JPH0160762B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a measurement method in a clinical chemistry automatic analyzer and improvements to the device.

Generally, in the case of a so-called single multi-type automatic clinical chemistry analyzer that measures multiple items in one reaction line, a sample is dispensed at a predetermined position into a reaction tube held by a turret-shaped feeding device, and then, A reagent corresponding to the measurement item is injected at a predetermined position and transferred to a predetermined measurement position. At this measurement position, each of the reaction tubes is held in a measurement turret, and the measurement turret is rotated intermittently while being reacted with light from the light source. Currently, the sample in the tube is measured colorimetrically.

By the way, the above-mentioned measurement method conventionally employed in such automatic clinical chemistry analyzers is to dispose a sensitive element that receives the transmitted light that has passed through the reaction tube at each intermittent stop position of the measurement turret. This method requires a large number of parts, is expensive, requires complicated maintenance, and has the problem that all reaction tubes must be irradiated with light from the light source at the same time.

The present invention was devised in view of the current situation, and its purpose is to significantly reduce the number of parts because there is only one sensitive element for colorimetric measurement, and to achieve a simple configuration. The purpose of the present invention is to provide a measurement method and device for an automatic clinical chemistry analyzer that can improve the reliability of measurement results, reduce costs, facilitate maintenance, and perform colorimetric measurements with high precision. be.

In order to achieve this object, the present invention involves injecting a sample and a reagent into a plurality of reaction tubes, transporting them sequentially to a predetermined measurement position, and holding the reaction tubes on a measurement turret at the measurement position. When measuring a sample in an automatic clinical chemistry analyzer configured to carry out colorimetric measurements using light from a light source while sequentially and intermittently transferring the light, the light from the light source is reflected straight through a reflector and passed through a reaction tube. The structure is such that the transmitted light is received and measured by one sensing element fixedly disposed at the lower center, and the reflecting mirror is attached to the case during one intermittent movement of the measurement turret. This system is configured to continuously perform colorimetric measurements of reaction tubes held in a measurement turret while rotating for more than one rotation. In addition, in order to carry out the above method, the present invention includes a plurality of reaction tubes, a means for injecting a sample and a reagent into these reaction tubes and transporting them to a predetermined measurement position, and a means for carrying out the above reaction at this measurement position. A measurement turret that holds the tubes, a drive means that rotates the measurement turret intermittently to sequentially transport the reaction tubes, and an optical system that performs colorimetric measurement of the sample, etc. in the reaction tube held by the measurement turret. In the measuring device for a clinical chemistry automatic analyzer having a device, a reflecting mirror is interposed in the optical device to reflect the light source light and irradiate it to the reaction tube, and the transmitted light that has passed through the reaction tube is reflected at the center lower part. The light is received by a sensing element fixedly disposed on the mirror and colorimetrically measured, and the reflecting mirror rotates more than once along with the case during one intermittent movement of the measuring turret, and is held by the measuring turret. The system is designed to continuously perform colorimetric measurements of the reaction tube.

Hereinafter, the present invention will be described in detail based on an embodiment shown in the accompanying drawings.

The clinical chemistry automatic analyzer according to this embodiment is of the so-called single-multi type described above,
A sample is dispensed via a pipette at a predetermined position into a reaction tube 1 held in a turret-shaped feeding device, and then a reagent corresponding to the measurement item is injected from a sampler at another predetermined position and transferred to a measuring device S. and is transported intermittently by an appropriate drive device.

The reaction tubes 1 sequentially transferred to the measuring device S are sequentially held in a measuring turret 2, and the measuring turret 2 is rotated intermittently at predetermined intervals by a known intermittent drive device 3. The reaction tubes 1 are moved intermittently.

On the other hand, the light source light A from the measuring light source 4 arranged concentrically on the measuring turret 2 is reflected at right angles through the first reflecting mirror 5 and irradiated onto the reaction tube 1. Transmitted light transmitted through reaction tube 1
A' is guided through the second to fourth reflecting mirrors 6, 7, 8 to one sensing element 9 fixedly disposed in the direction in which the light source 4 hangs, and this sensing element 9 measures the received light. The light is measured colorimetrically and the color data is input into the memory device 10.

Further, the light source 4 and each of the reflecting mirrors 5 to 8 are housed in a sealed case 11 having a substantially U-shaped cross section.
3 to the reaction tube 1, and the irradiation hole 13
The structure is such that light enters the case 11 again through a hole 14 opened at a position facing the light and is guided to the sensing element 9.

The case 11 further includes a hollow shaft 1.
The measurement turret 2 is rotationally controlled via a drive device 15 so that it rotates at least one rotation during one intermittent movement, and a sensing element 9 is located below the shaft 12. It is disposed so as not to be involved in the rotation of the case 11.

Therefore, in the measuring device S according to this embodiment, the reaction tube 1 held on the measuring turret 2 can be continuously measured in a very short time while the case 11 rotates once, and at least Since the case 11 rotates more than once during one intermittent movement of the measuring turret 2, the reaction tube 1 is held in the measuring turret 2 until it is released from the measuring turret 2. Since the tube 1 can be measured several or ten times, measurement accuracy is improved, and temporal reaction changes of the sample can also be easily measured.The optical axis is also significantly eccentric due to the rotational vibration of the case 11, which improves measurement accuracy. This has the effect that there is no decrease in the amount of water.

Since this invention includes the above-mentioned configuration, the number of sensitive elements is significantly reduced and the configuration is simplified, which reduces costs and facilitates maintenance, especially in the colorimetric measurement of specimens in a so-called single-multi method automatic clinical chemistry analyzer. and the reliability of measurement results can be improved.

[Brief explanation of drawings]

The drawing shows a measuring device in a clinical chemistry automatic analyzer according to an embodiment of the present invention, and is a cross-sectional explanatory diagram showing the configuration of the measuring device. DESCRIPTION OF SYMBOLS 1... Reaction tube, 2... Measuring turret, 4... Light source, 5... (first) reflecting mirror, 9... Sensing element, A... Light source light, A'... Transmitted light, S... Measuring device.

Claims (1)

[Scope of Claims] 1. Injecting a sample and a reagent into a plurality of reaction tubes and sequentially transporting them to a predetermined measurement position, holding the reaction tubes in a measurement turret at the measurement position and sequentially and intermittently transporting the reaction tubes. In a measurement method for a clinical chemistry automatic analyzer configured to carry out colorimetric measurements using light source light, the light source light is reflected straight through a reflector and transmitted through a reaction tube, and this transmitted light is transmitted to the center lower part of the reaction tube. The reflector is configured to receive and measure light with one sensing element fixedly disposed on the mirror, and the reflecting mirror rotates one or more revolutions along with the case during one intermittent movement of the measuring turret and is held on the measuring turret. 1. A method for measuring in a clinical chemistry automatic analyzer, characterized in that the reaction tube is configured to continuously carry out colorimetric measurements. 2. A plurality of reaction tubes, a means for injecting specimens and reagents into these reaction tubes and transporting them to a predetermined measurement position, a measurement turret that holds the reaction tubes at this measurement position, and a means for intermittently transporting the measurement turret. In the measuring device for a clinical chemistry automatic analyzer, the measuring device has a driving means for sequentially transporting the reaction tubes by rotating the measuring device, and an optical device for colorimetrically measuring a sample, etc. in the reaction tube held in the measuring turret. A reflecting mirror is inserted in the optical device to reflect the light from the light source and irradiate it onto the reaction tube.The transmitted light that passes through the reaction tube is received by a single sensing element fixed at the bottom center and compared. In addition to performing color measurement, the reflecting mirror is configured to rotate one or more revolutions along with the case during one intermittent movement of the measurement turret, and to continuously perform colorimetric measurement of the reaction tube held by the measurement turret. Measuring device for clinical chemistry automatic analyzer.