JPH01279892A - アベルメクチン誘導体 - Google Patents

アベルメクチン誘導体

Info

Publication number
JPH01279892A
JPH01279892A JP1016527A JP1652789A JPH01279892A JP H01279892 A JPH01279892 A JP H01279892A JP 1016527 A JP1016527 A JP 1016527A JP 1652789 A JP1652789 A JP 1652789A JP H01279892 A JPH01279892 A JP H01279892A
Authority
JP
Japan
Prior art keywords
compound
hydroxy
compounds
avermectin
dehydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1016527A
Other languages
English (en)
Japanese (ja)
Inventor
Helmut H Mrozik
ヘルムート　エツチ．ムロツイク
Frank S Waksmunski
フランク　エス．ワクスムンスキ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPH01279892A publication Critical patent/JPH01279892A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP1016527A 1988-01-29 1989-01-27 アベルメクチン誘導体 Pending JPH01279892A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15018688A 1988-01-29 1988-01-29
US150,186 1988-01-29

Publications (1)

Publication Number Publication Date
JPH01279892A true JPH01279892A (ja) 1989-11-10

Family

ID=22533441

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1016527A Pending JPH01279892A (ja) 1988-01-29 1989-01-27 アベルメクチン誘導体

Country Status (6)

Country Link
US (1) US4895837A (de)
EP (1) EP0326357A3 (de)
JP (1) JPH01279892A (de)
AU (1) AU609570B2 (de)
NZ (1) NZ227699A (de)
ZA (1) ZA89538B (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006516585A (ja) * 2003-01-31 2006-07-06 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト アベルメクチンと殺菌作用を有する４”−または４’−位置で置換されたアベルメクチン単糖誘導体
JP2006518347A (ja) * 2003-01-31 2006-08-10 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 殺虫特性を有するアベルメクチン単糖誘導体

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ228866A (en) * 1988-05-02 1991-10-25 Merck & Co Inc Fluoro-substituted milbemycins and avermectins for combatting parasites and insects
US5120646A (en) * 1988-10-18 1992-06-09 Chen Shieh Shung T Process for the preparation of anthelmintive bioconversion products
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
US5322692A (en) * 1989-02-28 1994-06-21 American Cyanamid Company Sustained release bolus effective for the prolonged prevention, treatment or control of nematode, acarid and endo- and ectoparasitic infestations of ruminants
US5124258A (en) * 1990-09-12 1992-06-23 Merck & Co., Inc. Fermentation process for the preparation of ivermectin aglycone
US5070015A (en) * 1990-10-15 1991-12-03 Merck & Co., Inc. Novel avermectins are produced from known microorganisms
US5177063A (en) * 1991-03-11 1993-01-05 Merck & Co., Inc. Avermectin compounds with a 6,5-spiroketal ring system
US5171742A (en) * 1991-10-15 1992-12-15 Merck & Co., Inc. Avermectin compounds with a 6,5-spiroketal ring system ad a 23-acyl substituent
US5162363A (en) * 1992-03-18 1992-11-10 Merck & Co., Inc. 23-nor-23-thia avermectin analogs are active anthelmintic agents
US5229415A (en) * 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
US5241083A (en) * 1992-07-01 1993-08-31 Merck & Co., Inc. Process for converting the 13-α-hydroxy group of avermectin aglycones
US5411946A (en) * 1993-02-24 1995-05-02 Merck & Co., Inc. Avermectin derivatives
BR0009861A (pt) * 1999-02-09 2002-01-15 Kitasato Inst Derivados de avermectina
JPWO2002012261A1 (ja) * 2000-08-09 2004-01-15 社団法人北里研究所 エバーメクチン誘導体
WO2002012248A1 (en) * 2000-08-09 2002-02-14 The Kitasato Institute Avermectin derivatives
CR6574A (es) * 2001-02-27 2004-10-28 Syngenta Participations Ag Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
EG23124A (en) * 2001-02-27 2004-04-28 Syngenta Participations Ag Avermectins substituted in the 4-position having pesticidal properties
AR036486A1 (es) * 2001-08-28 2004-09-15 Syngenta Participations Ag Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion
AR040073A1 (es) * 2002-05-07 2005-03-16 Syngenta Participations Ag Derivados de 4''-desoxi-4''-(s)-amido avermectina y su uso como plaguicidas
GB0302308D0 (en) * 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0302547D0 (en) * 2003-02-04 2003-03-12 Syngenta Participations Ag Avermectins and avermectin monosaccharide substituted in the 4'- and 4" position having pesticidal properties
GB0320176D0 (en) * 2003-08-28 2003-10-01 Syngenta Participations Ag Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
JP5595412B2 (ja) 2008-12-04 2014-09-24 メリアル リミテッド 二量体アベルメクチン及びミルベマイシン誘導体
NZ600845A (en) 2009-12-17 2014-08-29 Merial Ltd Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
EP3351546B9 (de) 2011-12-02 2024-07-10 Boehringer Ingelheim Vetmedica GmbH Langwirkende injizierbare moxidectinformulierungen
CN104231022B (zh) * 2013-06-14 2018-10-09 南开大学 一种大环内酯类化合物的制备及应用
CN103421065B (zh) * 2013-07-03 2016-05-18 大庆志飞生物化工有限公司 一类新型阿维菌素衍生物及其制备方法
CN116491516B (zh) * 2023-03-02 2024-08-30 河北威远生物化工有限公司 甲氨基阿维菌素B2a及其盐类化合物在制备促进植物生长的药物中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5461197A (en) * 1977-10-03 1979-05-17 Merck & Co Inc Vermifuge cc076 derivative
JPS54145699A (en) * 1977-12-19 1979-11-14 Merck & Co Inc 133halo and 133deoxy derivative of cc076 compound
JPS5524165A (en) * 1978-08-04 1980-02-21 Merck & Co Inc Alkyl derivative of cc076 compound
JPS58167591A (ja) * 1982-03-16 1983-10-03 メルク　エンド　カムパニー　インコーポレーテッド ４”―アミノ―４”―デオキシアベルメクチン化合物及びその置換アミノ誘導体
JPS6267087A (ja) * 1985-09-13 1987-03-26 アメリカン・サイアナミツド・カンパニー マクロライド抗生物質およびその製法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4550160A (en) * 1979-08-13 1985-10-29 Merck & Co., Inc. Processes for the interconversion of C-076 compounds
US5019589A (en) * 1986-09-12 1991-05-28 American Cyanamid Company Δ23 -LL-F28249 compounds
NZ228866A (en) * 1988-05-02 1991-10-25 Merck & Co Inc Fluoro-substituted milbemycins and avermectins for combatting parasites and insects

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5461197A (en) * 1977-10-03 1979-05-17 Merck & Co Inc Vermifuge cc076 derivative
JPS54145699A (en) * 1977-12-19 1979-11-14 Merck & Co Inc 133halo and 133deoxy derivative of cc076 compound
JPS5524165A (en) * 1978-08-04 1980-02-21 Merck & Co Inc Alkyl derivative of cc076 compound
JPS58167591A (ja) * 1982-03-16 1983-10-03 メルク　エンド　カムパニー　インコーポレーテッド ４”―アミノ―４”―デオキシアベルメクチン化合物及びその置換アミノ誘導体
JPS6267087A (ja) * 1985-09-13 1987-03-26 アメリカン・サイアナミツド・カンパニー マクロライド抗生物質およびその製法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006516585A (ja) * 2003-01-31 2006-07-06 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト アベルメクチンと殺菌作用を有する４”−または４’−位置で置換されたアベルメクチン単糖誘導体
JP2006518347A (ja) * 2003-01-31 2006-08-10 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 殺虫特性を有するアベルメクチン単糖誘導体

Also Published As

Publication number Publication date
AU2883989A (en) 1989-08-03
ZA89538B (en) 1989-09-27
AU609570B2 (en) 1991-05-02
EP0326357A2 (de) 1989-08-02
US4895837A (en) 1990-01-23
NZ227699A (en) 1992-02-25
EP0326357A3 (de) 1989-10-25

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