JP4852218B2 - アルコール代謝促進剤組成物 - Google Patents

アルコール代謝促進剤組成物 Download PDF

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Publication number: JP4852218B2
Authority: JP; Japan
Prior art keywords: alcohol; hangover; fermentation; citrus molasses; alcohol metabolism
Prior art date: 2000-06-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2002505020A

Other languages

English (en)

Japanese (ja)

Other versions

JPWO2002000238A1 (ja

Inventor

憲司水本

一佐々木

真山口

高二矢島

秀夫長谷川

裕史有馬

英生大友

賢一中澤

栄志根岸

保子澤井

政雄高見

大介小堤

昌代有田

晃智粂

勝幸内田

肇角尾

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Meiji Co Ltd

Original Assignee

Meiji Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-20

Filing date

2001-06-20

Publication date

2012-01-11

2001-06-20 Application filed by Meiji Co Ltd filed Critical Meiji Co Ltd

2001-06-20 Priority to JP2002505020A priority Critical patent/JP4852218B2/ja

2003-09-24 Publication of JPWO2002000238A1 publication Critical patent/JPWO2002000238A1/ja

2012-01-11 Application granted granted Critical

2012-01-11 Publication of JP4852218B2 publication Critical patent/JP4852218B2/ja

2021-06-20 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

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Classifications

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- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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JP2009108099A (ja) *	2009-01-13	2009-05-21	Meiji Milk Prod Co Ltd	脳血管障害の予防または改善のための組成物
JP2013526324A (ja)	2010-05-13	2013-06-24	エアクラフトメディカルリミテッド	喉頭鏡挿入セクション構造
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5959185A (ja) *	1982-09-28	1984-04-04	Kawachichiyou	フル−ツ・スピリツツの製造方法
JPS61108366A (ja) *	1984-11-01	1986-05-27	Yasuji Yoshida	柑橘酒の製造法

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* Cited by examiner, † Cited by third party
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JPS60126066A (ja) *	1983-12-07	1985-07-05	Tadasu Sawabe	柑橘類の搾汁粕中に残存する果汁の回収方法および同回収装置
JP2678770B2 (ja) *	1988-08-30	1997-11-17	株式会社中埜酢店	新規食品素材の製造法
JP3262999B2 (ja) *	1997-04-03	2002-03-04	愛媛県農業協同組合連合会	柑橘類搾汁残渣の有効利用法

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5959185A (ja) *	1982-09-28	1984-04-04	Kawachichiyou	フル−ツ・スピリツツの製造方法
JPS61108366A (ja) *	1984-11-01	1986-05-27	Yasuji Yoshida	柑橘酒の製造法

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