JP6147670B2 - 改善された半減期を有する修飾された抗体 - Google Patents

改善された半減期を有する修飾された抗体 Download PDF

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JP6147670B2
JP6147670B2 JP2013544971A JP2013544971A JP6147670B2 JP 6147670 B2 JP6147670 B2 JP 6147670B2 JP 2013544971 A JP2013544971 A JP 2013544971A JP 2013544971 A JP2013544971 A JP 2013544971A JP 6147670 B2 JP6147670 B2 JP 6147670B2
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antibody
immunoglobulin
igg4
human
antibodies
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JP2014503209A (ja
JP2014503209A5 (2
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ウィルソン デイビッド
ウィルソン デイビッド
徹也 田浦
徹也 田浦
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テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P33/00—Antiparasitic agents
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    • A61P33/10—Anthelmintics
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

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JP2013544971A 2010-12-22 2011-12-22 改善された半減期を有する修飾された抗体 Active JP6147670B2 (ja)

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Application Number Priority Date Filing Date Title
US201061425858P 2010-12-22 2010-12-22
US61/425,858 2010-12-22
PCT/AU2011/001662 WO2012083370A1 (en) 2010-12-22 2011-12-22 Modified antibody with improved half-life

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JP2016255652A Division JP6334669B2 (ja) 2010-12-22 2016-12-28 改善された半減期を有する修飾された抗体

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JP2014503209A JP2014503209A (ja) 2014-02-13
JP2014503209A5 JP2014503209A5 (2) 2015-02-19
JP6147670B2 true JP6147670B2 (ja) 2017-06-14

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US (1) US9505826B2 (2)
EP (1) EP2654790B1 (2)
JP (2) JP6147670B2 (2)
KR (1) KR101941514B1 (2)
CN (1) CN103429261A (2)
AU (1) AU2011349049B2 (2)
BR (1) BR112013016235B1 (2)
CA (1) CA2824279A1 (2)
EA (1) EA201390923A1 (2)
ES (1) ES2720136T3 (2)
IL (1) IL227081B (2)
MX (1) MX2013007392A (2)
PT (1) PT2654790T (2)
WO (1) WO2012083370A1 (2)
ZA (1) ZA201305123B (2)

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