JP4981453B2 - シトクロムcタンパク質及びアッセイ - Google Patents

シトクロムcタンパク質及びアッセイ Download PDF

Info

Publication number
JP4981453B2
JP4981453B2 JP2006544552A JP2006544552A JP4981453B2 JP 4981453 B2 JP4981453 B2 JP 4981453B2 JP 2006544552 A JP2006544552 A JP 2006544552A JP 2006544552 A JP2006544552 A JP 2006544552A JP 4981453 B2 JP4981453 B2 JP 4981453B2
Authority
JP
Japan
Prior art keywords
cell
construct
cytochrome
promoter
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006544552A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008502316A (ja
Inventor
スタッブス,サイモン・ローレンス・ジョン
フランシス,マイケル・ジョン
クッシング,エイドリアン
イスマイル,ラマン・アジズ
Original Assignee
ジーイー・ヘルスケア・ユーケイ・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジーイー・ヘルスケア・ユーケイ・リミテッド filed Critical ジーイー・ヘルスケア・ユーケイ・リミテッド
Publication of JP2008502316A publication Critical patent/JP2008502316A/ja
Application granted granted Critical
Publication of JP4981453B2 publication Critical patent/JP4981453B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795Porphyrin- or corrin-ring-containing peptides
    • C07K14/80Cytochromes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/60Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00Detection of programmed cell death, i.e. apoptosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2006544552A 2003-12-19 2004-12-17 シトクロムcタンパク質及びアッセイ Expired - Fee Related JP4981453B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0329353.7 2003-12-19
GBGB0329353.7A GB0329353D0 (en) 2003-12-19 2003-12-19 Cytochrome C protein and assay
PCT/GB2004/005317 WO2005058960A1 (en) 2003-12-19 2004-12-17 Cytochrome c protein and assay

Publications (2)

Publication Number Publication Date
JP2008502316A JP2008502316A (ja) 2008-01-31
JP4981453B2 true JP4981453B2 (ja) 2012-07-18

Family

ID=30471316

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006544552A Expired - Fee Related JP4981453B2 (ja) 2003-12-19 2004-12-17 シトクロムcタンパク質及びアッセイ

Country Status (9)

Country Link
US (1) US8076148B2 (de)
EP (1) EP1716177B1 (de)
JP (1) JP4981453B2 (de)
AT (1) ATE458005T1 (de)
AU (1) AU2004299336B2 (de)
CA (1) CA2549523A1 (de)
DE (1) DE602004025625D1 (de)
GB (1) GB0329353D0 (de)
WO (1) WO2005058960A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ541666A (en) * 2005-08-05 2008-09-26 Elizabeth Cramer Methods of modulating apoptosis and platelet production using an isolated oligonucleotide, its compliment, a vector with the expression sequence or an isolated polypeptide all relating to cytochrome C
FR2926985B1 (fr) * 2008-02-06 2010-05-21 Oreal Association d'un rayonnement lumineux et d'un substrat de la cytochrome c oxydase pour ameliorer notamment l'apparence de la peau et/ou du cheveu
CN111727044A (zh) 2018-02-05 2020-09-29 深圳市原力生命科学有限公司 用于治疗癌症或炎性疾病的杂二环羧酸

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE184613T1 (de) 1995-09-22 1999-10-15 Novo Nordisk As Varianten des grünen fluoreszenzproteins, gfp
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
US6294330B1 (en) 1997-01-31 2001-09-25 Odyssey Pharmaceuticals Inc. Protein fragment complementation assays for the detection of biological or drug interactions
US6008378A (en) 1997-10-21 1999-12-28 The Regents Of The University Of California Synthetic molecules that specifically react with target sequences
US6054271A (en) 1997-10-21 2000-04-25 The Regents Of The University Of California Methods of using synthetic molecules and target sequences
US5932474A (en) 1997-10-21 1999-08-03 The Regents Of The University Of California Target sequences for synthetic molecules
EP1301786B1 (de) 2000-07-21 2005-11-30 Evotec AG Verfahren zur detektion der apoptose durch ermittlung von cytochrom c als apoptosespezifischem marker, der durch zelluläre ausschüttungsvorgänge ins extrazelluläre medium abgegeben wird
GB0109858D0 (en) 2001-04-23 2001-06-13 Amersham Pharm Biotech Uk Ltd Fluorscent proteins
EP1354953A1 (de) 2002-04-17 2003-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-Peptide zur Verwendung als therapeutische Mittel gegen Krebs und Autoimmunerkrankungen

Also Published As

Publication number Publication date
WO2005058960A1 (en) 2005-06-30
CA2549523A1 (en) 2005-06-30
US20090053748A1 (en) 2009-02-26
AU2004299336A1 (en) 2005-06-30
EP1716177B1 (de) 2010-02-17
AU2004299336B2 (en) 2008-04-24
GB0329353D0 (en) 2004-01-21
EP1716177A1 (de) 2006-11-02
JP2008502316A (ja) 2008-01-31
ATE458005T1 (de) 2010-03-15
US8076148B2 (en) 2011-12-13
DE602004025625D1 (en) 2010-04-01

Similar Documents

Publication Publication Date Title
JP5988101B2 (ja) 酸化ストレスインジケーター発現用核酸構築物とその使用
CN111212913A (zh) 多重测定
JPWO2017094885A1 (ja) リガンド蛍光センサータンパク質とその使用
JP3978139B2 (ja) Renillamulleriの緑色蛍光タンパク質をコードするヒト化ポリヌクレオチド配列
JP5954728B2 (ja) 蛋白質の分解活性を測定するためのプローブ試薬
KR100648761B1 (ko) 저산소증-유도성 인자 1α HIF-1α 변이체 및HIF-1α 조절제의 동정 방법
WO2013151511A1 (en) Modified Dual-Colour Protein
JP4981453B2 (ja) シトクロムcタンパク質及びアッセイ
KR102074590B1 (ko) 자가포식체 탐침용 프로브 및 이를 이용한 탐침 방법
Janczyk et al. Aurora A phosphorylates Ndel1 to reduce the levels of Mad1 and NuMA at spindle poles
US20040171005A1 (en) Codon-optimised nucleic acid coding for apoaequorin and uses thereof
EP1674478A1 (de) Fusionsproteine und Verfahren zum Nachweis von Protein-Protein Interaktionen in lebenden Zellen und Zellysaten, Nukleinsäuren kodierend für diese Fusionsproteine, sowie Vektoren und Kits, die diese enthalten
KR100997129B1 (ko) 유전자의 고속 기능분석을 위한 붉은형광단백질 융합단백질 생산용 벡터
US20240011070A1 (en) Methods and compositions for protease reporter assays and modulators
CN121335986A (zh) R环感测器
Yang et al. A Sensitive Green-Red FRET Sensor for Calpain-1 Utilizing Heterodimeric Fluorescent Proteins from Distinct Evolutionary Origins
WO2016038750A1 (ja) 分割型組換えルシフェラーゼ及びそれを用いた解析方法
CN116194468A (zh) 预测和操纵nmda受体介导的毒性的新手段
WO2007102507A1 (ja) タンパク質リン酸化インディケーター
WO2020090668A1 (ja) 細胞の糖取り込みを可視化するためのキメラタンパク質
Frazier Dnaconda’s Recommendation
Herzig Jr NRF-1 regulation of respiratory function: Involvement of phosphorylation and protein-protein interactions
Laughery Cellular localization and assembly of the Na, K-ATPase
Zou Using Aureochrome to Control Protein-Protein Interactions with Light
KR20070048386A (ko) p53 종양 억제단백질과 형광단백질의 융합단백질을발현하는 형질전환 세포주 및 이를 이용한 p53 종양억제단백질의 활성과 관련된 물질의 검색방법

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071217

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101012

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110111

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20110111

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110111

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110118

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110412

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110830

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111228

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20120220

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120321

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120420

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150427

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees