JP7072386B2 - 核酸の送達のための脂質および脂質ナノ粒子製剤 - Google Patents

核酸の送達のための脂質および脂質ナノ粒子製剤 Download PDF

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JP7072386B2
JP7072386B2 JP2017567367A JP2017567367A JP7072386B2 JP 7072386 B2 JP7072386 B2 JP 7072386B2 JP 2017567367 A JP2017567367 A JP 2017567367A JP 2017567367 A JP2017567367 A JP 2017567367A JP 7072386 B2 JP7072386 B2 JP 7072386B2
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JP2018521052A5 (2
JP2018521052A (ja
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シンヤオ ドゥ，
スティーブン エム． アンセル，
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Acuitas Therapeutics Inc
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    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07C233/00—Carboxylic acid amides
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    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/38—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
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    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C235/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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JP2017567367A 2015-06-29 2016-06-29 核酸の送達のための脂質および脂質ナノ粒子製剤 Active JP7072386B2 (ja)

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JP2021110236A JP7443296B2 (ja) 2015-06-29 2021-07-01 核酸の送達のための脂質および脂質ナノ粒子製剤
JP2024024365A JP7848256B2 (ja) 2015-06-29 2024-02-21 核酸の送達のための脂質および脂質ナノ粒子製剤

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US201562186210P 2015-06-29 2015-06-29
US62/186,210 2015-06-29
PCT/US2016/039999 WO2017004143A1 (en) 2015-06-29 2016-06-29 Lipids and lipid nanoparticle formulations for delivery of nucleic acids

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JP2018521052A JP2018521052A (ja) 2018-08-02
JP2018521052A5 JP2018521052A5 (2) 2019-07-25
JP7072386B2 true JP7072386B2 (ja) 2022-05-20

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JP2021110236A Active JP7443296B2 (ja) 2015-06-29 2021-07-01 核酸の送達のための脂質および脂質ナノ粒子製剤
JP2024024365A Active JP7848256B2 (ja) 2015-06-29 2024-02-21 核酸の送達のための脂質および脂質ナノ粒子製剤

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JP2024024365A Active JP7848256B2 (ja) 2015-06-29 2024-02-21 核酸の送達のための脂質および脂質ナノ粒子製剤

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US (3) US10221127B2 (2)
EP (2) EP3313829B1 (2)
JP (3) JP7072386B2 (2)
CN (2) CN114085198A (2)
AU (4) AU2016285852B2 (2)
CA (1) CA2990202A1 (2)
DK (1) DK3313829T3 (2)
ES (1) ES2984981T3 (2)
FI (1) FI3313829T3 (2)
HR (1) HRP20240865T1 (2)
HU (1) HUE067372T2 (2)
IL (2) IL283545B2 (2)
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Cited By (1)

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JP2021169462A (ja) * 2015-06-29 2021-10-28 アクイタス セラピューティクス インコーポレイテッド 核酸の送達のための脂質および脂質ナノ粒子製剤

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HRP20230209T1 (hr) * 2015-10-28 2023-04-14 Acuitas Therapeutics Inc. Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
LT3394030T (lt) 2015-12-22 2022-04-11 Modernatx, Inc. Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu
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US20190274968A1 (en) * 2016-10-27 2019-09-12 The Trustees Of The University Of Pennsylvania Nucleoside-modified rna for inducing an adaptive immune response
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CA3049991A1 (en) 2017-01-11 2018-07-19 The Trustees Of The University Of Pennsylvania Nucleoside-modified rna for inducing an immune response against zika virus
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