JPH02164803A - Stable microbicidal composition - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed Description of the Invention] Industrial Field of Application The present invention relates to 3-iodo-2-propynyl N-butyl carbamate (hereinafter referred to as I) (sometimes abbreviated as BC).
The present invention relates to a stable fungicidal composition useful as an industrial fungicide, characterized in that it contains white carbon and white carbon.

Problems to be Solved by the Prior Art and the Invention IPBc exhibits a strong antibacterial effect against microorganisms such as bacteria, molds, and yeasts, particularly against molds and yeasts, and is known as an excellent industrial antifungal agent. However, since IPBC is unstable in solution preparations, it is stabilized by adding epichlorohydrin (US Patent No. 4,276.21).
1). Even if it is in powder form, if it is prepared by diluting it with fine mineral powder such as clay, talc, bentonite, or diatomaceous earth in the form of a powder, wettable powder, or single microgranule, it may cause damage over time depending on the type of diluent. A phenomenon in which IPBC decomposes is observed, and the selection of a diluent is important in order to obtain a stable preparation. However, many of these diluents are natural products;
Quality is not necessarily constant. I want to do it, IP
It is very difficult to select a diluent that does not degrade BC. Furthermore, it is undesirable from the viewpoint of formulation costs that the range of selection is limited to a specific diluent.

This phenomenon has also been observed with organophosphorus insecticides and agricultural fungicides such as benlate [methyl-i(butylcarbamoyl)-2-benzimidazole carbamate], and the stabilization of each has been investigated (Special Publications Publication No. 3). /l-8
149, Special Publication No. 57-11282).

However, IPBC is known to have excellent antifungal properties, and its effect is relatively short-lasting, making it necessary to use a mixture in order to obtain a long-term antifungal effect. Therefore, benzimidazole compounds, which are ineffective against some molds but have excellent long-lasting antibacterial effects, such as 2-
A mixture with penzimitazole carbamic acid lower alkyl ester, 2-(4thiazolyl)benzimidazole, etc. was investigated, but it was found that the decomposition of IPBC tends to be accelerated. The object of the present invention is to
An object of the present invention is to provide a germicidal composition that is more efficient and effective in stabilizing the bacteria.

Means for Solving the Problems As a result of intensive studies on preventing the decomposition of IPBC, the present inventor surprisingly discovered that the stable bactericidal composition of the present invention is a white car that tends to promote the decomposition of normally unstable compounds. Depending on the intended use, a mixture of IPBC and white carbon can be applied directly or diluents commonly used with solid disinfectants, such as clay, talc,
It is mixed with one or a mixture of two or more of mineral fine powders such as hentonite and diatomaceous earth, and if necessary, emulsifiers and dispersants, such as soaps, sulfuric esters of higher alcohols, alkyl sulfonic acids, etc. Sodium lignin sulfonate), alkylaryl sulfonic acid, quaternary ammonium salts, fatty acid esters, various surfactants such as polyalkylene oxide type or anhydrosorbitol type, binders such as dextrin, spreading agents, wetting agents, By adding a stabilizer or the like as an auxiliary agent, it may be used in solid dosage forms such as powders, wettable powders, fine granules, and granules.

The amount added as a stabilizer for white carphone is IPBc.
About 01-50 parts by weight, preferably 1-50 parts by weight per 1 part by weight of
The amount is about 20 flI parts, more preferably about 0.6 to 5 parts by weight.

It was discovered that PON exhibits an excellent effect on preventing the decomposition of IPBC, and after further study, the present invention was completed.

That is, the present invention provides 3-iodo-2-propynyl N
- A stable germicidal composition characterized in that it contains butyl carbamate and white carbon.

The composition of the present invention in which white carbon is blended with IPBC is a composition that suppresses the decomposition of TPBC, exists stably, endures long-term storage, and exhibits sufficient antibacterial action. Furthermore, even in the mixture of IPBC and other benzimidazole compounds as described above, the decomposition of IPBC is suppressed and stabilized by blending white carbon. Such admixtures are also within the scope of this invention.

The IPBC used in the present invention has the formula %formula% It is a compound represented by

White carbon may also be used, such as commercially available white carbon.

When preparing the above-mentioned formulation, the amount of IPBC to be blended depends on the purpose and dosage form, but is usually about 0.1 to 90 parts by weight, preferably 0.1 to 90 parts by weight, based on 100 parts by weight of the entire formulation. ．．
The amount is 5 to 50 parts by weight, more preferably 1 to 20 parts by weight.

Furthermore, the composition of the present invention can be blended with various active substances other than IPBC, particularly bactericides, insecticides, deterioration inhibitors, etc., and used in the same manner as known fungicides. Such disinfectants that may be mixed into the composition of the present invention include organochlorine, bromine or iodine disinfectants, organophosphorus disinfectants, benzimidazole disinfectants, organic sulfur disinfectants, Examples of insecticides include phenolic fungicides and antibiotics, and examples of insecticides include natural insecticides, carbameth insecticides, and organophosphorus insecticides.

In particular, sterilizing compositions containing 2-henzimidazole-rubamic acid lower alkyl esters such as 2-penzimitazole-rubamic acid methyl ester and 2-<4 thiazolyl) benzimidazole and IPBC as the sterilizing substances are in this book. This is a more preferred embodiment of the invention.

When making a mixture with other active ingredients, the total amount of active ingredients is usually about 0.2 to 90 parts by weight based on 100 parts by weight of the entire preparation, depending on the active ingredients to be mixed and l'l. parts, preferably about 2 to 20 parts by weight. Also 11-) B C
For example, in the case of a mixture with the above-mentioned henzimitasol and ruhamic acid lower alkyl ester, the mixing ratio of the former and the other active ingredients is 1. The amount of the latter is 0.02 to 50 parts by weight, preferably 0.02 to 5iij 1 part.

The sterilizing composition of the present invention is usually produced by mixing 1)) I3C and White Horn Pone using a mixer or the like in a conventional manner.

Furthermore, if necessary, the above-mentioned diluent, auxiliary agent, and other condensable components can be blended and combined, and then the preparations in the various dosage forms described above can be produced by a conventional method. For example, in the case of wettable powders, it is usually mixed in a mixer and then ground in a grinder.
Furthermore, the sterilizing composition of the present invention is mixed with a hydrating powder, moxibustion-9, and has poor oral stability of IPBc, as shown in the following test examples.

Since the decomposition of IPBC is prevented according to the present invention, it is possible to form a mixture with other disinfectants, thereby providing a mixture that has excellent connectivity and exhibits a wide range of bactericidal and antifungal effects.

EXAMPLES Next, the present invention will be explained in more detail with reference to examples, but the present invention is not limited to these examples.

Example 1 (Wettable powder) 2.5 parts of IPBC (the following parts represent parts by weight), 2-benzimitazole carbamic acid methyl ester (hereinafter -1:
B (abbreviated as CM) 2.5 parts, white carbon 3 parts, New Calgen Bx-C (front car oil (a) M product) 4
1 part of lignin sulfonic acid sorter and 87 parts of clay were mixed in a mixer, and then ground and combined in a pulverizer to obtain a wettable powder.

Example 2 (Granules) 11] 2.5 parts of BC, 5 parts of BGM2, and a pot powder can be used. Furthermore, in the case of granules, they are generally manufactured by mixing the ingredients, adding water, etc., kneading them, and going through steps such as granulation and drying, but the method is not limited to the above-mentioned manufacturing method.

Originally, Ming's disinfectant compositions can be used for general industrial products or materials, such as adhesives (particularly gypsum plasters, etc.), paints, wood products,
It can be applied to all kinds of industrial products and materials made of organic materials, such as leather, textiles, wall materials, and ceiling materials, and can effectively prevent quality deterioration caused by microorganisms such as mold and yeast.

When applying the bactericidal composition of the present invention, it is possible to add the bactericidal composition in the dosage form described in - directly to the above products or materials, or add a solvent, diluent, filler, etc. as appropriate. It may be diluted and added. The application rate may be adjusted depending on the product or material to which these fungicidal compositions are applied, or the concentration of the active ingredient (in the case of mixtures of IPBC and other active ingredients, the concentration of the total amount) , about 0.001-0.01% by weight, preferably about 0.002-0.01% by weight.

6 parts of one bottle, New Calgen B
Co., Ltd. product), 1 part of lignin sulfonic acid sorter, 8 parts of dextrin, and 76 parts of clay in a mixer, and 12 parts of water.
%, kneaded, granulated with a granulator, and dried with a vibration dryer to form granules.

Example 3 (Granules) II) 5 parts of BC, 6 parts of White Carphone, 4 parts of New Calgen BX'-C (product of Maegya Yushi Co., Ltd.), 7 parts of lignin
, 1 part of Jl/7 ionic acid soda, 8 parts of Textrin,
Mix 76 parts of clay with a mixer, add 12% water and knead.
After granulating with a granulator, it is dried with a vibration dryer to form granules.

Example 4 (Wettable powder) 2.5 parts of IPBC, 2.5 parts of 2-(4-thiazolyl)penzimitazole (TBZ), 6 parts of white carphone,
New Calgen BX-C (Maeksha Yushi Co., Ltd. product) 4 parts,
1 part of lignin sulfonic acid sorter and 84 parts of clay are mixed in a mixer and then pulverized and mixed in a pulverizer to form a wettable powder.

Example 5 (powder) 1PBc2.5 parts, white carbon 6 parts, clay 91
5 parts in a mixer, and then pulverized and mixed in a pulverizer to form a powder.

Comparative example 1 (hydrating agent) 2.5 parts of IPBC, 2.5 parts of BGM, New Calken B
4 parts of X-C (manufactured by Maegya Yushi Co., Ltd.), 1 part of lignin sulfonic acid sorter, and 90 parts of clay were mixed in a mixer, and then pulverized and mixed in a pulverizer to form a wettable powder.

Comparative example 2 (hydrating agent) 2.5 parts of lPBc, 2.5 parts of BGM, 05 parts of PAP (product of Nippon Kagaku Kogyo Co., Ltd.), 4 parts of New Calken BX-C (product of Maeksha Yushi Co., Ltd.), lignin sulphate 1 part of phonic acid sorter and 89.5 parts of clay are mixed in a mixer, and then mixed and pulverized in a pulverizer to obtain a wettable powder.

Comparison flI3 (hydrating agent) 2.5 parts of lPBc, 2.5 parts of BGM, 3 parts of thiourea, 4 parts of New Calken B After mixing 87 parts with a mixer, the mixture is mixed and pulverized with a pulverizer to obtain a wettable powder.

Comparative Example 4 (Powder) 2.5 parts of IPBC and 97.5 parts of clay were mixed in a mixer and then pulverized and mixed in a pulverizer to form a powder.

Test Example [Effect of preventing decomposition of IPBC in BGM mixed preparations] For each composition of Examples and Comparative Examples, the remaining amount of IPBC after oral administration at 40°C was measured by high performance liquid chromatography (HPLC). The effect of preventing the decomposition of IPBC by adding carphone was investigated. The test results are shown in the deletion.

(Margins below) From the above results, the compositions of Examples 1 and 2 had a higher I PBC than the composition of Comparative Example 1, which did not contain white carbon.
It can be seen that the residual rate is very high and the stability is remarkably excellent. On the other hand, the organic phosphor stabilizer PA of Comparative Example 2
P has little effect on stabilizing I PBC, and thiourea, a stabilizer for benlate in Comparative Example 3, actually promotes decomposition.
It can be seen that the content of IPBC decreases already immediately after formulation.

Moreover, the composition of Example 5 of the present invention also had a higher I than the composition of Comparative Example 4 to which white carbon was not added.
It can be seen that PBC remains extremely stable over time.

Agent Patent Attorney Iwa 1) Hiroshi

Claims (3)

[Claims] (1) A stable sterilizing composition containing 3-iodo-2-propynyl N-butyl carbamate and white carbon. The composition according to claim 1, further comprising (2) 2-benzimidazole carbamic acid lower alkyl ester or a salt thereof. (3) The composition according to claim 1, further comprising 2-(4-thiazolyl)benzimidazole or a salt thereof.