JP4966933B2 - エスシタロプラムの製造方法 - Google Patents

エスシタロプラムの製造方法 Download PDF

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Publication number
JP4966933B2
JP4966933B2 JP2008224435A JP2008224435A JP4966933B2 JP 4966933 B2 JP4966933 B2 JP 4966933B2 JP 2008224435 A JP2008224435 A JP 2008224435A JP 2008224435 A JP2008224435 A JP 2008224435A JP 4966933 B2 JP4966933 B2 JP 4966933B2
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JP
Japan
Prior art keywords
hydroxybutyl
dimethylamino
fluorophenyl
benzonitrile
hydroxymethyl
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JP2008224435A
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English (en)
Japanese (ja)
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JP2009149600A5 (de
JP2009149600A (ja
Inventor
カルラ・デ・ファヴェリ
フローリアン・アントン・マルティン・フーバー
ロバート・ジェイムズ・ダンサー
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ハー・ルンドベック・アクチエゼルスカベット
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Publication of JP2009149600A5 publication Critical patent/JP2009149600A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2008224435A 2007-09-11 2008-09-02 エスシタロプラムの製造方法 Active JP4966933B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200701314 2007-09-11
DKPA200701314 2007-09-11

Publications (3)

Publication Number Publication Date
JP2009149600A JP2009149600A (ja) 2009-07-09
JP2009149600A5 JP2009149600A5 (de) 2012-01-12
JP4966933B2 true JP4966933B2 (ja) 2012-07-04

Family

ID=39735675

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008224435A Active JP4966933B2 (ja) 2007-09-11 2008-09-02 エスシタロプラムの製造方法

Country Status (52)

Country Link
EP (2) EP2061753B1 (de)
JP (1) JP4966933B2 (de)
KR (1) KR101054224B1 (de)
CN (1) CN101386583A (de)
AR (2) AR068174A1 (de)
AT (2) ATE518829T1 (de)
AU (1) AU2008212055C1 (de)
BE (1) BE1017548A6 (de)
BG (1) BG110206A (de)
BR (1) BRPI0804121B1 (de)
CA (1) CA2638499C (de)
CH (1) CH697885B1 (de)
CL (1) CL2008002686A1 (de)
CO (1) CO6140012A1 (de)
CY (2) CY2600B1 (de)
CZ (1) CZ2008537A3 (de)
DE (1) DE102008046530A1 (de)
DK (2) DK2061753T3 (de)
EA (1) EA012787B1 (de)
EE (1) EE00864U1 (de)
ES (2) ES2334875B1 (de)
FI (1) FI121570B (de)
FR (1) FR2920766A1 (de)
GB (1) GB2448848B (de)
GR (1) GR1006595B (de)
HR (2) HRP20080425A2 (de)
HU (1) HUP0800549A2 (de)
IE (1) IES20080708A2 (de)
IL (1) IL193845A (de)
IS (1) IS8758A (de)
LT (1) LT5577B (de)
LU (1) LU91479B1 (de)
LV (1) LV13813B (de)
ME (1) ME00176B (de)
MX (1) MX2008011451A (de)
MY (1) MY144210A (de)
NL (1) NL2001953C2 (de)
NO (1) NO20083756L (de)
NZ (1) NZ570884A (de)
PL (2) PL386026A1 (de)
PT (2) PT104169A (de)
RO (1) RO125301A2 (de)
RS (2) RS20080401A (de)
SE (1) SE533041C2 (de)
SG (1) SG151195A1 (de)
SI (2) SI22567A2 (de)
SK (1) SK500302008A3 (de)
TR (2) TR200806903A2 (de)
TW (1) TWI391383B (de)
UA (2) UA41919U (de)
WO (1) WO2009033488A1 (de)
ZA (1) ZA200807753B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7939680B2 (en) 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram
CN102796065A (zh) * 2011-05-27 2012-11-28 江苏豪森医药集团连云港宏创医药有限公司 一种制备光学纯度高的艾司西酞普兰的方法
CN104119240A (zh) * 2013-04-23 2014-10-29 中国人民解放军军事医学科学院毒物药物研究所 (S)-(-)-α-甲胺基苯丙酮的制备方法
CN103497145B (zh) * 2013-10-10 2016-01-27 南昌大学 一种光学纯多奈哌齐的制备工艺
CN104119248A (zh) * 2014-08-08 2014-10-29 广东东阳光药业有限公司 S-西酞普兰的制备方法
CN107074750B (zh) 2014-11-14 2022-03-25 浙江华海药业股份有限公司 一种拆分西酞普兰中间体5-氰二醇的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
AR034612A1 (es) 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
JP4505335B2 (ja) 2002-12-23 2010-07-21 ハー・ルンドベック・アクチエゼルスカベット ラセミ体シタロプラムジオール（ｒａｃｅｍｉｃｃｉｔａｌｏｐｒａｍｄｉｏｌ）および／またはＳ−もしくはＲ−シタロプラムジオールの製造方法、およびラセミ体シタロプラム、Ｒ−シタロプラムおよび／またはＳ−シタロプラムを製造するために、上記ジオールを使用する方法。
AU2003242990A1 (en) * 2003-01-17 2004-08-13 Pulla Reddy Muddasani Processes for the preparation of escitalopram and its precursor
US20090018351A1 (en) * 2003-11-12 2009-01-15 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
EP1877394A1 (de) * 2005-04-04 2008-01-16 Jubilant Organosys Limited Verfahren zur herstellung von escitalopram oder seinen säureadditionssalzen
US7939680B2 (en) * 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram

Also Published As

Publication number Publication date
TWI391383B (zh) 2013-04-01
CY2600B1 (en) 2010-03-03
EA012787B1 (ru) 2009-12-30
TW200906814A (en) 2009-02-16
ATE518829T1 (de) 2011-08-15
SI2061753T1 (sl) 2011-10-28
AU2008212055C1 (en) 2011-06-02
SE533041C2 (sv) 2010-06-15
BG110206A (en) 2009-03-31
RS51909B (sr) 2012-02-29
ME00176B (me) 2011-02-10
GR20080100581A (el) 2009-04-30
BE1017548A6 (fr) 2008-11-04
TR200806903A2 (tr) 2009-03-23
ES2334875B1 (es) 2010-10-27
AU2008212055B2 (en) 2010-08-12
GB2448848A (en) 2008-10-29
KR20090027185A (ko) 2009-03-16
FI121570B (fi) 2011-01-14
LT5577B (lt) 2009-06-25
DK200801265A (en) 2009-03-12
LT2008068A (en) 2009-03-25
DE102008046530A1 (de) 2009-03-19
NZ570884A (en) 2010-03-26
WO2009033488A1 (en) 2009-03-19
LU91479B1 (fr) 2010-03-11
NO20083756L (no) 2009-03-12
SE0801929L (sv) 2009-03-12
HUP0800549A2 (en) 2009-03-02
RS20080401A (sr) 2010-03-02
ZA200807753B (en) 2009-04-29
FI20085807A0 (fi) 2008-08-29
AU2008212055A1 (en) 2009-03-26
BRPI0804121B1 (pt) 2022-04-12
TR200907629A2 (tr) 2009-11-23
BRPI0804121A2 (pt) 2009-09-29
SG151195A1 (en) 2009-04-30
IS8758A (is) 2009-03-12
DK2061753T3 (da) 2011-09-26
NL2001953C2 (en) 2009-05-07
CA2638499A1 (en) 2008-11-21
AR068174A1 (es) 2009-11-11
HRP20080425A2 (hr) 2010-04-30
EP2061753B1 (de) 2011-08-03
PL2061753T3 (pl) 2011-12-30
CA2638499C (en) 2010-09-28
UA43461U (uk) 2009-08-25
UA41919U (uk) 2009-06-10
AR108885A2 (es) 2018-10-03
SK500302008A3 (sk) 2009-04-06
GR1006595B (el) 2009-11-16
IL193845A (en) 2011-03-31
LV13813B (en) 2008-11-20
PL386026A1 (pl) 2009-02-16
CH697885B1 (de) 2009-03-13
CN101386583A (zh) 2009-03-18
EA200801797A3 (ru) 2009-02-27
CY1111924T1 (el) 2015-11-04
CO6140012A1 (es) 2010-03-19
PT2061753E (pt) 2011-09-14
FR2920766A1 (fr) 2009-03-13
HU0800549D0 (en) 2008-10-28
IES20080708A2 (en) 2009-03-18
HRP20110636T1 (hr) 2011-10-31
CZ2008537A3 (cs) 2009-03-18
RO125301A2 (ro) 2010-03-30
ES2368294T3 (es) 2011-11-16
BRPI0804121A8 (pt) 2021-04-13
GB0815773D0 (en) 2008-10-08
SI22567A2 (sl) 2008-12-31
DK177075B1 (da) 2011-06-14
FI20085807L (fi) 2009-03-12
AT10984U1 (de) 2010-02-15
MX2008011451A (es) 2009-03-10
PT104169A (pt) 2009-02-02
NL2001953A1 (nl) 2008-12-22
EA200801797A2 (ru) 2008-12-30
MY144210A (en) 2011-08-15
ES2334875A1 (es) 2010-03-16
JP2009149600A (ja) 2009-07-09
EP2061753A1 (de) 2009-05-27
CL2008002686A1 (es) 2009-01-02
KR101054224B1 (ko) 2011-08-08
EE00864U1 (et) 2009-10-15
EP2397461A1 (de) 2011-12-21
MEP10108A (bs) 2010-10-10
GB2448848B (en) 2011-01-26

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