JPH0133475B2 - - Google Patents

Info

Publication number: JPH0133475B2
Authority: JP; Japan
Prior art keywords: formula; hydroxyphenyl; pharmaceutically acceptable; acetone; salts
Prior art date: 1979-05-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP7365080A

Other languages

English (en)

Japanese (ja)

Other versions

JPS55162793A (en

Inventor

Jei Fuiiraa Uiriamu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-31

Filing date

1980-05-30

Publication date

1989-07-13

1980-05-30 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1980-12-18 Publication of JPS55162793A publication Critical patent/JPS55162793A/ja

1989-07-13 Publication of JPH0133475B2 publication Critical patent/JPH0133475B2/ja

Status Granted legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 claims description 12
150000003839 salts Chemical class 0.000 claims description 12
125000004464 hydroxyphenyl group Chemical group 0.000 claims description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 23
QWOJMRHUQHTCJG-UHFFFAOYSA-N CC([CH2-])=O Chemical class CC([CH2-])=O QWOJMRHUQHTCJG-UHFFFAOYSA-N 0.000 description 9
239000000243 solution Substances 0.000 description 9
-1 2-hydroxyphenyl Chemical group 0.000 description 7
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
230000003115 biocidal effect Effects 0.000 description 4
HEWZVZIVELJPQZ-UHFFFAOYSA-N 2,2-dimethoxypropane Chemical compound COC(C)(C)OC HEWZVZIVELJPQZ-UHFFFAOYSA-N 0.000 description 3
229910052783 alkali metal Inorganic materials 0.000 description 3
150000001412 amines Chemical class 0.000 description 3
239000012736 aqueous medium Substances 0.000 description 3
239000003085 diluting agent Substances 0.000 description 3
239000000725 suspension Substances 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
239000012024 dehydrating agents‎ Substances 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000001990 intravenous administration Methods 0.000 description 2
239000007788 liquid Substances 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
239000000047 product Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
239000007858 starting material Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
FGQLGYBGTRHODR-UHFFFAOYSA-N 2,2-diethoxypropane Chemical compound CCOC(C)(C)OCC FGQLGYBGTRHODR-UHFFFAOYSA-N 0.000 description 1
GRWKNBPOGBTZMN-UHFFFAOYSA-N 2-benzyl-3-phenylpropane-1,2-diamine Chemical compound C=1C=CC=CC=1CC(N)(CN)CC1=CC=CC=C1 GRWKNBPOGBTZMN-UHFFFAOYSA-N 0.000 description 1
125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 description 1
125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
239000002253 acid Substances 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
239000000292 calcium oxide Substances 0.000 description 1
ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229940125782 compound 2 Drugs 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
229940093471 ethyl oleate Drugs 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
150000002646 long chain fatty acid esters Chemical class 0.000 description 1
238000000034 method Methods 0.000 description 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
239000003921 oil Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000002798 polar solvent Substances 0.000 description 1
ZUFQCVZBBNZMKD-UHFFFAOYSA-M potassium 2-ethylhexanoate Chemical compound [K+].CCCCC(CC)C([O-])=O ZUFQCVZBBNZMKD-UHFFFAOYSA-M 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000008215 water for injection Substances 0.000 description 1

Landscapes

Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP7365080A 1979-05-31 1980-05-30 33halocephalosporin derivative Granted JPS55162793A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4413579A	1979-05-31	1979-05-31

Publications (2)

Publication Number	Publication Date
JPS55162793A JPS55162793A (en)	1980-12-18
JPH0133475B2 true JPH0133475B2 (de)	1989-07-13

Family

ID=21930688

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP7365080A Granted JPS55162793A (en)	1979-05-31	1980-05-30	33halocephalosporin derivative

Country Status (1)

Country	Link
JP (1)	JPS55162793A (de)

1980
- 1980-05-30 JP JP7365080A patent/JPS55162793A/ja active Granted

Also Published As

Publication number	Publication date
JPS55162793A (en)	1980-12-18

Similar Documents

Publication	Publication Date	Title
KR850001630B1 (ko)	1985-10-31	암피실린 또는 아목시실린 및 페니실란산 1,1-디옥시드의 아세톤 화물로써 메탄디올의 비스-에스테르를 제조하는 방법
IE44641B1 (en)	1982-02-10	1,1-cycloalkyldiacetic acid imide derivatives and their use for preparing 1-aminomethyl-1-cycloalkylacetic acids
JPH03204868A (ja)	1991-09-06	アミノチアゾリル酢酸の新規なオキシム誘導体
KR840002407A (ko)	1984-07-21	세팔로스포린 유도체의 제조방법
DE69214784T2 (de)	1997-03-13	Verfahren zur herstellung von cephalosporinzwischenverbindungen
JPS638107B2 (de)	1988-02-19
US2522959A (en)	1950-09-19	2, 2-dinitro-1, 3-propanediol and method of preparing same
JPH0133475B2 (de)	1989-07-13
DE1670301B2 (de)	1975-05-07	7-(Pyridylmercaptoacetamido)cephalosporansäuren, deren Salze und Verfahren zu ihrer Herstellung
US2906772A (en)	1959-09-29	Resolution of di-2, 2-diphenyl-3-methyl-4-dimethylaminobutyronitrile
US3367948A (en)	1968-02-06	Novel d-threo-1-phenyl-2-amino-propane-1, 3-diol-derivatives
US3177203A (en)	1965-04-06	Penicillin derivatives
US2530570A (en)	1950-11-21	Pyrimidylmercapto-carboxylic acids
US2863873A (en)	1958-12-09	Esters of nicotinic acid
US3202666A (en)	1965-08-24	Substituted 9h-pyrido (3-4-b) indole-1 carboxylic acid and derivatives
US3161634A (en)	1964-12-15	Process of making nu-acyl derivatives of 6-amino-penicillanic acid
US2904551A (en)	1959-09-15	Chemical compounds and processes of preparing the same
US3882107A (en)	1975-05-06	Zinc chelate of 2,4-dihydroxy-1,4(2H)-benzoxazine-3-one
AU612414B2 (en)	1991-07-11	Cephalosporin derivatives with improved pharmacokinetics, process for their preparation, pharmaceutical compositions in which they are present and synthesis intermediate
US3100781A (en)	1963-08-13	Chloramphenicol glycinate and the production thereof
US2721200A (en)	1955-10-18	Sulfisoxazole compounds
US2449038A (en)	1948-09-07	Preparation of 3-substituted benzotetronic acid and salts thereof
EP0369511A1 (de)	1990-05-23	Verfahren zur Herstellung von quaternären ammonium- und phosphonium-substituierten Kohlensäureestern
US2741614A (en)	1956-04-10	N-isobutylnormorpfflne compounds
US3113134A (en)	1963-12-03	Process for the production of reserpic acid diesters