JP4659984B2 - 精神障害の処置のための３−テトラヒドロピリジン−４−イルインドール類 - Google Patents

精神障害の処置のための３−テトラヒドロピリジン−４−イルインドール類 Download PDF

Info

Publication number: JP4659984B2
Authority: JP; Japan
Prior art keywords: formula; compound; tetrahydropyridin; compounds; alkyl
Prior art date: 1998-10-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2000577167A

Other languages

English (en)

Japanese (ja)

Other versions

JP2002527515A (ja

Inventor

トウルプ，マルテイヌス・テイ・エム

バン・デル・ハイーデン，ヨハネス・エイ・エム

バン・ブリート，ベルナルド

テイプカー，ヤコブス

バンヘス，ローロフ

クルゼ，コルネリス・ジー

ビサー，ゲルベン・エム

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Duphar International Research Besloten Vennootshap

Original Assignee

Duphar International Research Besloten Vennootshap

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-16

Filing date

1999-10-15

Publication date

2011-03-30

1999-10-15 Application filed by Duphar International Research Besloten Vennootshap filed Critical Duphar International Research Besloten Vennootshap

2002-08-27 Publication of JP2002527515A publication Critical patent/JP2002527515A/ja

2011-03-30 Application granted granted Critical

2011-03-30 Publication of JP4659984B2 publication Critical patent/JP4659984B2/ja

2019-10-15 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

0 CN(CC1)CC=C1C(C=C*(*C=C)C=C1)=C1N(*)C=C Chemical compound CN(CC1)CC=C1C(C=C*(*C=C)C=C1)=C1N(*)C=C 0.000 description 3
ZXLYYQUMYFHCLQ-UHFFFAOYSA-N CN(C(c1c2cccc1)=O)C2=O Chemical compound CN(C(c1c2cccc1)=O)C2=O ZXLYYQUMYFHCLQ-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

JP2000577167A 1998-10-16 1999-10-15 精神障害の処置のための３−テトラヒドロピリジン−４−イルインドール類 Expired - Fee Related JP4659984B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP98203499.3		1998-10-16
EP98203499		1998-10-16
PCT/EP1999/007912 WO2000023441A1 (en)	1998-10-16	1999-10-15	3-tetrahydropyridin-4-yl indoles for treatment of psychotic disorders

Publications (2)

Publication Number	Publication Date
JP2002527515A JP2002527515A (ja)	2002-08-27
JP4659984B2 true JP4659984B2 (ja)	2011-03-30

Family

ID=8234230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2000577167A Expired - Fee Related JP4659984B2 (ja)	1998-10-16	1999-10-15	精神障害の処置のための３−テトラヒドロピリジン−４−イルインドール類

Country Status (28)

Country	Link
US (1)	US6391896B1 (de)
EP (1)	EP1121356B1 (de)
JP (1)	JP4659984B2 (de)
KR (1)	KR100619464B1 (de)
CN (1)	CN1140524C (de)
AR (1)	AR020773A1 (de)
AT (1)	ATE230741T1 (de)
AU (1)	AU750811B2 (de)
BR (1)	BR9914582A (de)
CA (1)	CA2346896C (de)
CZ (1)	CZ20011353A3 (de)
DE (1)	DE69904849T2 (de)
DK (1)	DK1121356T3 (de)
DZ (1)	DZ2917A1 (de)
ES (1)	ES2188260T3 (de)
HU (1)	HUP0104701A3 (de)
IL (2)	IL142589A0 (de)
NO (1)	NO320531B1 (de)
NZ (1)	NZ511289A (de)
PL (1)	PL195734B1 (de)
RU (1)	RU2222535C2 (de)
SI (1)	SI1121356T1 (de)
SK (1)	SK285764B6 (de)
TR (1)	TR200101808T2 (de)
TW (1)	TW577884B (de)
UA (1)	UA66888C2 (de)
WO (1)	WO2000023441A1 (de)
ZA (1)	ZA200103251B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2373855A1 (en) *	1999-05-12	2000-11-23	Solvay Pharmaceuticals B.V.	Method of treating psychotic disorders
AU772189B2 (en)	1999-08-23	2004-04-08	Solvay Pharmaceuticals B.V.	New phenylpiperazines
AR032711A1 (es)	2001-02-21	2003-11-19	Solvay Pharm Bv	Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
AR032712A1 (es) *	2001-02-21	2003-11-19	Solvay Pharm Bv	Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
US7371769B2 (en)	2004-12-07	2008-05-13	Solvay Pharmaceuticals B.V.	Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20070072870A2 (en)	2004-12-08	2007-03-29	Solvay Pharmeceuticals B.V.	Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
US20060227421A1 (en) *	2005-04-06	2006-10-12	Stover Carl A	Optical bodies including strippable boundary layers
US9709700B2 (en) *	2005-04-06	2017-07-18	3M Innovative Properties Company	Optical bodies including rough strippable boundary layers
WO2006107969A1 (en)	2005-04-06	2006-10-12	3M Innovative Properties Company	Optical bodies including rough strippable boundary layers and asymmetric surface structures

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4414113A1 (de)	1994-04-22	1995-10-26	Merck Patent Gmbh	3-Indolylpiperidine
US5576321A (en) *	1995-01-17	1996-11-19	Eli Lilly And Company	Compounds having effects on serotonin-related systems
ZA9711376B (en) *	1996-12-20	1998-07-21	Lundbeck & Co As H	Indole or dihydroindole derivatives

1999
- 1999-10-12 AR ARP990105138A patent/AR020773A1/es active IP Right Grant
- 1999-10-13 TW TW088117668A patent/TW577884B/zh not_active IP Right Cessation
- 1999-10-15 DE DE69904849T patent/DE69904849T2/de not_active Expired - Lifetime
- 1999-10-15 WO PCT/EP1999/007912 patent/WO2000023441A1/en not_active Ceased
- 1999-10-15 HU HU0104701A patent/HUP0104701A3/hu unknown
- 1999-10-15 ES ES99952604T patent/ES2188260T3/es not_active Expired - Lifetime
- 1999-10-15 TR TR2001/01808T patent/TR200101808T2/xx unknown
- 1999-10-15 CN CNB998135801A patent/CN1140524C/zh not_active Expired - Fee Related
- 1999-10-15 JP JP2000577167A patent/JP4659984B2/ja not_active Expired - Fee Related
- 1999-10-15 KR KR1020017004764A patent/KR100619464B1/ko not_active Expired - Fee Related
- 1999-10-15 AU AU64741/99A patent/AU750811B2/en not_active Ceased
- 1999-10-15 SK SK512-2001A patent/SK285764B6/sk not_active IP Right Cessation
- 1999-10-15 BR BR9914582-0A patent/BR9914582A/pt active Search and Examination
- 1999-10-15 SI SI9930196T patent/SI1121356T1/xx unknown
- 1999-10-15 CZ CZ20011353A patent/CZ20011353A3/cs unknown
- 1999-10-15 EP EP99952604A patent/EP1121356B1/de not_active Expired - Lifetime
- 1999-10-15 NZ NZ511289A patent/NZ511289A/xx not_active IP Right Cessation
- 1999-10-15 DK DK99952604T patent/DK1121356T3/da active
- 1999-10-15 IL IL14258999A patent/IL142589A0/xx active IP Right Grant
- 1999-10-15 US US09/807,408 patent/US6391896B1/en not_active Expired - Lifetime
- 1999-10-15 AT AT99952604T patent/ATE230741T1/de active
- 1999-10-15 CA CA002346896A patent/CA2346896C/en not_active Expired - Fee Related
- 1999-10-15 UA UA2001053312A patent/UA66888C2/uk unknown
- 1999-10-15 RU RU2001113272/04A patent/RU2222535C2/ru not_active IP Right Cessation
- 1999-10-15 PL PL99347329A patent/PL195734B1/pl not_active IP Right Cessation
- 1999-10-16 DZ DZ990217A patent/DZ2917A1/xx active
2001
- 2001-04-15 IL IL142589A patent/IL142589A/en not_active IP Right Cessation
- 2001-04-17 NO NO20011892A patent/NO320531B1/no not_active IP Right Cessation
- 2001-04-20 ZA ZA200103251A patent/ZA200103251B/en unknown

Also Published As

Publication number	Publication date
IL142589A (en)	2007-10-31
AU6474199A (en)	2000-05-08
HK1039333A1 (en)	2002-04-19
CA2346896C (en)	2008-12-09
EP1121356B1 (de)	2003-01-08
SI1121356T1 (en)	2003-04-30
CN1328553A (zh)	2001-12-26
BR9914582A (pt)	2001-07-03
NO20011892L (no)	2001-06-12
NO20011892D0 (no)	2001-04-17
WO2000023441A1 (en)	2000-04-27
DK1121356T3 (da)	2003-03-24
PL347329A1 (en)	2002-03-25
KR20010080183A (ko)	2001-08-22
ZA200103251B (en)	2002-07-22
JP2002527515A (ja)	2002-08-27
CN1140524C (zh)	2004-03-03
SK5122001A3 (en)	2001-10-08
NZ511289A (en)	2003-01-31
US6391896B1 (en)	2002-05-21
HUP0104701A2 (hu)	2002-04-29
KR100619464B1 (ko)	2006-09-05
SK285764B6 (sk)	2007-07-06
CZ20011353A3 (cs)	2001-09-12
AU750811B2 (en)	2002-07-25
RU2222535C2 (ru)	2004-01-27
TW577884B (en)	2004-03-01
PL195734B1 (pl)	2007-10-31
HUP0104701A3 (en)	2003-01-28
ES2188260T3 (es)	2003-06-16
IL142589A0 (en)	2002-03-10
DZ2917A1 (fr)	2004-06-20
DE69904849D1 (de)	2003-02-13
DE69904849T2 (de)	2003-11-13
UA66888C2 (uk)	2004-06-15
TR200101808T2 (tr)	2001-10-22
AR020773A1 (es)	2002-05-29
ATE230741T1 (de)	2003-01-15
CA2346896A1 (en)	2000-04-27
EP1121356A1 (de)	2001-08-08
NO320531B1 (no)	2005-12-19

Legal Events

Date	Code	Title	Description
2006-09-30	A621	Written request for application examination	Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060929
2008-06-11	RD02	Notification of acceptance of power of attorney	Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20080610
2010-06-08	A131	Notification of reasons for refusal	Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100608
2010-09-09	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100908
2010-12-09	TRDD	Decision of grant or rejection written
2010-12-21	A01	Written decision to grant a patent or to grant a registration (utility model)	Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20101221
2010-12-24	A01	Written decision to grant a patent or to grant a registration (utility model)	Free format text: JAPANESE INTERMEDIATE CODE: A01
2011-01-06	A61	First payment of annual fees (during grant procedure)	Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20101228
2011-01-07	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20140107 Year of fee payment: 3
2011-01-07	R150	Certificate of patent or registration of utility model	Free format text: JAPANESE INTERMEDIATE CODE: R150
2014-01-07	LAPS	Cancellation because of no payment of annual fees

Publication	Publication Date	Title
JP4919565B2 (ja)	2012-04-18	新規なフェニルピペラジン
JP4191826B2 (ja)	2008-12-03	新規なピペラジン及びピペリジン化合物
JP2003505373A (ja)	2003-02-12	ビフェニル誘導体、その製法及び薬剤としての使用
JPS60123485A (ja)	1985-07-02	インド−ル−３−カルボキサミド誘導体
JP2002530276A (ja)	2002-09-17	新規なピペラジンおよびピペリジン化合物
JP4659984B2 (ja)	2011-03-30	精神障害の処置のための３−テトラヒドロピリジン−４−イルインドール類
JP2959987B2 (ja)	1999-10-06	新規なベンゾジオキサン化合物、それらの製造方法およびそれらを含有する医薬組成物
JP2002544223A (ja)	2002-12-24	精神病性障害の治療方法
JP4178033B2 (ja)	2008-11-12	新規フェニルピペラジン
MXPA01003882A (es)	2002-06-05	3-tetrahidropiridin-4-il indoles para el tratamiento de trastornos psicoticos
HK1039333B (en)	2003-05-16	3-tetrahydropyridin-4-yl indoles for treatment of psychotic disorders
FR2773800A1 (fr)	1999-07-23	Derives de benzimidazole, leur procede de preparation et leur application en therapeutique
JPS6197283A (ja)	1986-05-15	ピペリジン誘導体、その製造法およびそれらを含有する医薬組成物