JP5346016B2 - Ｓ１ｐ１受容体アゴニストとしての新規ジカルボン酸誘導体 - Google Patents

Ｓ１ｐ１受容体アゴニストとしての新規ジカルボン酸誘導体 Download PDF

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Publication number: JP5346016B2
Authority: JP; Japan
Prior art keywords: benzyl; piperidine; oxadiazol; dicarboxylic acid; fluoro
Prior art date: 2007-06-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2010511664A

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English (en)

Japanese (ja)

Other versions

JP2010529977A5 (fr

JP2010529977A (ja

Inventor

マルク・カペ

ニコラ・ルヴォワン

イザベル・ベルビ−ベルトラン

フィリップ・ロベール

ジャン−シャルル・シュワルツ

ジャンヌ−マリー・ルコント

ジャイラジ・ディリプバイ・アラディエ

ムトゥクマラン・ナタラジャン・ピライ

バヴェシュ・モハンバイ・パンチャル

ジグネシュ・カンティラル・ジヴァニ

ビスワジット・サマンタ

ランジャン・クマール・パル

ラジャマンナール・センナティ

Original Assignee

ビオポロジェ

サン・ファーマ・アドバンスド・リサーチ・カンパニー・リミテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-15

Filing date

2008-06-16

Publication date

2013-11-20

2008-06-16 Application filed by ビオポロジェ, サン・ファーマ・アドバンスド・リサーチ・カンパニー・リミテッド filed Critical ビオポロジェ

2010-09-02 Publication of JP2010529977A publication Critical patent/JP2010529977A/ja

2013-08-15 Publication of JP2010529977A5 publication Critical patent/JP2010529977A5/ja

2013-11-20 Application granted granted Critical

2013-11-20 Publication of JP5346016B2 publication Critical patent/JP5346016B2/ja

Status Expired - Fee Related legal-status Critical Current

2028-06-16 Anticipated expiration legal-status Critical

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102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 title claims abstract description 25
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150000004684 trihydrates Chemical class 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications

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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
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Pulmonology (AREA)
Immunology (AREA)
Virology (AREA)
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Neurology (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
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JP2010511664A 2007-06-15 2008-06-16 Ｓ１ｐ１受容体アゴニストとしての新規ジカルボン酸誘導体 Expired - Fee Related JP5346016B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07290748A EP2014653A1 (fr)	2007-06-15	2007-06-15	Nouveaux dérivés d'acide dicarboxylique comme agonistes du recepteur S1P1
EP07290748.8		2007-06-15
PCT/EP2008/057571 WO2008152149A1 (fr)	2007-06-15	2008-06-16	Nouveaux dérivés d'acide dicarboxylique utilisés comme agonistes du récepteur s1p1

Publications (3)

Publication Number	Publication Date
JP2010529977A JP2010529977A (ja)	2010-09-02
JP2010529977A5 JP2010529977A5 (fr)	2013-08-15
JP5346016B2 true JP5346016B2 (ja)	2013-11-20

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ID=38645817

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2010511664A Expired - Fee Related JP5346016B2 (ja)	2007-06-15	2008-06-16	Ｓ１ｐ１受容体アゴニストとしての新規ジカルボン酸誘導体

Country Status (17)

Country	Link
US (1)	US8809539B2 (fr)
EP (2)	EP2014653A1 (fr)
JP (1)	JP5346016B2 (fr)
KR (1)	KR20100040853A (fr)
CN (1)	CN101784535A (fr)
BR (1)	BRPI0811712A2 (fr)
CA (1)	CA2693126A1 (fr)
CO (1)	CO6251262A2 (fr)
EA (1)	EA018826B1 (fr)
IL (1)	IL202741A0 (fr)
MA (1)	MA31447B1 (fr)
MX (1)	MX2009013733A (fr)
NZ (1)	NZ581933A (fr)
TN (1)	TN2009000524A1 (fr)
UA (1)	UA99132C2 (fr)
WO (1)	WO2008152149A1 (fr)
ZA (1)	ZA200908851B (fr)

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CA2703987A1 (fr) *	2007-11-08	2009-05-14	Pfizer Inc.	Derives d'acide cyclobutylcarboxylique
HRP20161133T1 (hr)	2008-07-23	2016-12-02	Arena Pharmaceuticals, Inc.	DERIVATI SUSPSTITUIRANE 1,2,3,4-TETRAHIDROCIKLOPENTA[b]INDOL-3-IL-OCTENE KISELINE KORISNI U LIJEČENJU AUTOIMUNIH I UPALNIH POREMEĆAJA
CN105816453B (zh)	2008-08-27	2021-03-05	艾尼纳制药公司	用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物
JP2012505836A (ja)	2008-10-17	2012-03-08	アカールファーマピーティーワイリミテッド	Ｓ１ｐ受容体モジュレーターおよびそれらの使用
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WO2011048409A1 (fr)	2009-10-20	2011-04-28	Astrazeneca Ab	Dérivés d'amine cyclique ayant une activité agoniste de récepteur adrénergique bêta-2 et antagoniste de récepteur muscarinique
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CN105503882B (zh)	2010-03-03	2019-07-05	艾尼纳制药公司	制备s1p1受体调节剂及其晶体形式的方法
ES2548683T3 (es) *	2010-04-23	2015-10-20	Bristol-Myers Squibb Company	Amidas del ácido 4-(5-isoxazolil o 5-pirrazolil-1,2,4-oxadiazol-3-il)-mandélico como agonistas de receptor de esfingosina-1-fosfato 1
US8318783B2 (en)	2010-04-27	2012-11-27	Allergan, Inc.	3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-aryl-1,2,4-oxadiazole derivatives as sphingosine-1 phosphate receptors modulators
US9050334B2 (en)	2010-07-16	2015-06-09	Innov88 Llc	MIF inhibitors and their uses
CN103124727B (zh)	2010-07-20	2015-03-25	百时美施贵宝公司	取代的3-苯基-1,2,4-噁二唑化合物
US20120214848A1 (en) *	2011-02-18	2012-08-23	Abbott Laboratories	[1,2,4]oxadiazol-3-yl acid salts and crystalline forms and their preparation
EP2511275A1 (fr)	2011-04-12	2012-10-17	Bioprojet	Nouveaux acides pipéridiniles monocarboxyliques comme agonistes du récepteur S1P1
AU2016205361C1 (en)	2015-01-06	2021-04-08	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the S1P1 receptor
PL3310760T3 (pl)	2015-06-22	2023-03-06	Arena Pharmaceuticals, Inc.	Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
WO2018119080A1 (fr) *	2016-12-21	2018-06-28	Cornell University	Composition et méthodes de traitement de troubles hépatiques
JP2020507610A (ja)	2017-02-16	2020-03-12	アリーナファーマシューティカルズ，インコーポレイテッド	腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法
KR20190116416A (ko)	2017-02-16	2019-10-14	아레나 파마슈티칼스, 인크.	원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
CN107827837B (zh) *	2017-11-21	2021-09-24	苏州朗科生物技术股份有限公司	鞘氨醇-1-磷酸受体调节剂化合物及其制备方法与应用
KR20200116953A (ko) *	2018-02-02	2020-10-13	고쿠리츠 다이가쿠 호진 교토 다이가쿠	안내 혈관 신생 및/또는 안내 혈관 투과성 항진을 수반하는 안과 질환의 예방 또는 치료를 위한 의약
AU2019280822A1 (en)	2018-06-06	2021-01-07	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the S1P1 receptor
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2007
- 2007-06-15 EP EP07290748A patent/EP2014653A1/fr not_active Withdrawn
2008
- 2008-06-16 CN CN200880100811A patent/CN101784535A/zh active Pending
- 2008-06-16 EA EA201000024A patent/EA018826B1/ru not_active IP Right Cessation
- 2008-06-16 BR BRPI0811712-8A2A patent/BRPI0811712A2/pt not_active IP Right Cessation
- 2008-06-16 NZ NZ581933A patent/NZ581933A/en not_active IP Right Cessation
- 2008-06-16 CA CA2693126A patent/CA2693126A1/fr not_active Abandoned
- 2008-06-16 MX MX2009013733A patent/MX2009013733A/es active IP Right Grant
- 2008-06-16 EP EP08761078.8A patent/EP2170850B1/fr active Active
- 2008-06-16 UA UAA200912896A patent/UA99132C2/ru unknown
- 2008-06-16 KR KR1020107000880A patent/KR20100040853A/ko not_active Ceased
- 2008-06-16 JP JP2010511664A patent/JP5346016B2/ja not_active Expired - Fee Related
- 2008-06-16 US US12/664,718 patent/US8809539B2/en not_active Expired - Fee Related
- 2008-06-16 WO PCT/EP2008/057571 patent/WO2008152149A1/fr not_active Ceased
2009
- 2009-12-11 TN TNP2009000524A patent/TN2009000524A1/fr unknown
- 2009-12-11 ZA ZA200908851A patent/ZA200908851B/xx unknown
- 2009-12-15 CO CO09143477A patent/CO6251262A2/es not_active Application Discontinuation
- 2009-12-15 IL IL202741A patent/IL202741A0/en unknown
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JP7464075B2 (ja)	2022-04-20	2024-04-09	株式会社大林組	プレストレス構造及びそれを用いたプレキャストコンクリート部材

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CO6251262A2 (es)	2011-02-21
BRPI0811712A2 (pt)	2014-11-04
EA201000024A1 (ru)	2010-06-30
ZA200908851B (en)	2010-07-28
EP2014653A1 (fr)	2009-01-14
EP2170850B1 (fr)	2014-09-24
IL202741A0 (en)	2010-06-30
TN2009000524A1 (en)	2011-03-31
KR20100040853A (ko)	2010-04-21
CA2693126A1 (fr)	2008-12-18
EA018826B1 (ru)	2013-11-29
EP2170850A1 (fr)	2010-04-07
CN101784535A (zh)	2010-07-21
MX2009013733A (es)	2010-04-22
WO2008152149A1 (fr)	2008-12-18
MA31447B1 (fr)	2010-06-01
UA99132C2 (ru)	2012-07-25
JP2010529977A (ja)	2010-09-02
NZ581933A (en)	2012-01-12
US20100249187A1 (en)	2010-09-30
US8809539B2 (en)	2014-08-19
AU2008263817A1 (en)	2008-12-18

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JP5346016B2 - Ｓ１ｐ１受容体アゴニストとしての新規ジカルボン酸誘導体 - Google Patents

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