de friedreich
JP7429032B2 (ja) *	2019-12-24	2024-02-07	学校法人順天堂	間質性肺炎モデル非ヒト動物の作製方法
CN112028892B (zh) *	2020-07-29	2022-12-16	天津全和诚科技有限责任公司	4-氨基-吡咯并三嗪衍生物在制备抗肺纤维化制剂中的应用

Citations (10)

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Publication number	Priority date	Publication date	Assignee	Title
JPS61158983A (ja) *	1984-12-28	1986-07-18	Yoshitomi Pharmaceut Ind Ltd	プリン誘導体
JPH02290821A (ja) *	1989-04-28	1990-11-30	Pias Arise Kk	コラーゲン合成阻害剤とその製造方法
JPH05221872A (ja) *	1991-12-19	1993-08-31	Fujisawa Pharmaceut Co Ltd	Ｗｓ７６２２ａモノまたはジ硫酸エステルを含む医薬組成物
JPH06345643A (ja) *	1993-06-04	1994-12-20	Hoechst Ag	置換ベンゾイルグアニジン、その製造方法、医薬または診断薬としてのその使用およびそれらを含有する医薬
WO1995029694A1 (fr) *	1994-04-28	1995-11-09	Snow Brand Milk Products Co., Ltd.	Accelerateur d'hydrolyse du collegene
WO1997037969A1 (fr) *	1996-04-10	1997-10-16	Ono Pharmaceutical Co., Ltd.	Inhibiteur de tryptase derives de guanidino
WO1998006433A1 (fr) *	1996-08-12	1998-02-19	Yoshitomi Pharmaceutical Industries, Ltd.	MEDICAMENTS COMPRENANT UN INHIBITEUR DE LA Rho KINASE
JPH10113187A (ja) *	1995-11-20	1998-05-06	Kirin Brewery Co Ltd	Ｒｈｏ標的タンパク質Ｒｈｏキナーゼ
JPH10218768A (ja) *	1997-02-10	1998-08-18	Asahi Chem Ind Co Ltd	増殖性疾患治療剤
WO1998047892A1 (fr) *	1997-04-24	1998-10-29	Ortho-Mcneil Corporation, Inc.	Imidazoles substitues utilisables dans le traitement de maladies inflammatoires

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2000
- 2000-03-21 WO PCT/JP2000/001728 patent/WO2000057913A1/fr not_active Ceased
- 2000-03-21 AT AT00909782T patent/ATE374026T1/de not_active IP Right Cessation
- 2000-03-21 US US09/937,221 patent/US6844354B1/en not_active Expired - Fee Related
- 2000-03-21 AU AU31969/00A patent/AU3196900A/en not_active Abandoned
- 2000-03-21 DE DE60036540T patent/DE60036540T2/de not_active Expired - Lifetime
- 2000-03-21 EP EP00909782A patent/EP1163910B1/fr not_active Expired - Lifetime
- 2000-03-21 CN CNB008079676A patent/CN1187090C/zh not_active Expired - Fee Related
- 2000-03-21 KR KR1020017012167A patent/KR100704704B1/ko not_active Expired - Fee Related
- 2000-03-21 HK HK02104514.7A patent/HK1042656A1/en unknown
- 2000-03-21 CA CA002368675A patent/CA2368675C/fr not_active Expired - Fee Related
- 2000-03-21 ES ES00909782T patent/ES2295009T3/es not_active Expired - Lifetime
- 2000-03-21 JP JP2000607663A patent/JP4531990B2/ja not_active Expired - Fee Related

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61158983A (ja) *	1984-12-28	1986-07-18	Yoshitomi Pharmaceut Ind Ltd	プリン誘導体
JPH02290821A (ja) *	1989-04-28	1990-11-30	Pias Arise Kk	コラーゲン合成阻害剤とその製造方法
JPH05221872A (ja) *	1991-12-19	1993-08-31	Fujisawa Pharmaceut Co Ltd	Ｗｓ７６２２ａモノまたはジ硫酸エステルを含む医薬組成物
JPH06345643A (ja) *	1993-06-04	1994-12-20	Hoechst Ag	置換ベンゾイルグアニジン、その製造方法、医薬または診断薬としてのその使用およびそれらを含有する医薬
WO1995029694A1 (fr) *	1994-04-28	1995-11-09	Snow Brand Milk Products Co., Ltd.	Accelerateur d'hydrolyse du collegene
JPH10113187A (ja) *	1995-11-20	1998-05-06	Kirin Brewery Co Ltd	Ｒｈｏ標的タンパク質Ｒｈｏキナーゼ
WO1997037969A1 (fr) *	1996-04-10	1997-10-16	Ono Pharmaceutical Co., Ltd.	Inhibiteur de tryptase derives de guanidino
WO1998006433A1 (fr) *	1996-08-12	1998-02-19	Yoshitomi Pharmaceutical Industries, Ltd.	MEDICAMENTS COMPRENANT UN INHIBITEUR DE LA Rho KINASE
JPH10218768A (ja) *	1997-02-10	1998-08-18	Asahi Chem Ind Co Ltd	増殖性疾患治療剤
WO1998047892A1 (fr) *	1997-04-24	1998-10-29	Ortho-Mcneil Corporation, Inc.	Imidazoles substitues utilisables dans le traitement de maladies inflammatoires

Also Published As

Publication number	Publication date
DE60036540D1 (de)	2007-11-08
EP1163910A1 (fr)	2001-12-19
ES2295009T3 (es)	2008-04-16
HK1042656A1 (en)	2002-08-23
CN1351504A (zh)	2002-05-29
EP1163910A4 (fr)	2003-11-12
AU3196900A (en)	2000-10-16
ATE374026T1 (de)	2007-10-15
KR100704704B1 (ko)	2007-04-09
US6844354B1 (en)	2005-01-18
CA2368675C (fr)	2008-08-12
KR20020019896A (ko)	2002-03-13
WO2000057913A1 (fr)	2000-10-05
DE60036540T2 (de)	2008-07-03
EP1163910B1 (fr)	2007-09-26
CN1187090C (zh)	2005-02-02
CA2368675A1 (fr)	2000-10-05

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Publication	Publication Date	Title
JP4531990B2 (ja)	2010-08-25	間質性肺炎・肺線維症の予防・治療薬
JP4509395B2 (ja)	2010-07-21	肝臓疾患の予防治療薬
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