JP7620123B2 - Ｌ－リシン生産能が向上したコリネバクテリウム・グルタミカム変異株及びそれを用いたｌ－リシン生産方法 - Google Patents

Ｌ－リシン生産能が向上したコリネバクテリウム・グルタミカム変異株及びそれを用いたｌ－リシン生産方法 Download PDF

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JP7620123B2
JP7620123B2 JP2023566852A JP2023566852A JP7620123B2 JP 7620123 B2 JP7620123 B2 JP 7620123B2 JP 2023566852 A JP2023566852 A JP 2023566852A JP 2023566852 A JP2023566852 A JP 2023566852A JP 7620123 B2 JP7620123 B2 JP 7620123B2
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lysine
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corynebacterium glutamicum
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JP2024515390A (ja
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ピョ ホン、イン
ヒ イ、ソン
ウン キム、ハ
ヒョン パク、ソク
ヒョン パク、ジュン
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シージェイ チェイルジェダング コーポレイション
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01001—Transketolase (2.2.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/101—Plasmid DNA for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/265—Micrococcus
    • C12R2001/28—Micrococcus glutamicus ; Corynebacterium glutamicum

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2023566852A 2021-04-30 2021-05-28 Ｌ－リシン生産能が向上したコリネバクテリウム・グルタミカム変異株及びそれを用いたｌ－リシン生産方法 Active JP7620123B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR10-2021-0056580 2021-04-30
KR20210056580 2021-04-30
KR10-2021-0067391 2021-05-26
KR1020210067391A KR102682180B1 (ko) 2021-04-30 2021-05-26 L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법
PCT/KR2021/006681 WO2022231056A1 (fr) 2021-04-30 2021-05-28 Variant de corynébactérium glutamicum ayant une capacité de production de l-lysine améliorée et procédé de production de l-lysine l'utilisant

Publications (2)

Publication Number Publication Date
JP2024515390A JP2024515390A (ja) 2024-04-09
JP7620123B2 true JP7620123B2 (ja) 2025-01-22

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JP2023566852A Active JP7620123B2 (ja) 2021-04-30 2021-05-28 Ｌ－リシン生産能が向上したコリネバクテリウム・グルタミカム変異株及びそれを用いたｌ－リシン生産方法

Country Status (10)

Country Link
US (1) US20250305014A1 (fr)
EP (1) EP4332230A4 (fr)
JP (1) JP7620123B2 (fr)
KR (1) KR102869884B1 (fr)
CN (2) CN115261294B (fr)
AU (1) AU2021443607B2 (fr)
BR (1) BR112023022512A2 (fr)
CA (1) CA3217305A1 (fr)
MX (1) MX2023012873A (fr)
WO (1) WO2022231056A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015500660A (ja) 2011-12-21 2015-01-08 シージェイ チェイルジェダン コーポレイション Ｌ−リジン生産能を有する微生物を用いてｌ−リジンを生産する方法
JP2015504688A (ja) 2012-01-30 2015-02-16 ミリアント・コーポレイションＭｙｒｉａｎｔ Ｃｏｒｐｏｒａｔｉｏｎ 遺伝子操作された微生物からのムコン酸の生成

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2374012A1 (fr) * 2000-03-17 2001-09-20 Degussa Ag Obtention par fermentation d'acides l-amines avec amplification du gene tkt
AU2004299729A1 (en) * 2003-12-18 2005-06-30 Basf Aktiengesellschaft Methods for the preparation of lysine by fermentation of corynebacterium glutamicum
KR100838038B1 (ko) 2006-12-29 2008-06-12 씨제이제일제당 (주) Ｌ-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용한 ｌ-라이신 생산 방법
CN101646687A (zh) * 2007-02-19 2010-02-10 赢创德固赛有限责任公司 通过过表达戊糖磷酸途径的酶在棒状细菌中生产甲硫氨酸的方法
US9169502B2 (en) * 2010-06-15 2015-10-27 Paik Kwang Industrial Co., Ltd. Method of producing L-lysine using a Corynebacterium glutamicum microorganism
KR101504900B1 (ko) * 2013-06-27 2015-03-23 백광산업 주식회사 트랜스케톨라아제 유전자 프로모터 변이체 및 이의 용도
KR101564753B1 (ko) * 2013-12-26 2015-11-13 백광산업 주식회사 코리네형 세균 유래의 치환된 개시코돈을 포함하는 재조합 벡터, 형질전환된 숙주세포 및 이를 이용한 아미노산의 생산방법
KR20200026881A (ko) 2017-06-07 2020-03-11 지머젠 인코포레이티드 코리네박테리움 글루타미컴으로부터의 프로모터 및 보조 유전자 발현을 조절하는 데 이의 용도
KR102139806B1 (ko) 2020-02-13 2020-07-30 씨제이제일제당 (주) 변이형 LysE를 포함하는 미생물, 및 이를 이용한 L-아미노산 생산 방법
CN113308426B (zh) * 2021-05-27 2022-10-18 齐鲁工业大学 一种改造tk基因5′端序列的重组棒状杆菌及其应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015500660A (ja) 2011-12-21 2015-01-08 シージェイ チェイルジェダン コーポレイション Ｌ−リジン生産能を有する微生物を用いてｌ−リジンを生産する方法
JP2015504688A (ja) 2012-01-30 2015-02-16 ミリアント・コーポレイションＭｙｒｉａｎｔ Ｃｏｒｐｏｒａｔｉｏｎ 遺伝子操作された微生物からのムコン酸の生成

Also Published As

Publication number Publication date
US20250305014A1 (en) 2025-10-02
WO2022231056A1 (fr) 2022-11-03
KR102869884B1 (ko) 2025-10-14
EP4332230A1 (fr) 2024-03-06
CN115261294B (zh) 2024-03-29
KR20240000419A (ko) 2024-01-02
MX2023012873A (es) 2024-01-24
CA3217305A1 (fr) 2022-11-03
CN117511834A (zh) 2024-02-06
EP4332230A4 (fr) 2025-06-25
JP2024515390A (ja) 2024-04-09
AU2021443607B2 (en) 2025-05-08
AU2021443607A1 (en) 2023-11-16
BR112023022512A2 (pt) 2024-01-02
CN115261294A (zh) 2022-11-01

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