JPH0210442Y2 - - Google Patents

Description

[Detailed description of the invention] This invention relates to a simple blood analyzer.

Blood contains many different chemical components.

The concentration of these chemical components remains within a certain range as long as the organism is healthy, but when the equilibrium state of the organism is disrupted due to disease or the like, the concentration of these components changes. For example, there are rapid increases in various oxygen levels during acute hepatitis, and changes in serum colloid reactions during diffuse hepatitis. Therefore, accurately measuring the concentration of blood components collected from a living body is important for rationally diagnosing diseases, monitoring progress, and determining treatment strategies, and various blood analyzers have been developed. I've been

For example, it was disclosed in Japanese Patent Application Laid-Open No. 53-81292. The invention described in this publication includes a disk in which a plurality of through holes are arranged equally on the same circle, which is rotatable in the horizontal direction, and measuring elements loaded in the through holes are sequentially
A liquid sample such as blood or serum is dispensed, and the progress or result of the reaction of the sample is photometrically analyzed for changes in color density using a photometer equipped directly below one through hole.
Although it is convenient in that liquid samples can be treated as solids, the structure of the mechanism for feeding the measuring element to the disk and the mechanism for removing the element after photometry is complex, large, and expensive, making it difficult for general practitioners to handle. It was not something that could be easily installed.

In view of the above points, this idea was developed by installing a disk in which a plurality of through holes into which measuring elements can be inserted from the top surface are equally arranged on the same circle, and rotatable in the horizontal direction within the disk chamber. In a simple blood analyzer comprising a photometry section directly below the hole, a rotary table on which the central part of the disk is placed is provided in the disk chamber, and at the center of rotation of the rotary table and its eccentric position, A shaft head and a pin are provided that fit into the disk center hole and the positioning hole, so that the measuring element can be removed from the disk after photometry and loaded with the disk, and when the disk is returned to the disk chamber, It is an object of the present invention to provide a simple blood analyzer that is small, relatively inexpensive, and whose positioning can be performed easily and accurately.

Next, this invention will be explained based on an embodiment shown in the accompanying drawings.

1 is a constant temperature room that is always maintained at a constant temperature (30 to 40 degrees Celsius) by heating means 2 such as a heater, 3 is a constant temperature room 1
A disk chamber 3 is provided in the center of the upper part of the disk chamber 3, and the disk chamber 3 has a bottom plate 4 having a concave cross section and a transparent opening/closing lid 5.
It consists of. A ventilation hole 6 is provided in the bottom plate 4 of the disk chamber 3, through which air warmed in the thermostatic chamber 1 is convected into the disk chamber 3. A rotary table 7 is provided at the center of the bottom plate 4 of the disk chamber 3 on which a central portion of the disk 19 is placed through a through hole 8. Reference numeral 9 denotes a shaft rod that supports the rotary table 7, and the lower end of the shaft rod 9 is fitted into a shaft cylinder 10 which is rotatably held at the bottom of the thermostatic chamber 1, as shown in FIGS. 4 and 5. A spring 11 is inserted and loaded into the shaft cylinder 10.
is being suppressed upward by

Note that the shaft rod 9 engages with a vertical hole 12 provided on the side surface of the shaft tube 10 via a pin 13, and while the range of vertical movement is restricted, the rotation of the shaft rod 9 is integral with the shaft tube 10. It is starting to be done.

Reference numeral 14 denotes a measuring element, and the measuring element 14 has a sheet member 15 impregnated with a reagent that develops color by reacting with blood components as shown in the second figure, and an exposed window 16 at the center of the upper and lower surfaces.
It is held by a flat frame member 17 having a diameter of 16'. As shown in the third figure, a plurality of measuring elements 14 (6 in the figure) are arranged along the outer periphery of the disk 19.
) is loaded into the provided through hole 18. The through hole 18 has a stepped portion on its inner circumferential surface so that it can support a measuring element loaded from the top side. Even if the exposure window 16,1
6' coincides with the center of the through hole 18. This measuring element is prepared impregnated with a different reagent for each chemical component of blood, but at least 18
If you have a variety, you'll probably be satisfied. The remaining measurement elements that cannot be placed on the disk 19 are placed on a spare disk (not shown) and stored in a storage (not shown) provided in the constant temperature room 1 to be preheated. It's getting old.

A rotary table 7 on which the central portion of the disk 19 is placed.
A disk 19 is located at the rotation center position and its eccentric position.
A shaft head 9' and a pin 21 are provided to match the center hole 20 and the positioning hole 22 of. Therefore,
The disk 19 can be easily removed, and when it needs to be returned, it can be easily and accurately returned by simply aligning the center hole 20 of the disk with the shaft head 9' of the rotary table 7 and aligning the positioning hole 22 with the pin 21. can be done. That is, one through hole 18 of the disk 19 can be correctly aligned with a photometric section 25, which will be described later, provided directly below it, and a pipette insertion section 31 provided in the opening/closing lid 5 of the disk chamber 3.

Although the center hole 20 and the positioning hole 22 are provided separately in this embodiment, they may be provided in conjunction with each other in the shape of a keyway.

Further, the rotation of the disk 19 is
Although a part of the opening/closing lid 9 is made to protrude outside from the front notch 23 of the lid 5 and can be opened and closed manually, it may be rotated electrically.

Further, the rotation of the disk 19 can be stopped at each angle of the through hole 18. As a means for this, in this embodiment, a notch means 24 is provided on the lower surface of the shaft cylinder 10 which rotates integrally with the shaft rod 9.

Reference numeral 25 denotes a photometric section, and the photometric section 25 is installed as shown in FIG. 7 through a photometric through hole 26 provided in the bottom plate 4 of the disk chamber 3. The photometry section 2
5 is a photometric light beam of a certain wavelength emitted from a light source 27 and separated through a filter 28 as shown in FIG. 2
5c and irradiates the back surface of the measuring element 14, and the reflected light from the irradiated back surface of the measuring element 14 is taken out to the light receiving element 29 via the optical fiber 25b passing through the center of the condensing lens 25c. It's getting old. 30 is a display window that digitally displays the optical information received by the light receiving element 29 through a sensor and an automatic calculation device (not shown).

Reference numeral 31 denotes a pipette insertion portion provided in the opening/closing lid 5 of the disk chamber 3, and the pipette insertion portion 31 allows a pipette (not shown) inserted into the pipette insertion portion 31 to pass through the measuring element 14 placed in one of the through holes 18 of the disk 19. It is located in the center so that blood can be dispensed accurately.

32 and 33 are two swing levers whose free ends are locked to the upper surface of a flange body 34 provided in the middle of the shaft rod 9;
The base ends of the swing levers 32 and 33 are pivotally connected to a common pin 36 inserted through a wall plate 35 erected inside the constant temperature room 1.

Reference numeral 37 is a first lever that moves one swinging lever 32 downward.
The push button 38 is a second push button that moves the other swinging lever 33 downward. These first and second push buttons 37 and 38 are used to lower the shaft 9 via the swing levers 32 and 33 and bring the disk 19 into close contact with the bottom plate 4 of the disk chamber 3. be. The fact that this disk 19 is in close contact with the bottom plate 4 of the disk chamber 3 means that the through hole for photometry provided in the bottom plate 4 as shown in FIG.
This means that the back surface of the measuring element is brought into contact with the top of the cone-shaped cover 25e of the condensing lens 25c that protrudes into the disk chamber 3 from 6. In other words,
This is to keep the photometric distance constant. Note that the first push button 37 is for end point assay and the second push button 38 is for rate assay.
The second push button 38 is provided with a stop lever 39 that holds the second push button in a depressed state, and a rotating lever 40 that operates to release the stop lever 39 when the second push button 38 is pushed down further. In the figure, 41 is a measurement start switch, and 42 is a photometry switch that is closed when the first and second pushbuttons 37 and 38 are lowered.

As described above, this invention provides a disk in which a plurality of through holes into which measuring elements can be inserted from the top surface are arranged equally on the same circle, and is rotatable in the horizontal direction within the disk chamber. In a simple blood analyzer comprising a photometry section directly below, a rotary table on which the center of the disk is placed is provided in the disk chamber, and the center of the disk is located at the center of rotation of the rotary table and its eccentric position. Since it is characterized by having a shaft head and a pin that match the holes and positioning holes, each through-hole of the disk is equipped with a measuring element impregnated with a reagent that reacts and develops a color with the blood component to be analyzed. After dispensing a blood sample into this measuring element and performing photometry, the measuring elements can be removed and loaded one by one to the outside of the disk chamber, and when the disks are returned to the disk chamber again, This can be done easily and accurately by simply aligning the center hole of the disk with the shaft head of the rotary table and aligning the positioning hole with the pin. That is, the photometric section provided directly below one of the through holes of the disk can always be correctly aligned with the pipette insertion section provided on the opening/closing lid of the disk chamber, and various other excellent effects can be achieved.

[Brief explanation of the drawing]

The figures show one embodiment of this invention, and Fig. 1 is a perspective view of the external appearance with the opening/closing lid of the disk chamber open;
The figure is a cross-sectional perspective view of the measuring element, Fig. 3 is a perspective view of the disk on which the measuring element is placed, Fig. 4 is a front sectional view of the disk installed in the disk chamber, and Fig. 5 is a front sectional view of the disk installed in the disk chamber.
Figure 6 is a perspective view showing the actuating means of the disk, Figure 6 is a perspective view of the second push button, Figure 7 is a sectional view showing the relationship between the through hole of the disk and the photometry section, and Figure 8 is a sectional view during photometry. It is. 3...Disc chamber, 4...Bottom plate, 5...Opening/closing lid, 7...Rotary table on which the disk is placed, 8...Through hole, 9...Shaft rod, 9'...Shaft head, 14...Measurement Element, 18... Through hole, 19... Disc, 20... Center hole, 21... Pin, 22... Positioning hole, 25
. . . Photometering section, 29 . . . Light receiving element.

Claims (1)

[Scope of utility model registration request] A disk having a plurality of through holes arranged equidistantly on the same circle into which measurement elements can be fitted from the top surface is provided in a disk chamber so as to be rotatable in the horizontal direction, and a photometric section is provided directly below one of the through holes of the disk. In the simple blood analyzer, a rotary table on which the central part of the disk is placed is provided in the disk chamber, and a disk center hole and a positioning hole are aligned with the rotational center position of the rotary table and its eccentric position. A simple blood analyzer characterized by having a shaft head and a pin.