WO2002000238A1 - Compositions favorisant le metabolisme de l'alcool - Google Patents

Compositions favorisant le metabolisme de l'alcool Download PDF

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Publication number
WO2002000238A1
WO2002000238A1 PCT/JP2001/005259 JP0105259W WO0200238A1 WO 2002000238 A1 WO2002000238 A1 WO 2002000238A1 JP 0105259 W JP0105259 W JP 0105259W WO 0200238 A1 WO0200238 A1 WO 0200238A1
Authority
WO
WIPO (PCT)
Prior art keywords
fermentation
alcohol
yeast
hangover
citrus molasses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2001/005259
Other languages
English (en)
Japanese (ja)
Inventor
Kenji Mizumoto
Hajime Sasaki
Makoto Yamaguchi
Takaji Yajima
Hideo Hasegawa
Hirofumi Arima
Hideo Otomo
Kenichi Nakazawa
Eiji Negishi
Yasuko Sawai
Masao Takami
Daisuke Kotsutsumi
Masayo Arita
Akitomo Kume
Katsuyuki Uchida
Hajime Tsunoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Dairies Corp
Original Assignee
Meiji Milk Products Co Ltd
Meiji Dairies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Milk Products Co Ltd, Meiji Dairies Corp filed Critical Meiji Milk Products Co Ltd
Priority to JP2002505020A priority Critical patent/JP4852218B2/ja
Priority to AU2001274564A priority patent/AU2001274564A1/en
Publication of WO2002000238A1 publication Critical patent/WO2002000238A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
    • C12G3/05—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides
    • C12G3/055—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides extracted from plants

Definitions

  • the present invention relates to an alcohol metabolism promoter composition and a composition for preventing and improving sickness or hangover.
  • Acetaldehyde is highly toxic and can cause gastrointestinal discomfort, nausea, headaches and hangovers. Therefore, it is important to quickly remove acetoaldehyde from blood after alcohol consumption to prevent sickness and hangover. Therefore, it is considered that an oral substance having an action of enhancing the activity of aldehyde dehydrogenase, that is, an oral substance which promotes the metabolism of acetoaldehyde, is effective in preventing or improving the above-mentioned sickness and hangover.
  • Such oral substances include, for example, alcohol metabolism promoters (JP-A-7-285881) containing, as an active ingredient, a peptide having a molecular weight of 200 to 4,000 obtained by enzymatic degradation of corn protein, and pork with protease. Processing And an alcohol metabolism promoting substance containing a processed pork product (JP-A-11-276116), or a hangover-preventive food containing isoflavonoid as an active ingredient (JP-A-2000-7694).
  • alcohol metabolism promoters JP-A-7-285881
  • Processing And an alcohol metabolism promoting substance containing a processed pork product (JP-A-11-276116), or a hangover-preventive food containing isoflavonoid as an active ingredient JP-A-2000-7694.
  • An object of the present invention is to provide a unique alcohol metabolism promoter composition that promotes aldehyde dehydrogenase activity but does not substantially affect alcohol dehydrogenase activity. It is another object of the present invention to provide a sickness or hangover prevention improving composition containing the composition as an active ingredient. Disclosure of the invention
  • the present inventors have proposed that a composition obtained by mixing a concentrated solution of an alcoholic fermentation product of citrus molasses with a cordyceps sinensis extract in rats before orally administering ethanol to rats was compared to a control.
  • a composition obtained by mixing a concentrated solution of an alcoholic fermentation product of citrus molasses with a cordyceps sinensis extract in rats before orally administering ethanol to rats was compared to a control.
  • no significant change was observed in the blood ethanol concentration, but it was found that the blood acetoaldehyde concentration was significantly reduced.
  • the mechanism of this result was examined by an enzyme reaction system to which a concentrated solution of an alcohol fermentation product of citrus molasses was added.
  • the concentrate enhanced the activity of aldehyde dehydrogenase.
  • this concentrate has no effect on the activity of alcohol dehydrogenase, and that this concentrate is useful for preventing and improving sickness or hangover.
  • the present invention provides an alcohol metabolism accelerator composition containing a fermentation product obtained by subjecting citrus molasses to alcohol fermentation using a yeast belonging to the genus Saccharomyces, and a composition for preventing and improving sickness or hangover.
  • the present invention also provides an alcohol metabolism promoter composition and a sickness or hangover prevention / improvement composition containing the above-mentioned fermentation product and Cordyceps sinensis extract. Further, the present invention provides the use of the above fermentation product for producing an alcohol metabolism promoter composition and a composition for preventing and improving sickness or hangover.
  • the present invention provides an alcohol metabolism promoter for the fermentation product and cordyceps extract described above.
  • the present invention also provides a composition and a use for producing a composition for preventing or improving hangover or hangover.
  • the present invention provides a method for promoting alcohol metabolism, and a method for preventing or improving sickness or hangover, which comprises administering an effective amount of the above composition. Furthermore, the present invention provides a method for promoting alcohol metabolism, and a method for preventing and improving sickness or hangover, which comprises administering an effective amount of the above composition and a cordyceps extract.
  • Figure 1 shows that rats were given an oral dose of 2,00 Omg / kg of a concentrate of citrus molasses fermentation product and an oral dose of 200 mg / kg of a cordyceps extract, 200 mg / kg of a concentrate.
  • 4 is a graph showing the effect of subsequent oral ethanol administration on blood alcohol concentration.
  • FIG. 2 is a graph showing the effect on blood acetoaldehyde concentration. *: P ⁇ 0.05 (Student's tes t)
  • FIG. 3 is a graph showing the effect of a concentrate of a fermented product of citrus molasses on alcohol dehydrogenase activity in vitro.
  • FIG. 4 is a graph showing the effect on aldehyde dehydrogenase activity.
  • a method for producing citrus molasses is known (for example, JP-A-10-276578).
  • Juice cake produced when juice is produced by squeezing citrus fruits such as Unshu mandarin oranges contains about 10 to 15% soluble solids and has a high water content.
  • This squeezed lees (including epicarp, pericarp, and carcinoma membrane) was added with slaked lime to facilitate dehydration, limed, and squeezed to obtain Brix 50-
  • the viscous liquid concentrated to 70% is called “citrus molasses”. It also removes insoluble components such as pulp from citrus molasses
  • the soybean is called “depulp citrus molasses", which can also be used in the present invention.
  • citrus fruits examples include, in addition to Unshu mandarin oranges, citrus fruits such as summer oranges, Iyokan, grapefruit, mandarin orange, and lemon;
  • a composition having an alcohol metabolism promoting effect of the present invention can be obtained.
  • Alcohol fermentation of citrus molasses can be performed according to an alcohol fermentation method using molasses as a raw material, which is known to those skilled in the art. Since citrus molasses has a high insoluble pulp content, when used as a food material, it is preferable to dilute so that it can be centrifuged and centrifuge to remove the pulp. This depulpted citrus molasses contains a large amount of sugars that can be assimilated by yeast. Therefore, for the purpose of concentrating active ingredients, depulpted citrus molasses is subjected to alcohol fermentation treatment with yeast, and assimilable sugar in the citrus molasses is converted into ethanol and carbon dioxide to increase the ratio of active ingredients. do.
  • nitrogen sources such as ammonium sulfate, ammonia water, and urea as nutrients, and if necessary, phosphates such as lime superphosphate and ammonium phosphate.
  • yeast the commercially available baker's yeast Saccharomyces cerevisiae is the best, but other yeasts such as .formosens is, S. carl sbergens is, S. el l ipsoideus, S.
  • the composition may also be in the form of a dry powder.
  • Cordyceps is a microorganism belonging to the ascomycetes (Ascomycetes), the ergots (Cl avic ipitales), the ergot fungi (Hypocreaceae) and the cordyceps genus (Cordyceps), and is a microorganism having a complete generation and an incomplete generation.
  • Cordyceps has been prized since ancient times for its fruiting body as a potion for longevity and longevity or as a potion for nutrition and tonicity. In this way, Cordyceps sinensis, which has been prized as a traditional Chinese medicine, is usually obtained by pulverizing the fruit body and taking it.
  • cordyceps for use in the present invention can also use the above fruiting bodies. It is preferable to use an extract obtained by extracting an active ingredient from mycelium with hot water (for example, W096 / 00580 and JP-A-8-12588). It was found that the addition of the extract to the fermentation product of citrus molasses further increased the aldehyde dehydrogenase activity.
  • the operation of culturing and extracting the mycelium of Cordyceps sinensis is a known method (for example, W096 / 00580 and JP-A-8-12588).
  • the cultured mycelium of Cordyceps s inens is added with malt extract, yeast extract, peptone, potato broth, glucose, vitamins, amino acids, nucleic acids, proteins, and, if necessary, host components such as insects. Inoculate the medium and perform liquid or solid culture. For large-scale culture, use liquid culture in an aeration-stirred fermenter (100 to 30 O rpm). Culture is performed at pH 4 to 7, at a culture temperature of 20 to 30 ° C, 3 to 10 days. After completion of the culture, the cultured mycelia are extracted with hot water (85 to: L 00 ° C).
  • extraction may be carried out with water or an aqueous solvent containing a small amount of an acid, base or organic solvent soluble in water. Remove the residue by centrifugation or filtration. The resulting caterpillar fever
  • the water extract may be used as it is in the present invention, or may be concentrated by a conventional method or used as a freeze-dried powder.
  • Cordyceps sinensis extract enhances the enzyme activity is not clear, but Cordyceps sinensis extract has an effect of increasing hepatic blood flow (Food Style 21, vol. 2, No. 5, 1998) and AT in the liver.
  • the action of increasing the amount of P production Jpn. J. PHarmacol., 70: 85-88, 1996) is known. It is considered that the increase in hepatic blood flow by the cordyceps extract promotes the influx of the fermentation product into the liver and increases aldehyde dehydrogenase activity in hepatocytes.
  • the fermented product of citrus molasses has a good flavor and can be taken orally as it is, the fermented product can be formulated into a dosage form containing an effective amount to prevent sickness and hangover.
  • Such formulation techniques are well-known to those skilled in the art.
  • the effective dose can not be calculated clearly even if the same amount of alcohol is consumed, and the absorption and metabolism rate is extremely large due to differences in body weight, constitution, etc. i to iog (in terms of dry solids) z It is estimated to be an adult.
  • citrus molasses has been used as a food material for many years, and its safety has been assured by many years of eating experience.
  • the fermented product of the present invention or the fermented product and a cordyceps extract may be used by adding an effective amount thereof directly to food or drink at the time of eating or drinking in order to prevent sickness or hangover.
  • you may process into foods and drinks containing an effective amount. For example, as a drink, sugar 10%, acidity 0.1%, fruit juice 2-3%, flavor 0.1%, fermented product of citrus molasses 5.3%, and cordyceps extract 1.7% And adjust the pH to 3.5-4.0, then heat sterilize at 65 ° C for 10 minutes, then cool and bottle.
  • Foods and drinks may include, in addition to the above, health foods, dietary supplements, and therapeutic foods. Furthermore, in order to reduce bad breath after drinking, foods that have an action to prevent bad breath (For example, green tea polyphenol).
  • foods that have an action to prevent bad breath For example, green tea polyphenol.
  • the depulp molasses was dissolved in warm water.
  • Ammonium sulfate as a nutrient source (nitrogen source), A-Break G-109 as an antifoaming agent, and citric acid as a pH adjuster were each dissolved in 5 times the amount of water and added to the above-prepared pulp molasses solution.
  • the preparation solution was adjusted so that the Brix sugar content was 13 ⁇ 1% and the pH was 5 ⁇ 0.2.
  • the amount of depulp molasses in the preparation liquid was 27% (weight).
  • the charge liquid was cooled to 34 ⁇ 4 ° C after batch sterilization (85 ° C, 15 minutes).
  • the prepared solution was inoculated with baker's yeast (0.5%) and fermented.
  • the yeast was inactivated by heating (85 ° C, 15 minutes), and sludge (yeast cells, pulp) contained in the fermentation broth was removed by a fully automatic pressing machine and a filter press. The supernatant was then plate sterilized (134, 3 seconds). Insoluble components generated during sterilization were removed with a Cuno filter and concentrated under reduced pressure. This concentrate was re-sterilized (8 ° C., 30 seconds) and then cooled to obtain 10 kg of the alcohol metabolism promoting composition (Bri x 45 ⁇ 2%) of the present invention.
  • D medium composition in 1 L: sucrose 40.0 g, K 2 HP0 4 4.0 g, Asuparagin 0.5 g, (NH 4) 2 HP0 4 2.0 g, MgS0 4 ⁇ 7H 2 0 2.0 g, CaC0 3 0.25 g, CaCl 2 0.1 g, yeast extract B-2 4.0 g, pH 5.6
  • 150 L 150 L
  • 15 OmL of the above seed culture solution was inoculated, and the mixture was cultured at 25 ° C, pH 5.5, DO 50%, and stirred at 157 ° C for 3 days. During this time, the generated foam was treated by adding a silicone defoamer.
  • the 150 L culture obtained by the culture was subjected to cell separation treatment using a clarifier to obtain an aqueous suspension of the cells. This was kept at 90 to 95 ° C for 2 hours to perform a heat extraction treatment, followed by clarification by a clarifier to obtain a supernatant. This was filtered using aseptic filters of 0.45 rn and 0.22 zm to obtain 80 L of a pale yellow hot water extract (800 g of solid dry weight).
  • a hangover preventive drink was manufactured using the following ingredients (unit: kg). Concentrate of fermented product of citrus molasses (obtained in Production Example 1): 52.5 Cordyceps extract (obtained in Production Example 2): 16.7 Sugar: 40
  • the bottle was aseptically filled with 12 OmL to obtain a hangover preventive drink.
  • test rats Six-week-old male Wistar rats (weight 160-170 g) were used.
  • the test substance used was the concentrate of the fermented product of citrus molasses obtained in Example 1 and the cordyceps extract obtained in Example 2.
  • test groups (1) Concentrate 2, 000mg / kg administration group, (2) Cordyceps sinensis extract 200 mg / kg + concentrate 2, 000mg / k g administered group, and (3) negative control
  • the blood alcohol concentration at 1 hour and 3 hours after oral administration of ethanol was 200 mg / kg concentrate and 200 mg / kg + concentrate No statistically significant difference was observed between the 200 mg / kg administration group and the distilled water administration group (1 OmL / kg), which was a negative control group.
  • the activity of alcohol dehydrogenase and aldehyde dehydrogenase was measured by utilizing the conversion of coenzyme, 3-NAD, into NADH when these enzymes react.
  • 3— NAD and NADH show a difference in the maximum absorption wavelength in the ultraviolet, and 0—NAD shows NADH absorption near 34 Onm.
  • measuring the ultraviolet absorption at 340 mn can be used as an indicator of the redox activity of alcohol dehydrogenase and aldehyde dehydrogenase.
  • Enzyme solution Alcohol dehydrogenase (SIGMA, EC 1.1.1.1, derived from zebra liver, 5munits / mL)
  • EDTA lmM Enzyme solution Aldehyde dehydrogenase (SIGMA, EC 1. 2.1.5, derived from baker's yeast, 0.5 Units / mL)
  • the enzyme reaction solution was prepared so that the total amount was 0.2 mL.
  • the substrate was added last, and the absorbance at 34 O nm was measured immediately after the addition of the substrate. Thereafter, the reaction was carried out at 37 ° C for 10 minutes.
  • the absorbance at 34 O nm after the reaction was measured, the increase in the absorbance was calculated, and the increase in enzyme activity was examined.
  • Fig. 3 shows the activity of alcohol dehydrogenase
  • Fig. 4 shows the activity of aldehyde dehydrogenase. Even when the fermentation concentrate was added at various concentrations to the alcohol dehydrogenase reaction system, no change was observed in the enzyme activity compared to the case without the addition (Fig. 3).
  • the aldehyde dehydrogenase activity is enhanced, and when used in combination with a Cordyceps sinensis extract, the enzyme activity is further enhanced and the duration is extended. Oral intake before drinking can reduce or reduce unpleasant symptoms such as hangovers and sickness. Furthermore, since it does not affect alcohol dehydrogenase activity, it is expected that it will not hinder drunkenness.
  • the alcohol metabolism-promoting composition of the present invention enhances alcohol metabolism by continuously ingesting the composition, thereby predicting alcohol dependence and organ damage such as liver. It is thought to be useful for prevention

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Abstract

L'invention concerne des compositions uniques favorisant le métabolisme de l'alcool, qui contiennent un produit de fermentation alcoolique de mélasses de citrus éventuellement mélangé à un extrait de ver de plante qui stimule l'activité de la déshydrogénase d'aldéhyde, mais n'a sensiblement pas d'effet sur l'activité de la déshydrogénase de l'alcool. L'invention concerne en outre des boissons et des aliments destinés à prévenir le sentiment de nausée et de gueule de bois dus à l'excès de consommation de boissons, qui contiennent ces compositions.
PCT/JP2001/005259 2000-06-20 2001-06-20 Compositions favorisant le metabolisme de l'alcool Ceased WO2002000238A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2002505020A JP4852218B2 (ja) 2000-06-20 2001-06-20 アルコール代謝促進剤組成物
AU2001274564A AU2001274564A1 (en) 2000-06-20 2001-06-20 Compositions promoting alcohol metabolism

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000184354 2000-06-20
JP2000-184354 2000-06-20

Publications (1)

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WO2002000238A1 true WO2002000238A1 (fr) 2002-01-03

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PCT/JP2001/005259 Ceased WO2002000238A1 (fr) 2000-06-20 2001-06-20 Compositions favorisant le metabolisme de l'alcool

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AU (1) AU2001274564A1 (fr)
WO (1) WO2002000238A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009108099A (ja) * 2009-01-13 2009-05-21 Meiji Milk Prod Co Ltd 脳血管障害の予防または改善のための組成物
EP2128239A1 (fr) * 2008-05-29 2009-12-02 Young-Sam Jang Additifs de liqueur d'alcool et leur procédé de préparation
JP2012105571A (ja) * 2010-11-16 2012-06-07 Fuji Oil Co Ltd 練製品及びその製造法
US10758114B2 (en) 2010-05-13 2020-09-01 Aircraft Medical Limited Laryngoscope insertion section structure

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5959185A (ja) * 1982-09-28 1984-04-04 Kawachichiyou フル−ツ・スピリツツの製造方法
JPS60126066A (ja) * 1983-12-07 1985-07-05 Tadasu Sawabe 柑橘類の搾汁粕中に残存する果汁の回収方法および同回収装置
JPS61108366A (ja) * 1984-11-01 1986-05-27 Yasuji Yoshida 柑橘酒の製造法
JPH10276578A (ja) * 1997-04-03 1998-10-20 Ehime Pref Gov Seika Nogyo Kyodo Kumiai Rengokai 柑橘類搾汁残渣の有効利用法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2678770B2 (ja) * 1988-08-30 1997-11-17 株式会社中埜酢店 新規食品素材の製造法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5959185A (ja) * 1982-09-28 1984-04-04 Kawachichiyou フル−ツ・スピリツツの製造方法
JPS60126066A (ja) * 1983-12-07 1985-07-05 Tadasu Sawabe 柑橘類の搾汁粕中に残存する果汁の回収方法および同回収装置
JPS61108366A (ja) * 1984-11-01 1986-05-27 Yasuji Yoshida 柑橘酒の製造法
JPH10276578A (ja) * 1997-04-03 1998-10-20 Ehime Pref Gov Seika Nogyo Kyodo Kumiai Rengokai 柑橘類搾汁残渣の有効利用法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2128239A1 (fr) * 2008-05-29 2009-12-02 Young-Sam Jang Additifs de liqueur d'alcool et leur procédé de préparation
JP2009108099A (ja) * 2009-01-13 2009-05-21 Meiji Milk Prod Co Ltd 脳血管障害の予防または改善のための組成物
US10758114B2 (en) 2010-05-13 2020-09-01 Aircraft Medical Limited Laryngoscope insertion section structure
US11510563B2 (en) 2010-05-13 2022-11-29 Covidien Ag Laryngoscope insertion section structure
JP2012105571A (ja) * 2010-11-16 2012-06-07 Fuji Oil Co Ltd 練製品及びその製造法

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AU2001274564A1 (en) 2002-01-08
JP4852218B2 (ja) 2012-01-11

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