JPH01242529A - Lipid metabolism improving agent - Google Patents

Abstract

PURPOSE:To oblain a lipid metabolism improving agent containing 4' galactosyllactose as an active ingredient, giving no side effect to human, capable of exhibiting excellent effect to improvement of lipid metabolism in human body and useful for keeping human health. CONSTITUTION:4'-Galactosyllactose[=O-beta-D-galactopyranosyl-(1 4)-O-beta-D- galactopyranosyl-(1 4)-D-glucose] is contained as an active ingredient. The agent may be a mixture containing other saccharide, protein, lamiral, etc., in addition to the above-mentioned active ingredient and when the above- mentioned active ingredient is used in combination of other lipid lowering agent, e. g., pantetherine (general name) or probucol(general name) [manufactured by DAIICHI SEIYAKU], lipid improving effect exhibits excellent effect com pared with the case separately used. The agent is used at an amount of active ingredient of 1-40g, preferably 3-20g/body/day and may be separately administered several times, preferably orally applied and may be used in blend with other food.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention provides 0-β-D-galactopyranosyl-(1→4) having the formula, which is highly effective for humans.
-〇-β-D-galactopyranosyl(l→4)-D-
4'-galactosyllactose (denoted by glucose)
The present invention relates to a lipid metabolism improving agent containing 4'-GL) as an active ingredient.

[Prior art and problems] It has been pointed out that abnormalities in lipid metabolism have an important causal relationship with the development and acceleration of arteriosclerosis, and there is a desire for drugs that correct abnormalities in lipids such as cholesterol, triglycerides, and free fatty acids. . As a result, various lipid-lowering agents have been developed, but these drugs also exhibit side effects, which limits their use.

There are a wide variety of factors that affect blood cholesterol and triglyceride levels, and it is known that among blood lipids, cholesterol and triglyceride are metabolized differently in the body. Therefore, the mechanism of action of lipid-lowering agents is complex, and they may act on either part of cholesterol or triglyceride metabolism to lower both or only one type of lipid. Also,
The effects may vary depending on the type of animal. Clinical results also sometimes differed from animal studies.

Animal studies using hyperlipidemic rats have shown that dietary fiber and certain indigestible sugars are effective.

It has also been reported that when 4'-OL is used in combination with cellulose, the blood pressure of mature SII R increases and the plasma total cholesterol level decreases (41st L1 Society of Nutrition and Food Science General Meeting 1).
There is also a collection of abstracts from Mizo, 1988, p. 118), but its clinical effects on humans have not been clarified.

[Problems to be Solved by the Invention] The present invention was invented in view of the current situation, and provides a method for reducing cholesterol and triglycerides by constantly taking iJ% in humans without any side effects. The object of the present invention is to provide a substance that facilitates lipid improvement by increasing HDL-cholesterol.

[Means for Solving the Problems] The inventors have discovered that constant intake of a sugar mixture containing 4'-GL as an active ingredient is significantly effective in improving lipid metabolism in the human body, leading to the present invention.

4'-GL used in the present invention is disclosed in Japanese Patent Application Laid-Open No. 60-251896.
No., JP-A-61-236790, JP-A-61-271
No. 999, JP-A-61-289856, JP-A-62-
130695 and the like can be used.

The lipid metabolism improving agent of the present invention contains 4'-GL as an active ingredient, and may be a mixture containing other carbohydrates, proteins, minerals, etc.

In addition, when used in combination with other lipid-lowering agents such as Pantocin (trade name) and Synlestal (manufactured by Dai-Pharmaceutical Co., Ltd.), the lipid-improving effect becomes greater than when each agent is used alone. As for the amount used per day.

Although it is difficult to specify due to individual differences and weight differences, 1g
40g, preferably 3g to 20g.

These can also be used in several parts.

There are no particular restrictions on the method of using 4'-GL, but oral application is preferred. It can also be mixed with other foods.

[Effects of the Invention] The 4'-OL of the present invention is extremely useful as a lipid improving agent in maintaining human health in modern times where many adult diseases are occurring due to abnormal lipid metabolism.

[Example] The present invention will be explained below based on examples.

Example 1 In this example, the subject was an 81-year-old woman undergoing rehabilitation after a fracture, and 4''-GL with a purity of 95% was used.

8g was dissolved in warm water and taken once daily.

As a result, a significant decrease in total cholesterol was observed in the first month after administration, and triglyceride levels also decreased slightly.

On the other hand, HD L-cholesterol increased one month after administration, and as shown in Figure 1, a steady improvement effect was observed.

Example 2 In this example, the subject was an 80-year-old woman undergoing rehabilitation after a cerebral infarction. 8 g of 4'-GL with a purity of 95% was dissolved in warm water and taken once daily.

As a result, after administration, total cholesterol and triglyceride steadily decreased, and HDL-cholesterol slightly increased, indicating an improvement effect as shown in FIG. 2. When administration was stopped, the effect disappeared and the value returned to the same level as before administration.

Example 3 In this example, 4. '-GL shows the combined effect of synlestal and pantocin.

The subject was a 46-year-old man who was a long-term bedridden patient.

This subject will receive 2 tablets of synlestal, 2 tablets of pantocin (2 tablets),
00■) Three tablets were administered for a long period of time, but no lipid-improving effect was observed.

Therefore, this subject was given 4'-G'L with a purity of 95%,
8g, Synlestal 2 tablets, Pantocin (200■)
When 3 tablets were administered in combination, as shown in Figure 3, total cholesterol, triglyceride, I (DL-cholesterol) improved to J-term level due to the combined administration with 4'-GL.

When administration is stopped, total cholesterol, I-I D L
- Regarding cholesterol, the effect continued for one month, but after two months, the effect disappeared and the value became the same as before administration.

[Brief explanation of the drawing]

Fig. 1 is a graph showing the medicinal efficacy of the first embodiment of the present invention;
The figure is a graph showing the medicinal efficacy of the second embodiment of the present invention, and FIG. 3 is a graph showing the medicinal efficacy of the third embodiment of the present invention.

Claims (1)

[Claims] A lipid metabolism improving agent containing 4'-galactosyllactose as an active ingredient.